• Title, Summary, Keyword: Injection site reaction

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Comparison of local reaction at injection site following intramuscular administration with three commercial atrophic rhinitis vaccines in pigs

  • Kim, Myung-Hyee;Kwon, Taeyong;Yoo, Sung J.;Seo, Sang won;Park, Jun Woo;Lyoo, Young S.
    • Korean Journal of Veterinary Service
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    • v.41 no.4
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    • pp.251-255
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    • 2018
  • Bordetella bronchiseptica and Pasteurella multocida are two main pathogens responsible for atrophic rhinitis (AR), which causes considerable economic losses in swine industry worldwide. Commercial vaccine has been widely used to prevent the damage from AR in Korea. Adverse effects of vaccination at the injection site have been reported, which results in the numerous complaint from farms. However, data on about local reaction at the injection site remains limited. In this study, we compared the local adverse effects of three commercial vaccines following intramuscular injection. The results showed that no gross lesion was founded at the injection sites of all three vaccines. In histopathologic examination, a various level of lesions was identified. Especially, the local reaction of vaccine including saponin as an adjuvant showed the lowest level of histopathological lesions, when compared to those of oil-based and vitamin E-based vaccines. Therefore, this study would provide the information about the extent of local reaction at the injection site and help the farmer to select AR vaccine in order to avoid adverse reaction due to vaccination.

과망간산을 이용한 지하수내 TCE 제거효과 평가

  • Yang Seung-Gwan;Go Seok-O
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • pp.53-56
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    • 2005
  • A Laboratory study was conducted to evaluate the kinetics of oxidation of trichloroethylene (TCE) in groundwater by potassium permanganate $(KMnO_4)$, Consumption of permanganate by TCE and aquifer materials was also evaluated to obtain an appropriate injection rate of $KMnO_4$. TCE degradation by $KMnO_4$ in the absence of aquifer material showed effective with pseudo-first order rate constant, $k_{obs}=1.8110^{-3}\;s^{-1}\;at\;KMnO_4=500mg/L$. TCE oxidation by $KMnO_4$ was found to be second order reaction and the rate constant, $k=0.65{\pm}0.08\;M^{-1}s^{-1}$, was independent of pH changes. $KMnO_4$ consumption rate by groundwater sampled from field site was not significant, indicating that groundwater containing negligible amount of dissolved organic matter does not have any influence on the $KMnO_4$ degradation. Meanwhile, aquifer materials from field site were actively reacted with permanganate, resulting in the significant consumption of $KMnO_4$. It might be attributed to the existence of metal oxides in aquifer materials, Based on the rate constants obtained from this study, appropriate injection rate of permanganate and TCE removal rate in groundwater could be estimated.

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Nicolau Syndrome following Diclofenac Injection in an Emergency Department (응급실에서 디클로페낙 근주 후 발생한 니콜라우 증후군 1례)

  • Chung, Sang-Won;Kang, Ji-Hoon;Yeo, Jun-Mo;Ko, Jai-Woog
    • Journal of The Korean Society of Clinical Toxicology
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    • v.9 no.2
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    • pp.101-104
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    • 2011
  • Nicolau syndrome is a rare adverse reaction at the site of an intramuscular injection, and is characterized by severe pain immediately after the injection and rapid development of distinct skin lesions. As this syndrome is rare, it may be overlooked at the early clinical phase and subsequently, clinical outcomes may be worse due to delay in treatment. We report on a female who developed Nicolau syndrome following intramuscular diclofenac injection, which required surgical reconstruction. Understanding the characteristics of Nicolau syndrome and careful surveillance for relevant clinical features may help physicians to more quickly diagnose and treat this condition.

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Effect of precooling on pain during local anesthesia administration in children: a systematic review

  • Tirupathi, Sunny Priyatham;Rajasekhar, Srinitya
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.20 no.3
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    • pp.119-127
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    • 2020
  • This study was conducted to determine how precooling reduces the subjective reported pain and objective pain and to evaluate the effectiveness of precooling the injection site before administration of local anesthesia in children. Electronic databases (PubMed, Ovid SP, Cochrane Central Register of Controlled Trials) were searched for publications from 1980 to 2020. Studies were screened for titles and abstracts, followed by full-text evaluation of included reports. Six studies were included in this systematic review. The primary outcome evaluated was the pain perception or the subjective pain reported by the child receiving the injection. The secondary outcome evaluated was objective pain evaluated in each study. Among 5 studies that evaluated child reported pain scores on a visual analogue scale (VAS), 4 studies reported lower scores in the precooling group and one study reported a higher VAS score in the precooling group than in children treated with 20% benzocaine topical anesthesia. Among 6 studies that evaluated the pain reaction of children by Sound Eye Motor (SEM) score, 4 studies reported a lower SEM score in the precooling group, one study reported no significant difference between the precooling and control groups, and one study reported higher SEM scores in the precooling group than in children treated with 20% benzocaine topical anesthesia. Within the limits of this systematic review, evidence suggests that precooling the injection site with ice can be an effective adjunct to topical anesthesia in reducing both subjective and objective pain during local anesthesia administration in children.

Local Subcutaneous Injection of Erythropoietin Might Improve Fat Graft Survival, Whereas Continuous Infusion Using an Osmotic Pump Device Was Harmful by Provoking an Overwhelming Foreign Body Reaction in a Nude Mouse Model

  • Kim, Eun Key;Lee, Yeonhoon;Lee, Hee Jong;Hong, Joon Pio
    • Archives of Aesthetic Plastic Surgery
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    • v.24 no.3
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    • pp.128-133
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    • 2018
  • Background Since the survival of grafted fat requires successful revascularization, we hypothesized that local delivery of erythropoietin (EPO), a hemangiogenic and antiapoptotic factor, might enhance the survival of fat grafts in a nude mouse model. Methods Our experiment consisted of 2 parts. The first involved direct injection of EPO or saline at the grafting site before fat grafting and for 4 days afterwards. In the second part, EPO or saline was delivered continuously for 1 week via an osmotic pump device, and a group without an implantable pump represented the control group. After 16 weeks, the surviving fat grafts were weighed and subjected to histomorphometry. Results In the first experiment, fat graft survival was higher in the EPO-injected group, but not statistically significant (69.2% vs. 59.2%; P=0.21). Histomorphometry showed significantly higher levels of microvessel formation and less cystic degeneration in the EPO-injected group. In the second experiment, the survival rate was significantly lower in both pump groups than in the control group (40.7% in the EPO pump group, 7.7% in the saline pump group, and 66.7% in the control group). Conclusions Local injection of EPO into the fat graft site appeared to improve graft survival, with increased angiogenesis, suppressed inflammation, and decreased degeneration. However, the insertion of an osmotic pump exerted detrimental effects on graft survival and the histomorphometric profiles of the fat graft compared with the control group due to the overwhelming foreign body reaction.

Hybrid Biomaterial of PLGA Microspheres and Hyaluronic Acid as a Potential Injectable Bulking Agent for Urologic and Dermatologic Applications

  • Cho, Eui-Ri;Kang, Sun-Woong;Kim, Byung-Soo
    • 한국생물공학회:학술대회논문집
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    • pp.644-647
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    • 2003
  • Materials currently used as an injectable bulking agent in the dermatologic and urologic fields revealed several drawbacks such as particles migration, inflammatory reaction, allergic reaction, rapid volume shrinkage, and necessity of a donor site. In this study, we have developed injectable biomaterial comprising poly (DL- lactide-co-glycolide)(PLGA) and hyaluronic acid gel to overcome these problems. PLGA is a biocompatible synthetic material and hyaluronic acid is a common substance found in living organisms. We examined the feasibility of injection through needle and tested biocompatibility in animal model. After transplantation, injected sites and distant organs were examined histologically to verify a new tissue formation, inflammation, and particles migrations. Injected volume was maintained approximately 80 percent for 2 months. Results demonstrated that the developed material was injectable through various gauges of needles and induced a new bulking tissue formation without serious inflammatory reaction.

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Antihyperalgesic Effects of Ethosuximide and Mibefradil, T-type Voltage Activated Calcium Channel Blockers, in a Rat Model of Postoperative Pain (흰쥐의 술 후 통증 모델에서 T형 칼슘 통로 차단제인 Ethosuximide와 Mibefradil의 항통각과민 효과)

  • Shinn, Helen Ki;Cha, Young Deog;Han, Jeong Uk;Yoon, Jeong Won;Kim, Boo Seong;Song, Jang Ho
    • The Korean Journal of Pain
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    • v.20 no.2
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    • pp.92-99
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    • 2007
  • Background: A correlation between a T-type voltage activated calcium channel (VACC) and pain mechanism has not yet been established. The purpose of this study is to find out the effect of ethosuximide and mibefradil, representative selective T-type VACC blockers on postoperative pain using an incisional pain model of rats. Methods: After performing a plantar incision, rats were stabilized on plastic mesh for 2 hours. Then, the rats were injected with ethosuximide or mibefradil, intraperitoneally and intrathecally. The level of withdrawal threshold to the von Frey filament near the incision site was determined and the dose response curves were obtained. Results: After an intraperitoneal ethosuximide or mibefradil injection, the dose-response curve showed a dose-dependent increase of the threshold in a withdrawal reaction. After an intrathecal injection of ethosuximide, the threshold of a withdrawal reaction to mechanical stimulation increased and the increase was dose-dependent. After an intrathecal injection of mibefradil, no change occurred in either the threshold of a withdrawal reaction to mechanical stimulation or a dose-response curve. Conclusions: The T-type VACC blockers in a rat model of postoperative pain showed the antihyperalgesic effect. This effect might be due to blockade of T-type VACC, which was distributed in the peripheral nociceptors or at the supraspinal level. Further studies of the effect of T-type VACC on a pain transmission mechanism at the spinal cord level would be needed.

고온공기주입시 지중온도에 의한 ISR의 변화

  • 박기호;박민호;이의신;신항식
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • pp.91-94
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    • 2003
  • A field pilot-scale demonstration of an enhanced SVE using hot air injection and extraction was conducted to remove diesel range compounds from subsurface soils at a site in J-city, Korea. The objective of demonstration was to evaluate field ISR by intrinsic microorganism after an application study of hot air-SVE technology and to calculate each first-order kinetic with soil temperature. TPH concentration of contaminated soil at the site was approximately 2, 000~11, 000 mg/kg (average 6, 900 mg/kg) with depths greater than 5 m bgs. The 1st-order reaction rate constants, k were 0.0438(@about5$0^{\circ}C$), 0.0564(@4$0^{\circ}C$), and 0.0685(@33$^{\circ}C$) d-1 respectively.

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Survey on the Side Effects of the Vesicant Chemotherapy (정맥으로 투여하는 발포성 항암제의 합병증)

  • Choi Eun-Sook;Kim Keum-Soon;Joo Myung-Soon;Kim Bok-Ja
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.7 no.3
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    • pp.415-428
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    • 2000
  • The purpose of this study was to identify side effects of the vesicant chemotherapy. The study was designed to be a descriptive survey. The subjects of this study were 88 patients with various types of cancer, primary lung cancer(25.0%), advanced gastric cancer(25.0%), breast cancer(20.5%), etc. The mean age was 44.8 years old(range: 16-68). The questionnaire was completed by nurses of the outpatient unit and chemotherapy ward, and intravenous nurse specialist. The results of the study were as follows: 1) Chemotherapy was administered with a 23G scalp needle and 24G insyte. Injection site was dorsum of hands(64.7%), cephalic vein(19.3%). Successful rate for the first attempt was 88.6%. The first & second cycle chemotherapy was 29.5% each.. Mainly used drugs were Navelbine(34.1%), Adriamycin(20.5%). 2) Venous Problems after chemotherapy were pain(13.6%) incurred by venous, mainly due to the administration of Navelbine; redness at the inravenous site(12.5%) and itching sense 2.3% Non-venous problems were nausea (18.2%), dullness(14.8%), vomiting(8.0%), facial flushing(6.8%), anxiety(5.7%). Subjective discomforts after chemotherapy were generalized arm pain at the injection side(14.8%), dizziness(6.8%), weakness(5.7%) and general bodyache(5.7%). Systemic anaphylactic reaction and extravasation did not occur. 3) Non-venous problem after chemotherapy were nausea, vomiting & anorexia. Frequency of chemotherapy related to side effects were itching, facial flushing, and nausea(p< .05). Day of chemotherapy related to side effects were nausea & vomiting(p< .05). Site of chemotherapy related to side effects were redness(p< .05). Frequency of venipuncture related to side effects were redness(p< .05). Conclusively, cancer chemotherapy patients have had some venous problem. They need appropriate venous access devices for chemotherapy. And other non-venous problem will be managed appropriately. Further research was required to identify the rate of venous complication or side effects of vesicant chemotherapy.

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Corn Growth and Development influenced by Potential CO2 Leakage from Carbon Capture and Storage (CCS) Site (지중저장 이산화탄소의 잠재적 누출 모사에 따른 옥수수 초기 반응 및 생장 연구)

  • Kim, You Jin;Chen, Xuanlin;He, Wenmei;Yoo, Gayoung
    • Journal of Climate Change Research
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    • v.8 no.3
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    • pp.257-264
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    • 2017
  • Carbon capture and storage (CCS) technology has been suggested as an ultimate strategy for mitigating climate change. However, potential leakage of $CO_2$ from the CCS facilities could lead to serious damage to environment. Plants can be a bio-indicator for $CO_2$ leakage as a cost-effective way, although plants' responses vary with plant species. In this study, a greenhouse experiment was conducted to investigate the relation between the $CO_2$ tolerance of corn species and the initial physiological responses to the elevated soil $CO_2$ concentration. Treatment groups included CI (99.99% $CO_2$ gas injection) and BI (no gas injection). Mean soil $CO_2$ concentration for the CI treatment was 19.5~39.4%, and mean $O_2$ concentration was 6.6~18.4%. The soil gas concentrations in the BI treatment were at the ambient levels. In the CI treatment, chlorophyll content was not decreased until the $13^{th}$ day of the $CO_2$ injection. On the $15^{th}$ day, leaf starch content and stomatal conductance were increased by 89% and 25% in the CI treatment compared to the BI treatment, respectively. This might be due to the compensatory reaction of corn to avoid high soil $CO_2$ stress. However, the prolonged $CO_2$ injection decreased chlorophyll content after 13 days. After $CO_2$ injection, plant biomass was reduced by 25% in the CI treatment compared to the BI treatment. Due to the inhibited root growth, leaf phosphorous and potassium contents were decreased by 54% on average in the CI treatment. This study indicates that corn has a high tolerance to soil $CO_2$ concentration of 30% for 2 weeks by its compensatory reactions such as an maintenance of chlorophyll content and an increase in stomatal conductance.