In this paper, we give estimates of the Hankel determinant H2(1) in a novel class 𝓝 (𝜀) of analytical functions in the unit disc. In addition, the relation between the Fekete-Szegö function H2(1) and the module of the angular derivative of the analytical function p(z) at a boundary point b of the unit disk will be given. In this association, the coefficients in the Hankel determinant b2, b3 and b4 will be taken into consideration. Moreover, in a class of analytic functions on the unit disc, assuming the existence of angular limit on the boundary point, the estimations below of the modulus of angular derivative have been obtained.