• Title, Summary, Keyword: Fibrosum Gypsum

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The Effects of Gypsum Fibrosum on Renal Functional and Histopathological Disorder in Chronic Renal Failure Rat Model (석고(石膏)가 만성 신부전 Rat의 신기능 보호 및 조직학적 변화에 미치는 영향)

  • Byun, Sang-Hyuk
    • The Journal of Internal Korean Medicine
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    • v.29 no.4
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    • pp.871-886
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    • 2008
  • Objective : Gypsum fibrosum has been traditionally used in treatment of febrile diseases and recently been shown to have anti-inflammatory effect. Chronic renal failure has a serious clinical symptoms including proteinuria, azotemia, anemia, and hyperlipidemia and has characteristic histopathological changes, glomerular hypertrophy, infiltration of inflammatory cells, and crescentic sclerosis, We investigated the effects of gypsum fibrosum on renal functional and histopathological disorder in chronic renal failure rat model induced 5/6 nephrectomy. Methods : Using Sprague-Dawley rats, CRF was induced by 5/6 nephrectomy. The rats were divided into 3 groups, normal, conrol, and gypsum administered orally with gypsum fibrosum 500mg/kg/day. Body weight, 24 hr proteinuria, hematologic analysis, and histological morphologic changes were followed up after 8 weeks. The glomerular macrophage/monocyte infiltration, $TGF-{\beta}_1$, type IV collagen, and angiotensin II type1 receptor($AT_1$) were evaluated by immunohistochemistry. Resuls : In the CRF control group, functional parameters and histopathologic changes clearly indicated the development of CRF. 24 hr proteinuria significantly increased in the CRF control group over the normal group, and serum creatinine level was lower in the gypsum group than in the control group, LDL-cholesterol was significantly lower in the gypsum group than in the control group. Morphological investigations showed a variety of characteristic features of CRF, glomerular hypertrophy, increasing cellular density of glomerulus, deposition of extra-cellular matrix, fibrotic change, and glomerular sclerosis in the control group, but in the gypsum group, these features diminished significantly. In observation of renal type IV collagen and $AT_1$ expression, positive area significantly increased in the control group over the normal group, and it significantly decreased in the gypsum group compared to the control group. Conclusions : Our findings suggest that gypsum fibrosum inhibits $AT_1$ and type IV collagen expression in renal tissues and attenuates progression of glomerulosclerosis and interstitial fibrosis in chronic renal failure rats, which lead to amelioration of renal function. From these results, we suggest that gypsum fibrosum may have renoprotective effects and could be a useful remedy agent for treating chronic renal failure.

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The Bibiographical investigation of effect of GYPSUM FIBROSUM in Dongyi Soose Bowon (동의수세보원(東醫壽世保元)에서의 석고(石膏)의 약리(藥理)에 대한 문헌적(文獻的) 고찰(考察))

  • Jung, Kwang-hee;Koh, Byung-hee;Song, Il-byung
    • Journal of Sasang Constitutional Medicine
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    • v.12 no.1
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    • pp.110-119
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    • 2000
  • 1. Purpose and Method We do not have the Sasagn Consitutional Pharmacology exactly. So we use Sasagn Consitutional medical herbs based on the theory of Yin-yang and the five elements herbology. So I try to objectify Sasagn Consitutional Classification of Gypsum Fibrosum in DongyiSooseBowon. Among the soyangin(少陽人) Pyobyung(表病) prescription, Fever MangYin Symptom(fever, headache, diarrhea) prescription include Gypsum Fibrosum, Cold MangYin Symptom(cold, pain in abdomen, diarrhea) prescription does not include Gypsum Fibrosum. So, I to make manifest the spirit of using Gypsum Fibrosum in Soyangin(少陽人) PyoByung(表炳), and the differences of two symptom, and the literature on this subject, I searched oriental medical books. 2. result 1. The management of Gypsum Fibrosum is to grind and make powder. 2. The spirit of using Gypsum Fibrosum in Soyangin(少陽人) Fever MangYi Symptom(fever, headache, diarrhea) prescription is Cleanse the Inside fever and Down the Outside Yin. 3. Fever MangYin Symptom(fever, headache, diarrhea) prescription include Gypsum Fibrosum, Cold MangYin Symptom(cold, pain in abdomen, diarrhea) prescription does not include Gypsum Fibrosum. and The Important syndrome of using Gypsum Fibrosum in Soyangin(少陽人) Fever MangYin Symptom(fever, headache, diarrhea) is fever and headache. 4. Gypsum Fibrosum is The representative herb on Soyangin FeverSymptom. 5. The site of therapeutic action of Gypsum Fibrosum is Wiguk(胃局) - Upper Juncho

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A case with schizophrenia (전광증(癲狂症) 환자(患者) 치험(治驗) 1례(例))

  • Kim Tae-Heon;Kim Geun-Woo;Song Ji-Hyoung
    • Journal of Oriental Neuropsychiatry
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    • v.12 no.2
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    • pp.223-230
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    • 2001
  • We experienced one case of schizophrenia. A patient who has hypertetyion & c.v.a as a past history was suffer from conspitation, headache, nausea, sweating, insomnia, & etc. This study is peformed to find out gypsum fibrosum enema theraphy has a clinical effect on constipation with schizophrenia. Gypsum fibrosum enema theraphy has a sufficient effect. Altought, the most important thing is that schizophrenia is almost due to seven feelings. So maybe more and more studies are need in the schizophrenia & seven feelings.

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The Study on the "Sanghanron(傷寒論)"'s Mahanggamsuktang(麻杏甘石湯) ("상한론(傷寒論)"의 마행감석탕(麻杏甘石湯)에 대한 연구(硏究))

  • Bang, Jung-Kyun
    • Journal of Korean Medical classics
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    • v.25 no.1
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    • pp.163-171
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    • 2012
  • Objective : There are lots of wrong treatment cases in the "Sanghanron". Therefore, search the symptoms that before performed the wrong treatment is important, and that can be a another way to study "Sanghanron". Method : I'll have to figure out "Sanghanron" related publications. Result : The symptoms of Mahanggamsuktang already had the symptoms of Mahwantang(麻黃湯) and the fever of Lung before performed the wrong treatment. Because pathogenic heat is blockaged in the Lung, so we use the Mahanggamsuktang. Conclusion : The efficacies of this drug are disseminating Lung Gi(肺氣) and clearing heat. However, as the rise and fall of fever, the amount of HERBA EPHEDRAE(麻黃) and GYPSUM FIBROSUM(石膏) can be adjusted.

A Study on the mineral of substance used in mental disease. (정신질환(精神疾患)에 사용된 광물성(鑛物性) 약재(藥材)에 대한 고찰(考察))

  • Heo Seong;Ku Byung-Su
    • Journal of Oriental Neuropsychiatry
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    • v.10 no.1
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    • pp.159-177
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    • 1999
  • In the study on the mineral substance used in Dong Eu Bo Gam(range of 'Sin') and the recent prescription of china, the results were as follows. 1. According to Dong Eu Bo Gam, Realgar was used for Sa-Su most often and Gold-leaf, Succinum, especially Cinnabaris were used for amnesia, epilepsy, a general term of manic-depressive psychosis too. The most kinds of mineral substance used for epilepsy. 2. According to recent prescription of china, Fossilia Ossis Mastodi got the most, and Succinum, Cinnabaris, Lapis Chloriti, Haematitum, Magnetitum, Gypsum Fibrosum, Fossilia Dentis Mastodi, iron powder were used frequently. For external application, Sulfur was too. And most kinds of mineral substance were used for epilepsy and schizophrenia. 3. Realgar, Gold-leaf, Succinum, Cinnabaris, Lapis Chloriti, Haematitum, Magnetitum, Gypsum Fibrosum, Fossilia Dentis Mastodi, iron powder have drug effect for mental disease, especially for epilepsy induced by terror. 4. For Application of mineral substance, it should be considered that the chemical elements of mineral substance act on human body. 5. For drug effect, it is important to make clear of original prescription.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXX) -Effects of Mahaengkamsuk-tang on Analgesic, Antipyretic, Antiinflammatory, Secretion of Repiratory Tract, Isolated Ileum and Blood Pressure- (생약(生藥) 복합(複合) 제제(製劑)의 약효(藥效) 연구(硏究)(제30보)(第30報) -마행감석탕(麻杏甘石湯)이 진통(鎭痛), 해열(解熱), 소염(消炎), 거담, 적출장관(摘出腸管) 및 혈압(血壓)과 호흡(呼吸)에 미치는 영향(影響)-)

  • Hong, Nam-Doo;Jeong, Gyu-Mahn;Moon, Jeong-Ho;Joo, Soo-Man
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.223-231
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    • 1986
  • Experimental studies were conducted to investigate for the effect of Mahaengkamsuk-tang on analgesic, antipyretic, antiinflammatory, secretion of respiratory tract, isolated ileum. Mahaengkamsuk-tang was composed of Ephedrae Herba, Armenicae Semen, Glycyrrhizae Radix, Gypsum Fibrosum. The following results has been obtained; analgesic and antipyretic actions were obtained. Anti-inflammatory effects in the paw edema induced by 1% dextran was significantly shown in rats. Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contractions of isolated ileum of mice induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Expectorant effect was shown in rabbits. Continuous hypotensive action was seen.

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A Literature Studies on the use of apply the drug to the Dental and Paradental disease (齒牙 및 齒周疾患에 使用되는 藥物에 관한 文獻的 考察)

  • Lee, Jun-Seong;Rheu, Hyun-Sin;Seo, Hyung-Sik;Rho, Seok-Seon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.14 no.2
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    • pp.44-83
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    • 2001
  • The result were as follows: 1. Apply the drug to the Dental and Paradental digease is used to be very busy on the Gypsum Fibrosum( 石膏) and Asari herba cum Radice(細辛). 2. Apply the drug to the Dental and Paradental digease is clearing away heat and helping sweat 3. Apply the drug to the Dental and Paradental digease is cold and hot. 4. Apply the drug to the Dental and Paradental digease is pungent, bitter and sweet. 5. Apply the drug to the Dental and Paradental digease is non-toxic. 6. Apply the drug to the Dental and Paradental digease is used to be very busy on the chanel of liver and stomach.

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Hyeongok's Sabeetang Was Combined According to the Theory for Properties and Tastes of Herbal Medicines (현곡(玄谷) 사비탕(瀉脾湯)의 구성한약과 그 기미배오(氣味配伍) 분석)

  • Park, Tae-Yeol;Kim, Gyeong-Cheol;Shin, Soon-Shik
    • Herbal Formula Science
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    • v.15 no.1
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    • pp.137-144
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    • 2007
  • Background and Objectives : There are three kinds of formulas for purging the spleen to cure its sthenic syndrome based on the types of preparation formulas : Sabeetang, Sabeehwan, Sabeesan and Sabeeeum. Another formulas called Sahwangtang, Sahwangsan. Sahwangeum is to purge the yellow colour of spleen. There are 8 kinds of Sabeetang, 3 kinds of Sabeehwan, 3 kinds of Sabeesan, 1 kind of Sabeeeum, 4 kinds of Sahwangtang, 7 kinds of Sahwangsan, and 1 kind of Sahwangeum. Combination of herbal medicines, carried out in formulas for purging the spleen, consists of various kinds depending on medical scientists' personal experience in medical treatment without any general principles, which makes it difficult to apply it to clinical use. The objectives of this study lie in theoretical establishment of Sabeetang for curing the sthenic syndrome of spleen through analyzing the component medicines and combination principles of Hyeongok's Sabeetang, and furthermore, maximizing the clinical use of Sabeetang. Methods : This study analyzed the component medicines and combination principles of Hyeongok's Sabeetang based on the theory for properties and tastes of herbal medicines from the ${\ulcorner}$Yellow Emperor's Canon of Internal Medicine${\lrcorner}$ , the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's Sabeetang is an odd prescription, composed of 7 kinds of ingredients : No.1 Rhizoma Coptidis (2don;7.5g), No.2 Fructus Gardeniae (1don;3.75g), No.3 Ramulus Cinnamomi (1don), No.4 Gypsum Fibrosum (1don), No.5 Fructus Aurantii Immaturus (1don), No.6 Cortex Magnoliae Omcinalis (1don), and No.7 Radix Et Rhizoma Rhei (1don) Results : There are three methods for curing the sthenic syndrome of spleen according to the five elements doctrine : purging the spleen, purging the lung and invigorating the liver. First, if you suffer from the sthenic syndrome of the spleen, you need to purge your spleen. There are two available methods, including taste and property purgation according to the theory for properties and tastes of herbal medicines. They each imply the bitter taste and the cool property purge the spleen. In the case of taste purgation, two herbal medicines with bitter taste. Rhizoma Coptidis and Fructus Gardeniae, are combined into the principal and assistant herbal medicine, respectively. For property purgation, three herbal medicines with the cool property, Gypsum Fibrosum, Fructus Aurantii Immaturus and Radix Et Rhizoma Rhei, are combined into adjuvant herbal medicines. Secondly, if you suffer from the sthenic syndrome of the spleen, you need to purge your lung which is child in the mother-child relationship in inter-promotion among the five elements. There are two methods to purge the lung, including taste and property purgation according to the theory for properties and tastes of herbal medicines. They each mean the pungent taste and the warm property purge the lung. Therefore, it is important to use pungent herbal medicines for taste purgation and warm ones for property purgation. Both pungent and warm herb and property invigoration to invigorate the liver with warm property. Therefore, it is important to use pungent herbal medicines for taste invigoration and warm ones for property invigoration. Both pungent and warm herbal medicines, Ramulus Cinnamomi and Cortex Magnoliae Officinalis, were combined to invigorate the liver and purge the lung. In addition, Gypsum Fibrosum are combined as dispatcher herbal medicine, leading all the herbal medicines composing the formula to the spleen. Conclusions : First, to cure the sthenic syndrome of the spleen, the methods of purging the spleen and the lung, and invigorating the liver should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's Sabeetang is combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

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Literatural Study on the cause of a disease and prescription in migraine (편두통(偏頭痛)의 원인(原因)과 처방(處方)에 대한 문헌적(文獻的) 고찰(考察))

  • Kim, Jong-In;Hwang, Chi-Won
    • Journal of Haehwa Medicine
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    • v.8 no.2
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    • pp.171-189
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    • 2000
  • By Literatural studying on migraine, The results were obtained as fallow : 1. A different name on migraine were called hemicrania(頭偏痛, 邊頭痛, 偏頭風). 2. In the cause of a disease in migraine, the cases were clasified into the fallowing kind : internal cause were a decline in energy and blood(氣血具虛), external cause were outside evil(外邪) in wind cold heat wetness(風寒暑濕), non internal, external cause were exhaustion. The right side migraine were concerned phlegm heat, the right side migraine were concerned wind decline in blood. 3. Migraine is appeared on the side, For the reason, liver function in excess of normal limits(肝陽上亢), a sudden of liver fire(肝火) is becomeed of invasion upon soyangkuong(少陽經) in internal external cause 4. Usage method of medicines is appeared that order underclothes theraphy(內服法), to pump out in nose theraphy, to join head theraphy(頭點法), heating smoke theraphy(熏煙法) 5. CNIDII RHIZOMA(川芎) is in mostly general use for migraine, in that order LEDEBOURIELLAE RADIX(防風) ANGELICAE DAHURICAE RADIX(白芷) ASARI HERBA CUM RADICE(細辛) NOTOPTERYGII RHIZOMA(羌活) GLYCYRRHIZAE RADIX(甘草) CHRYSANTHEMI FLOS(菊花) BUPLEURI RADIX(柴胡) SCUTELLARIAE RADIX(黃芩) ANGELICAE GIGANTIS RADIX(當歸) GYPSUM FIBROSUM(石膏) MENTHAE HERBA(薄荷) GLYCYRRHIZAE RADIX(炙甘草) VITICIS FRUCTUS(蔓荊子), nature is in mostly general hot warm(辛溫), bitter cold(苦寒), guikuong(歸經) is in mostly general liver gall kuong(肝膽經), efficacy is in mostly general to remove wind pain (祛風止痛) and to down fire(瀉火).

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The Origin, Changes and Compositive Principles of Yangkyuksanhwa-tang (양격산화탕(凉膈散火湯)의 기원(基源), 변천과정(變遷過程) 및 구성원리(構成原理))

  • Park, Byung-Joo;Lee, Jun-Hee;Lee, Eui-Ju;Koh, Byung-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.23 no.2
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    • pp.184-193
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    • 2011
  • 1. Objectives: This paper investigates the origin, the progressive changes and the constructive principles of Yangkyuksanhwa-tang (凉膈散火湯). 2. Methods: Yangkyuksanhwa-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusion: 1) The Yangkyuksanhwa-tang most likely originates from Sodokeum, Yangkyuksan, Baekho-tang and Indongdeung. 2) Sodoksanhwa-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)" progressively transformed into Chungyangsanghwa-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Yangkyuksanhwa-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Sangso symptomatology (上消證). 3) Yangkyuksanhwa-tang is composed of 9 herbs. Of these, Schixonepetae herba(荊芥), Ledebouriellae Radix(防風), Forsythiae fructus(連翹), Menthae Herba(薄荷), Gardeniae fructus(梔子) scatter the Hwa-qi(火氣), and Rehmanniae Radix(生地黃), Gypsum fibrosum(石膏), Anemarrhenae(知母) put off the Stomach-heat(胃熱), whereas Lonicerae caulis(忍冬藤) support the prevention of carbunculosis(癰疽).