• Title/Summary/Keyword: Linkage and Association

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A System of Managing Connection to Science and Technology Information Services (과학기술 학술정보 서비스 연계 관리 시스템)

  • Lee, Mikyoung;Jung, Hanmin;Sung, Won-Kyung
    • Proceedings of the Korea Contents Association Conference
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    • pp.823-826
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    • 2008
  • This paper shows linkage management for external services. There are many services for specific entities such as DBLP and OntoWorld. OntoFrame, as a Semantic Web-based research information service portal, aims at one-stop service in ways that it connects external services with hyperlinks. For managing the linkage, linkage rules are manually edited by human administrators and automatically verified and tested by linkage management system. It consists of linkage rule management, linkage rule verification, linkage test, and dynamic link generation. Linkage rule management creates and edits linkage rules to connect external services on the Web. After finished rule editing and verification step, linkage management invokes linkage test with entity list. Only valid links are visible to enable users to click on our system, and thus it increases user's reliability on the system.

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THE EFFECTS OF POPULATION SIZE AND DOMINANCE OF QUANTITATIVE TRAIT LOCI (QTL) ON THE DETECTION OF LINKAGE BETWEEN MARKERS AND QTL FOR LIVESTOCK

  • Jeon, G.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.8 no.6
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    • pp.651-655
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    • 1995
  • A simulation study on detection of linkage between genetic markers and QTL in backcross design was conducted. The effects of various sample sizes and the degree of QTL dominance on detention of linkage were examined by using a simple regression analysis. The results indicated that as sample size increased, the standard error of the estimated slope became smaller. When the dominance effect of QTL was complete, the estimated slope tended to be negative but was statistically not significant at all with type I error of greater than 50%. With complete linkage between genetic Marker and QTL, the estimated intercept value was smallest but the estimated slope was largest as expected. In most cases with various degree of dominance and sample sizes, when the actual recombination rate became larger, greater values were obtained for the slope except in the case of complete dominance of QTL.

Strategies of Home Health Care Services Linkages in Korea Based on Delphi Technique (델파이 기법을 이용한 우리나라 재가간호서비스 연계방안)

  • Lee, Seung-Hee;Lim, Ji-Young
    • The Journal of the Korea Contents Association
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    • v.12 no.12
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    • pp.282-290
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    • 2012
  • Today, home health care services needs a linkage plan of the customized home visiting health service in public health center, the medical institute home health care service, and home visiting nursing service based on long term care insurance for the elderly program which acknowledges the independence and professionalism of the home health care services while minimizing overlap through linking the projects. So, this study was performed by applying the Delphi technique, which draws agreement from professional opinion, to determine a method to link home health care services in Korea. The results of this study are as follows. Specialists agreed on 24 important items within the two domains of institutional linkage and medical linkage. And the significance of this study is as follows. The 24 items deduced for the approved nursing service linkage plan are expected to improve the home health care service business system, enhance the quality of home health care service, and bring increased satisfaction for service recipients. Also, seeking ways to minimize overlap in service can increase the effectiveness of health care and public health management at a national level. In addition, it is considered that this will ultimately reduce public medical costs as well as improve home health care service.

A Study on the Technological Network between Innovative Clusters in Korea - With Special Reference to the Network Analysis of Co-invention - (국내 혁신클러스터의 기술혁신 연계관계 연구 : 공동발명의 네트워크 분석을 중심으로)

  • Park, Hyun-Woo;Yoo, Sun-Hi
    • Journal of Korea Technology Innovation Society
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    • v.10 no.1
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    • pp.98-120
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    • 2007
  • This study analyzed the linkage relations of technological innovation between Daedeok Innopolis and other seven innovative clusters in industrial complexes which have played important roles as innovative centers in Korea. To begin with, we selected major technologies of Daedeok Innopolis for which the linkage with other clusters of innovative activities was analyzed quantitatively and graphically with association matrices, network analysis and dendrogram. Based on this network analysis, we analyzed the technological linkage among clusters and found the direction and strength of technological cooperation of the Daedeok Innopolis with other innovative clusters by technology field. This study analyzed the technological network between the Daedeok Innopolis and other clusters on 6 technology fields in which Daedeok has innovative capabilities. In the analysis was measured the centrality of Daedeok compared with that of other clusters in areas where Daedeok is relatively active in innovative activities. As a result, Daedeok showed the highest centrality with the active innovative activities. Except Daedeok, Banwol-Sihwa cluster showed the highest centrality in all of the 6 technology fields. Putting all the centrality of each innovative cluster and the linkage relations of Daedeok Innopolis together, it need to consider the following policy directions to strengthen the innovative linkage with other clusters. In Daedeok's main technology areas, it needs to increase the regional linkage with the clusters with relatively high centrality and relatively low linkage with Daedeok. For Changwon, Wonju and Gunsan with which Daedeok has the relatively low innovative linkage, it need to examine a new policy to improve the linkage with technologies related with the industry other clusters are nurturing. When Daedeok formulates a plan to cooperate with other clusters, it does not only have to consider the linkage relations of technological innovation analyzed in this study and but also has to examine the cooperative strategies from the comprehensive point of view considering every aspect of their strategic industries, supportive policies, industrial base and competitiveness. This study analyzed the linkage relations between regions based on the network analysis of patents only by co-invention. Consequently, it did not examine the factors inducing the co-invention, which is a limitation of the study and is to be investigated in the future. Also, the exploratory analysis on determinants of linkage intensity and the strategies to get synergy effects through solidified linkage will be the issues of further study.

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Detection of QTL for Carcass Quality on Chromosome 6 by Exploiting Linkage and Linkage Disequilibrium in Hanwoo

  • Lee, J.H.;Li, Y.;Kim, J.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.1
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    • pp.17-21
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    • 2012
  • The purpose of this study was to improve mapping power and resolution for the QTL influencing carcass quality in Hanwoo, which was previously detected on the bovine chromosome (BTA) 6. A sample of 427 steers were chosen, which were the progeny from 45 Korean proven sires in the Hanwoo Improvement Center, Seosan, Korea. The samples were genotyped with the set of 2,535 SNPs on BTA6 that were imbedded in the Illumina bovine 50 k chip. A linkage disequilibrium variance component mapping (LDVCM) method, which exploited both linkage between sires and their steers and population-wide linkage disequilibrium, was applied to detect QTL for four carcass quality traits. Fifteen QTL were detected at 0.1% comparison-wise level, for which five, three, five, and two QTL were associated with carcass weight (CWT), backfat thickness (BFT), longissimus dorsi muscle area (LMA), and marbling score (Marb), respectively. The number of QTL was greater compared with our previous results, in which twelve QTL for carcass quality were detected on the BTA6 in the same population by applying other linkage disequilibrium mapping approaches. One QTL for LMA was detected on the distal region (110,285,672 to 110,633,096 bp) with the most significant evidence for linkage (p< $10^{-5}$). Another QTL that was detected on the proximal region (33,596,515 to 33,897,434 bp) was pleiotrophic, i.e. influencing CWT, BFT, and LMA. Our results suggest that the LDVCM is a good alternative method for QTL fine-mapping in detection and characterization of QTL.

Multiple Linkage Disequilibrium Mapping Methods to Validate Additive Quantitative Trait Loci in Korean Native Cattle (Hanwoo)

  • Li, Yi;Kim, Jong-Joo
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.7
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    • pp.926-935
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    • 2015
  • The efficiency of genome-wide association analysis (GWAS) depends on power of detection for quantitative trait loci (QTL) and precision for QTL mapping. In this study, three different strategies for GWAS were applied to detect QTL for carcass quality traits in the Korean cattle, Hanwoo; a linkage disequilibrium single locus regression method (LDRM), a combined linkage and linkage disequilibrium analysis (LDLA) and a $BayesC{\pi}$ approach. The phenotypes of 486 steers were collected for weaning weight (WWT), yearling weight (YWT), carcass weight (CWT), backfat thickness (BFT), longissimus dorsi muscle area, and marbling score (Marb). Also the genotype data for the steers and their sires were scored with the Illumina bovine 50K single nucleotide polymorphism (SNP) chips. For the two former GWAS methods, threshold values were set at false discovery rate <0.01 on a chromosome-wide level, while a cut-off threshold value was set in the latter model, such that the top five windows, each of which comprised 10 adjacent SNPs, were chosen with significant variation for the phenotype. Four major additive QTL from these three methods had high concordance found in 64.1 to 64.9Mb for Bos taurus autosome (BTA) 7 for WWT, 24.3 to 25.4Mb for BTA14 for CWT, 0.5 to 1.5Mb for BTA6 for BFT and 26.3 to 33.4Mb for BTA29 for BFT. Several candidate genes (i.e. glutamate receptor, ionotropic, ampa 1 [GRIA1], family with sequence similarity 110, member B [FAM110B], and thymocyte selection-associated high mobility group box [TOX]) may be identified close to these QTL. Our result suggests that the use of different linkage disequilibrium mapping approaches can provide more reliable chromosome regions to further pinpoint DNA makers or causative genes in these regions.

A Study on the Development of the Data Linkage Method for Performance-based on Port Facility Maintenance Decision Marking System (성능기반의 항만시설물 유지관리 의사결정체계 개발을 위한 데이터 연계방안 도출에 관한 연구)

  • Kim, Yong-Hee;Kang, Yoon-Koo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.11
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    • pp.9-18
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    • 2020
  • Recently, studies of integrated management platform and performance-based maintenance decision-marking systems have proceeded to the efficient management of port facilities. The purpose of this study was to manage and operate port facilities based on performance and to provide long-term durability and budgetary execution. Thus, it is essential to secure basic data to be analyzed in an integrated platform and decision-marking system. This study derived the data linkage measures to secure port facility design and management information. The target of deriving the data linkage was the POMS (Port Facility Management System) currently in operation by the MOF (Ministry of Oceans and Fisheries). To derive data linkage, analyze the database of POMS and select the data required for the operation-integrated platform and decision-marking system. The final data linkage target was determined by compiling the requirements of the relevant experts and selecting the final target of three groups (port and facility information, management information, and user information). As a result, the API interface design was prepared for detailed linked data and data linkage framework between the linkage data of POMS. The provision of real-time data linkage between POMS and integrated platform is expected to improve the operational efficiency of the integrated platform.

A Study on Factors to affect Performance Satisfaction of Comprehensive Child Care Services of Child Care Center Workers (보육시설종사자의 포괄적 보육서비스 수행 만족도에 영향을 미치는 요인 연구 -지역사회자원과의 연계를 중심으로-)

  • Park, Mi Jeong
    • Korean Journal of Childcare and Education
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    • v.3 no.2
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    • pp.108-122
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    • 2007
  • The objective of this study was to examine factors that affect service linkage and Satisfaction of Comprehensive child care services through Community resources linkage. The subjects were 370 child care center workers providing child care services in Busan. The results showed that: First, in personal factors, maintenance of service interchange for maintenance of relationship with other facilities had significant effect on the satisfaction level, Second, in the case of organizational factors, closeness with linkage facility, sufficient business capital, positiveness for linkage, and preparedness of internal provisions for linkage had significant effect on the satisfaction level. Third, in the case of environmental factors, proximity with linkage agencies, level of environment fostering, and level of cooperation with linkage agencies had significant influence.

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Recent Advances in Sheep Genome Mapping

  • Crawford, A.M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.12 no.7
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    • pp.1129-1134
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    • 1999
  • The rapid development of the sheep genetic linkage map over the last five years has given us the ability to follow the inheritance of chromosomal regions. Initially this powerful resource was used to find markers linked to monogenic traits but there is now increasing interest in using the genetic linkage map to define the complex of genes that control multigenic production traits. Of particular interest are those production traits that are difficult to measure and select for using classical quantitative genetic approaches. These include resistance to disease where a disease challenge (necessary for selection) poses too much risk to valuable stud animals and meat and carcass qualities which can be measured only after the animal has been slaughtered. The goal for the new millennium will be to fully characterise the genetic basis of multigenic production traits. The genetic linkage map is a vital tool required to achieve this.

Development of 4-Bar Linkage Orthotic Knee Joint (4절 연쇄 보조기무릎관절의 개발)

  • Kim, Jang-Hwan;Yi, Jin-Bock
    • The Journal of the Korea Contents Association
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    • v.11 no.12
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    • pp.317-325
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    • 2011
  • This study aims to develop the stance-control typed 4-bar linkage orthotic knee joint that replace the locked orthotic knee joint for the disabled with poliomyelitis and muscle weakness of lower limb. Unlike the existing stance-control orthotic knee joint, there are no needs of electric power, connecting circuit, bulky compomnets, etc, because this 4-bar linkage orthotic knee joint is controled by geometric locking. To evaluate the 4-bar linkage orthotic knee joint, a subject participated in this study who has been diagnosed with lower limb poliomyelitis and have used locked type orthotic knee joint. In the results of analysis of subject's gait using 3-dimentional motion analysis system, this 4-bar linkage orthotic knee joint provide the stability during stance phase and knee flexion during swing phase.