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Gustatory evoked potential induced by stimulation of solution in human

  • Min, Byung-Chan;Park, Se-Jin;Sakamoto, Kazuyoshi
    • Proceedings of the ESK Conference
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    • pp.17-25
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    • 1997
  • The evoked potentials for concentrations of solutions of the four qualities of tastes(i.e., sweet, salty, sour, and bitter tastes) were measured. The solution was applied to the chorda tympani nerve located on the left side of the tongue at 20mm from the tip and 15mm left from the center line. The evoked potentials were detected from Cz referred to A1(left lobe) with the ground at the Fpz position. The Maximum potential level and its latency were evaluated. The individual threshold level of concentration of the solutions of four tastes were measured. Artificial saliva was used as a control solution. The evoked positive potentials for four qualities of tastes (i.e., gustatory evokde potentials) were found to be around 150ms by averaging eight responses. The arbitrary concentration of the solutions were presented by the relative concentration, which was the ratio of the arbitrary concentration to the individual threshold level. The characteristic relations between the latency and the relative concentration ;and those between the potential level and the relative concentration were evaluated. These evalutions showed that (1) the latencies for salty and bitter tastes denoted the minimum values due to for the change of relative concentration, and that (2) the latency for sour taste decreased as the relative concentrations increased, while the latency for sweet taste denoted the inverse tendency, Sinificant differences between any two maximum potential levels were not recognized. A response latencies to sucrose were abolished after treatment of tongue by a sweet-suppressing agent.

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A study on the intraoral factor related to oral malodor (구취발생에 관여하는 구강내부요인에 관한 연구)

  • Jung, Mi-Ae;Lee, Eun-Sook
    • Journal of Korean society of Dental Hygiene
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    • v.8 no.1
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    • pp.119-131
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    • 2008
  • This study was peformed in order to find out the relationship between the causing factors and the production of each gas 01 oral malodor, to contribute the oral malodor control at dental clinic as well as to establish the effective application of malodor control project for public oral health program 127 patients from 20 to 40 years old who had been visited for preventive dental cares were participated for the study. Such items as caries status, periodontal status, salivary flow, viscosity, pH. Snyder test, plaque deposit and tongue plaque were checked through the oral examination in order to find out the contributing factors Hydrogen sulfide, Methyl mercaptan, Di-methyl sulfide and Ammonia gas components were checked with Oral-Chroma and Attain, the oral malodor check units. Not only the corelation coefficiencies but also the multi-way variance analysis were calculated between each causing factor and each component of oral malodor gases to estimate the contributing factors of the oral malodor. 1. There was no relationship between the caries status and each component pf the oral malodor such as sulfur compound or Ammonia, both in laboratory test and VAS test (pF0.05). It revealed negative relationship between Hydrogen sulfide and FT(rM-0.1904. pE0.05) as well as the VAS and FT (rM-0.210. pE0.05). S0, it was estimated that the less oral malador was recognized when caries state changed to filled state in Hydrogen sulfide laboratory test or VAS test 2. High relationship was showed between salivary flow and Hydrogen sulfide (rM-0.183, pM0.039), Methyl mercaptan(rM-0.234, p-0.008). Dimethyl sulfide(rM-0.234, pM0.008) and Ammonia(-0.361. pM0.001) gas(pE0.05). 3. There was a high relationship between M-PHP(Modified-Patient Hygiene Performance Index) and tong plaque all kinds of sulfide(rM0.249. pM0.005). Ammonia gas component(rM0.232, pM0.009). 4. It was found that considerable relationship was appeared between the periodontal status and Ammonia gas (rM0.274, pM0.002), so, it should be needed to control Ammonia. Such dental Cares as the prevention or early treatment of periodontal disease and the accelerating the salivary flow as well as reducing the amounts and activities of filament or spiral typed oral micro-organism were recommended for adults, not only for dental care program at the dental clinics but also for public health programs, in order to promote the oral health and quality of file for individual and community peoples.

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Changes in pH values in the oral cavity according to the intake method of powdered probiotics (분말형 프로바이오틱스 섭취방법에 따른 구강 내 pH 변화)

  • Hwang, Young-Sun;Lee, Min-Kyung;Kim, Myoung-Hee
    • Journal of Korean society of Dental Hygiene
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    • v.19 no.6
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    • pp.1099-1107
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    • 2019
  • Objectives: The purpose of this study was to investigate the changes in pH in the oral cavity using the probiotic intake method. Methods: A total of 109 participants were enrolled and randomly assigned to three groups. Participants in the control group did not ingest powdered probiotics, those in experimental group 1 ingested powdered probiotics by dissolving them on the tongue, and those in experimental group 2 dissolved powdered probiotics on the tongue and rinsed with water. pH values were measured 5 times in all. The significance of each group was examined by the Kruskal-Wallis test. The trend over time was expressed as a graph with groupwise means and confidence intervals, considering repeated measurement data. Results: A significant difference was found between the control group and experimental group 1 at two time-points, i.e., immediately after intake and 3 min after ingestion. As a result of the time trend, the pH value of experimental group 2 was smaller than that of experimental group 1, compared to the control group. Conclusions: Studies have shown that taking probiotics with water may help reduce changes in oral pH. Probiotics should be aware of live bacteria and provide consumers with more detailed information on proper dosage and precautions.

Evaluation after Applicated a Mold to a Paraneoplastic Autoimmune Multiorgan Syndrome Patient with Hypervascular Ulcer in the Oral Cavity during Treatment with Mold Brachytherapy (Paraneoplastic Autoimmune Multiorgan Syndrome으로 인하여 구강 내 국소적으로 발생한 과다혈관성 궤양의 방사선 근접치료 시 자체 제작한 Mold의 유용성 평가)

  • Park, Ju-Kyeong;Lee, Sun-Young;Lim, Seok-Geon;Kwak, Geun-Tak;Lee, Seung-Hun;Kim, Yang-Su;Hwang, Ho-In;Cha, Seok-Yong
    • The Journal of Korean Society for Radiation Therapy
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    • v.21 no.1
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    • pp.25-31
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    • 2009
  • Purpose: Evaluate the mold we have made to improve the reproducibility of the patient position and make homogeneous dose distribution to the treatment volume effectively when treating the patient who has hypervascular ulcer on her tongue caused by paraneoplastic autoimmune multiorgan syndrome by mold brachytherapy. Materials and Methods: The mold is consisted of upper and lower parts. We inserted 2 mm of lead sheet on the gums toward the oral cavity to protect them from unnecessary irradiation during the treatment. We had planned on orthogonal images obtained the patient. 200 cGy was delivered in every fraction with a total dose of 3000 cGy. To evaluate the effect of the lead sheet, we made a measurement with a phantom that has gums and tongue made of tissue with an equivalent material (bolus). Five of TLDs were placed on the interesting points of gums to measure the dose during irradiation with lead sheet and without lead sheet for three times respectively. Results: The result of the measurement without lead sheet are A: 33.9 cGy, B: 30.1 cGy, C: 31.8 cGy, D: 23.3 cGy, E: 24.1 cGy. The results of measurement with lead sheet are A: 20.6 cGy, B: 18.8 cGy, C: 19.6 cGy, D: 14.7 cGy, E: 15.1 cGy. Conclusion: Since we are using the mold made in our department during the treatment of the patient with hypervascular ulcer on tongue, we could deliver a proper dose to the treatment volume. In addition, the mold provided highly accurate and reproducible treatment and reduced the dose to the gums and teeth. Therefore, the possibility of side effects could be decreased significantly.

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AN ACOUSTIC ANALYSIS OF PRONUNCIATION IN CHILDREN WITH ANGLE'S CLASS II DIV. 1 MALOCCLUSION (Angle씨 II급 1류 부정교합아동의 발음에 관한 음향학적 연구)

  • Park, Yun-Chung;Lee, Sang-Hoon;Shon, Dong-Su
    • THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY
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    • v.24 no.1
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    • pp.95-111
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    • 1997
  • The human speech organ consists of respiration system (lung, larynx), phonation system (vocal cord), articulation system (esophagus, pharynx, uvula, teeth, gingiva, palate, tongue, lip) and resonating system(oral cavity, nasal cavity, paranasal sinus). Because teeth are components of the articulation system, it has been reported that the persons with abnormally positioned teeth generally have abnormal occlusion and pronunciation. In this study, using /ㅅ(s)/, the most commonly mispronunced consonant in children with malocclusion, and the seven single vowels, /사(sa), 서($s\delta$), 소(so), 수(su), 스($s\omega$), 시(si), 세(se)/ and / ㅏ(a), ㅓ($\delta$), ㅗ(o), ㅜ(u), ㅡ($\omega$), 1(i), ㅔ(e)/ were recorded and analyzed using speech analysis program on computer by measuring formants and compared them for investigating the differences in pronunciation in children with Angle's class I occlusions and those with Angle's class II div.1 malocclusion. The result were as follows: 1. In the Angle's Class II div.1 group, there were no significant differences in F1 of all recorded sounds as compared with Angle's Class I group(p>0.05). 2. In the consonants, there were significant differences in F2 of /스($s\omega$)/ and F2/F1 ratio of /사(sa), 서($s\delta$), 시(si)/ between the two group(p<0.05). 3. In the vowels, there were significant differences F2/F1 ratio of /ㅓ($\delta$)/(p<0.05) and no significant differences in F2/F1 ratio between two group(p>0.05). 4. In the consonants, there were significant differences in F2 and F2/F1 ratio when succeeding vowels were high or low, and F2/F1 ratio when front in accordance with tongue position (p<0.05). 5. In the vowels, there were no significant differences in formant in accordance with tongue position(p>0.05)

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Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis

  • You, Hyang-Suk;Yang, Min-Young;Kim, Gun-Wook;Cho, Hyun-Ho;Kim, Won-Jeong;Mun, Je-Ho;Song, Margaret;Kim, Hoon-Soo;Ko, Hyun-Chang;Kim, Moon-Bum;Kim, Byung-Soo
    • Annals of dermatology
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    • v.29 no.1
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    • pp.1-5
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    • 2017
  • Background: Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD). Objective: We intended to investigate the efficacy and safety of SLIT in Korean patients with AD. Methods: A total of 34 patients with AD and immunoglobulin E (IgE)-proven HDM sensitization (Class ${\geq}3$) were recruited. Eczema area and severity index (EASI) score, total serum IgE level, specific IgE assays to Dermatophagoides pteronyssinus, D. farinae, and adverse effects were recorded during follow-up. "Responder" was defined as a patient with ${\geq}30%$ improvement in EASI score after SLIT. Results: Twenty-three patients continued SLIT for 12 months or more, whereas 3 patients (8.8%) dropped out because of exacerbation of dermatitis, and 8 patients (23.5%) were lost to follow-up. The average duration of SLIT treatment was 22.4 months (range, 12~32 months). EASI scores reduced significantly after 6 months of treatment (p<0.05) compared with those at baseline. A total of 18 patients were determined to be responders to SLIT after 6 months. Total and specific IgE serum levels did not significantly reduce after SLIT. No patients experienced serious adverse events, with the exception of two patients who developed transient lip and tongue swelling. Conclusion: Our study demonstrated that SLIT with HDM extracts is effective and tolerable in Korean patients with AD. Further controlled long-term trials are required to reinforce the current results.

Elevation of Nitric Oxide Synthase Activity by Dimethyladenosine from Silkworm Pupae in Aged Rats

  • Ahn, Mi-Young;Han, Jea-Woong;Hong, Yoo-Na;Hwang, Jae-Sam
    • Toxicological Research
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    • v.24 no.3
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    • pp.169-174
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    • 2008
  • This study examined the mechanisms underlying the effects of the vasorelaxation active substance(VAS), dimethyladenosine-5'-L-arabinose, and its partial purification fraction on nitric oxide synthase in improving erectile dysfunction with particular focus on the nitric oxide (NO)-cGMP pathways. Two rat models, 9-month-old SD rats and 11-month-old SD rats, were given VAS(40 mg/kg per day) for 4 days, The aqueous fraction of silworm male pupae extract; semi-purified VAS(100 mg/kg per day) for 10 days, respectively. The NOS activities of the following three enzymes were examined: neuronal NO synthase(nNOS), inducible NOS(iNOS), endothelial NOS(eNOS), vascular endothelial growth factor on endothelial cells(VEGF) and anti-inflammation effect of Tumor necrosis factor-$\alpha$. The results showed increases in the nitric oxide synthase activities. Western blotting of the tissue homogenate showed an increase in the nNOS level in the brain and tongue, and an increase in the endothelial NO synthase(eNOS) level in penis. However, there was little association with VEGF production in HUVEC endothelial cells and no relationship with TNF-$\alpha$ which showed low levels.

한국어 자음약화현상과 인접모음의 고저성

  • Lee Suk-Hyang
    • MALSORI
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    • no.33_34
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    • pp.43-55
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    • 1997
  • This study examined one of the hypotheses on the consonant reduction in Korean inferred from the Articulatory Phonology framework through phonetic experiments: Degree of consonant reduction depends on the height of the neighboring vowels--the lower the height of the neighboring vowel is, the higher the degree of reduction of stop closure period is. The results of this study, in general, turned out to support the hypothesis with some cases requiring other phonetic considerations, e.g., rate of some tongue tip movement in the case of dental lenis stop /t/ or the facts that bilabial lenis stop /p/ share its primary articulators, lips, with the neighboring vowel /u/ and that for bilabial closure, the upper lip lowers more for compensation of little movement of lower lip when its raising gets disturbed for some reasons.

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An Experimental Phonetic Analysis on Japanese Vowels of Japanese Natives (일본인 화자의 일본어 모음에 관한 실험음성학적 분석)

  • Lee Jae-Gang
    • MALSORI
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    • no.33_34
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    • pp.57-69
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    • 1997
  • In this paper, 1 will try to examine the aspects of formants, based on the LPC analysis. In this analysis, five Japanese vowels (a, i, u, e, o) will experience two kinds of experiments: vowels in isolated forms, and vowels in carrier sentences. The analysis results of Japanese vowels of the Japanese natives show a peculiar feature that Japanese vowels form respective vowel groups. Each Japanese vowel makes a statistically significant difference. In the Fl analysis of the vowels grouped by the informant's sex, Japanese vowel (a) shows the greatest standard deviation without regard to the informant's sex. In the F2 analysis of Japanese vowels, each vowel has a statistically significant difference. The fact that the male's [u] shows great standard deviation means that there is a great difference of the frontness of the tongue among the Japanese males in articulating [u]. Isolated vowels and carried vowels show statistically little significance between Fl and F2 frequency values. In another contrastive analysis between the isolated vowel group and the carried vowel group, whether a vowel is articulated in isolation or in a sentence appears to have little effect on its formant frequency.

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The effect of dental health education on dental health knowledge, dental health behavior of adult group (구강보건교육 프로그램이 성인집단의 구강보건지식 및 구강건강행위에 미치는 영향)

  • Lee, Hyang-Nim
    • Journal of Korean society of Dental Hygiene
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    • v.4 no.1
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    • pp.93-103
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    • 2004
  • This study was conducted to evaluated the effects of improvement on dental health behavior and dental health knowledge of adult group through dental health education program, the study subjects were 75, education group being 37(male 19, female 18) and non-education group being 38(male 19, female 19). who being in 2 office. The results of this study were as follow: 1. In the primary survey, the education group and non-education group showed no differences in sex, age, job year, income, smoking, self-rated dental health statues, DMFT index, a number of cervical abrasion tooth, dental health behavior, dental health knowledge. 2. before education program the use of tooth brushing method of horizontal+vertical was 40.6%, after education program the use of tooth brushing method of rolling was 89.2% in education group. 3. after education program the tooth brushing times was increased after-meal brushing, especially increased from 40.5% to 93.8% at after midday meal brushing. 4. the difference of mean change of dental health knowledge score after oral health education program had been studied. dental health knowledge score increased in 9.8 in the education group and non-education group in 1.6(pE0.001). 5. the difference of mean change of oral health promotion behavior after oral health education program had been studied, the frequence of tooth brushing(pE0.05), flossing(pE0.001), tongue brushing(pE0.001) was significantly increased in education group compare to non-education group. Above findings suggest that dental health education program was effective in improving the dental health behavior, dental health knowledge of the adult group.

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