• Title, Summary, Keyword: Inonotus obliquus

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Effects of Inonotus obliquus Extracts on Immunomodulating Activity

  • Song, Kee-Cheol;Choi, Byung-Lyul;Shin, Jang-Woo;Son, Jin-Young;Yoo, Hwa-Seung;Cho, Jung-Hyo;Lee, Yeon-Weol;Son, Chang-Gue;Cho, Chong-Kwan
    • The Journal of Korean Medicine
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    • v.28 no.4
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    • pp.27-41
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    • 2007
  • Aim : This study aimed at elucidating the effects of Inonotus obliquus on anti-tumor effects in vivo and immune-based characterization of the mushroom as a potential candidate for cancer remedy. Methods : To investigate the immunomodulatory effects of Inonotus obliquus, we investigated macrophage functions and NK cell activities through the measurement of NO production of macrophage, NK cell cytotoxicity and expressions of cytokines and genes regulating immune responses, in addition to pulmonary metastasis model in vivo. Results : Inonotus obliquus showed general cytotoxicity at high concentrations over the 100 ${\mu}g/m{\ell}$ on the both of normal and cancer cell lines. Inonotus obliquus showed both inhibitory and promotive effects on pulmonary colonization of CT-26 cell depending on period or route of administration in vivo. Conclusion : From these results, it cannot be concluded that Inonotus obliquus has cancer-specific activity. Furthermore, Inonotus obliquus has the provability to show adverse effects differently according to the concentration and the method of administration.

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Nutrition Contents and Health Status, Blood Glucose Response Effect for NIDDM Patients of Inonotus Obliquus in Culturing Method by Using Unpolished Rice (현미에서 배양된 차가버섯 분말의 영양성분과 제2형 당뇨환자의 건강지표 및 혈당관련인자에 미치는 영향)

  • Kim, Won-Jong;Koo, Jae-Geun;Lee, Tae-Hun;Han, Jong-Hyun;Park, Sung-Hye
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.1
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    • pp.114-118
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    • 2005
  • The purpose of this study was to investigate the possibility of Inonotus obliquus as an functional resource. To assess the effects of Inonotus obliquus in culturing method by using unpolished rice in 15non-insulin dependent diabetes mellitus persons, we examined changes of hematological and chemical variables, DM indices content in serum during the Inonotus obliquus supplementation. GOT, GPT concentrations were significantly decreased. But TIBC content was significantly increased. Fasting glucose level during Inonotus obliquus supplementation was decreased respectively. These results show that modest dose of Inonotus obliquus in culturing method by using unpolished rice supplementation can decrease fasting blood glucose level without any changes in health indices and nutrition status of the non-insulin dependent diabetes mellitus person. These results indicated that Inonotus obliquus in culturing method by using unpolished rice diet is effective therapeutic regimen for the control of metabolic derangements in diabetes mellitus. Also, the results imply that Inonotus obliquus in culturing method by using unpolished rice can be used as possible functional food materials. However, large amounts of Inonotus obliquus in culturing method by using unpolished rice showed be used cautiously application.

Studies on the anti-pulmonary tuberculosis of Inonotus obliquus (차가버섯의 항결핵 활성에 대한 연구)

  • Song, Ho-Yeon;Lee, Dae-Jin;Lee, Byung-Eui
    • Journal of Mushroom
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    • v.9 no.4
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    • pp.190-193
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    • 2011
  • Inonotus obliquus is a traditional medicine mushroom that was developed from traditional medicine originating in ancient. It has been applied for cancer or immunotherapy, but its effect on pulmonary tuberculosis is not reported. Therefore, we measured the pulmonary tuberculosis therapeutic effect of methyl alcohol extract from MGIT 960 system with fluorescent indicator. Inonotus obliquus extract showed 14 day more inhibitory activity than the positive control. In addition, the anti-pulmonary tuberculosis activity of Inonotus obliquus was $50{\mu}m$. These results suggest that Inonotus obliquus methyl alcohol extracts could contribute to inhibition of pulmonary tuberculosis.

Dyeing Properties and Antibacterial Activity of Cotton Fabric with Inonotus obliquus (차가버섯 추출염액을 이용한 면직물의 염색성과 항균효과)

  • Kim, Sung-Hee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.33 no.11
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    • pp.1774-1780
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    • 2009
  • The dyeing properties of cotton fabric with Inonotus obliquus are studied by investigating the effect of dyeing conditions on dye uptakes such as, the concentration of Inonotus obliquus, dyeing temperature, time, and pH values. In addition, the effects of mordants on dye uptakes and antibacterial activities are also investigated. The results are summarized as follows: The dye uptakes of dyed fabrics were increased gradually with an increasing concentration of Inonotus obliquus. K/S values were the highest when the dyeing temperature and time were at $60^{\circ}C$ and 60 minutes, respectively. As for the changes of pH values of dyeing solution, K/S values recorded the highest at pH3-pH5. Antibacterial activities of Inonotus obliquus dyeing solution showed a significant effect in dyed cotton fabric with mordanting.

The Change of Comfort Properties of Cotton and Hanjee Fabrics with Natural Dyeing and Functional Mineral Treatment (면섬유 및 한지섬유의 자연염색 및 기능성광물처리에 의한 쾌적성의 변화)

  • Kim, Sung-Hee
    • Fashion & Textile Research Journal
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    • v.12 no.2
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    • pp.219-223
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    • 2010
  • In this study, the comfort properties of cotton and Hanjee fabrics dyed with Inonotus obliquus and treated with illite were evaluated and compared. Results were as follows; 1) W/T values and WC/W values of cotton and Hanjee fabrics were decreased when they were dyed with Inonotus obliquus and treated with illite. 2) Although air permeability of cotton fabrics was higher than that of Hanjee fabrics, air permeability of cotton and Hanjee fabrics dyed with Inonotus obliquus and treated with illite was decreased. 3) Thermal conductivity of cotton and Hanjee fabrics dyed with Inonotus obliquus was increased whereas thermal retain property was decreased. 4) Water absorption of Hanjee fabrics was higher than that of cotton fabrics. Water absorption of cotton and Hanjee fabrics dyed with Inonotus obliquus and treated with illite was increased. 5) Deodorization rate of Hanjee fabrics was greater than that of cotton fabrics.

Antioxidant and Anticancer Effects of Fermentation Vinegars with Phellinus linteus, Inonotus obliquus, and Pleurotus ostreatus (상황버섯, 차가버섯, 느타리버섯 발효식초의 항산화와 항암활성 효과)

  • Chung, Bong-Hwan;Seo, Hun-Seok;Kim, Hong-Sig;Woo, Sun-Hee;Cho, Yong-Gu
    • Korean Journal of Medicinal Crop Science
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    • v.18 no.2
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    • pp.113-117
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    • 2010
  • The antioxidant and anticancer activities of Phellinus linteus, Inonotus obliquus, and Pleurotus ostreatus according to extraction methods were measured. The contents of polyphenolic compounds were higher in fermented extracts than those in water extracts. The contents were 192.4mg/100 $m{\ell}$ for Inonotus obliquus vinegar, 186.9 mg/100 $m{\ell}$ for Phellinus linteus vinegar, and 156.5 mg/100 $m{\ell}$ for Pleurotus ostreatus vinegar, respectively. EDA(electron donating ability) in Phellinus linteus that was highest among mushrooms was 83.9% in the water extract and 96.8% in the fermented extract. The growth of stomach cancer cells, SNU-719 was inhibited 62.4%, 65.5%, and 53.0% by Phellinus linteus vinegar, Inonotus obliquus vinegar, and Pleurotus ostreatus vinegar, respectively and also the growth of liver cancer cells, Hep3B was inhibited 67.1%, 68.3%, and 57.6% by Phellinus linteus vinegar, Inonotus obliquus vinegar, and Pleurotus ostreatus vinegar, while the growth of normal cell, DC2.4 was not affected. Even though Phellinus linteus and Inonotus obliquus showed higher inhibition in cancer cell growth, Pleurotus ostreatus can be efficiently used for antioxidant and anticancer activities due to their cheap price in the market.

Effect of Medium Compositions on the Mycelial Growth of Inonotus obliquus (차가버섯의 균사체 성장에 대한 배지성분의 영향)

  • Choi, Keun Ho
    • Korean Chemical Engineering Research
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    • v.43 no.3
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    • pp.419-424
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    • 2005
  • Effect of temperature($22-32^{\circ}C$), pH(5-7) and medium composition on the mycelial growth for the submerged culture of Inonotus obliquus. The concentrations of glucose, starch, peptone, yeast extract, $K_2HPO_4$, $MgSO_4{\cdot}7H_2O$ and $CaCl_2$ were examined in the ranges of 30-120 g/L, 0-10 g/L, 0-20 g/L, 0-15 g/L, 0-2 g/L, 0-1.5 g/L and 0-0.5g/L, respectively. The maximum mycelial growth of Inonotus obliquus was obtained for $26-27^{\circ}C$ and pH 6. The concentrations of glucose, yeast extract and $CaCl_2$, which gave the maximum mycelial growth of Inonotus obliquus, were 70 g/L, 5 g/L and 0.1 g/L, respectively. In the cases of starch, peptone and $K_2HPO_4$, the mycelial growth of Inonotus obliquus increased with increasing the concentrations. However, as the concentration of $MgSO_4{\cdot}7H_2O$ increased, the mycelial growth of Inonotus obliquus decreased. The medium for maximum mycelial growth of Inonotus obliquus consisted of (per 1 L): glucose, 70 g; peptone, 5-20 g; starch, 10 g; yeast extract, 5 g; $K_2HPO_4$, 2 g and $CaCl_2$, 0.1 g.

Effect of Inonotus obliquus Extract on the Expression MMPs and HAS-2 (차가버섯 추출물의 MMPs 발현 저해 및 HAS-2 발현 증가효과)

  • Lee, So-Hun;Park, Sun-Hee;Lee, Kang-Hyuk;Park, Soo-Jin;Kim, Young-Heui
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.37 no.3
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    • pp.237-245
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    • 2011
  • In order to investigate the possibility of Inonotus obliquus extract as an active ingredient for wrinkle-care cosmetics, we prepared 70 % ethanolic extract of Inonotus obliquus and measured its DPPH radical scavenging activity and elastase inhibitory activity. We also evaluated the effect of Inonotus obliquus extract on expression of MMPs and HAS-2 in fibroblast and HaCaT cell, respectively. Inonotus Obliquus extract showed DPPH radical scavenging activity and elastase inhibitory activity in a dose-dependant manner ($SC_{50}$ = 91 ${\mu}g$/mL, $IC_{50}$=124 ${\mu}g$/mL). Inonotus obliquus extract inhibited the expression of MMP-1 mRNA 50 ~ 79 % at concentrations of 5 ~ 25 ${\mu}g$/mL, and reduced the expression of MMP-2 around 20 % at a concentration of 10 ${\mu}g$/mL. And it also reduced the expression of MMP-9 54 ~ 70 % in tconcentrations of 5 to 25 ${\mu}g$/mL. Furthermore, Inonotus obliquus extract increased HAS-2 mRNA expression in a dose-dependent manner in concentrations of 5 to 25 ${\mu}g$/mL without cytotoxicity. These results suggested that Inonotus Obliquus extract could be useful as an active ingredient for wrinkle-care cosmetics.

Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma (Inonotus obliquus (차가버섯) 추출물의 EBV 양성 인간위암에 대한 in vivo 항종양 효능 연구)

  • Lee, Seulki;Cho, Hyosun
    • Korean Journal of Microbiology
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    • v.52 no.4
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    • pp.482-486
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    • 2016
  • Inonotus obliquus is a medicinal mushroom with a variety of biological activities. It has reported to have strong anti-cancer, antioxidant and anti-inflammatory properties. EBV+ gastric carcinoma is one of the most common EBV-associated cancers that were caused by latent EBV infection. In this study, we investigated the anti-cancer effects of ethanol extract of I. obliquus using in vivo xenograft animal models implanted with EBV+ human gastric carcinoma (SNU719). We also explored the molecular mechanisms responsible for its anti-cancer activity. The result indicated that the extract of I. obliquus had an anti-cancer effect in in vivo xenograft mice with EBV+ gastric carcinoma (SNU719). Extract of I. obliquus also showed a great effect on inducing the expression of p53, p21 and Bax in tumor tissue derived from EBV+ human gastric carcinoma, and these were correlated with increased expressions of the cleaved forms of caspase-9 and Parp. Also, I. obliquus attenuated the expression of viral proteins, BZLF-1 and LMP-2 in tumor tissue from EBV+ human gastric carcinoma.

Optimization of Microencapsulation of Inonotus obliquus Extract Powder by Response Surface Methodology and Its Application into Milk

  • Ahn, Sung-Il;Chang, Yoon-Hyuk;Kwak, Hea-Soo
    • Food Science of Animal Resources
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    • v.30 no.4
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    • pp.661-668
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    • 2010
  • This study was carried out to optimize microencapsulation conditions for Inonotus obliquus extract powder with mediumchain triacylglycerol (MCT) using response surface methodology (RSM), and to determine the possibility of adding encapsulated I. obliquus extract to milk toward improving the functionality of milk. and to investigate the effects of added encapsulated I. obliquus extract on the physicochemical and sensory properties of the product. The microencapsulation efficiency of I. obliquus extract powder was investigated with respect to three variables (ratios of core material to coating material, amounts of water added, and spray pressure) in RSM. The optimal conditions for microencapsulation of I. obliquus extract powder were obtained from the ratio of core material to coating material (2.92:10) and the amount of water added (0.5 mL); the spray pressure had an insignificant effect on the microencapsulation (p<0.05). Adding encapsulated I. obliquus extract into milk did not significantly affect either color (L, a and b values) or thiobarbituric acid (TBA) values. Sensory test revealed that there were significant improvements in brownish, herb flavor, and bitterness scores for encapsulated I. obliquus extract-added milk as compared with those for uncapsulated I. obliquus extract-added milk. Based on the data obtained from the present study, it is concluded that microcapsules of I. obliquus extract powder could be applicable to milk without remarkably adverse effects on physicochemical and sensory properties