• Title, Summary, Keyword: Drug eruptions

Search Result 17, Processing Time 0.034 seconds

A case of Drug Eruptions of Soyangin patient mistreated with Taeumin (- 음인(太陰人) 오치(誤治)로 인하여 약진(藥疹)이 발생한 소양인(少陽人) 환자(患者) 1례(例))

  • Lim, Jin-Ny;Lee, Tae-Gyu;Kim, Sang-Bok;Koh, Byung-Hee;Song, Il-Byung;Jeong, Yong-Jae
    • Journal of Sasang Constitutional Medicine
    • /
    • v.15 no.1
    • /
    • pp.118-122
    • /
    • 2003
  • In this study, it is experienced that Drug eruptions of Soyangin patient mistreated with Taeumin, The patient was 61 years old, female. She entered our hospital for Stroke and sicked Drug eruptions by mistreatment of Taeumin, After we prescribed Yanggyuksanhwatang(凉膈散火湯), had the general improvement of drug eruptions. Drug eruptions is related to Yangdokbalban(陽毒發斑) in Oriental medicine. The Yangdokbalban(陽毒發斑) of Soyangin is classed as Wisuyulliyulbyung(胃受熱裏熱病). This is a kind of dermatitis caused by Wiyul(胃熱). We classified this as Soyangin-Liyuuljeung(小陽人裏熱證) and prescribed Yangdokbaekhotang(陽毒白虎湯) and Yanggyuksanhwatang(凉膈散火湯). In the result, we had the general improvement of Yangdokbalban(陽毒發斑).

  • PDF

Drug eruption by antihistamine mistaken for chronic urticaria in a child

  • Lee, Gun Moo;Chu, Shou-Yu;Kang, Sung Yeon;Kim, Hyo-Bin;Park, Jin-Sung;Kim, Ja Kyoung
    • Clinical and Experimental Pediatrics
    • /
    • v.62 no.2
    • /
    • pp.75-78
    • /
    • 2019
  • Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax [hydroxyzine] or leptizine [levocetirizine]), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and eruptions. Levocetirizine induced wheals in the skin prick test and a rash in the oral drug provocation test. In contrast, ketotifen induced no reaction in the skin prick test but showed a positive reaction in the oral provocation test. Our case report highlights that children can experience the same types of adverse reactions as seen in adults, and cross-reactivity between various antihistamines can occur.

A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test

  • Kim, Jakyoung;Park, Shinyoung;Jung, Chul Min;Oh, Chee Won;Kwon, Jae-Woo
    • Allergy, Asthma & Immunology Research
    • /
    • v.9 no.3
    • /
    • pp.281-284
    • /
    • 2017
  • Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, we performed LTT and a patch test, and successfully proved CS as the offending drug in this patient, who had been treated with multiple anti-Tb drugs. These observations suggest that CS should be considered a possible cause of LDE and that LTT can be an option for the diagnosis of LDE.

A Case of Lichenoid Drug Eruption Caused by Antituberculosis Drug (항결핵제에 의해 유발된 편평태선양 약진 1례)

  • Lee, Soo-Keoung;Choi, Jong-Soo;Kim, Ki-Hong
    • Yeungnam University Journal of Medicine
    • /
    • v.12 no.2
    • /
    • pp.405-411
    • /
    • 1995
  • Lichenoid drug eruption is lichenoid skin eruptions caused by certain drugs and compounds, and can be identical or similiar to lichen planus. A 75-year-old woman who had taken antituberculosis medication(INH, ethambutol, rifampin) for 4 months developed pruritic generalized erythematous papular eruptions on the trunk and extremities, alopecia and nail dystropy. Histopathologic findings were hyperkeratosis, hypergranulosis, hydrophic degenaration of basal layer, band like lymphohistiocytic infiltration in the upper dermis and perivascular lymphohistiocytic infiltration in the deep dermis. She was treated with systemic corticosteroid, and then skin lesion were slightly improved. After termination of antituberculosis medication, skin lesions were markedly improved with residual hyperpigmentation. Alopecia and nail dystrophy were also improved.

  • PDF

A Case of Docetaxel Induced Subacute Cutaneous Lupus Erythematosus (비소세포 폐암환자에서 Docetaxel 투여 중 발생한 아급성 피부 홍반루푸스 1예)

  • Shin, Jung Ar;Huh, Chul Woong;Kwon, Ji Eun;Kim, Hyung Jung;Ahn, Chul Min;Chang, Yoon Soo
    • Tuberculosis and Respiratory Diseases
    • /
    • v.66 no.5
    • /
    • pp.380-384
    • /
    • 2009
  • Drug-induced subacute cutaneous lupus erythematosus (SCLE) is associated with use of the following classes of medications: anti-hypertensives, anti-cholesterolemia, anti-psychotics, and anti-inflammatory drugs. Docetaxel is an anti-neoplastic agent, which is widely used for treatment of non-small cell lung cancer. Few cases of docetaxel-induced SCLE have been reported in the medical literature. Here, we report the case of a 58-year-old female patient who developed drug-induced SCLE after administration of docetaxel. After 4 cycles of chemotherapy with docetaxel and cisplatin, erythematous skin eruptions developed on the patient's face. Skin biopsies of the eruptions were remarkable for interfacing dermatitis with basement membrane thickening. Immunofluorescent study revealed characteristic features of SCLE, including granular deposition of IgM, C3, and apoptotic bodies along the basement membrane. The skin eruptions resolved gradually after cessation of drug and with the use of topical corticosteroids.

Constitutive Expression and Changes of Cytochrome P450 Isozymes mRNAs by Vehicles (Petrolatum, DMSO, Ethanol) in Rat Skin Using Semi-quantitative RT-PCR

  • Lee, Ai-Young;Lee, Kyung-Hoon;Ko, Duck-Sung;Chey, Won-Young
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.5 no.5
    • /
    • pp.407-412
    • /
    • 2001
  • Many drugs are primarily metabolized by the cytochrome P450s (CYPs). Drug metabolites would be important allergens for adverse drug reactions such as drug eruptions. Skin tests with a suspected drug have conducted to identify causative drugs of drug eruptions, with vehicles such as white petrolatum, DMSO, ethanol. This study will compare the expression of rat CYP isozyme mRNAs between the skin and the liver, with examining an effect of the vehicles on the cutaneous CYPs using semi-quantitative RT-PCR. Thirty-two Sprague-Dawley rats between the ages of six and eight weeks were divided as four groups. One group was used to compare the constitutive mRNA expression between skin and liver, while the others were to examine the effects of three vehicles. The ratios of expression of CYP1A2, CYP2B1/2, CYP2E1, CYP3A1, and CYP4A1 were significantly higher in the liver than the skin. However, CYP1A1 and CYP2C11 were higher in the skin than liver. The effects of vehicles were quite different; white petrolatum significantly induced CYP1A1 (p=0.012) and CYP2C11 mRNAs, while ethanol inhibited CY P1A1 and CYP2B1/2. DMSO did not make any changes. The results suggest that rat skin can participate in drug metabolism with their own CYP isozymes. The effects of vehicles on the cutaneous CYP expression should not be ignored and may be applied for determination of an appropriate vehicle for certain drug(s).

  • PDF

Three Cases of Autoimmune Progesterone Dermatitis

  • You, Hye Rin;Yun, Sook Jung;Kim, Sung Jin;Lee, Seung-Chul;Won, Young Ho;Lee, Jee-Bum
    • Annals of dermatology
    • /
    • v.29 no.4
    • /
    • pp.479-482
    • /
    • 2017
  • Autoimmune progesterone dermatitis is a rare cyclic premenstrual reaction to progesterone produced during the luteal phase of the menstrual cycle. The clinical symptoms of autoimmune progesterone dermatitis overlap with other forms of dermatosis such as erythema multiforme, eczema, fixed drug eruption, urticaria, and angioedema. We experienced 3 cases of autoimmune progesterone dermatitis. All patients had a recurrent history of monthly skin eruptions. Skin lesions normally began a few days before menstruation and resolved a few days later. Patients were confirmed to have autoimmune progesterone dermatitis by the results of the progesterone intradermal test. All three patients had different clinical findings such as erythema annulare centrifugum, urticaria, contact dermatitis, and rosacea. Because patients presented with variable clinical manifestations, they could have been easily misdiagnosed. The patients were treated with oral contraceptive, antihistamine and steroids for symptom control. We propose that dermatologists should consider autoimmune progesterone dermatitis in cases of recurrent cyclic skin eruptions in female patients. Further, if this condition is suspected, thorough history taking including that on menstrual cycle and intradermal progesterone test should be performed.

Neosensitization to Multiple Drugs Following Valproate-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome

  • Song, Jae Min;Jung, Young Eun;Park, Joon Hyuk;Kim, Moon Doo;Cheon, Min Seok;Lee, Chang In
    • Psychiatry investigation
    • /
    • v.14 no.4
    • /
    • pp.518-520
    • /
    • 2017
  • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is associated with severe skin eruptions, fever, hematological abnormalities, and multi-organ involvement. Although aromatic anticonvulsant drugs have been frequently associated with the manifestation of DRESS syndrome, its induction following treatment with nonaromatic anticonvulsants, such as valproate, has rarely been reported. Moreover, there are limited data regarding the development of neosensitization related to chemically unrelated drugs following an episode of DRESS syndrome. Here, a case of neosensitization to multiple drugs is described. The present case report describes a female patient who experienced neosensitization to amoxicillin, olanzapine, and quetiapine following the manifestation of DRESS syndrome induced by valproate.

A Case of Skin Eruption Occurred after Switching Formulation of Quetiapine Fumarate (Quetiapine Fumarate의 제형 변경 후 발생한 피부 발진 1예)

  • Kwon, Yong-Seok;Lim, Se-Won
    • Korean Journal of Biological Psychiatry
    • /
    • v.16 no.4
    • /
    • pp.266-270
    • /
    • 2009
  • Adverse drug reactions are very common in clinical practice, and skin is one of the most frequent organs for adverse drug reactions. We report a case of a 71-year-old male patient who developed skin eruptions after switching formulation of quetiapine immediate release(IR) to quetiapine extended release(XR). He had been taking quetiapine IR(400mg/day) for treatment of manic episode which was developed one year ago. The patient showed great improvement of symptoms after taking quetiapine IR for about one year, thus dosage of medication was reduced to 50mg/day on the average. Unfortunately dose reduction has tended to worsen symptoms, so dose of quetiapine was increased again to 200mg/day with formulation changes to XR. Two days after he took new formulation, erythematous papules were occurred over his anterior neck and ventral side of left wrist. As he stopped quetiapine XR, the skin lesions gradually subsided. And he was successfully treated with readministration of quetiapine IR without any skin lesions.

  • PDF

Levofloxacin-induced Fixed Drug Eruption: A Case Report (Levofloxacin 유발 고정약진 1예)

  • Han, Sung Soo;Oh, Eui Hyun;Kwon, Hyoung Il;Ko, Joo Yeon;Ro, Young Suck;Kim, Jeong Eun
    • Korean journal of dermatology
    • /
    • v.55 no.7
    • /
    • pp.445-448
    • /
    • 2017
  • Fixed drug eruptions (FDEs) are characterized by the presence of site-specific recurrence of a solitary or multiple, well-circumscribed, erythematous macules or patches that recur with each exposure to a particular medication. Several drugs including non-steroidal anti-inflammatory drugs, non-opioid analgesics, sedatives, anticonvulsants, sulfonamides, and tetracycline have been associated with an increased risk of inducing FDE. A 45-year-old woman with known history of levofloxacin use presented with erythematous patches on her face and left forearm. Although a patch test to levofloxacin showed a negative reaction, intradermal tests to assess hypersensitivity to levofloxacin were positive, and she was diagnosed with levofloxacin-induced FDE. Her antibiotic was switched to moxifloxacin, which she tolerated well. Moxifloxacin did not show cross-reactivity. Because of the widespread use of fluoroquinolones, it is important to consider these as possible etiological agents in cases of FDE. We describe a case of FDE diagnosed using positive intradermal tests to detect sensitivity to levofloxacin.