• Title, Summary, Keyword: Crohn disease

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Surgical treatment of perianal fistula in Crohn's disease (크론병에서 복잡성 항문주위 샛길의 수술적 치료)

  • Kim, Sohyun
    • Yeungnam University Journal of Medicine
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    • v.34 no.2
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    • pp.169-173
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    • 2017
  • Perianal Crohn's disease is a major problem that impair quality of life. This article reviews the current surgical treatment of Crohn's perianal fistula. Fistulotomy and loose seton are commonly used surgical methods for treatment of perianal Crohn's disease. Mucosal advancement flap and fibrin glue are used in this treatment, despite a lake of controlled trials. Fecal diversion is disturbingly high in complicated complex perianal fistula in Crohn's disease. Ligation of intersphincteric fistula and autologous or allogenic stem cells are new surgical procedures for treatment of Crohn's disease that need further studies. Treatment success might be improved by multimodal treatment and new surgical and medical treatment options.

A Case of Crohn Disease (Crohn병 1례)

  • Kim, Ji-Eun;Kim, Jun-Ho;Lee, Dong-Seok;Kim, Doo-Kwun;Choi, Sung-Min;Kim, Woo-Taek
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.2 no.2
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    • pp.227-232
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    • 1999
  • Crohn disease is a chronic transmural inflammatory disease that may involve any portion of the gastrointestinal tract. An increased incidence of Crohn disease in the general population has been reported, along with a greater than threefold increase of Crohn disease in children under the age of 16 years noted in a recent study. Crohn disease may be seen as early as infancy, but the most common pediatric age of onset is during the teenage period. We experienced a case of Crohn disease in 6 year old male child complained abdominal pain, oral aphthous ulcers, arthralgia, anorexia, and growth failure. A brief review of related literature is also presented.

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A case report of Crohn's disease (크론씨병 치험 1례)

  • Na, Won-Gyung;Yang, Mi-Ra;Lee, Hae-Ja;Park, Eun-Jung
    • The Journal of Pediatrics of Korean Medicine
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    • v.16 no.2
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    • pp.51-58
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    • 2002
  • Crohn's disease is an indolent, chronic inflammatory bowel disease capable of involving the entire alimentary tract. The exact etiology and pathogenesis remain unknown despite a long and intensive research, but the finding of various abnormalities of the immune response in patients with Crohn's disease has led to the concepts that immune mechanism is involved in the pathogenesis of this disease. Recently, we have experienced a case of Crohn's disease. So the purpose of this study is to examine the efficacy of Oriental medicine for Crohn's disease.

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Pediatric Magnetic Resonance Enterography: Focused on Crohn's Disease

  • Lee, So Mi;Kim, Woo Sun;Choi, Young Hun
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.18 no.3
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    • pp.149-159
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    • 2015
  • Crohn's disease is a chronic idiopathic inflammatory disease of the intestines characterized by frequent relapse and remission. It often develops in children and adolescents, who are vulnerable to repeated exposure to ionizing radiations. Magnetic resonance enterography (MRE) is an increasingly important radiation-free imaging modality that is used to evaluate pediatric patients with Crohn's disease. MRE can evaluate extraluminal and extraintestinal abnormalities as well as the status of the bowel wall. In addition, MRE has an advantage in the evaluation of the small bowel involvement. MRE can be used for the initial diagnosis of Crohn's disease, and can aid in the assessment of disease activity and complications such as penetrating and fibrostenotic diseases. The aims of this article are to review the MRE technique for obtaining diagnostic and high-quality images and to discuss interpretations of imaging findings in patients with Crohn's disease.

Recent Trends of Infliximab Treatment for Crohn's Disease

  • Kim, Mi-Jin;Choe, Yon-Ho
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.15 no.1
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    • pp.19-22
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    • 2012
  • Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract and characterized by relapsing and remitting episodes, with progression over time to complications of stricture, fistulas, or abscesses. The etiology is unknown, although the common opinion is that the disease arises from a disordered immune response to the gut contents in genetically predisposed individuals. Infliximab is a mouse-human chimeric antibody against tumor necrosis factor ${\alpha}$, and has proven to be effective in active Crohn's disease for both induction and maintenance therapy. Despite the growing experience with infliximab in Crohn's disease, optimal treatment strategies still need to be determined. The purpose of this review is to summarize the current knowledge on the use of infliximab in Crohn's disease and to discuss the yet-unsolved issues.

Change in the treatment strategy for pediatric Crohn's disease

  • Kim, Mi-Jin;Choe, Yon-Ho
    • Clinical and Experimental Pediatrics
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    • v.53 no.9
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    • pp.830-833
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    • 2010
  • Crohn's disease is characterized by chronic inflammation involving any portion of the gastrointestinal tract. Treating Crohn's disease is a major challenge for clinicians, as no curative therapy currently exists. Pediatric Crohn's disease is characterized by frequent relapses, a wide extent of disease, a high prevalence of extraintestinal manifestations, and a severe clinical course. The classic therapeutic approach is known as the 'step-up' strategy, and follows a progressive course of treatment intensification as disease severity increases. Although this approach is usually effective for symptom control, many patients become either resistant to or dependent on corticosteroids. The efficacy of infliximab suggests that, rather than a progressive course of treatment, early intense induction may reduce complications associated with conventional treatment and improve quality of life. Intensive early therapy with infliximab is known as the 'top-down' strategy. Such therapy offers the potential for altering the natural history of Crohn's disease, and is changing treatment paradigms. However, the relatively new concept of an early aggressive or 'top-down' treatment approach is not yet widely accepted, especially in pediatric patients. The results of our current study demonstrate that early and intensive treatment of pediatric Crohn's disease patients with infliximab, at initial diagnosis, was more effective for maintaining remission and reducing flares.

Oral Symptoms Related to Vitamin B12 Deficiency in a Patient with Crohn's Disease

  • Lee, Joo-Hee;Park, Youn-Jung;Kwon, Jeong-Seung;Kim, Young-Gun;Ahn, Hyung-Joon
    • Journal of Oral Medicine and Pain
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    • v.42 no.1
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    • pp.25-27
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    • 2017
  • Crohn's disease is an inflammatory bowel disease which affects whole gastrointestinal tract from mouth to anus. Crohn's disease may present both oral manifestation and gastrointestinal symptom-abdominal pain, diarrhea, weight loss, anorexia, fever, and growth failure. The prevalence rate of oral manifestation is approximately between 0.5% and 20%. The oral lesion could be the first sign of Crohn's disease. We present a case of Crohn's disease in a patient who did not show typical oral manifestations but had nonspecific aphthous like ulceration and burning sensation for many years. Through this case, we suggest approaches for the diagnosis and treatment of the oral lesion of Crohn's disease.

A Study on the Quality of life of the Patients with Crohn's Disease (크론병 환자의 삶의 질에 관한 연구)

  • Kim, Yu-Na;Kim, Kyung-Hee
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.17 no.4
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    • pp.557-565
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    • 2010
  • Purpose: This study was conducted to investigate the factors influencing the quality of life among the patients with Crohn's disease. Method: Data were collected from 97 Crohn's disease patients between September 17 and October 20 in 2009. The collected data were analyzed by SPSS program. Results: There were significant differences in the participants' quality of life depending on their age, economic status, pain, diarrhea, weight loss, Crohn's disease activity index (CDAI), and use of medications such as antidiarrhotica, steroid, and analgesics. The results also showed the correlations between the participants' qualities of life and thier pain, CDAI, anxiety, depression, perceived health condition, and of body image. Finally, the factors affecting the quality of life in patients with Crohn's disease included anxiety, perceived health state, pain, and CDAI. The explanatory power of these factors was 79.5%. Conclusion: The results imply that controlling the patients' pain and providing emotional support for anxiety reduction are crucial. In a similar vein, tailored nursing interventions considering individual patients' conditions are believed to help the patients positively perceive their disease. A future research, can conduct further investigations of these factors from more diverse perspectives, which is expected to promote more effective nursing strategies for Crohn's disease patients.

Building an Ontology-Based Diagnosis Process of Crohn's Disease Using the Differentiation Rule (감별 규칙을 이용한 온톨로지 기반 크론병 진단 프로세스 정의)

  • Yoo, Dong Yeon;Park, Ye-Seul;Lee, Jung-Won
    • KIPS Transactions on Software and Data Engineering
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    • v.7 no.11
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    • pp.443-450
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    • 2018
  • Crohn's disease, which is recently increasing in Korea, may be seen throughout the gastrointestinal tract and cause various symptoms. In particular, Crohn's disease is especially difficult to diagnose with several symptoms similar to other ulcerative colonic diseases. Thus, some studies are underway to distinguish two or more similar diseases. However, the previous studies have not described the procedural diagnosis process of it, which may lead to over-examination in the process. Therefore, we propose a diagnosis process of Crohn's disease based on the analysis of redundancy, sequential linkage and decision point in the diagnosis of Crohn's disease, so that it enables to identify ulcerative colonic diseases with symptoms similar to Crohn's disease. Finally, we can distinguish the colon diseases that have symptoms similar to Crohn's disease and help diagnose Crohn's disease effectively by defining the proposed process-oriented association as an ontology. Applying the proposed ontology to 5 cases showed that more accurate diagnosis was possible and in one case it could be diagnosed even with fewer tests.

Diagnosis and treatment of Crohn's disease (크론병의 진단과 치료)

  • Kim, Hyun-Soo
    • Journal of the Korean Medical Association
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    • v.60 no.6
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    • pp.484-490
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    • 2017
  • Crohn's disease is a chronic and relapsing disease that is not easily controlled with medications. It is characterized by progressive transmural inflammation, and ultimately leads to stricture and penetrating complications requiring surgery. Over the past decades, the prevalence of Crohn's disease has gradually increased in Korea. Conventional treatments with aminosalicylates, steroids, and immunosuppressants are inadequate to control its symptoms and complications. Biologic therapy shows promise for controlling disease activity and promoting mucosal healing. Despite the development of several medical therapies, the treatment of Crohn's disease remains challenging. Individually tailored treatment according to an endoscopic or symptomatic assessment is required.