• Title, Summary, Keyword: Microneedle

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A Study on Transdermal Drug Delivery System with Microneedle System in the Field of Skin Care (마이크로니들을 이용한 경피약물전달의 피부 미용학적 접근)

  • Kim, Sung-Jun
    • KSBB Journal
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    • v.26 no.4
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    • pp.277-282
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    • 2011
  • The penetration of outside material into skin is not easy. It is since the skin, which is a very hard barrier, protects the body against outside chemical and physical stimulation. Microneedle system which can help improve drug penetration into skin is advancing variously in transdermal drug delivery system (TDDS) in the field of skin care. After inserting microneedle into skin by using electrical or artificial forces, it makes microhole and drug penetration easily and induces natural skin rejuvenation. Diffusion and penetration of drug by optical and electrical force of microneedle is better for fast and effective TDDS. This is more developed than the traditional method such as the manual stamp, roller, and meso gun. The drug absorbed into dermal layer by microneedle helps revive and repair damaged skin. In the future, utilization of microneedle for skin care will progress constantly because of its human-friendly biodegradable materials and the development of the no pain microneedle.

Fabrication of Microneedle Array Using Inclined LIGA Process (경사 LIGA 공정을 이용한 미세 바늘 어레이의 제작)

  • Moon, Sang-Jun;Lee, Seung-S.
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.28 no.12
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    • pp.1871-1876
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    • 2004
  • We demonstrate a novel fabrication technology for the microneedle array that can be used in the medical test field, which is transdermal drug delivery and blood analyte sampling. Previous researchers have used silicon-processed micromachining, a reactive ion etching, and molding techniques for the fabrication of microneedle array. However, these fabrication techniques have somewhat limitations apply to the microneedle array fabrication according to its application. Inclined LIGA process is suggested to overcome these problems. This process provides easier, sharper and longer out-of-plane microneedle array structure than conventional silicon-processed fabrication method did. Additionally, because of the advantage of the LIGA process based on mold fabrication for mass production, the polymer, PMMA(PolyMethylMethAcrylate), based microneedle array is useful as the mold base of nickel electroplating process; on the other hand, silicon-processed microneedle array is used in itself. In this research, we fabricate different types of out-of-plane microneedle array, which have different shape of tip, base and hole structure, using the inclined LIGA process. The fabricated microneedles have proper mechanical strength, height and sharpness to puncture human hand epidermis or dermis with less pain and without needle tip break during penetrating the skin.

Skin permeability of compounds loaded within dissolving microneedles dependent on composition of sodium hyaluronate and carboxymethyl cellulose

  • Park, Youbin;Kim, Bumsang
    • The Korean Journal of Chemical Engineering
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    • v.34 no.1
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    • pp.133-138
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    • 2017
  • Dissolving microneedles are transdermal delivery systems designed to mechanically penetrate the skin and fully dissolve in the skin in a minimally invasive manner. In this study, the skin permeability of compounds encapsulated in microneedles was controlled by changing the composition of microneedle materials. Sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) were chosen as structural materials and amylopectin was used to increase the mechanical strength of microneedles. To determine the effect of microneedle composition on skin permeability, microneedle properties such as mechanical strength and solubility were investigated according to various compositions of SH and CMC. When the CMC fraction in the needle increased, the mechanical strength of the microneedle increased, leading to high skin permeability of rhodamine B, a model compound. Using microneedles, significantly higher skin permeability of niacinamide was also obtained. These results indicate that the microneedles developed in this study improved the skin permeability of compounds loaded in the needle, and the skin permeability could be tuned by changing the composition of microneedle materials.

Case Study of Treating Acne Scars Using Reconstruction of Skin Scars and Auto Microneedle Therapy System (흉터복원술과 자동 미세침(Auto Microneedle Therapy System, AMTS)을 이용한 여드름 흉터의 치험례)

  • Heo, Jeong-Eun;Yun, Jeong-Min;Shin, Sang-Ho
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.26 no.4
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    • pp.127-134
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    • 2013
  • Objective : Acne is very common disease, it can leave permanent scars. However, there are few reports about it in oriental medicine academia. This study performed to evaluate the effect of reconstruction of skin scars and auto microneedle therapy system on acne scars. Methods : Six patients were treated by using reconstruction of skin scars and auto microneedle therapy system. We compared the degree of treatment of acne scars on pre and post case photos and Qualitative Global Acne Scarring Grading System(QGASC). Satisfaction degree were asked from the patients. Results & Conclusion : After comparing case photos and QGASC, observing patients satisfaction, it can be considered that reconstruction of skin scars and auto microneedle therapy system to be valid acne scars treatment.

Silicon-micromachined Microneedle for Suction and Injection of Bio Samples

  • Paik, Seung-Joon;Kim, Jong-Pal;Kim, Se-Tae;Park, Sang-Jun;Chung, Seok;Chang, Jun-Keum;Chun, Kuk-Jin;Cho, Dong-Il
    • 제어로봇시스템학회:학술대회논문집
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    • pp.178.6-178
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    • 2001
  • Silicon-micromachined microneedle for a biofluid diagnosis system is developed. To fabricate microneedles, two sets of processes are used. One is making buried microchannels in silicon wafer using silicon isotropic etch with a SF6 plasma and then trench-refilling. The other is releasing the body of the microneedle by deep silicon etch. The microneedle has a 4 mm-length and about 12 $\mu\textrm{m}$ diameter buried microchannel, a 1.5 mm$\times$l.5 mm-area reservoir, and about 180 $\mu\textrm{m}$thickness body. Preliminary results indicate that microneedles are capable of flowing fluidic samples. The microneedle with a buried microchannel is expected to be integrated with in vitro diagnosis systems and microfluidic devices.

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Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Pattern Hair Loss

  • Ro, Byung In;Lee, Suk Young;Kim, Jong Baik;Shin, Hang Cheol
    • Korean journal of dermatology
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    • v.55 no.8
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    • pp.504-510
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    • 2017
  • Background: A growth factor cocktail (GFC) including fibroblast growth factor 9 (FGF9) in combination with microneedling is an effective and safe treatment for patients with androgenetic alopecia (AGA). However, there is a lack of studies evaluating its effects based on microneedle depth. Objective: This study aimed to evaluate the effects of a GFC including FGF9 on hair growth in patients with AGA, and compare the differences in efficacy according to microneedle depth. Methods: The study was performed on patients with AGA who were treated with topical GFC including FGF9 with microneedling once every 2 weeks for 3 months. The scalp was divided into right and left sides, and treated with GFC including FGF9 (right side) and normal saline (left side). The microneedle depth was 0.8 mm for both sides. A total of 22 patients (11 males and 11 females) were enrolled. GFC including FGF9 was topically applied with a microneedle medical device. Treatment efficacy was evaluated through phototrichogram and digital photograph analyses after 6 repeated treatments for 3 months. Results: The phototrichogram images showed that 3 months of treatment with GFC including FGF9 with microneedling increased hair density ($27.4{\pm}4.4/cm^2$) and diameter ($2.7{\pm}2.7{\mu}m$); increases in hair density ($5.7{\pm}4.4/cm^2$) and diameter ($2.2{\pm}2.3{\mu}m$) were also seen in the region of the scalp that received normal saline. These results were statistically significant (p<0.05). The treatment effect was not significantly different between microneedle depths of 0.8 mm (used in this study) and 0.5 mm (used in our previous study) in terms of both hair density and hair diameter. Conclusion: GFC including FGF9 with microneedling is an effective and safe treatment for patients with AGA. According to the results of this study and our previous report, we believe that microneedle depths of 0.5~0.8 mm can sufficiently stimulate the scalp to increase drug-delivery.

Current Trend of Scalp Care Technology of Microneedle Using Fermented Soybean (대두 발효물을 이용한 마이크로니들 두피케어에 관한 최신 동향)

  • Kim, Eun-Ju;Jung, Hyun-Ki;Kim, Sung-Jun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.36 no.4
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    • pp.241-251
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    • 2010
  • In recent years, the number of people suffering from depression due to hair loss has been increasing. The treatment methods such as clinical pathology and vanity surgery have been developed. There are therapies and materials for hair growth promotion and hair loss prevention. But the effectiveness of such therapies and materials is not fully evaluated and some side-effects have been reported. In this study, microneedle therapy using very thin and delicate needles promotes absorption of drug. During this therapy, the microneedle makes micro holes that help absorbion of drugs into the scalp. In this study, absorbion of fermented soybean were evaluated. The ingredient has antioxidant, antiandrogen, and antithrombosis effect for alopecia. The fermented soybean is more effective for complex hair loss when used with microneedle. It is because of the microneedle's excellent drug delivery system (DDS). This therapy that increases the absorption of fermented soybean is a very useful scalp care method which prevents, treats and controls alopecia. This microneedle therapy using fermented soybean is an advanced technology for scalp care.

Transdermal Delivery of FITC-Ovalbumin with Microneedle System (마이크로 피부침을 이용한 FITC-OVA의 경피흡수)

  • Jang, Woo-Young;Lee, Chang-Rae;Seo, Seong-Mi;Lee, Bong;Kim, Moon-Suk;Khang, Gil-Son;Lee, Han-Gu;Lee, Hai-Bang
    • Journal of Pharmaceutical Investigation
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    • v.35 no.6
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    • pp.403-409
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    • 2005
  • For transdermal delivery of large molecular drugs such as vaccine and protein drugs, novel microneedle treatment device with roll was designed. The roll dimension is 1.43 cm diameter and 2.8 cm perimeter. Total number of microneedle on the roll is 3,360 with $230\;{\mu}m$ height and $740\;{\mu}m$ distance. The pore with $150\;{\mu}m$ depth and $35\;{\mu}m$ diameter on the skin was made by the designed microneedle device. This system could be achieved without pain. The permeation rates of FITC labelled ovalbumin (FITC-OVA, molecular weight: 45,000 g/mol) as a model protein were determined by modified Franz diffusion cells using skins of hairless mice or SD rats which were treated by using microneedle device two or four times. The average penetration fluxes of model protein increased from 674 to $872\;{\mu}g/cm^{2}{\cdot}hr$ as the number of treatment to make pore increased from two to four times. In conclusion, we confirmed the possibility of using the designed microneedle treatment device for transdermal delivery of the large molecular drugs.

Prestrain-induced Reduction in Skin Tissue Puncture Force of Microneedle (초기변형률에 의한 미소바늘의 피부조직 관통력 감소)

  • Kim, Jonghun;Park, Sungmin;Nam, Gyungmok;Yoon, Sang-Hee
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.10
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    • pp.851-856
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    • 2016
  • Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.