• Title, Summary, Keyword: Medicinal Plant

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Molecular approaches for improvement of medicinal and aromatic plants

  • Kumar, Jitendra;Gupta, Pushpendra Kumar
    • Plant Biotechnology Reports
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    • v.2 no.2
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    • pp.93-112
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    • 2008
  • Medicinal and aromatic plants (MAPs) are important sources for plant secondary metabolites, which are important for human healthcare. Improvement of the yield and quality of these natural plant products through conventional breeding is still a challenge. However, recent advances in plant genomics research has generated knowledge leading to a better understanding of the complex genetics and biochemistry involved in biosynthesis of these plant secondary metabolites. This genomics research also concerned identification and isolation of genes involved in different steps of a number of metabolic pathways. Progress has also been made in the development of functional genomics resources (EST databases and micro-arrays) in several medicinal plant species, which offer new opportunities for improvement of genotypes using perfect markers or genetic transformation. This review article presents an overview of the recent developments and future possibilities in genetics and genomics of MAP species including use of transgenic approach for their improvement.

In Vitro Propagation of Medicinal Herbs in Korea

  • An, Chanhoon;Song, Jeongho
    • Journal of Forest and Environmental Science
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    • v.34 no.1
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    • pp.77-81
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    • 2018
  • Mass production of forest medicinal plants is related to quality control of raw medicinal materials. Plant tissue culture is an important technology to produce high-quality plant materials. Numerous factors are reported to influence the success of in vitro regeneration of medicinal plants. Embryogenesis is known to be the most effective techniques and it has developed in some medicinal plant species. Various in vitro cultural condition for direct and/or indirect somatic embryogenesis systems have developed in Epimedium koreaum, Bupleurum falcatum, Paeonia lactiflora, Chrysanthemum zawadskii, Houttuynia cordata etc. In this study, we provide the present statue and information of in vitro propagation techniques that is able to apply as an efficient system for rootstock propagation system of forest medicinal plants.

The Root from Heracleum moellendorffii Exerts Anti-Inflammatory Activity via the Inhibition of NF-κB and MAPK Signaling Activation in LPS-Stimulated RAW264.7 Cells

  • Park, Su Bin;Kim, Ha Na;Kim, Jeong Dong;Park, Gwang Hun;Son, Ho-Jun;Eo, Hyun Ji;Song, Jeong Ho;Jeong, Hyung Jin;Jeong, Jin Boo
    • Proceedings of the Plant Resources Society of Korea Conference
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    • pp.96-96
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    • 2018
  • Although the roots of Heracleum moellendorffii (HM-R) have been long treated for inflammatory human diseases, scientific evidence for the anti-inflammatory activity of HM-R is not sufficient. In this study, we investigated anti-inflammatory activity and mechanism of action of HM-R in LPS-stimulated RAW264.7 cells. HM-R blocked LPS-induced NO and PGE2 production, but not HM-L. HM-R inhibited LPS-induced overexpression of iNOS, COX-2, $IL-1{\beta}$ and IL-6 in RAW264.7 cells. HM-R inhibited LPS-induced $NF-{\kappa}B$ signaling activation through blocking $I{\kappa}B-{\alpha}$ degradation and p65 nuclear accumulation. In addition, HM-R inhibited MAPK signaling activation by attenuating the phosphorylation of ERK1/2, p38 and JNK. Furthermore, HM-R inhibited attenuated LPS-mediated overexpression of the osteoclast-specific factors such as NFATc1, cathepsin K, MCP-1 and TRAP. These results indicate that HM-R may exert anti-inflammatory activity by inhibiting $NF-{\kappa}B$ and MAPK signaling activation. From these findings, HM-R has potential to be a candidate for the development of chemopreventive or therapeutic agents for the inflammation and inflammatory diseases.

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Growth Characteristics, Main Constituents and Antioxidant Activities in Local Accessions of Sophora flavescens AIT. (고삼 수집종의 생육특성, 주요성분 및 항산화 활성)

  • Kwon, A Reum;Kim, Sun Ick;Seong, Bong Jae;Jee, Moo Geun;Lee, Ka Soon;Kim, Hyun Ho;Doh, Eun Soo
    • Korean Journal of Medicinal Crop Science
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    • v.28 no.5
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    • pp.360-370
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    • 2020
  • Background: Sophora flavescens AIT root is used as a herbal medicine in Asian culture. This study was aimed at selecting the best cultivars, by comparing growth characteristics, active ingredients, and antioxidant activities. Methods and Results: A total twenty nine accessions of S. flavescens were collected from five different regions in Korea. Plant height, leaf length, peduncle length, fresh root weight, and seed weight were the growth characteristics selected. Antioxidant activity was determined by measuring the total polyphenol (TPC) and total flavonoid contents (TFC) as well as the radical scavenging activity of DPPH, ABTS and FRAP. Oxymatrine and matrine, active ingredients in S. flavescens were analyzed by HPLC. Results indicated that accession YS-11 had the highest plant height (152.5 cm) and peduncle length (54.0 cm). The fresh root weight was highest in JA-01 at 4.9 kg, while the highest total seed weight was recorded in accession BH-04 at 77.7 g. The YS-03 accession contained the highest oxymatrine and matrine total contents (0.9616% and 0.9638%, respectively). Accessions BH-02, YS-11, YS-05, and MJ-03 had the highest levels of antioxidant activity (p < 0.05). Oxymatrine showed a high correlation with TPC and FRAP. TPC showed high correlations with TFC, DPPH, ABTS and FRAP. TFC showed a high correlation with DPPH. Conclusions: The superior lines can be selected for use as standard variety breeding material by comparing the growth characteristics of the accessions.

Growth Characteristics and Paeoniflorin Content in Introduced Peony Varieties (도입 작약의 생육특성과 페오니플로린 함량)

  • Kim, Jeong-Hye;Park, So-Deuk;Kim, Jae-Chul;Park, Jun-Hong
    • Korean Journal of Medicinal Crop Science
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    • v.9 no.2
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    • pp.139-145
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    • 2001
  • Peony has been cultivated as medicinal plant in East and also its beautiful flower was acknowledged over the world. In West, numerous peony varieties were developed for ornamental use but not in the country. Ninety two varieties of ornamental peony were introduced from U.S.A. and investigated in Uisong Medicinal Plant Experiment Station during $1997{\sim}1999$. For most of them, their growth habit were good in the country. Their flower colors were clearer and stems were thicker and stronger than domestic peonies. Some of them showed vigorous growth and made very high yield of root. Most of varieties showed proper content of paeoniflorin, medicinal component of peony, for medicinal use.

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Thermotolerant Transgenic Ginseng (Panax ginseng C.A. Meyer) by Introducing Isoprene Synthase Gene through Agrobacterium tumefaciens-mediated Transformation

  • Kim, Ok-Tae;Hyun, Dong-Yun;Bang, Kyong-Hwan;Jung, Su-Jin;Kim, Young-Chang;Shin, Yu-Su;Kim, Dong-Hwi;Kim, Swon-Won;Seong, Nak-Sul;Cha, Seon-Woo;Park, Hee-Woon
    • Korean Journal of Medicinal Crop Science
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    • v.15 no.2
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    • pp.95-99
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    • 2007
  • The cost of conventional cultivation of ginseng (Panax ginseng C.A. Meyer) is very expensive, because shadow condition should be maintained during cultivation periods owing to inherently weak plant for high-temperature. Therefore, application of plant biotechnology may be possible to overcome these difficulties caused by conventional breeding of ginseng. Transgenic plants were produced via Agrobacterium tumefaciens Gv3101, both carrying the binary plasmid pBI121 mLPISO with nptII and Iso (isoprene synthase) gene. Integration of the transgenes into the P. ginseng nuclear genome was confirmed by PCR analysis using nptII primers and Iso primers. RT-PCR result also demonstrated the foreign isoprene synthase gene in three transgenic plant lines (T1, T3, and T5) which was expressed at the transcriptional level. When whole plants of transgenic ginseng were exposed to high temperature at $46^{\circ}C$ for 1 h, a non-transformed plant was wilted from heat shock, whereas a transgenic plant appeared to remain healthy. We suggest that the introduction of exogenous isoprene synthase is considered as alternative methods far generating thermotolerance ginseng.

[ $\alpha$ ]-Glucosidase Inhibitors from the Roots of Codonopsis lanceolata Trautv

  • Jung, Suk-Whan;Han, Ae-Jin;Hong, Hae-Jin;Choung, Myoung-Gun;Kim, Kwan-Su;Park, Si-Hyung
    • Journal of Applied Biological Chemistry
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    • v.49 no.4
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    • pp.162-164
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    • 2006
  • The roots of Codonopsis lanceolata afforded tangshenoside I(1) and $\beta$-adenosine (2) as $\alpha$-glucosidase inhibitors. Their structures were unambiguously determined by 1D and 2D NMR data including HMQC and HMBC experiments. Compounds 1 and 2 exhibited weak $\alpha$-glucosidase inhibitory activities in vitro with $IC_{50}$ of 1.4 and 9.3 mM, respectively.

Taxonomic identity of Dioscorea coreana (Prain & Burkill) R. Kunth

  • JEONG, Dae-Hui;KIM, Jae-Young;JO, Hyeong-Jun;PARK, Hong-Woo;LEE, Kang-Hyup;JI, Seong-Jin;CHUNG, Gyu-Young
    • Korean Journal of Plant Taxonomy
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    • v.50 no.2
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    • pp.232-238
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    • 2020
  • The identity of Dioscorea coreana (Prain & Burkill) R. Kunth is recognized during the re-identification process of Korean Dioscorea specimens. Given the relatively few pieces of information, including few descriptions and research papers, this species has been misidentified as D. tokoro, which has a similar leaf shape, but D. coreana is distinguished from D. tokoro by the absence of a pedicel in the male flower, the green color of the tepal, and the shapes of the fruit and seed. Thus, detailed descriptions, illustrations, and photographs of D. coreana and a key to the Korean Dioscorea, including this species, are presented.