• Title, Summary, Keyword: Moschus

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An effect of the Moschus were injected on the brain of mice (사향(麝香)이 생쥐의 뇌손상(腦損傷)에 미치는 영향(影響))

  • Lee, Bo-Young;Kang, Seok-Bong
    • The Journal of Korean Medicine
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    • v.16 no.2
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    • pp.299-311
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    • 1995
  • The studies were investigated in the coma time and the survival time induced by KCN, the duration of breathing after decapitation, the survival time following ligation of both common carotid arteries and the survival time after it is treated for normobaric bypoxia with a nitrogen gas, a carbon dioxide gas or a vaccum in mice. The results were as follows: 1. In histotoxic anoxia, Moschus(0.4mg/kg, p.o) demonstrated a protective effect on coma induced by a sublethal dose of KCN(1.8mg/kg, i.v.) in mice. 2. Mice subjected to a lethal dose of KCN(3.0mg/kg, i.v.) did not die by administration of Moschus. 3. Moschus was significantly extended the duration of breathing after decapitation in mice. 4. Moschus showed a significant extension of survival time in mice following ligation of both common carotid arteries. 5. In the normobaric hypoxia with a nitrogen gas, Moschus showed a significant extension of survival time in mice. 6. In the normobaric hypoxia with a carbon dioxide gas, Moschus showed a significant shortness of survival time in mice. 7. In the normobaric hypoxia with a vaccum, Moschus showed a significant extension of survival time in mice. From the above results, it is suggested that Moschus demonstrated protective effects on the brain damages induced by cerebral anoxia.

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A Literary Study on Moschus (사향에 대한 문헌적 고찰)

  • Lee, Kyu-Jae;Yoon, Hyu-Chul;Lee, Jin-Seon;Kwon, Ki-Rok
    • Journal of Pharmacopuncture
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    • v.8 no.3
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    • pp.71-77
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    • 2005
  • Objective : Literary investigation of existing data was conducted to verify effects of Moschus and its herbal acupuncture, and determine quality management through component analysis. Results : Following results were obtained through literary investigation. 1. Deer musk (Moschus) is dried navel gland secretions of the adult male musk deer. 2. Moschus is known to be effective for treating various febrile diseases, to revive senses, heart and abdominal pain, complications from cerebral hemorrhage, angina, and others. 3. Single dosage of Moschus is between $0.03{\sim}0.1g$ and should not exceed 1g. Normally taken as powder or pill and may be used externally. 4. Moschus also has protective effects for the liver cells, and experiments revealed possible efficacies for hyperlipidemia, brain damage, hypertension, and etc. 5. For herbal acupuncture usage, Fel Ursi, Bezoar Bovis, and Moschus are used as a mixture (BUM), and it's known to be effective for protecting the liver and treating arthritis. 6. For component analysis of Moschus, aromatic matter 'muscone' should be used as a standard matter.

Bibliographic Study on the Moschus used to Acute Stage of Stroke (중풍급성기(中風急性期)에 활용(活用)되는 사향(麝香)에 관(關)한 문헌적(文獻的) 고찰(考察))

  • Huh, Jae-Hyeok;Kim, Sae-Gil;An, Ill-Hoe;Shin, Sun-Ho;Moon, Byung-Soon;Sung, Gang-Kyung
    • The Journal of Korean Medicine
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    • v.16 no.2
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    • pp.100-114
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    • 1995
  • This bibliographic study was designed to research indications of the Moschus which was representatively used for resuscitation in acute stage of stroke throughout successive books of oriental medicine. Especially, in this study, severe cases with disturbance of consciousness and acute stage of stroke were investigated. The results were summarized as the followings: 1. The Moschus was dried material which secreted from aromatic vescicle of Moschus moschiferus L.. which was pungent in flavor, warm in nature, nontoxic and strongly aromatic. The Moschus removed the obstruction in the channels and used to early stage of stroke. 2. The Moschus was aromatic resuscitatable medicine, which recovered disturbance of consciousness due to stroke. 3. The Moschus had excitatory actions of respirtory center and vascular motor center, heart stimulating action, inhibitatory action of the platelet aggregation and anti thrombin action and recovered cerebral ischemic change. According to these actions, the Moschus could be used cerebral infarction. 4. Prescriptions included the Moschus was used to symptoms of unconsciousness, secretion, stuporous mental state, dysarthria, facial palsy and hemiplegia. That was Angungwoohwangh wan(安宮牛黃丸), Woohwangchungshimwon(牛黃淸心元), Sahyangsohaphangwon(麝香蘇合香元), etc. According to the above mentioned results, the Moschus was aromatic resuscitatable medicine which was used for symptoms of conscius disturbance, convulsion, sudden fainting etc., promoted cerebral blood flow and had good effect on acute stage of stroke and severe cases with conscious disturbance. Therefore, it is considered that the Moschus must be studied for effect of cerebral infarction and hemorrhage in clinic with animal's and pharmacological experimental results.

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Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice (사향이 CCl4로 유발된 mouse의 간 손상에 미치는 영향)

  • Park, Jae-Seuk;Kim, Seung-Wook;Lee, Kyu-Jae;Kwon, Ki-Rok
    • Journal of Pharmacopuncture
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    • v.9 no.1
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    • pp.45-52
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    • 2006
  • Objectives : This study was aimed at investigating liver protection mechanism of Moschus by inducing liver toxicity through $CCl_4$ in mice and evaluated histological and serological findings. Methods : Experiment groups was categorized into untreated normal group, $CCl_4$ treated control group, and orally administered Moschus experiment group. At the termination of experiment, gross examination of the liver as well as histological findings, and Total protein, Total bilirubin, Direct bilirubin SGOT, SGPT, and ALP contents in the serum were evaluated. Results : 1. For gross examination and histological findings, $CCl_4$ treated control group showed destroyed lobular structure, increased fibrosis, as well as hepatic cirrhosis. For the group treated with Moschus, the lobular structure suffered less damage, and showed lower level of fibrosis and liver cirrhosis compared to the control group. 2. For serum analysis, Total protein were significantly increased in the Moschus experiment group than the control group. 3. Total bilirubin didn't show significant differences between the two groups. but direct bilirubin was significantly increased in the Moschus experiment group than the control group. 4. SGOT, SGPT, were significantly decreased in the normal and Moschus experiment groups compared to the control group. 5. ALP was significantly decreased in the normal group compared to the control group, but Moschus experiment group didn't show significant differences compared to the control group. Conclusion : Taken together, Moschus can be effectively used for recovering the liver functions and further researches must be conducted to verify the efficacies of Moschus bile juice.

The Effects of Moschus and Herbal Combination with Moschus by Oral Administration at Memory and Activation of Brain Ability on Rats (사향(麝香) 및 사향(麝香) 배합(配合) 한약제제(韓藥製劑)의 구강(口腔) 투여(投與)가 백서(白鼠)의 기억(記憶) 및 뇌기능(腦機能) 활성(活性)에 미치는 영향)

  • Chung, Hyun-Ju;Lee, Yu-Kyung;Chae, Jung-Won
    • The Journal of Pediatrics of Korean Medicine
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    • v.23 no.1
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    • pp.95-113
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    • 2009
  • Objectives This study was investigated to find how the orally administrated Moschus, herbal combination with Moschus, and herbal combination improves the rats' memory and rats' liver. These medications are generally known asthe memory improvement. Methods This study used the Sprague Dawley rats. They were divided into two groups - SD rats and orally administrated Saline(Control group). 0.473 mg/kg Moschus(HM-A), 153.9 mg/kg herbal composition without Moschus(HM-B), and 165.95 mg/kg herbal composition with Moschus combined(HM-C) Control, saline were orally administered. Each group was trained in the eight-arm radial maze task at the conditions of before oral administrated, and also right after third, sixth, and eighth by oral administration. Lastly, these animals were killed and were tested for brain tissue and serum AST/ALT level to measure how the medications were effected to the liver function. Results The result of radial eight-arm maze task test, the HM-B and HM-C groups showed significant decrease in mistakes from the fourth day of testing. Whereas, the HM-A group showed increasing in the error rate. HM-A and HM-C group of rats had significantly increased amount of acetylcholinesterase in the CA1 region of hippocampus, compared to the control group. Whereas, HM-B and HM-C group had increased level of ChAT compared to the control group. On the other hand, each experimental group did not show any significant difference to the level of serum AST/ALT and the weight ratio of the liver to the body. Conclusions This study provided evidences that the orally administered memory improvement herbal medication, and Moschus were effective to improve memory.

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Effects of Moschus Herbal-acupuncture on Hyperlipidemia Rats induced by Triton WR-1339 (사향약침액(麝香藥鍼液)이 Triton WR-1339로 유발된 흰쥐의 고지혈증(高脂血症)에 대한 실험적(實驗的) 연구(硏究))

  • Soh, Kyung-Sun;Jeong, Chan-Gil;Kim, Kwang-Ho;Lee, Sang-Woon;Kang, Dae-In
    • Journal of Pharmacopuncture
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    • v.6 no.1
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    • pp.61-66
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    • 2003
  • In order to study the effects of Moschus Herbal-acupuncture on hyperlipidemia, we divided the rats into three groups(Normal group, Control group & Sample group) and performed the experimental research. Hyperlipidemia rats were induced by Triton WR-1339(150mg/kg) for 3days. Sample group was injected Moschus Herbal-acupuncture 0.1 ml/200g for 3 days and control group was injected equal dose of saline. And then we measured the amount of serum total cholesterol, triglyceride, phospholipid and HDL-cholesterol. The results were as follows : 1.Moschus Herbal-acupuncture showed decreasing effects on total cholesterol, triglyceride and phospholipid levels in serum significantly(p<0.05). 2.Moschus Herbal-acupuncture showed increasing effects on HDL-cholesterol level in serum significantly(p<0.05). According to the above results, Moschus Herbal-acupuncture showed significant decreasing effects on hyperlipidemia and it is considered that it is appropriate to apply for hyperlipidemia.

Eye Irritation Test of Fel Ursi, Bovis Calculus & Moschus Pharmacopuncture Solutions for Eye Drop (점안용 웅담.우황.사향 약침액의 안점막자극실험)

  • Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.3
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    • pp.105-111
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    • 2008
  • Objective: The aim of this study is to investigate the safety of Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods: The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was applied eyewash in the left eye of the rabbits, the author observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results: 1. After Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was applied eyewash in the left eye of the rabbits, there wasn t physical problem at 9 rabbits. 2. After Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was applied eyewash in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions: In this study, it was observed that Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution didn't induced eye irritation in rabbits.

Antihepatotokic Activity of Bezoar Bovis and Moschus (우황과 사향의 간세포 보호효과)

  • 최영주;이미경;손여원;이흠숙;김영중;민홍기
    • Biomolecules & Therapeutics
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    • v.4 no.3
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    • pp.271-274
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    • 1996
  • The antihepatotoxic activity of Bezoar Bovis and Moschus was investigated by in vitro assay method using galactosamine and carbon tetrachloride-induced cytotoxicity in primary-cultured rat hepatocytes. The antihepatotoxic activity was evaluated by measuring the level of glutamate pyruvate transaminase and sorbitol dehydrogenase which were released from the necrotic hepatocytes to the culture medium. In galactosamine-intoxicated hepatocytes, the chloroform fraction of Bezoar Bovis reduced the level of glutamate pyruvate transaminase and sorbitol dehydrogenase resulting in 65% and 59% protection, respectively. The n-Hexane fraction of Moschus resulted in 45% and 40% protection, respectively in this system. In the case of carbon tetrachloride-intoxicated rat hepatocytes, Bezoar Bovis did not have significant effect and only the aqueous fraction of Moschus showed 42% and 40% protection, respectively.

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The Experimental Study of Efficacy in Using Fel Ursi, Bovis Calculus & Moschus Pharmacopuncture Solution as Eye Drop (점안용 웅담.우황.사향약침액의 유효성 평가)

  • Seo, Hyung-Sik
    • Journal of Pharmacopuncture
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    • v.12 no.3
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    • pp.41-47
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    • 2009
  • Objectives : This experimental study was performed to investigate the efficacy of Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods : After administering Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution on bacterial species(Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans) which cause Keratitis, MIC(Minimum Inhibition Concentration) and the size of inhibition zone were measured. Anti-bacterial potency was also measured using the size of inhibition zone. Results : There was no response to MIC on bacterial species(Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans) after Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution was medicated. Conclusions : The present study suggests that Fel Ursi, Bovis Calculus & Moschus pharmacopuncture solution dosen't have anti-bacterial effects on bacterial species(Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans) which cause Keratitis. These study result recommends that more research on other herbal medicines of eye drop for Keratitis are required.

The Effect of Aucklandiae Radix.Moschus(木香.麝香)'s for Delayed Neuronal Death in Hypoxia (목향(木香) 및 사향(麝香)이 저산소증 유발 배양 대뇌신경세포에 미치는 영향)

  • Jeong Sung-Hyun;Shin Gil-Cho;Lee Won-Chu;Moon Il-Su;Ryu Do-Kyun
    • The Journal of Internal Korean Medicine
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    • v.24 no.2
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    • pp.348-357
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    • 2003
  • Objectives : The purpose of this investigation is to evaluate the effects of Aucklandiae Radix Moschus(木香 麝香)and to study the mechanism for neuronal death protection in hypoxia with Embryonic day 20 (E20) cortical cells of a rat (Sprague Dawley). Methods : E20 cortical cells used in this investigation were dissociated in Neurobasal media and grown for 14 days in vitro (DIV). On 14 DIV, Aucklandiae Radix Moschus(木香 麝香) was added to the culture media for 72 hrs. On 17 DIV, cells were given a hypoxic shock and further incubated in normoxia for another three days. On 20 DIV, Moschus(麝香)'s effects for neuronal death protection were evaluated by LDH assay and the mechanisms were studied by Bcl-2, Bak, Bax, caspase family. Results : This study indicate that Aucklandiae Radix(木香)'s effects for neuronal death protection in normoxia and Scutellariae Radix(麝香)'s effects for neuronal death protection in hypoxia were confirmed by LDH assay in culture method of Embryonic day 20(E20) cortical neuroblast. Moschus(麝香)'s mechanism for neuronal death protection in hypoxia is to increase the anti-apoptosis protein Bcl-2. Conclusions : It may be reasonable to propose that Moschus(麝香) protects delayed neuronal death in hypoxia by increasing Bcl-2, thereby reducing mitochondrial permeability transition(PT) pores, the cytochrome c channels.

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