• Title, Summary, Keyword: Ellagic

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Components of Potentilla Species -Isolation and Identification of 3, 3', 4-tri-O-methylellagic acid- (Potentilla속 식물의 성분연구 -3, 3', 4-tri-O-methylellagic acid의 분리 및 동정-)

  • Kim, Hack-Seang
    • YAKHAK HOEJI
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    • v.33 no.6
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    • pp.377-379
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    • 1989
  • The methylated compound of ellagic acid was isolated from Potentilla chinensis (Rosaceae). The isolated compound was 3, 3', 4-tri-O-methylellagic acid, [2, 3, 7-trimethoxy-8-hydroxy[1] benzopyrano-[5, 4, 3, cde][1] benzopyran-5, 10-dione], $C_{17}H_{12}O_8$, m.p. $293-295^{\circ}C$. The isolation of trimethylellagic acid was conducted by the column chromatography and the identification of the compound was carried out by the methods of IR, NMR and MS spectroscopy.

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Studies on the Pharmacological Actions and Biological Active Components of Korean Traditional Medicine (V) -Isolation of an Antimicrobial Phenolic Compound from Duchesnea indica- (한국전통생약의 약리작용과 활성물질에 관한 연구(V) -사매(蛇?)의 항균성분획의 페놀성물질-)

  • Lee, Ihn-Rhan;Lee, Yun-Sil;Han, Yong-Nam
    • YAKHAK HOEJI
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    • v.32 no.5
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    • pp.308-312
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    • 1988
  • A phenolic compound isolated from the ethylacetate extract of Duchesnea indica (Andr.) Focke (Rosaceae) showed antimicrobial activities against Staphylococcus aureus, Shigella dysentriae and Pseudomonas aeruginosa. This compound was identified as ellagic acid by spectral analysis.

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Phenolic Compounds from the Leaves of Rubus coreanum (복분자 딸기 잎의 페놀성 물질)

  • 이민원
    • YAKHAK HOEJI
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    • v.39 no.2
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    • pp.200-204
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    • 1995
  • Chemical examination of the leaves of Rubus coreanum has led to the isolation and characterization of six phenolic compounds. The structures of these compounds were elucidated as kaempferol(l), quercetin(2), sodium salt of quercetin 3-O-$\beta$-D-glucuronide(3), sodium carboxylate of quercetin 3-O-$\beta$-D-glucuronide(4), ellagic acid(5) and sanguiin H-5(6) on the basis of physicochemical and spectroscopic evidences.

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Antioxidative Activity of Solvent Fraction and Isolation of ANtioxidative Compound from Chestnut Husk (밤 귀피의 용매분획별 항산화 활성과 항산화 물질의 분리)

  • 권은정;김영찬;권미선;김창섭;강우원
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.30 no.4
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    • pp.726-731
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    • 2001
  • To enhance the utilization of chestnut husk discarded in the processing company antioxidative activities and compounds were investigated. Antioxidative activities of solvent fractions from chestnut husk were examined by benzoic acid hydroxylation method ferric thiocyanate method and DPPH test. Ethyl acetate fraction showed strong antioxidative activities comparable to BHA. Active compounds were isolated and purified from ethyl acetate fraction by Sephadex LH-20 column chromatography and preparative HPLC. A major active compound gallic acid was identified by $^{1}$H and $^{13}$ C-NMR. The phenolic acid contents was analyzed by GC and ellagic acid (172.22 mg%) and gallic acid (107.39 mg%) were major phenolic acid of chestnut husk.

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Beta-carotene prevents the spermatogenic disorders induced by exogenous scrotal hyperthermia through modulations of oxidative stress, apoptosis, and androgen biosynthesis in mice

  • Yon, Jung-Min;Kim, Jae Seung;Lin, Chunmei;Park, Seul Gi;Gwon, Lee Wha;Lee, Jong-Geol;Baek, In-Jeoung;Nahm, Sang-Seop;Nam, Sang-Yoon
    • Korean Journal of Veterinary Research
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    • v.59 no.2
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    • pp.59-67
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    • 2019
  • We investigated whether ${\beta}$-carotene (${\beta}-CA$) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice were intraperitoneally treated with 10 mg/kg of ${\beta}-CA$ or EA daily for 13 days consecutively. During this time, mice were subjected to transient scrotal heat stress in a water bath at $43^{\circ}C$ for 20 min on day 7, and their testes and blood were obtained on day 14 for histopathologic and biochemical analyses. Heat stress induced significant testicular weight reduction, germ cell loss and degeneration, as well as abnormal localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) and manganese superoxide dismutase (MnSOD) in spermatogenic and Leydig cells. Heat stress also altered the levels of oxidative stress (lipid peroxidation, SOD activity, and PHGPx, MnSOD, and $HIF-1{\alpha}$ mRNAs), apoptosis (Bax, Bcl-xL, caspase 3, $NF-{\kappa}B$, and $TGF-{\beta}1$ mRNAs), and androgen biosynthesis (serological testosterone concentration and $3{\beta}$-hydroxysteroid dehydrogenase mRNA) in testes. These changes were all improved significantly by ${\beta}-CA$ treatment, but only slightly improved by EA treatment. These findings indicate that ${\beta}-CA$, through modulations of oxidative stress, apoptosis, and androgen biosynthesis, is a potent preventive agent against testicular injuries induced by scrotal hyperthermia.

Antioxidant Properties of Tannic Acid and its Inhibitory Effects on Paraquat-Induced Oxidative Stress in Mice

  • Choi, Je-Min;Han, Jin;Yoon, Byoung-Seok;Chung, Jae-Hwan;Shin, Dong-Bum;Lee, Sang-Kyou;Hwang, Jae-Kwan;Ryang, Ryung
    • Food Science and Biotechnology
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    • v.15 no.5
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    • pp.728-734
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    • 2006
  • The tannins represent a highly heterogeneous group of water-soluble plant polyphenols that may play an important role in antimutagenic and antioxidant properties. We investigated the antioxidant function of tannic acid in comparison to other phenolic compounds including catechin, chlorogenic acid, cinnamic acid, ellagic acid, and gallic acid for their ability to scavenge several stable radicals and reactive oxygen species (ROS) such as ${\bullet}DPPH^+$, ${\bullet}ABTS^+$, hydrogen peroxide, hydroxyl radical, and superoxide radical. The ability of tannic acid to decrease paraquat-induced lipid oxidation in mouse liver and lung through its antioxidant properties was also assessed. The results showed that almost all the tested compounds have stable radical scavenging activity except cinnamic acid. Tannic acid, gallic acid, and ellagic acid demonstrated remarkable ROS scavenging properties toward $H_2O_2$, ${\bullet}OH^-$, ${\bullet}O_2^-$ and especially only tannic acid could inhibit paraquat-induced lipid peroxidation effectively in mouse liver and lung. Based on these results, it appears that increased number of galloyl and ortho-hydroxyl groups enhances the antioxidant activity of phenolic compounds and tannic acid is evaluated as the most effective antioxidant among all the tested compounds. These results suggest that the tannins, especially tannic acid, can be used as therapeutic agent for various diseases caused by ROS.

Rubus coreanus Extract Attenuates Acetaminophen Induced Hepatotoxicity; Involvement of Cytochrome P450 3A4

  • Lee, Young-Ik;Whang, Kyung-Eun;Cho, Jin-Sook;Ahn, Byung-Min;Lee, Sang-Bum;Dong, Mi-Sook;Kim, Tae-Hyun
    • Biomolecules & Therapeutics
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    • v.17 no.4
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    • pp.455-460
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    • 2009
  • Foods of plant origin, especially fruits and vegetables, have attracted attention because of their potential benefits to human health. In this report, Rubi Fructus (RF), the dried unripe fruit of Rubus coreanus Miq (Rosaceae) and ellagic acid (EA) purified from RF were used to test their potential hepatoprotective effect against acetaminophen (AAP)-induced hepatotoxicity in rats. RF extract (RFext) and EA reduced the elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in serum and the content of lipid peroxide in liver by AAP administration, while the increment of the cellular glutathione (GSH) content and the induction of glutathione S-transferase (GST) and glutathione peroxidase (GSH-PX) which were decreased by AAP administration. RFext and EA from RFext did not affect the two major form of cytochrome P450s, cytochrome P450 2E1 (CYP2E1) and cytochrome P450 1A2 (CYP1A2), but downregulated the cytochrome P450 3A4 (CYP3A4) related to the conversion of AAP to N-acetyl-P-benzoquinone imine (NAPQI). These results suggest that RFext and EA from RF exhibit a hepatoprotective effect not only by increasing antioxidant activities but also by down-regulating CYP3A4 in the AAP-intoxicated rat.

The Antioxidant Activities of Acetone Extracts of Chestnut Inner Shell, Pine Needle and Hop (율피, 솔잎, 호프의 아세톤 추출물의 항산화작용)

  • Oh, Seung-Hee;Kim, Yong-Wook;Kim, Myoung-Ae
    • Journal of the Korean Society of Food Culture
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    • v.19 no.4
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    • pp.399-406
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    • 2004
  • The extracts 70% acetone from chestnut inner shell, pine needle and hop flower were added to soybean oil, lard, soybean oil-water emulsion and lard-water emulsion in order to test the antioxidant activity compared with ${\alpha}-tocopherol$, respectively. Induction period was determined by Rancimat and the antioxidant activities were recorded in the order of pine needle>chestnut inner shell>hop>tocopherol in the soybean oil, and in the order of tocopherol>chestnut inner shell>pine needle>hop in the lard treatment. These three extracts showed similar high antioxidant activity by peroxide value test in soybean oil, soybean oil-water emulsion, lard and lard water emulsion, respectively. The chestnut inner shell extract would be the highest antioxidant agent among the extracts tested in this study. Ellagic acid of chestnut inner shell and flavanol of pine needle would increase the antioxidant activity according to analysis result of polyphenol compound, respectively.

Studies on the Utilization of Chestnut Bur(1) - Components of Chestnut Bur - (밤송이 이용(利用)에 관(關)한 연구(硏究) (1) - 밤송이 성분(成分) -)

  • Kim, Jae-Kwang;Kong, Young-To;Jo, Jae-Myeong
    • Journal of the Korean Wood Science and Technology
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    • v.15 no.4
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    • pp.59-63
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    • 1987
  • As the production of chestnuts from chestnut trees has been increased annually in the past several years in this country, developing the utilities of chestnut bur has been considered as one of main research problems. Therefore. in this paper, the chemical components were analysed to find a way of utilizing the chestnut bur. It was proved that chestnut bur is abundant in extractives (hot water 16.0%, 1%-NaOH 40.6%) and tannin content (16.5%). Of the tannin, the soluble tannin (3.2%) content is higher than condensed tannin (2.2%), and gallic acid content(3.3-3.9%) is slightly higher than ellagic acid(2.8-3.0%), For more effectively utilizing as a tannin resources, the chestnut bur should be collected immediately after yield of chestnuts, maybe in October every year.

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Study on Antioxidant Effects of Acorn(Quercus acutissima CARRUTHERS) Components;I. The Separation and Identification of Tannin Components from Acorn (상수리 성분의 항산화 효과에 관한 연구;제I보 상수리 타닌 성분의 분리 및 동정)

  • Shin, Doo-Ho;Cho, Jung-Soon;Jung, Seung-Tai
    • Journal of the Korean Applied Science and Technology
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    • v.10 no.1
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    • pp.93-101
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    • 1993
  • This study aimed to search for separate and identify of Quercus acutissima CARRUTHERS tannins. Tannins were extracted with methanol and ethylacetate from acorn powder and identified TLC, UV spectrum, HPLC, IR, GC/MS, and $^{1}H$ NMR. Three spots($R_{f}$ 0.94, 0.84 and 0.29) detected on TLC. These spots gave dark blue color fairly on spraying with 0.3% potassium ferricyanid${\cdot}$0.3% ferricchloride reagent, and these tannins identified as gallic acid, caffeic acid and ellagic acid by UV spectrum, HPLC, IR, GC/ MS, and $^{1}H$ NMR.