• Title, Summary, Keyword: Global synthesis

Search Result 162, Processing Time 0.041 seconds

Comparison of Substructure Synthesis Methods based on Global and Local Coordinates (전역좌표계에 근거한 부분구조합성법과 국부좌표계에 근거한 부분구조합성법의 비교)

  • Kwak, Moon-K.;Na, Sung-Soo;Bae, Byung-Chan
    • Transactions of the Korean Society for Noise and Vibration Engineering
    • /
    • v.16 no.7
    • /
    • pp.712-719
    • /
    • 2006
  • This paper is concerned with the comparison of substructure synthesis methods based on global and local coordinates. The substructure synthesis methods based on the global coordinates were first proposed for the dynamic analysis of complex structure and the substructure synthesis method based on the local coordinates was proposed to solve the dynamic problem of tree-like structure. However, the conceptual difference between two methods in solving the dynamic problem has never been explained. In this paper, a structure consisting of two beams is considered to show the conceptual difference of two methods. The dynamic formulation shows the characteristics and differences of two methods explicitly. The procedure for choosing proper substructure modes in each method is also explained in detail. In addition, the advantage of the substructure synthesis method based on the local coordinate system is discussed based on the numerical example. Numerical examples show how two methods are applied to the addressed problem.

Screening of New Antibiotics Inhibiting Bacterial Peptide deformylase (PDF)

  • Kim, Hyun-Joo;Seol, Min-Jung;Park, Hee-Soo;Lee, Jong-Kook;Choi, Soo-Young;Kwak, Jin-Hwan
    • Proceedings of the PSK Conference
    • /
    • /
    • pp.163.4-163
    • /
    • 2003
  • Peptide deformylase (PDF) is essential and unique to bacteria for cytoplasmic protein synthesis, but not required in eukaryotes, thus making it an attractive target for the discovery of novel antibacterial drugs. Protein synthesis in eubacteria, under normal conditions, is initiated by formyl-methionyl-tRNA. PDF removes the formyl-group of N- formylmethionine of newly synthesized polypeptides to produce a mature protein. In this study, a pdf gene from Staphylococcus aureus 6538p was cloned in pET-14b vector and transformed in Escherichia coli BL21 (DE3). (omitted)

  • PDF

Interaction art using Video Synthesis Technology

  • Kim, Sung-Soo;Eom, Hyun-Young;Lim, Chan
    • International Journal of Advanced Culture Technology
    • /
    • v.7 no.2
    • /
    • pp.195-200
    • /
    • 2019
  • Media art, which is a combination of media technology and art, is making a lot of progress in combination with AI, IoT and VR. This paper aims to meet people's needs by creating a video that simulates the dance moves of an object that users admire by using media art that features interactive interactions between users and works. The project proposed a universal image synthesis system that minimizes equipment constraints by utilizing a deep running-based Skeleton estimation system and one of the deep-running neural network structures, rather than a Kinect-based Skeleton image. The results of the experiment showed that the images implemented through the deep learning system were successful in generating the same results as the user did when they actually danced through inference and synthesis of motion that they did not actually behave.

Activation of Signaling Pathways for Protein Synthesis by Korean Mistletoe (Viscum album coloratum) Extract in a Mouse Model of Muscle Atrophy (근위축 마우스 모델에서 한국산 겨우살이 추출물에 의한 단백질 합성 신호전달 경로의 활성화)

  • Jeong, Juseong;Park, Choon-Ho;Kim, Inbo;Kim, Jong-Bae
    • The Korean Journal of Food And Nutrition
    • /
    • v.30 no.2
    • /
    • pp.371-377
    • /
    • 2017
  • Muscle atrophy is characterized by a decrease in the mass of the muscle. With an increase in life expectancy and chronic illnesses, the incidence of muscle atrophy is increasing and the quality of life of patients is decreasing. Thus, reducing muscle atrophy is of high clinical and socio-economic importance. Mistletoe is a semi-parasitic plant that has been used as a traditional medicine in many countries to treat various human illnesses. It has been reported that Korean mistletoe extract (KME) has diverse biological functions including anti-tumor, anti-oxidant, anti-diabetic, anti-obesity properties, and extension of lifespan. Especially, we have recently reported that KME improves exercise endurance in mice, indicating its beneficial roles in enhancing the capacity of skeletal muscle. In this study, we investigated whether KME could activate the signaling pathway related to protein synthesis in a mouse model of muscle atrophy. Interestingly, KME efficiently activated the Akt/mTOR pathway, and Akt and mTOR are important signaling hub molecules for the acceleration of protein synthesis in muscle cells. In addition, KME also increased the activity of S6 kinase which is involved in the regulation of muscle cell size. Moreover, the ERK activity, required for transcription of ribosomal RNA for protein synthesis, was also enhanced in KME-treated mouse muscle. These data support the idea that KME increases muscle mass via increased protein synthesis. Our findings also suggest that Korean mistletoe might be a promising candidate for the development of functional foods that are beneficial for preventing muscle atrophy.

Synthesis of FDR-SPC Resin and PIV Measurement for Frictional Drag-reduction (마찰저항 저감을 위한 고분자 수지 합성 및 PIV 유동장 계측)

  • Chung, Sungwoo;Kim, Eunyoung;Chun, Ho Hwan;Park, Hyun;Lee, Inwon
    • Journal of the Korean Society of Visualization
    • /
    • v.12 no.1
    • /
    • pp.49-53
    • /
    • 2014
  • In this study, a novel FDR-SPC is first synthesized in this study. The drag reducing functional radical such as PEGMA (Poly(ethylene) glycol methacrylate) has been utilized to participate in the synthesis process of the SPC. The types of the baseline SPC monomers, the molecular weight and the mole fraction of PEGMA were varied in the synthesis process. The resulting SPCs were coated to the substrate plates for the subsequent hydrodynamic test for skin friction measurement. In a low-Reynolds number flow measurement using PIV (Particle Image Velocimeter), a significant reduction in Reynolds stress was observed in a range of specimen, with the maximum drag reduction being 15.9% relative to the smooth surface.

Automatic Synthesis of Chemical Processes by a State Space Approach (상태공간 접근법에 의한 화학공정의 자동합성)

  • 최수형
    • Journal of Institute of Control, Robotics and Systems
    • /
    • v.9 no.10
    • /
    • pp.832-835
    • /
    • 2003
  • The objective of this study is to investigate the possibility of chemical process synthesis purely based on mathematical programming when given an objective, feed conditions, product specifications, and model equations for available process units. A method based on a state space approach is proposed, and applied to an example problem with a reactor, a heat exchanger, and a separator. The results indicate that a computer can automatically synthesize an optimal process without any heuristics or expertise in process design provided that global optimization techniques are improved to be suitable for large problems.

A State Space Modeling and Evolutionary Programming Approach to Automatic Synthesis of Chemical Processes

  • Choi, Soo-Hyoung;Lee, Bom-Sock;Chung, Chang-Bock
    • 제어로봇시스템학회:학술대회논문집
    • /
    • /
    • pp.1870-1873
    • /
    • 2004
  • The objective of this study is to investigate the possibility of chemical process synthesis purely based on mathematical programming when given an objective, feed conditions, product specifications, and model equations for available process units. A method based on a state space approach is proposed, and applied to an example problem with a reactor, a heat exchanger, and a separator. The results indicate that a computer can automatically synthesize an optimal process without any heuristics or expertise in process design provided that global optimization techniques are improved to be suitable for large problems.

  • PDF

Storing Digital Information in Long-Read DNA

  • Ahn, TaeJin;Ban, Hamin;Park, Hyunsoo
    • Genomics & Informatics
    • /
    • v.16 no.4
    • /
    • pp.30.1-30.6
    • /
    • 2018
  • There is urgent need for effective and cost-efficient data storage, as the worldwide requirement for data storage is rapidly growing. DNA has introduced a new tool for storing digital information. Recent studies have successfully stored digital information, such as text and gif animation. Previous studies tackled technical hurdles due to errors from DNA synthesis and sequencing. Studies also have focused on a strategy that makes use of 100-150-bp read sizes in both synthesis and sequencing. In this paper, we a suggest novel data encoding/decoding scheme that makes use of long-read DNA (~1,000 bp). This enables accurate recovery of stored digital information with a smaller number of reads than the previous approach. Also, this approach reduces sequencing time.

Determination of representative emotional style of speech based on k-means algorithm (k-평균 알고리즘을 활용한 음성의 대표 감정 스타일 결정 방법)

  • Oh, Sangshin;Um, Se-Yun;Jang, Inseon;Ahn, Chung Hyun;Kang, Hong-Goo
    • The Journal of the Acoustical Society of Korea
    • /
    • v.38 no.5
    • /
    • pp.614-620
    • /
    • 2019
  • In this paper, we propose a method to effectively determine the representative style embedding of each emotion class to improve the global style token-based end-to-end speech synthesis system. The emotion expressiveness of conventional approach was limited because it utilized only one style representative per each emotion. We overcome the problem by extracting multiple number of representatives per each emotion using a k-means clustering algorithm. Through the results of listening tests, it is proved that the proposed method clearly express each emotion while distinguishing one emotion from others.