• Title, Summary, Keyword: Burning mouth syndrome

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Change of the Amylase Secretion on the Rat Submandibular Gland in the Restraint Stress Condition (구속스트레스에 의한 백서 악하선의 Amylase 분비 변화)

  • Koo, Han-Mi;Au, Q-Schick;Chun, Yang-Hyun;Hong, Jung-Pyo
    • Journal of Oral Medicine and Pain
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    • v.32 no.1
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    • pp.57-67
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    • 2007
  • In currently, stress diseases are increased that present several sign and symptoms. Under stress condition, there are dry mouth, burning mouth syndrome, oral mucosa diseases and halitosis more frequently. Changing of salivary proportion is checked in almost patients with changing of function and structure in salivary gland. This study purpose are what effect stress does on salivary gland, and a-amylase on salivary gland. This study was resulted that 1. Under restraint stress, acinar cells are vacuolization and changing of intercellular spaces are separated, and peripheral tissues of duct are changed 2. Acinar cells were shrunk after 3 hours under restraint stress, intercellular space was separated after 6hours, peripheral tissues of duct started to change after 72 hours, and acinar cells and peripheral tissues of duct were all severely changed after 168hours. 3. In immunohistochemical study, amylase reaction was showed partially and irregularly after 3 hours, was getting little milder after 6 hours. And amylase reaction was gradually increased from the time of 12 hours after experiment up to the time of 48 hours after experiment. But after 168 hours, amylase appearance was diminished. According this result, emotional stress can change of salivary gland structure, and amylase secretion, the important digestive enzyme from salivary gland is changed and it is supposed to make digestive disorder and to make halitosis efficiency. So, we need to study about secretion of amylase.

Clinical Features Affecting the Efficacy of Systemic Clonazepam for Management of Burning Mouth Syndrome (구강작열감증후군의 치료를 위한 전신적 클로나제팜의 투여 시 환자의 임상적 특징에 따른 효능의 차이에 관한 연구)

  • Min, Bo-Kyong;Jung, Jae-Kwang;Choi, Jae-Kap
    • Journal of Oral Medicine and Pain
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    • v.37 no.3
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    • pp.161-167
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    • 2012
  • Burning mouth syndrome(BMS) is defined as chronic, painful burning sensation in the oral mucosa. Treatments for BMS include medication and psychiatric interventions. Capsaicin, alpha-lipoic acid, and topical and systemic clonazepam showed more effective in reducing the symptoms of BMS in the previous studies. The purpose of this study is to evaluate of the therapeutic efficacy of systemic clonazepam in BMS and to elucidate the relationships between such a efficacy and various clinical features, including age, pain intensity, pain duration, previous dental history and condition of oral mucosa. A retrospective clinical records audit was performed of patients diagnosed with BMS between January 2011 and August 2012. Patients were prescribed 0.5 mg clonazepam two times daily. Pain was assessed by patients on an 11-point numeric rating scale (NRS; 0 to 10) before and 1-2 weeks after systemic administration of clonazepam. The efficacy of clonazepam was evaluated in terms of patient's age, initial pain intensity, pain duration, presence or absence of precipitating event, condition of the tongue, presence or absence of denture. A total of 50 patients (46 women, 4 men) were included in this study. The patients were divided into two or three groups according to above clinical features. The amount of mean NRS reduction in patients with severe initial pain was $3.33{\pm}2.74$, whereas that in patients with mild initial pain was $1.64{\pm}1.54$. The amount of mean NRS reduction in oldest patients was $3.53{\pm}1.94$ (${\geq}$70yrs), and those in another younger patients were $2.88{\pm}1.80$(< 60yrs) and $1.54{\pm}2.86$(60yrs ${\leq}$ age < 70yrs), respectively. It was concluded that the older patients and the patients with higher intensity of initial pain tend to show better efficacy of clonazepam. However, There were no statistically significant differences according to pain duration, presence or absence of precipitating events, tongue fissuring, and wearing dentures.

Low-Level Laser Therapy in Dentistry (임상가를 위한 특집3 - 치과 영역에서의 저출력레이저요법)

  • Im, Yeong-Gwan;Kim, Ji-Yeon;Kim, Byung-Gook
    • The journal of the Korean dental association
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    • v.49 no.11
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    • pp.679-687
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    • 2011
  • Low-level laser therapy (LLLT) is the application of light to pathology to promote tissue regeneration, reduce inflammation, and relieve pain. LLLT has a photochemical effect whereby the light is absorbed and exerts a chemical change. The clinical applications of LLLT include improvement in wound and bone healing processes, control of pain and tooth hypersensitivity, modulation of periodontal inflammation, the prevention and treatment of cancer therapy-induced oral mucositis, management of burning mouth syndrome, and improvement in temporomandibular disorder symptoms. Further research is needed to better elucidate the cellular mechanisms of LLLT and provide a solid scientific basis for the clinical application of LLLT in dentistry.

Analysis of Female Lichen Planus Patients with SCL-90-R (SCL-90-R을 이용한 여성 편평태선 환자분석)

  • Kim, Ik-Hwan;Kim, Chang-Yong;Kim, Kyung-Hee;Huh, Joon-Young;Ok, Soo-Min;Jeong, Sung-Hee;Ahn, Yong-Woo;Ko, Myung-Yun
    • Journal of Oral Medicine and Pain
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    • v.36 no.4
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    • pp.235-243
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    • 2011
  • Personal characteristics of female lichen planus patients were analyzed psychologically using the SCL-90-R. The subjects were 51 female lichen planus patients who visited Orofacial pain clinic of the Department of Oral Medicine, Pusan National University Yangsan Dental Hospital from 2009 to 2010. The female control group were collected from Pusan Kyungnam area. 45 female burning mouth syndrome patients, 36 female temporomandibular joint disorder patients, 23 female trigeminal neuralgia patients were subjected at Orofacial pain clinic of the Department of Oral Medicine, Pusan National University Hospital from 1998 to 2010. 1. Lichen planus patients group, burning mouth syndrome patient group, temporomandibular joint disorder patients group, trigeminal neuralgia patients group and the control group were within normal range. 2. The T-Scores of O-C, IS, DEP, ANX, HOS, PHOB in lichen planus patients group were significantly higher than in the control group. 3. The T-Scores of O-C, IS, DEP, ANX, PAR, PSY in chronic group was significantly higher than in acute group. 4. The T-Scores of SOM, O-C, DEP, ANX, in burning mouth syndrome patients group was significantly higher than in lichen planus patient group. 5. There was no significant T-score difference between lichen planus group and temporomandibular joint disorder patient group. 6. There was no significant T-score difference between lichen planus group and trigeminal neuralgia patient group.

Correlation between Qi-Stagnation and Pressure Pain Threshold on $CV_{17}$ (Danzhong : 膻中) in Burning Mouth Syndrome Patients - In the Perspective of Quantification of Pressure Pain Threshold on $CV_{17}$ by using Algometer - (구강작열감증후군 환자에서 기울과 전중($CV_{17}$)압통의 상관성 - Algometer를 이용한 전중압통의 정량화 측면에서 -)

  • Kang, Kyung;Kim, Jin-Sung;Seon, Jong-Ki;Son, Ji-Hee;Kim, Ju-Yeon;Jang, Seung-Won;Son, Ji-Young;Lee, Hyun-Ju;Ryu, Bong-Ha
    • The Journal of Internal Korean Medicine
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    • v.33 no.4
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    • pp.498-510
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    • 2012
  • Objectives : This study was designed to find out whether there is a correlation between qi-stagnation score and pressure pain threshold (PPT) on acupuncture point $CV_{17}$ in burning mouth syndrome (BMS) patients. Methods : Thirty BMS patients who newly visited Oral Disease Clinic at the Kyung Hee University Korean Medicine Hospital were surveyed. The subjects were evaluated on age, illness duration, sex, self-assessed severity of BMS, qi-stagnation score, and PPT on 3 acupuncture points ($CV_{17}$, Rt. $SP_9$, Lt. $SP_9$). Results : There was significant correlation between age and PPT on $CV_{17}$ (p=0.005). Therefore, partial correlation analysis with age as control variable was done, and the result showed significant correlation between qi-stagnation score and PPT on $CV_{17}$ (p=0.001). Qi-stagnation diagnostic point by PPT on $CV_{17}$ was suggested as 3.8056 $kg/cm^2$ based on the fact that diagnostic score is 28.50 in the qi-stagnation questionnaire. Furthermore, considering that PPT is effected by age, we could attain qi-stagnation diagnostic equation of PPT on $CV_{17}$, that is suggested as $0.047{\times}(age)+0.848kg/cm^2$. PPT of 3 acupuncture points ($CV_{17}$, Rt. $SP_9$, Lt. $SP_9$) was compared, and the result showed that PPT was significantly lower on $CV_{17}$ (w/Rt $SP_9$: p=0.022, w/Lt. $SP_9$: p=0.012). Also, significance and correlation coefficient with qi-stagnation were higher on $CV_{17}$ (p<0.001, r=-0.620) than Rt. $SP_9$ (p=0.023, r=-0.413) or Lt. $SP_9$ (p=0.014, r=-0.444). Conclusions : The result of this study suggested that PPT on $CV_{17}$, measured quantitatively by algometer, had a strong correlation with qi-stagnation score in BMS patients. Therefore, the study showed that $CV_{17}$ can be a useful acupuncture point in diagnosing qi-stagnation by measuring PPT in BMS patients.

Quality of Life in Korean Patients with Burning Mouth Syndrome (한국인을 대상으로 한 구강작열감증후군 환자의 삶의 질 평가)

  • Park, Ju-Hyun;Kwon, Jeong-Seung;Choi, Jong-Hoon;Ahn, Hyung-Joon
    • Journal of Oral Medicine and Pain
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    • v.36 no.2
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    • pp.81-89
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    • 2011
  • The purpose of this study was to evaluate the individually perceived quality of life in Korean patients with BMS using two questionnaires : the Medical Outcome Short Form Health Survey Questionnaire (SF-36) and the Oral Health Impact Profile (OHIP-49). This cross-sectional study included sixty subjects diagnosed with BMS and sixty healthy subjects as controls. All subjects in this study completed two questionnaires: the Medical Outcome Short Form Health Survey Questionnaire (SF-36) and the Oral Health Impact Profile (OHIP-49), which had been translated into Korean and subsequently validated for use in Korea. All of the subscales in the SF-36 exhibited significantly lower scores in BMS patients than control groups. Comparison of the mean SF-36 scores between the two groups revealed the greatest differences to be for the subscales of physical pain and role emotional (role limitations due to emotional problems). The mean score on each subscale of the OHIP-49 was significantly higher in BMS patients than control groups. Comparison of the mean OHIP-49 scores between the two groups revealed the greatest difference to be for the subscale of physical pain. These findings demonstrated that BMS had an impact on various components of a patient's quality of life. BMS patients exhibited more impaired results and a poorer quality of life than control groups.

Self-inflicted Tongue Ulceration in a Patient with Tourette Syndrome: A Case Report (뚜렛 증후군 환자에서 자해로 인한 혀 손상 : 증례 보고)

  • Lee, Kkotnim;Kim, Miae;Hwang, Inkyung;Park, Jihyun;Mah, Yonjoo
    • THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY
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    • v.43 no.3
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    • pp.327-333
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    • 2016
  • Tourette's syndrome is a chronic neuropsychiatric disorder characterized by the presence of vocal and multiple motor tics. Tics are defined as brief, intermittent, repetitive, unpredictable, purposeless, and stereotyped movements or sounds. Some patients experience physical pain from intense and complex tics. In addition, motor tics can result in self-injury which is a common feature of Tourette's syndrome. A 9-year-old boy was referred by the department of neuropsychiatry because of a severe tongue laceration. His parents reported that he had been biting his tongue irregularly for 2 months before referral and suffered from an intense burning sensation. The repeated biting resulted in ulcers on the tongue, which quickly worsened and led to progressive difficulty chewing and swallowing food. We offered to give him a two-piece removable appliance to limit tongue biting; it was made of soft silicone and fitted to both the maxillary and mandibular arches. As we emphasized that the device could help alleviate his pain, he agreed to accept it and adapted well. Just 3 weeks later, his tongue lesions had healed significantly.

Clinical Characteristics of Patients with Taste Disorders (미각 장애 환자의 임상적 특성에 관한 연구)

  • Lee, Eun-Jin;Park, Won-Kyu;Nam, Jin-Woo;Yun, Jong-Il;Kho, Hong-Seop
    • Journal of Oral Medicine and Pain
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    • v.34 no.4
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    • pp.341-351
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    • 2009
  • There is tremendous variability in the ways patients present with taste problems. Because of complex and multifactorial etiological background, it is not simple to evaluate patients with taste disorders. Accurate assessment of patients' status by prudent, thorough history taking and symptom analysis is the most essential for exact diagnosis of taste disorders. The aim of this study was to investigate the clinical characteristics of patients with taste problems as a primary complaint. Consecutive series of 50 patients (12 males and 38 females, mean age $53.6\;{\pm}\;14.7$ years) were included for the present study. All subjects were requested to complete a comprehensive questionnaire. Clinical evaluation procedures included oral examination, interview, questionnaire analysis, panoramic radiography, blood test and measurement of salivary flow rate. The obtained results were as follows: 1. Among the patients, 36 patients (72%) complained of oral mucosal pain or burning sensation. Of these patients, 18 patients (36%) were diagnosed as burning mouth syndrome. 2. Nineteen patients (38%) complained of subjective oral dryness. The flow rate of unstimulated whole saliva was less than 0.1 mL/min in 14 patients (28%) and 17 (34%) had a stimulated whole salivary flow rate of less than 0.5 mL/min. 3. Among the types of taste disorders, hypogeusia, the most frequently reported, was found in 25 patients (50%), dysgeusia in 18 patients (36%), phantogeusia in 15 patients (30%), hypergeusia in 10 patients (20%), and ageusia in 5 patients (10%). Nineteen patients (38%) reported more than one type of taste disorder and the most frequent combination was dysgeusia + hypogeusia (n=6, 12%). 4. Based on data from the medical and dental histories and examinations, the patients were assigned to 12 probable causal categories. Taste disorders due to oral mucosal diseases and idiopathic taste disorder were the most frequent (n=9; 18%, each), followed by psychogenic taste disorder (n=8; 16%), drug-induced taste disorder (n=7; 14%), and taste disorder due to dry mouth (n=6; 12%). These 5 categories of taste disorder accounted for 78% of all cases in this study.

A Study on the Clinical Characteristics of Burning Mouth Syndrome (구강내 작열감 증후군의 임상적 특징에 관한 연구)

  • Jin-Woo Chung;Ki-Yong Hyun;Sung-Woo Lee
    • Journal of Oral Medicine and Pain
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    • v.19 no.2
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    • pp.7-23
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    • 1994
  • 구강내 작열감 증후군은 객관적 징후없이 구강점막에 작열감을 나타내는 만성동통장애이다. 다양한 원인요소들이 제시되어 있지만, 이러한 요소들의 관련성에 대해서는 아직 분명하지 않은 실정이다. 그러므로, 이러한 구강내 기능이상의 근본적이고 효과적인 치료를 위해서는 다양한 임상적 관찰과 원인요소의 분석등이 계속 연구 조사되어져야 할 것이다. 저자는 구강내 작열감 증후군의 증상을 호소하는 112명의 환자의 임상적 특징에 대해 조사하고자, 환자군과 대조군에 대해 구강내 작열감 증후군에 관한 설문조사 및 구강검사와 혈액학적 검사를 시행하였으며, 점도계를 사용하여 구강내 작열감 증후군 환자의 자극이 전타액의 점도를 측정하였다. 또한, 환자의 심리적 요인을 파악하고자 간이정신진단검사를 실시한 결과 다음과 같은 결론을 얻었다. 1. 구강내 작열감 증후군은 주로 페경기 전후의 여성에서 많이 나타났으며, 호발부위는 혀, 치주 및 치조점막, 구개, 협점막의 순이었다. 2. 구강내 작열감 증후군 환자에게서 대조군 비해 구강건조감, 미각 및 수면장애, 빈혈, 소화기 장애, 두통과 기타 다른 신체불편감의 호소 등이 더 많이 나타났다. 3. 혈액학적 검사결과, 구강내 작열감 증후군 환자중의 26%와 12%에서 각각 혈중 엽산농도와 철분농도의 저하를 나타냇다. 4. 자극시 분비된 전타액의 점도는 40대와 50대이상의 연령군에서 구강내 작열감 증후군 환자가 정상인에 비해 높았다.(p<0.01). 5. 구강내 작열감 증후군 환자군의 간이정신진단검사의 각 증상차원 및 전체지표의 T점수의 평균치는 정상범위내에 있었으며, 신체화(SOD)와 우울 (DEP)차원의 평균치가 가장 높았다.

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