• Title, Summary, Keyword: Herbal medicine

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Hepatoprotective Effects of 25 Herbal Formulas in Primary Rat Hepatocytes (한약 처방 25종에 대한 간 보호 효과 비교 연구)

  • Jin, Seong Eun;Jeong, Soo-Jin;Shin, Hyeun-Kyoo;Ha, Hyekyung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.27 no.5
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    • pp.617-624
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    • 2013
  • The purpose of this study is to investigate the protective effects of 25 herbal formulas on acetaminophen (APAP) or D-galactosamine (D-GalN)-induced hepatotoxicity in primary rat hepatocytes. Cell viability was measured using by Cell Counting Kit-8. 15 kinds of herbal formulas significantly reversed the cell viabilities of D-GalN-treated rat hepatocytes compared with D-GalN alone (p<0.05). In particular, 9 herbal formulas (Bangpungtongseong-san, Bojungikgi-tang, Galgeun-tang, Gumiganghwal-tang, Guibi-tang, Sagunja-tang, Samsoeum, Pyeongwi-san and Yijin-tang) showed the potent protective effects. However, 8 herbal formula exerted weak protective effects and 2 herbal formula did not exert effects on hepatotoxicity by D-GalN. On APAP-induced hepatotoxicity, 7 kinds of herbal formulas increased the viabilities of hepatocytes compare with APAP alone (p<0.05). These results could be provide a valuable information for the future in vivo or clinical studies to predict the hepatoprotective effects of herbal formulas.

Screening of Korean Herbal Medicines with Inhibitory Effect on Aldose Reductase (VIII) (한국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VIII))

  • Lee, Yun Mi;Kim, Young Sook;Kim, Joo Hwan;Kim, Jin Sook
    • Korean Journal of Pharmacognosy
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    • v.44 no.2
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    • pp.168-175
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    • 2013
  • Aldose reductase (AR) plays a central role in the development of the diabetic complications. Eighty one Korean herbal medicines have been investigated for inhibitory activities on AR. Among them, fourteen herbal medicines exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG) as positive control. Particularly, Xanthium strumarium (fruit, whole plant), Ilex cornuta (stem and leaf), Vitex rotundifolia(stem), Sophora flavescens (whole plant), Platycarya stobilacea (flower) showed two times more potent inhibitory activity than 3,3-tetramethyleneglutaric acid (TMG).

Screening of Korean Herbal Medicines with Inhibitory Effect on Aldose Reductase (IX) (한국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(IX))

  • Choi, So-Jin;Kim, Young Sook;Kim, Joo Hwan;Kim, Jin Sook
    • Korean Journal of Pharmacognosy
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    • v.45 no.4
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    • pp.354-358
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    • 2014
  • Aldose reductase (AR) has been demonstrated to play important role in the development of the diabetic complications such as diabetic retinopathy, diabetic neuropathy and diabetic nephropathy. To discover novel treatments for diabetic complications from natural sources, 69 Korean herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Eleutherococcus sessiliflorus (stems), Artemisia japonica (whole plants), Wisteria floribunda (leaves), Eurya japonica (stems, twigs and leaves, leaves), Ampelopsis brevipedunculata (stems) exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid as positive control.

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (VII) (한국약용식물의 최종당화산물 생성저해활성 검색(VII))

  • Choi, So-Jin;Kim, Young Sook;Song, Yoo Jin;Lee, Yun Mi;Kim, Joo Hwan;Kim, Jin Sook
    • Korean Journal of Pharmacognosy
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    • v.43 no.4
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    • pp.345-351
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    • 2012
  • In this study, 49 Korean herbal medicines have been investigated with an in vitro evaluation system using glycation end products (AGEs) formation inhibitory activity. Of these, 18 herbal medicines ($IC_{50}$ < $50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Of these, five herbal medicines ($IC_{50}$ < $50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, Mallotus japonicus (twigs and leaves), Rhus javanica (twigs and leaves), Boehmeria nivea (whole plants), Quercus acuta (stems), and Eurya japonica (stems) showed more potent inhibitory activity (approximately 9-37 fold) than the positive control aminoguanidine ($IC_{50}=76.47{\mu}g/ml$).

A Survey of the Status of Management and Prices of Herbal Medicines: Traditional Korean Medicine Institutions (한방의료기관의 한약 관리 및 가격 현황에 대한 연구)

  • Huang, Dae-Sun;Shin, Hyeun-Kyoo
    • The Journal of Korean Medicine
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    • v.32 no.5
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    • pp.90-99
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    • 2011
  • Objectives: Comparison of the status of herbal medicine management carried out by traditional Korean medicine hospitals and clinics, and changes in the prices of the herbal medicines offered by them. Methods: A questionnaire survey was conducted for 126 traditional Korean medicine hospitals and 4,200 traditional Korean medicine clinics. Questionnaire sheets were dispatched to them by mail in 2008. Rate of response: 57 hospitals (45.2%) and 465 clinics (11.0%) Results: 1. Concerning the herbal medicines kept by them, the hospitals and the clinics kept 295 and 147 kinds of medicine, respectively, on average. As for their monthly expenditure on the purchase of herbal medicines, the hospitals spent an average of KRW 28.38 million while the clinics spent an average of KRW 1.64 million. 2. The average monthly expenditure of the clinics on the purchase of herbal medicines decreased by 32% from 2006, which can be interpreted as a reduction of their business. 3. The prices of herbal medicines for disease treatment ranged from KRW 140,000~190,000 per jae(dosage form) in the hospitals compared to KRW 140,000~168,000 in the clinics. 4. Compared to 1994, the prices of herbal medicines used for disease treatment have risen, whereas the prices of herbal medicines used as tonics have decreased. Conclusions: There are no conspicuous differences between the hospitals and the clinics in terms of the prices charged for herbal medicines, regardless of whether they are used to treat diseases or prescribed as tonics.

Current Research Trend of Herbal Medicine in Pharmacoepidemiology (약물역학분야의 한약연구동향)

  • Woo, Yeonju
    • Journal of Society of Preventive Korean Medicine
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    • v.22 no.3
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    • pp.11-19
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    • 2018
  • Objectives : The aim of this study is to investigate the current research trend of herbal medicine based on the published articles in pharmacoepidemiologic journals. Methods : A total of 3 electronic journals, Pharmacoepidemiology and Drug Safety(PDS), Drug Safety and Journal of Pharmacoepidemiology and Risk Management(JPERM) from January 2013 to August 2018 were used for searching articles about herbal medicine. Selected articles were reviewed and classified under 5 categories-collection of adverse events in herbal medicine, statistical modeling and methodology, pharmaco-epidemiologic outcome study, drug utilization review(DUR), risk management system and regulation. Results : A total of 8 articles were finally included for analysis. 2 articles were categorized in collection of adverse events in herbal medicine, 1 was statistical modeling and methodology, 2 were pharmacoepidemiologic outcome study and 3 were risk management system and regulation. There was no article in DUR. And then pharmacoepidemiologic research trends of herbal medicine were summarized in classification of 5 categories. Conclusions : To sum up with these 8 articles of herbal medicine in pharmacoepidemiologic journals, herbal medicine was of interesting concern among researchers. The need for research on safety and risk management of herbal medicine is steadily increasing, pharmacoepidemiologic research about herbal medicine must be activated in Korea.

Analysis of the Properties and Tastes In Hyeongok's Formulas for Invigorating Five Viscera and their Ingredients (현곡(玄谷) 오장(五臟) 보방(補方)의 조성 약물과 그 기미배오(氣味配伍) 분석)

  • Shin, Soon-Shik
    • Herbal Formula Science
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    • v.19 no.1
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    • pp.131-144
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    • 2011
  • Objectives : The objective of this study lies in theoretical establishment of formulas for invigorating five viscera for curing the asthenic syndrome of five viscera through analyzing the component medicines and combination principles of Hyeongok's formulas for invigorating five viscera, and furthermore, maximizing the clinical use of them. Methods : This study analyzed the component medicines and combination principles of Hyeongok's formulas for invigorating five viscera based on the theory for properties and tastes of herbal medicines from the "Yellow Emperor's Canon of Internal Medicine", the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine, and the five elements doctrine. Hyeongok's formulas for invigorating five viscera are Bogantang, Boseemtang, Bobeetang, Bopyeotang, and Boshintang. Results : There are three methods for curing the asthenic syndrome of five viscera according to the five elements doctrine: in case of Bogantang invigorating the liver, invigorating the kidney and purging the lung; Boseemtang, invigorating the heart, invigorating the liver and purging the kidney; Bobeetang, invigorating the spleen, invigorating the heart and purging the liver; Bopyeotang, invigorating the lung, invigorating the spleen and purging the heart; Boshintang, invigorating the kidney, invigorating the lung and purging the spleen. Conclusions : First, to cure the asthenic syndrome of five viscera, the methods of invigorating five viscera, and purging five viscera should be used according to the five elements doctrine. Secondly, herbal medicines appropriate for those treatment methods should be chosen according to the theory for properties and tastes of herbal medicine and thirdly, the combination of those herbal medicines should be carried out according to the theory for principal herbal medicine, assistant herbal medicine, adjuvant herbal medicine, dispatcher herbal medicine. As a good example, Hyeongok's formulas for invigorating five viscera are combined according to the above theories. In conclusion, this formula was created by applying to the theory for properties and tastes of herbal medicines.

A Review of the Domestic Study Trends on Dermatosis Gravidarum Treated with Herbal Medicine (임신성 피부질환의 한약 치료에 대한 국내 연구 동향)

  • Hong, Ka-Kyung;Kang, Su-Jin;Kim, Sun-Kyung;Kim, Song-Baek
    • The Journal of Korean Obstetrics and Gynecology
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    • v.33 no.1
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    • pp.59-75
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    • 2020
  • Objectives: The purpose of this study is to investigate the domestic study trends on dermatosis gravidarum treated with herbal medicine. Methods: We searched for studies of dermatosis gravidarum treated with herbal medicine published until September 2019, through 6 Korean web databases. After searching studies, we analyzed selected studies. Results: As a result, eight studies were included in this study, all of which were case reports. Three studies used herbal medicine alone, three studies used herbal medicine with acupuncture, and two studies used herbal medicine with other treatment. In all of eight studies, herbal medicine treatment was effective for dermatosis gravidarum. Conclusion: This study shows that herbal medicine could be helpful in treating dermatosis gravidarum. However, in order to consolidate the foundation of herbal medicine treatment for dermatosis gravidarum, more case reports and high-quality clinical researches are needed.

Analysis the Correlation of Filtration Rate of Herbal-acupunctures and Pain Score of Herbal Acupuncture Stimulation (약침제재별 여과속도와 약침 시술시 느끼는 통증의 상관성 분석)

  • Baek, Seung-Tae;Byun, Hyuk;Park, Min-Je;Lee, Seung-Deok;Kim, Kap-Sung
    • Journal of Acupuncture Research
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    • v.23 no.6
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    • pp.85-101
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    • 2006
  • Objectives : This study was designed to find out correlation of filtration rate of herbal-acupunctures and pain score of herbal acupuncture stimulation. Methods : Filtration rate of Hwangryunhaedoktang herbal acupuncture, Kidney yang deficiency number two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus Elaphus herbal acupuncture, BUM herbal acupuncture and Carthami Flos herbal acupuncture were measured at the korean institute of herbal acupuncture. And Hwangryunhaedoktang herbal acupuncture, Kidney yang deficiency number two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus Elaphus herbal acupuncture, BUM herbal acupuncture and Carthami Flos herbal acupuncture were injected at Xie points of the subjects. Results : Ranking of herbal acupunctures filtration rates is the same as ranking of pain score and duration time of herbal acupuncture. Correlation analysis result of herbal acupunctures filtration rates and herbal acupuncture VAS with a simple linear regression analysis is that correlation coefficient of Hwangryunhaedoktang herbal acupuncture, Kidney Yang Deficiency Number Two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus elaphus herbal acupuncture, BUM herbal acupuncture. Carthami Flos herbal acupuncture is 0.44, 0.53, 0.58, 0.76, 0.47 and 0.54. Correlation analysis result of herbal acupuncture's filtration rates and herbal acupuncture stimulation's duration time is that correlation coefficient of Hwangryunhaedoktang herbal acupuncture, Kidney Yang Deficiency Number Two herbal acupuncture, Hominis Placenta herbal acupuncture, Cervus Elaphus herbal acupuncture, BUM herbal acupuncture, Carthami Flos herbal acupuncture is -0.09, 0.11, -0.07, 0.28, -0.11 and -0.09. Conclusion : We found the correlation of filtration rate of herbal-acupunctures and pain score of herbal-acupuncture stimulation. This study help to control pain amount and pain duration time of herbal acupuncture treatment. And this study improve acupuncture theory of herbal acupuncture.

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Monitoring of Heavy Metal Contents in Commercial Herbal Medicines (유통 한약재의 중금속 잔류실태 조사)

  • Jang, Seol;Kim, Tae Hee;Lee, Ah Reum;Lee, A Yeong;Choi, Goya;Kim, Ho Kyoung
    • Korean Journal of Medicinal Crop Science
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    • v.20 no.6
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    • pp.434-439
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    • 2012
  • This study was conducted to determine the contents of heavy metal in commercial herbal medicines. The monitoring of lead, arsenic, cadmium and mercury was carried out on 100 samples with 10 kinds of herbal medicines. The contents of heavy metal were measured by inductively coupled plasma atomic emission spectrometry (ICP-AES) and mercury analyzer. The mean values of heavy metal contents for herbal medicines were Pb 1.87 mg/kg, As 0.39 mg/kg, Cd 0.26 mg/kg and Hg 0.021 mg/kg. Of the total samples, 19 samples (19%, 4 types) were violated the KFDA regulatory guidance of heavy metal in herbal medicines (9 samples on Pb, 10 samples on Cd). Among these 19 unsuitable samples, 16 samples were domestic and 3 samples were imported. Therefore, we need continuously monitoring to ensure confidence and safety for these herbal medicines.