• Title, Summary, Keyword: Isopyrazam

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Method Development and Validation for Analysis of Isopyrazam Residues in Agricultural Products (농산물 중 살균제 Isopyrazam의 개별 잔류분석법 확립)

  • Kim, Ji-Yoon;Kim, Ja-Young;Ham, Hun-Ju;Do, Jung-Ah;Oh, Jae-Ho;Lee, Young-Deuk;Hur, Jang-Hyun
    • The Korean Journal of Pesticide Science
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    • v.17 no.2
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    • pp.84-93
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    • 2013
  • Validated analytical methods for isopyrazam are meager or lacking. In the present study, a single residual analytical method was developed for isopyrazam in selected commodities. Isopyrazam was analyzed in brown rice, soybean, green pepper, mandarin, cucumber, and Korean melon. We tried different solvents and methods through extraction, partition and purification steps to obtain best analytical results. For isopyrazam samples were extracted with acetonitrile, concentrated and partitioned with n-hexane, clean-up using florisil with n-hexane/ethylacetate (70/30) and analyzed with HPLC/UVD. The limit of quantitation (LOQ) for isopyrazam was 1.0 ng (S/N > 10) and method LOQ (MLOQ) was 0.04 mg $kg^{-1}$. Recovery ranged through 81.0~105.3% (syn-isomer) and 80.8~105.6% (anti-isomer) at fortification level of 0.04 (MLOQ), 0.4 (10 ${\times}$ MLOQ), and 2.0 (50 ${\times}$ MLOQ). The coefficient of variation (CV) for isopyrazam was less than 10% regardless of sample types. These results were further confirmed with LC/MS, respectively. The proposed method is highly reproducible and sensitive and is suitable for routine analysis.

Residues of New Fungicide, Isopyrazam on Cucumber and Oriental Melon (Pyrazolecarboxamide계 살균제 Isopyrazam의 오이 및 참외 중 잔류특성)

  • Han, Ye-Hoon;Lee, Cheol-Yong;Park, Kwee-Doo;Park, Kwang-Wook;Lee, Kyu-Seung
    • The Korean Journal of Pesticide Science
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    • v.17 no.1
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    • pp.13-19
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    • 2013
  • Isopyrazam, a new pyrazolecarboxamide fungicide developed by Syngenta, was highly active against foliar powdery mildew pathogens on cucumber, oriental melon and various vegetables. Following foliar applications on cucumber and oriental melon, crop residues were determined using high performance liquid chromatography. For all studies, limit of quantification was 0.02 mg/kg and minimum detection level was 2.0 ng and recoveries were 83.0-88.0% on cucumber, 92.4-104.5% on oriental melon. Isopyrazam was detected 0.07-0.72 mg/kg on cucumber and < 0.02-0.68 mg/kg on oriental melon, respectively. The TMDI (Theoretical Maximum Dailly Intake) of isopyrazam on cucumber and oriental melon was estimated to less than 1.765% of ADI.

Underestimation of Dietary Exposure to Pesticide Residues in Relation to Residue Definition in South Korea (국내 잔류농약 residue definition과 관련된 식이노출의 과소평가)

  • Lee, Mi-Gyung
    • Journal of Food Hygiene and Safety
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    • v.35 no.5
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    • pp.452-458
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    • 2020
  • In this study we aimed to find out pesticide types with probability for underestimation of dietary exposure to pesticide residues in Korea by comparing the residue definitions between Korea and Codex standards. In addition, we sought to establish priorities regarding the necessity of review concerning pesticide types and their impacts based on the risk assessment and dietary exposure underestimation. As a result, we found that according to the residue definition information, 44 pesticides have probability for underestimation in terms of dietary exposure assessments. Among them, 24 pesticides have priority for review of dietary exposure underestimation and its impacts on risk assessment, based on the ADI values of pesticides, Korean MRL information and toxicological information of metabolite. The 24 pesticides were as follows: acibensolar-S-methyl, chlorfenapyr, chlorothalonil, cyantraniliprole, cyclaniliprole, cyflumetofen, dithiocarbamates, fenamidone, fenpyroximate, fluazifop-P-butyl, fluopicolide, flupyradifuron, fluxapyroxad, glyphosate, hexythiazox, isoprothiolane, isopyrazam, myclobutanil, penthiopyrad, propiconazole, spinetoram, spiromesifen, spirotetramat, trifloxystrobin. Furthermore, chlorfenapyr, chlorothalonil, dithiocarbamates and fenamidone may have considered a top priority for review due to greater toxicity of metabolite. This study could be of great use for improvement on risk assessment approaches in South Korea regarding pesticide residues in food commodities.