• Title/Summary/Keyword: Hyperthermia

Search Result 298, Processing Time 0.196 seconds

Massive Rhabdomyolysis Following Cardiopulmonary Bypass

  • Kim, Young Sam;Yoon, Yong Han;Kim, Joung Taek;Baek, Wan Ki
    • Journal of Chest Surgery
    • /
    • v.47 no.2
    • /
    • pp.181-184
    • /
    • 2014
  • Here, we report a case of massive rhabdomyolysis following an uncomplicated repair of a ventricular septal defect in a five-month-old baby. Postoperatively, the patient was hemodynamically stable but metabolic acidosis continued, accompanied by fever and delayed mental recovery. The next day, he became comatose and never regained consciousness thereafter. The computed tomography of the brain revealed a diffuse brain injury. The patient followed a downhill course and eventually died on postoperative day 33. An unusually high level of creatine phosphokinase was noticed, peaking (21,880 IU/L) on postoperative day 2, suggesting severe rhabdomyolysis. The relevant literature was reviewed, and the possibility of malignant hyperthermia obscured by cardiopulmonary bypass and hypothermia was addressed.

Mild Hyperthermia-induced Cell Cycle Arrest under P53-dependent Pathway in Human Cells

  • Jung, Hwa-Jin;Yim, Sung-Vin;Park, Seungjoon;Jung, Joo-Ho;Jung, Jee-Chang;Seo, Young-Rok
    • Proceedings of the Korean Society of Toxicology Conference
    • /
    • 2003.10b
    • /
    • pp.114-114
    • /
    • 2003
  • p53 has identified as a tumor suppressor protein to protect cells from DNA damage. p53, also well known for a transcription factor, can activate genes such as p21, bax, gadd45 and induce a number of the responses such as differentiation, senescence, DNA repair, apoptosis and the inhibition of angiogenesis to protect cells. Many mechanisms of p53 activation have been studied.(omitted)

  • PDF

Improvement of Heating Pattern in RF Hyperthermia -Simultaneous Application of Dielectric Heating and Induction Heating-

  • Sakakibara, Norifumi;Ochiai, Makoto;Hayakawa, Yoshinori
    • Proceedings of the Korean Society of Medical Physics Conference
    • /
    • 2002.09a
    • /
    • pp.478-480
    • /
    • 2002
  • Heating by RF wave is divided into dielectric heating and induction heating. Dielectric heating and induction heating from outside the body have the compensatory heating pattern. While surface fat layer is heated by dielectric heating, it is not heated by induction heating. While the peripheral part at the middle of the electrodes is not heated by dielectric heating, it is heated by induction heating. By the simultaneous application both modalities, heating pattern seems to be more uniform and improved. Computer simulation of Finite Element Method (FEM) using ANSYS was conducted to dielectric heating with the results of above-mentioned feature. Theoretical considerations by the uniform RF magnetic field in a cylinder and textbooks support the feature of the above-mentioned heating pattern of induction heating. Further computer simulation of FEM using ANSYS will be conducted to simultaneous application of dielectric heating and induction heating to verify and will be reported.

  • PDF

Electron Spin Resonance (ESR) and Microwave Absorption Studies of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Hyperthermia Applications

  • Choi, Yong-Ho;Yi, Terry;Kim, Do-Kyung
    • Journal of the Korean Ceramic Society
    • /
    • v.48 no.6
    • /
    • pp.577-583
    • /
    • 2011
  • Stabilized biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by controlled coprecipitation method for hyperthermia application. ESR measurements determined that all of the interactions in the individual SPIONs (1 nm and 11 nm) were antiferromagnetic in nature because the ions contributed to the magnetization with a range of magnetic moments. In-situ monitoring of the temperature increment was performed, showing that the microwave absorption rate of the SPIONs was dispersed in an appropriate host media (polar or non-polar solvents) during microwave irradiation. Microwave absorption energy rates and heat loss of SPIONs in solvent were calculated by non-linear data fitting with an energy balance equation. The microwave absorption rates of SPIONs dispersed in solvent linearly increases when the concentration of SPIONs increases, implying that the microwave absorption rate can be tunable by changing the concentration of SPIONs.

A Case report of Seupon (Shiwen, 습온) with Gyeonggwol (Jingjue, 경궐) (경궐을 동반한 습온 치험 1예)

  • Park Sung-Ho;Song Yun-Kyung;Lim Hyug-Ho
    • The Journal of Korean Medicine
    • /
    • v.25 no.3
    • /
    • pp.203-211
    • /
    • 2004
  • Objectives : We report an unusual case of a 57-year old woman with spasticity following fever of unknown origin (the origin of her fever was not certain by western medical diagnosis). Malignant hyperthemia with spasticity couldn't be cured by general western medical therapy, and furthermore the function of liver and renal system was worsened as a consequence of drugs. Methods : We diagnosed the watery state of the patient as seupon (습온) with gyeonggwol (경궐) through pattern identification (변증) of symptoms and signs. Results : This patient who had spasticity with malignant hyperthermia was treated by optical management of herb medicine and acupuncture, and should need long-term observation. Conclusions : We want to show that trial by febrile diseases can solve fever and spasticity.

  • PDF

A Basic Study on the Estimation of Noninvasive Temperature Distribution in Carcinoma Cell for the Hyperthermia (가온요법을 위한 암조직 세포의 무침습 온도분포 추정에 관한 기초연구)

  • Lee, Myeon-Seop;Kim, Nak-Hwan;Hong, Seung-Hong
    • Journal of Biomedical Engineering Research
    • /
    • v.7 no.1
    • /
    • pp.11-20
    • /
    • 1986
  • In the clincal application of Hyperthermia, tissue temperature measurements are made at only a few selecte4 locations because of patient tolerance and practical clinical limitation. Since it is necessary to know the complete carcinoma cell temperature field in order to treat effectively, The difficulty of making such estimates from only a few point compounded because of the lack of knowledge of the carcinomoma cell blood perfusion characteristics. To solve the temperature on carcinoma cell, A noninvasive method (the finite element method) is used. The simulation results show that the finite element method is promising for estimating the complete corcinoma cell temerature distribution, if some knowledge of the blood perfusion pattern is available.

  • PDF

Computation of Temperature Rise in the Human Liver Caused by Hyperthermia Antenna (Hyperthermia용 안테나에 의해서 인체간에 유기되는 온도 상승량 계산)

  • Shin, Kook-Sun;Kim, Nam
    • Proceedings of the Korea Electromagnetic Engineering Society Conference
    • /
    • 2002.11a
    • /
    • pp.328-331
    • /
    • 2002
  • Hyperthermia용 안테나의 성능은 안테나의 임피던스매칭과 안테나 주위 조직의 SAR 분포에 의해서 결정된다. 본 논문에서는 FDTD 해석법을 이용하여 Coaxial-Slot 안테나를 계단형(stair-caseing)으로 근사화하여 분석하였고, 가열 특성을 개선시킬 수 있는 Hyperthermia용 안테나를 설계하였다. 또한 팁으로부터 슬롯 중심까지의 거리( $L_{ts}$ )와 슬롯 폭을 변화시키면서 hyperthermia 안테나의 공진 특성을 분석하였고 계단형 모델로 근사화된 안테나에서 간에 유기 되는 SAR 1g 평균 첨두치를 계산하였다. 본 논문에서 제안하는 안테나의 SAR 값은 1g 평균 첨두치는 180.7 W/kg으로 나타났고 최대 온도는 상승량은 8.6$^{\circ}C$로 나타났다.

  • PDF

Ventricular Septal Defect Closure in a Neonate with Osteogenesis Imperfecta

  • Jang, Woo Sung;Choi, Hee Jeong;Kim, Jae Bum;Kim, Jae Hyun
    • Journal of Chest Surgery
    • /
    • v.52 no.3
    • /
    • pp.162-164
    • /
    • 2019
  • A male patient weighing 2.5 kg was admitted for respiratory difficulty, and a large ventricular septal defect (VSD) was diagnosed. During care, sudden right leg swelling with a femur shaft fracture occurred. The patient's father had a history of recurrent lower extremity fractures; thus, osteogenesis imperfecta was considered. The patient's respiratory difficulty became aggravated, and VSD repair in the neonatal period was therefore performed with gentle sternal traction and great vessel manipulation under total intravenous anesthesia to prevent malignant hyperthermia. The patient was discharged without notable problems, except minor wound dehiscence. Outpatient genetic testing revealed that the patient had a COL1A1/COL1A2 mutation.