• Title, Summary, Keyword: Clinical form

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A case report form based on Shanghanlun six clinical patterns and provisions (『상한론(傷寒論)』 육경(六經) 제강(提綱)과 조문(條文)에 근거한 증례(證例) 작성법(作成法))

  • Lim, Jae Eun;Lee, Seong Jun
    • 대한상한금궤의학회지
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    • v.5 no.1
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    • pp.1-17
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    • 2013
  • Objective : The purpose of this study is to help korean medical doctors write case reports based on Shanghanlun six clinical patterns and provisions accurately and effectively. Methods : To achieve the purpose of this study, we reviewed Shanghanlun six clinical patterns and provisions. After this, we formed a case report form according to the importance of Korean medical terms in Shanghanlun. Results : Through this study, we got the consistency and unity of case reports based on Shanghanlun six clinical patterns and provisions. Conclusions : This case report form is designed for gathering clinical data which are organized clearly according to the diagnostic system based on Shanghanlun six clinical patterns and provisions.

Long-Term Clinical Course of a Korean Patient with Chronic Neuropathic (type III) Gaucher Disease

  • Lee, Jun Hwa
    • Journal of Interdisciplinary Genomics
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    • v.1 no.2
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    • pp.15-18
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    • 2019
  • Gaucher disease (GD) is an autosomal recessive inborn error of metabolism resulting from a deficiency in ${\beta}$-glucocerebrosidase (GBA) activity that leads to the accumulation of glucocerebroside in macrophages in multiple organs, such as the bone marrow, liver, spleen, and brain. GD can be classified into three clinical types: type 1 (non-neuropathic form, OMIM #230800); type II (acute neuropathic form, OMIM #230900); and type III (chronic neuropathic form, OMIM #231000). Type III is the subacute form of neuropathic GD. The best available treatment for GD is long-term enzyme (imiglucerase) replacement therapy (ERT) performed every two weeks. This report describes the long-term clinical course of a patient with type III GD who was treated with ERT for 18 years.

A Neonatal Form of Alexander Disease Presented with Intractable Seizures and Obstructive Hydrocephalus

  • Yoo, Il Han;Hong, Won Gi;Kim, Hunmin;Lim, Byung Chan;Hwang, Hee;Chae, Jong-Hee;Kim, Ki Joong;Hwang, Yong Seung
    • Journal of Genetic Medicine
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    • v.10 no.2
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    • pp.113-116
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    • 2013
  • Alexander disease is a rare degenerative leukodystrophy caused by dominant mutations in glial fibrillary acidic protein (GFAP). The neonatal form of Alexander disease may manifest as frequent and intractable seizures or obstructive hydrocephalus, with rapid progression leading to severe disability or death within two years. We report a case of a 50-day-old male who presented with intractable seizures and obstructive hydrocephalus. His initial magnetic resonance imaging (MRI) suggested a tumor-like lesion in the tectal area causing obstructive hydrocephalus. Despite endoscopic third ventriculostomy and multiple administrations of antiepileptic drugs, the patient experienced intractable seizures with rapid deterioration of his clinical status. After reviewing serial brain MRI scans, Alexander disease was suspected. Subsequently, we confirmed the de novo missense mutation in GFAP (c.1096T>C, Y366H). Although the onset was slightly delayed from the neonatal period (50 days old), we concluded that the overall clinical features were consistent with the neonatal form of Alexander disease. Furthermore, we also suspected that a Y366 residue might be closely linked to the neonatal form of Alexander disease based on a literature review.

Tumor Therapy Applying Membrane-bound Form of Cytokines

  • Kim, Young-Sang
    • IMMUNE NETWORK
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    • v.9 no.5
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    • pp.158-168
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    • 2009
  • Tumor therapy using cytokines has been developed for last two decades. Several recombinant cytokines and tumor cell vaccines produced by cytokine gene transfer have been in clinical trials, but several side effects hamper routine clinical applications. Many cytokines are originally expressed as membrane-bound form and then processed to secretory form exerting paracrine effects. Though functional differences of these two types of cytokines are elusive yet, the membrane-bound form of cytokine may exert its effects on restricted target cells as a juxtacrine, which are in physical contacts. With the efforts to improve antitumor activities of cytokines in cancer patients, developing new strategies to alleviate life-threatening side effects became an inevitable goal of tumor immunologists. Among these, tumor cell vaccines expressing cytokines as membrane-bound form on tumor cell surface have been developed by genetic engineering techniques with the hope of selective stimulation of the target cells that are in cell-to-cell contacts. In this review, recent progress of tumor cell vaccines expressing membrane-bound form of cytokines will be discussed.

Mandibular Clinical Arch Forms in Koreans with Normal Occlusions (한국인 정상교합자의 하악 치열궁 형태)

  • Yun, Young-Kuk;Kook, Yoon-Ah;Kim, Seong-Hoon;Mo, Sung-Seo;Cha, Kyung-Suk;Kim, Jong-Ghee;Tae, Ki-Chul
    • The korean journal of orthodontics
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    • v.34 no.6
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    • pp.481-487
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    • 2004
  • The purpose of this study was to clarify morphologic characteristics between mandibular clinical arch forms in Koreans with normal occlusions. The study included data from 102 Koreans. The most facial portion of 13 proximal contact areas was digitized from photocopied images of the mandibular dental arches. Clinical bracket points were calculated for each tooth based on mandibular tooth thickness data. Four linear and two proportional measurements were taken. The dental arches were classified into ovoid, square and tapered forms. The frequency distributions of the three mandibular arch form classifications were determined and compared between male and female subjects. No significant differences in arch form size were found between the sexes. However, there were a few differences in molar width. It was useful to classify mandibular clinical arch forms present in normal occlusion samples into ovoid, square and tapered categories. The frequency of the ovoid form was the highest, and that of the square form was the second highest. The tapered arch form was found in less than 10 percent of subjects. No significant differences in their frequency distributions and dimensions were shown between males and females.

Clinical presentation with 『PangYakHapPyon(方藥合編)』 in Korean medicine (방약합편과 한의학 임상표현)

  • Ju, Da Hyun;Kim, Byoung Soo
    • The Journal of Korean Medicine
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    • v.40 no.1
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    • pp.1-11
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    • 2019
  • Objectives: The aim of this study is to introduce the Clinical presentation and announce the importance of developing Clinical presentation of Korean medicine and suggest about development direction of Clinical presentation of Korean medicine. Methods: To Investigate the Clinical presentation used in western medicine. I think that Clinical presentation of Korean medicine is a systematic list of Korean medicine symptoms and a standard syndrome differentiation and treatment(辨證論治). So I would like to offer "PangYakHapPyon(方藥合編)" as a basis for developing Clinical presentation of Korean medicine. Results: The clinical presentation term has become widespread in use at Calgary Medical college. Calgary Medical college created a list of 120 clinical presentations In 1991. In Korea, 101 clinical presentations were made in 2016. "PangYakHapPyon(方藥合編)" has been used effectively for over 130 years and widely used in the public. In addition, "PangYakHapPyon(方藥合編)" is summarized in the symptoms and prescriptions that occur frequently in Korea. Conclusions: For the globalization and standardization of Korean medicine, Clinical presentation of Korean medicine should be developed. The overall form of Clinical presentation of Korean medicine uses the form of Clinical presentation of Canada and a standard syndrome differentiation and treatment(辨證論治) for diagnosis and treatment is based "PangYakHapPyon(方藥合編)".

Status Report on Usage of Electronic Case Report Form for Clinical Study (임상연구 전자증례기록지의 사용 현황 조사)

  • Baek, Young-Hwa;Kim, Ho-Seok;Lee, Si-Woo;Jin, Hee-Jeong
    • The Journal of the Korea Contents Association
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    • v.12 no.12
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    • pp.714-720
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    • 2012
  • With the help of information technology, it is the most important to collect clinical data correctly in clinical trials. For this, recently, in many pharmaceutical companies and Clinical Research Organizations (CRO) have tried to adopt an Electronic Case Report Form (eCRF) system. The eCRF system is a computerized system designed for collecting and managing clinical data in clinical trials. Although the eCRF is recognized as a significant system for clinical trials, until now there are no widely useable, due to the huge effort and expense at the initiatory stage of adopting eCRF system. In this study, we inquired the use of eCRF system developed for clinical trial at Korea Institute of Oriental Medicine. Especially, we focused on the time required for entering clinical data into the eCRF, hours of use, and the number of queries according to the time flow.

Using a Cellular Automaton to Extract Medical Information from Clinical Reports

  • Barigou, Fatiha;Atmani, Baghdad;Beldjilali, Bouziane
    • Journal of Information Processing Systems
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    • v.8 no.1
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    • pp.67-84
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    • 2012
  • An important amount of clinical data concerning the medical history of a patient is in the form of clinical reports that are written by doctors. They describe patients, their pathologies, their personal and medical histories, findings made during interviews or during procedures, and so forth. They represent a source of precious information that can be used in several applications such as research information to diagnose new patients, epidemiological studies, decision support, statistical analysis, and data mining. But this information is difficult to access, as it is often in unstructured text form. To make access to patient data easy, our research aims to develop a system for extracting information from unstructured text. In a previous work, a rule-based approach is applied to a clinical reports corpus of infectious diseases to extract structured data in the form of named entities and properties. In this paper, we propose the use of a Boolean inference engine, which is based on a cellular automaton, to do extraction. Our motivation to adopt this Boolean modeling approach is twofold: first optimize storage, and second reduce the response time of the entities extraction.

Successful Treatment of Lupoid Cutaneous Leishmaniasis with Glucantime and Topical Trichloroacetic Acid (A Case Report)

  • Nilforoushzadeh, Mohamad Ali;Sadeghian, Giti;Jaffary, Fariba;Ziaei, Hengameh;Shirani-Bidabad, Liela;Mahzoni, Parvin
    • The Korean Journal of Parasitology
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    • v.46 no.3
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    • pp.175-177
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    • 2008
  • Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. Herein, we describe a case of this clinical form that was resistant to 2 courses of treatments: systemic glucantime and then a combination therapy with allopurinol and systemic glucantime. However, marked improvement was seen after a combination therapy with topical trichloroacetic acid solution (50%) and systemic glucantime, and there were no signs of recurrence after 1 yr of follow-up.

Research Design for the Verification of Constitutional Prescription Determinants (체질처방 결정요인 확인을 위한 연구설계)

  • Jin, Hee-Jeong;Kim, Sang-Hyuk;Baek, Young-Hwa;Jang, Eun-Su;Ryu, Jong-Hyang;Lee, Si-Woo
    • Journal of Sasang Constitutional Medicine
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    • v.27 no.2
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    • pp.222-230
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    • 2015
  • Objectives The purpose of this study is to design a research to find clinical factors involved in the decision-making process for determining the constitutional prescription based on prospective clinical data. Methods We have created a draft of the case report form. Therefore, seven constitutional experts was interviewed for additional items to be important used to determine the constitutional prescription in clinic. Interviews were done from December 2012 to March 2014, experts per person 2-3 times, took time of about 120 minutes per interview. Since then, we developed the final case report form through the expert meeting. At the same time, the developing the electronic case report form (eCRF) and the protocol to collect constitutional treatment cases was also discussed. Results & Conclusions The items of the case report form were subject general, lifestyle, health measurement, record of expert, prescription and evaluation after medication. The part of the clinical symptoms of the record of expert allowed to be recorded in the 5-point scale for the collection of quantitative data as much as possible. Assuming a re-visit of the patient, if necessary, twice the recording were to be possible. At the same time, the eCRF and the protocol to collect constitutional treatment cases were also developed. In this study, it will be able to more objectively standardize the medical decision making process that the experts of constitutional prescription decision. As a result, it will be possible to provide the standardized constitutional medical services.