• Title, Summary, Keyword: GLM

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Gliricidia leaf meal and multi-enzyme in rabbits diet: effect on performance, blood indices, serum metabolites and antioxidant status

  • Oloruntola, Olugbenga David;Agbede, Johnson Oluwasola;Ayodele, Simeon Olugbenga;Ayedun, Eyanlola Soladoye;Daramola, Olajumoke Temidayo;Oloruntola, Deborah Adebukola
    • Journal of Animal Science and Technology
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    • v.60 no.10
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    • pp.24.1-24.8
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    • 2018
  • Background: Following the ban on the importation of import-dependent fed ingredients in most developing countries, the need to look inward for local content is now compelling. Thus, leaf meals that have phytogenic additive potentials are envisaged will be a viable feed ingredient in rabbit diets. Methods: The effect of dietary inclusion of gliricidia leaf meal (GLM) with or without multi-enzyme (E) supplementation in rabbits was investigated using ninety-six 35-day old rabbits of crossbreed (Newzealand and Chinchilla). One basal diet that met the requirements of growing rabbit was formulated (Diet 1). Thereafter, another two diets were formulated to contain 15% GLM and 15% GLM plus multi-enzyme at 1 g/kg and designated as diets 2 and 3 respectively. The rabbits were randomly distributed into the 3 diets (32 rabbits/treatment; 4 rabbits/replicate) and fed their respective experimental diets for 8 weeks. Results: The body weight and daily weight gain of the rabbits fed on GLM free diet and those on GLM-based diets (diets 1 and 2) were similar at finishing period of 63-91 day but have lower (P < 0.01) values than those rabbits fed GLM + E based diet (diet 3) at finishing period (63-91 days) and whole fattening period (35-91 days). The apparent dry matter and crude protein digestibility of rabbits fed control diet and those fed 15% GLM based diet were lower (P < 0.05) than those fed 15% GLM + E-based diet. Triglycerides concentration of rabbits fed 15% GLM-based diet without enzyme addition were lower (P < 0.05) than those observed for rabbits on the rest test diets. Cholesterol and Low-Density Lipoprotein levels of rabbits fed 15% GLM and 15% GLM + E-based diets were lower (P < 0.05) than those fed the GLM free diet. The superoxide dismutase and glutathione peroxidase of rabbits fed the GLM free diet (diet 1) were significantly (P < 0.05) lower than those fed the 15%GLM and 15% GLM + E-based diets. Conclusion: Dietary inclusion of GLM at 15% of the diet did not have a negative effect on the rabbits postweaning period (35-63 days) but will require multi-enzyme supplementation to enhance growth indices at finishing period (63-91 day) without precipitating negative effect on the rabbits' health status.

Application and Understanding of Regression Analysis in the Quality Improvement Activities (식스시그마 품질개선 단계에서 GLM 회귀분석의 이해와 적용)

  • Choi, Sung-Woon
    • Proceedings of the Safety Management and Science Conference
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    • pp.539-550
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    • 2010
  • The study presents the application strategy and understanding of regression analysis with GLM(Generalized Linear Model) unifying with other statistical techniques such as correlation analysis and design of experiment(DOE). The quidelines proposed in this paper can be used for practioners to implement GLM and ANOVA(Analysis of Variance) for the DMAIC 5 steps of six sigma breakthrough.

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Antifibrotic effects of oriental herbs GLM001 on liver cirrhosis induced by bile duct ligation

  • Jeong, Bong-Ho;Kim, Hee-Seok;Kim, Chul;Kim, Jae-Sung;Bae, Heung-Mo;Kwon, In-Sook;Lee, Cheol-Han;JeKal, Seung-Ju;Yu, Byung-Su
    • Advances in Traditional Medicine
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    • v.2 no.2
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    • pp.94-100
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    • 2002
  • Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic diseases. In this study, the antifibrotic effects of GLM001 on liver cirrhosis were examined in bile duct ligated rats and patients with hepatic diseases. GLM001 (250 mg/kg rat weight/ day) was administrated to cirrhotic rats for 4 weeks and to humans for 14 weeks. Bile duct ligated rats significantly increased liver collagen content and biochemical markers of hepatic injury. Liver histology showed collagen fiber deposition was increased and the normal architecture was lost with large zones of necrosis being observed frequently. GLM001 administrated rats showed significantly decreased liver collagen content, and accumulation of collagen fiber in histological analysis. Patients, who were treated with GLM001, showed decreases in biochemical markers of hepatic diseases. These results demonstrate the usefulness of GLM001 as an antifibrotic agent for liver cirrhosis.

Antifungal Activity of Glycycoumarin to Candida albicans (Glycycoumarin 감초성분의 항진균효과)

  • Lee, Jue-Hee;Lee, Young-Mi;Han, Yong-Moon
    • YAKHAK HOEJI
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    • v.55 no.3
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    • pp.234-239
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    • 2011
  • Glycycoumarin, a 3-arylcoumarine isolated from Glycyrrhizae radix (a family of Leguminosae), is reported to have anti-bacterial activity. However, its antifungal activity is still unknown. In this present study, the antifungal activity of glycycoumarin (GLM) against Candida albicans, a polymorphic fungus was investigated. Possible mechanism such as blocking of the hyphal induction was also analyzed. By the in-vitro susceptibility analysis, GLM showed anticandidal activity, resulting in an almost complete inhibition of the fungal growth at a concentration of 320 ${\mu}g/ml$, which was equivalent to the efficacy of fluconazole at the same dose. In the murine model of disseminated candidiasis GLM enhanced resistance of mice against the disseminated disease (P<0.05), resulting in 60% protection of GLM-treated mice group during a period of 21-day observation. As for its mechanism of the antifungal activity, GLM blocked hyphal production, one of the important of virulence factors by the fungus, from the yeast form of C. albicans (P<0.01). These data indicate that GLM may contribute to the perspectives that focus on the development of a novel agent with antifungal activity specific for C. albicans infection.

The Effect of GLM 002, an Oriental Medicine, on Blood Pressure and Plasma Lipids in Spontaneously Hypertensive Rats

  • Yu Byung Soo;Kim Hee Seok;Keon In Sook;Lee Cheol Han;Baek Seung Hwa
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.5
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    • pp.1505-1511
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    • 2004
  • Inhibition of angiotensin converting enzyme (ACE) activity is one of the common antihypertensive methods functioned by drugs such as captopril, lisinopril and enalapril to serve as inhibitors of ACE. This study was designed to compare the effects of enalapril, an angiotensin-converting enzyme inhibitor and GLM002, an oriental medicine, on tail systolic pressure, aorta and plasma properties in spontaneously hypertensive rats (SHR) after 4 weeks of treatment. During the treatment, blood pressure was depressed to normal in GLM002 and enalapril groups. The treatments of enalapril and GLM002 were discontinued in 4 weeks. One week after the treatment stop, systolic blood pressure was smoothly increased in both groups; the increment of blood pressure was slightly greater in GLM002-SHR, but the increment of plasma ACE activity was proportionately similar in each group. In the aspects of the triglyceride, HDL and total cholesterol level, those levels were slightly different among each group. We also conducted clinical dosage of GLM002 to the patients who have mild and severe hypertension for approximately 7 weeks. Clinical treatments also showed remarkable efficiencies on blood pressure (systolic blood pressure, diastolic blood pressure), complete blood count (CBC) routine, differ count (NEUTRO, LYM, MONO, EOS and BASO) and R-chemistry. We conclude that GLM002, like already proven enalapril, plays a role as an angiotensin-converting enzyme inhibitor, and can be suggested as a drug candidate for curing hypertension.

Multi-Site Stochastic Weather Generator for Daily Rainfall in Korea (시공간구조를 가지는 확률적 강우 모형)

  • Kwak, Minjung;Kim, Yongku
    • The Korean Journal of Applied Statistics
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    • v.27 no.3
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    • pp.475-485
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    • 2014
  • A stochastic weather generator based on a generalized linear model (GLM) approach is a commonly used tools to simulate a time series of daily weather. In this paper, we propose a multi-site weather generator with applications to historical data in South Korea. The proposed method extends the approach of Kim et al. (2012) by considering spatial dependence in the model. To reduce this phenomenon, we also incorporate a time series of seasonal mean precipitations of South Korea in the GLM weather generator as a covariate. Spatial dependence was incorporated into the model through a latent Gaussian process. We apply the proposed model to precipitation data provided by 62 stations in Korea from 1973{2011.

Small area estimation of the insurance benefit for customer segmentations (고객집단별 보험금에 대한 소지역 추정)

  • Kim, Yeong-Hwa;Kim, Ki-Su
    • Journal of the Korean Data and Information Science Society
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    • v.20 no.1
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    • pp.77-87
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    • 2009
  • Bayesian methods have been focused in recent years for solving small area estimation problems. In this paper, the hierarchical Bayes procedure is implemented via MCMC techniques and compared with the results of One-way, GLM-Normal, and GLM-Gamma cases by analyzing real data of insurance benefit for customer segmentations. After analyzing insurance benefit real data for customer segmentations, we can conclude that the insurance benefit estimator through the small area estimation is more efficient than the estimators by other methods. In addition, we found that the small area estimation gave accurate estimation result for the small number domains.

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Extension and Review of Restricted and Unrestricted Mixed Models in the Generalized Linear Models (GLM에서 제약과 비제약 혼합모형의 고찰 및 확장)

  • Choi, Sung-Woon
    • Proceedings of the Safety Management and Science Conference
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    • pp.185-192
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    • 2009
  • The research contributes extending and reviewing of restricted (constrained) and unrestricted (unconstrained) models in GLM(Generalized Linear Models). The paper includes the methodology for finding EMS(Expected Mean Square) and $F_0$ ratio. The results can be applied to the gauge R&R(Reproducibility and Repeatability) in MSA(Measurement System Analysis).

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The Impact of Admission Indices and Social-Demographic Features on Grade Point Average (GLM을 이용한 대학학업성취도 분석)

  • 최국렬;이동석
    • The Korean Journal of Applied Statistics
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    • v.13 no.1
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    • pp.11-18
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    • 2000
  • 대학의 학업성취도를 나타내는 평점평균은 많은 요인의 영향을 받는 것으로 알려져 있다. 본 논문은 형행입시제도하에서 획득 가능한 요인과 평점평균과의 관련성을 일반 화선형모형(GLM)을 이용하여 통계적으로 분석·평가하고자 한다. 여기서 얻어진 경과는 요즈음 변화가 모색되고 있는 입시제도나 대학교육제도의 개선에 적으나마 도움이 되는 기초자료를 제공할 수 있으리라 믿어진다. 분석자료는 1996, 97학년도 인제대학교에 입학한 학생들의 입시자료와 96,97학년도의 평점평균, 기숙사입사 여부 등을 대상으로 삼았다.

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Safety Critical I&C Component Inventory Management Method for Nuclear Power Plant using Linear Data Analysis Technic

  • Jung, Jae Cheon;Kim, Haek Yun
    • Journal of the Korea Society of Systems Engineering
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    • v.16 no.1
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    • pp.84-97
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    • 2020
  • This paper aims to develop an optimized inventory management method for safety critical Instrument and Control (I&C) components. In this regard, the paper focuses on estimating the consumption rate of I&C components using demand forecasting methods. The target component for this paper is the Foxboro SPEC-200 controller. This component was chosen because it has highest consumption rate among the safety critical I&C components in Korean OPR-1000 NPPs. Three analytical methods were chosen in order to develop the demand forecasting methods; Poisson, Generalized Linear Model (GLM) and Bootstrapping. The results show that the GLM gives better accuracy than the other analytical methods. This is because the GLM considers the maintenance level of the component by discriminating between corrective and preventive.