• Title, Summary, Keyword: Osteoporosis

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Dairy Dietary Calcium and Osteoporosis - An Overview

  • Jayaprakasha, H.M.;Yoon, Y.C.
    • Journal of Dairy Science and Biotechnology
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    • v.22 no.2
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    • pp.143-150
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    • 2004
  • The osteoporosis is a disease characterized by lower bone mineral content, deterioration of bone tissue and a reduction in the protein and mineral matrix of the bone. The bone becomes more porous leading to increased bone fragility and risk of fracture, particularly of the hip, spine and wrist. Osteoporosis can result in disfigurement, lowered self·esteem, reduction or loss of mobility, and decreased independence. Adequate calcium intake through milk and milk products in childhood and adolescence is a decisive marker for obtaining a maximum bone mass (peak adult bone mass) and f3r the prevention of osteoporosis. Calcium is one of the most critical nutrients associated with the osteoporosis. Dietary calcium is of great significance for healthy skeletal growth and development. The bone mineral content and bone mineral density of young adults is directly related to the calcium intake through milk and dairy products. Milk and milk products are the important sources of calcium as the richness and bioavailability of this nutrient is very high as compared to other food products. If enough calcium is not supplemented through diet, calcium from the bone will be depleted to maintain the blood plasma calcium level. The article focuses on the various issues related to osteoporosis manifestation and the role of dietary calcium especially calcium derived from dairy products.

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The Relationship between Treating, after Treated of Osteoarthritis, Osteoporosis and Quality of Life in Korean Adults: Based on the 2010 Korean Community Health Survey

  • Jegal, Hyuk;Jun, Hyun Ju;Kim, Ki Jong
    • Journal of International Academy of Physical Therapy Research
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    • v.6 no.1
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    • pp.828-832
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    • 2015
  • The purpose of this study was to investigate the relationship the quality of life, osteoarthritis and osteoporosis in the Republic of Korea. This study was utilized raw data from the 2010 KCHS. In total, 229,229 individuals participated in the 2010 survey. The final analysis was identified 22,545 individuals who had been diagnosed by a doctor with arthritis or osteoporosis. To identify the relationship between the quality of life - related after treated or treating of arthritis, osteoporosis, A multiple linear regression analysis was performed. Treating group for osteoarthritis of their quality of life has statistically been less than after treated group(B=-.068, p<.001). Treating group for osteoporosis of their quality of life has statistically been less than after treated group(B=-.083, p<.001). Non-treatment group who was diagnosed by doctor, but no treated subject for osteoarthritis of their quality of life has statistically been less than after treated group(B=-.075, p<.001). Non-treatment group that was diagnosed by doctor, but no treated subject for osteoporosis of their quality of life has statistically been less than after treated group(B=-.045, p<.001). Non-treatment group who was diagnosed by doctor, but no treated subject for osteoporosis and arthritis of their quality of life has statistically been less than after treated group(B=-.0121, p<.001). as a result of those data, we understand that the decision maker for treatment has been chosen by quality of life, including pain, mobility activity and so on.

Association of the TREML2 and HTR1E Genetic Polymorphisms with Osteoporosis

  • Jung, Dongju;Jin, Hyun-Seok
    • Biomedical Science Letters
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    • v.21 no.4
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    • pp.181-187
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    • 2015
  • Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

Level of Concern about Osteoporosis-related Factors, Life-style and Dietary intake of University and College Female Students (여대생의 골다공증 관련 요인에 대한 관심, 생활습관 및 음식섭취)

  • Kim, Young-Mi;Kim, Myoung-Hee
    • Journal of muscle and joint health
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    • v.8 no.2
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    • pp.287-301
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    • 2001
  • Osteoporosis is a age-related metabolic disorder. Currently there is no cure, but there are measures that can prevent or deter the development of osteoporosis. Futhermore lifestyle among risk factors of osteoporosis may be modifiable. Osteoporotic preventive health promotion behavior may be more effective at early adult when they make formation of peak bone mass. The purpose of this study is to identify the demographic variables, life-style and level of concern about osteohealth-related factors according to the health promotion behavior among university female students. The result are following: 1. The highest level of concern about osteoporosis-related factor is sufficient sleeping. 2. The highest level of dietary about osteoporosis-related factors are vegetable and fruit. 3. Level of concern about osteoporosis-related factors according to demographic variables are not significantly different, but dietary were significantly different in age, height and income. 4. Level of concern about osteoporosis-related factors according to lifestyle are significantly different in weekly hour of exercise and weight control, and dietary are significantly different in milk intake at elementary school and present. 5. Level of concern about osteoporosis-related factors have correlated positively with dietary. University and College female students who participated in this study have concerned middle at calcium intake and exercise, but two variables are significantly different in lifestyle and dietary. Because of two variables are modifiable, it should be regarded importantly in nursing domain. We suppose that preventive education of osteoporosis is necessary to reach peak bone mass and to maintain bone mass consistently among the University and College female students.

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The literatural study on the oriental cognizance and acupuncture-moxibustion therapy of osteoporosis (골다공증(骨多孔症)의 한의학적(韓醫學的) 인식(認識)과 침구치료(鍼灸治療)의 문헌연구(文獻硏究))

  • Kim, Dong-Soo;Kim, Young-Il
    • Journal of Haehwa Medicine
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    • v.18 no.1
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    • pp.9-18
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    • 2009
  • Objectives and Methods: The treatments of osteoporosis in occidental medicine are need complementations for reason of low-continuation and adverse-drug-reaction. So we would have literature centered consideration both oriental medical cognition and acupuncture-moxibustion therapy in osteoporosis. Results: 1. Deficiency of bone marrow caused by heat in the kidney and deficiency of kidney Gi, is causative of osteoporosis in pathology in oriental medicine. 2. Bone flaccidity and bone impediment are similar with osteoporosis. Withered bone comes under pathogenesis of bone flaccidity. And heavy debilitating disease of the bone is exacerbation of bone impediment. 3. In acupuncture-moxibustion therapy of osteoporosis, Bladder Meridian of Foot Taeyang, Kidney Meridian of Foot Soeum, Gallbladder Meridian of Foot Soyang, Lung Meridian of Hand Taeeum, Large Intestine Meridian of Hand Yangmyeong, Spleen Meridian of Foot Taeeum, Conception Channel, Stomach Meridian of Foot Yangmyeong, and Heart Meridian of Hand Soeum are used much in the order named. 4. In acupuncture-moxibustion therapy of osteoporosis, Hyeonjong(GB39, 7times), Daejeo(BL11, 3times), Sanggwan(GB3, 2times), Sinsu(BL23, 2times), Gyeoksu(BL17, 2times), Honmun(BL47, 2times), Buryu(KI7, 2times), Taebaek(SP3, 2times), Sanggu(SP5, 2times), Sangnyeom(LI9, 2times) are used much in the order named. Conclusions: In treatment of osteoporosis, we could make full use of acupuncture-moxibustion therapy. And we need active and persistent study about osteoporosis.

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Incidence of Osteoporosis and Falls and Predictors of Fracture Risk in Postmenopausal Women (폐경 후 여성 골다공증과 낙상의 실태 및 골절 위험 예측요인)

  • Ahn, Sukhee;Kim, Yunmi;Chun, Nami;Lee, Sook-Hee
    • Korean Journal of Women Health Nursing
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    • v.18 no.4
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    • pp.237-247
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    • 2012
  • Purpose: The purpose of this study was to investigate the incidence of osteoporosis and falls and their consequences, and to identify predictors of fracture risk in the postmenopausal women. Methods: A total of 687 postmenopausal women were recruited through a stratified convenience sampling. A structured questionnaire was used to obtain osteoporosis and fall history and details of their most recent fall. To predict fracture risk factors, we collected demographic and physical health variables related osteoporosis and fall. Fracture risk was measured by FRAX$^{(R)}$ to calculate 10-year probability of major osteoporotic and hip fracture. Results: The prevalence of osteoporosis was 22.1%, and 66.4% of them had treatments for osteoporosis. The incidence of falls during the past year was 19.2% and 38.6% of those who fell suffered consequent fractures. Women with history of osteoporosis and falls were significant predictors of 10-year probability of major osteoporotic and hip fracture. Other significant predictors were history of fracture, chronic disease, surgical menopause, lower BMI, poorer perceived health and no job. Conclusion: It appears that history of osteoporosis and falls are main predictors of fracture risk. Nursing assessment should be performed by detail history taking for osteoporosis, fall, chronic disease, and fracture to screen fracture risk group among postmenopausal women.

Structural Model for Osteoporosis Preventive Behaviors in Postmenopausal Women: Focused on their Own BMD Awareness (폐경여성의 골다공증 예방행위 구조모형: 골밀도인지를 중심으로)

  • Park, Young Joo;Lee, Sook Ja;Shin, Nah Mee;Kang, Hyun Cheol;Kim, Sun Haeng;Kim, Tak;Jeon, Song I;Cho, In Hae
    • Korean Journal of Adult Nursing
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    • v.25 no.5
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    • pp.527-538
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    • 2013
  • Purpose: The purpose of this study was to develop a model that explains causal relationships between post-menopausal women's osteoporosis general knowledge and awareness of their own bone mass density(BMD) and their osteoporosis health beliefs and preventive behaviors. Methods: Retrospective design using structural equation model tested seven variables by using questionnaires of osteoporosis knowledge test, osteoporosis health belief scale, osteoporosis self-efficacy scale, and osteoporosis preventive behaviors scale. 162 middle age and post-menopausal women were recruited. Results: Mediating effect of health beliefs was not significant in the relationship between BMD awareness and preventive behaviors. Instead, BMD awareness had a direct influence on the preventive behaviors that is strong and significant. Between the relationship of the BMD awareness and health beliefs, direct pathways of perceived threat, relative benefits, and self-efficacy were not significant. However, relative benefits and self-efficacy showed direct influence on the preventive behaviors. Conclusion: Having middle age women get their BMD test done in order for them to be aware of their own BMD results might be a critical strategy to promote osteoporosis preventive behaviors. There is a need to develop diverse strategies to enhance their self-efficacy which has been shown to be important to osteoporosis preventive behaviors.

Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women

  • Ko, Young-Jin;Kim, Ji Young;Lee, Joongyub;Song, Hong-Ji;Kim, Ju-Young;Choi, Nam-Kyong;Park, Byung-Joo
    • Journal of Preventive Medicine and Public Health
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    • v.47 no.1
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    • pp.36-46
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    • 2014
  • Objectives: To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history. Methods: We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged ${\geq}65$ years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria: previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period <90 days. We categorized the daily levothyroxine doses into 4 groups: ${\leq}50{\mu}g/d$, 51 to $100{\mu}g/d$, 101 to $150{\mu}g/d$, and > $150{\mu}g/d$. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status. Results: Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the > $150{\mu}g/d$ group, compared with the 51 to $100{\mu}g/d$ group, was 1.56 (95% CI, 1.03 to 2.37) in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the > $150{\mu}g/d$ group, compared with the 51 to 100 ${\mu}g/d$ group, was 1.93 (95% CI, 1.14 to 3.26). Conclusions: While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.

Relationship between Osteoporosis and Cardiovascular Risk Factors according to Sasang Constitution in Rural Wonju Cohort (원주농촌코호트에서 사상체질별 심혈관위험인자와 골다공증의 관계)

  • Song, Hak-Soo;Choi, Jae-Wan;Yu, Jun-Sang;Park, Jong-Ku
    • Journal of Sasang Constitutional Medicine
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    • v.25 no.2
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    • pp.81-97
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    • 2013
  • Objectives The purpose of this study was to investigate the relationship between osteoporosis and cardiovascular risk factors according to Sasang constitution. Methods A total of 1773 participants, over 40 years old, were examined as part of a community-based cohort in Wonju city in Gangwon province of South Korea, from June 2006 to August 2009. We measured bone mineral density by Achilles ultrasonometer, serum levels of lipids, fasting blood sugar, insulin and other cardiovascular risk factors like blood pressure and waist circumference. Constitution was verified by a Sasang constitution specialist using the results of PSSC(Phonetic System for Sasang Constitution), facial photos and a simplified Sasang constitutional questionnaire. Results The prevalence rate was 11.2% in total participants, and 10.6% in Soyangin, 10.4% in Taeeumin and 13.9% in Soeumin. In general characteristics, educational and economic property and exercise were concerned with osteoporosis. Systolic blood pressure, pulse rate and total cholesterol were significantly high in osteoporosis group. Age and menopause were the key risk factors for osteoporosis. There was a significantly high prevalence in Soeumin for osteoporosis in men alone. Low physical activity was a major risk factor for osteoporosis. Waist circumference and hip circumference had significantly high odds ratio and weight had significantly low odds ratio. By Sasang constitution, Soyangin has the negative correlation with free fatty acid, Taeeumin has the negative correlation with waist circumference, pulse rate, systolic blood pressure, total cholesterol and low density lipoprotein and Soeumin has the positive correlation with body fat amount. Conclusions Regimens on osteoporosis should be considered according to Sasang constitution. Cardiovascular diseases should be considered according to Sasang constitution. Soeumin should be cautious of osteoporosis and gain weights and reasonable amount of fat food. Soyangin had better do exercise lower body and eat little food containing triglyceride. Taeeumin had better lose weights and eat little cholesterol food.

Gender Difference in Osteoporosis Prevalence, Awareness and Treatment: Based on the Korea National Health and Nutrition Examination Survey 2008~2011 (골다공증 유병률, 인지율, 치료율 및 영향요인의 성별 비교: 국민건강영양조사 자료(2008~2011년) 활용)

  • Kim, Yunmi;Kim, Jung Hwan;Cho, Dong Sook
    • Journal of Korean Academy of Nursing
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    • v.45 no.2
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    • pp.293-305
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    • 2015
  • Purpose: The aim of the study was to assess and identify gender differences in factors associated with prevalence, awareness, and treatment of osteoporosis. Methods: Data for 3,071 men and 3,635 women ($age{\qeq}50$) from the Korea National Health and Nutrition Examination Survey 2008~2011 were included. Osteoporosis was defined by World Health Organization T-score criteria. Impact factors and odds ratios were analysed by gender using multivariate logistic regression. Results: Osteoporosis prevalence rates were 7.0% in men and 40.1% in women. Osteopenia rates were 45.5% and 46.0% respectively. Among respondents with osteoporosis, 7.6% men and 37.8% women were aware of their diagnosis. Also 5.7% men with osteoporosis and 22.8% women were treated. Higher prevalence was found among respondents who were older, at lower socioeconomic levels, with lower body mass index and shorter height in both genders, and among women with fracture history, and non-hormonal replacement therapy. Awareness and treatment rates for the risk groups were similar compared to the low risk controls for both genders. Fracture history increased awareness and treatment rates independently for both genders. Women with perceived poor health status and health screening had increased awareness and treatment rates, but not men. Conclusion: Results indicate that postmenopausal women have a higher prevalence of osteoporosis than men and awareness and treatment rates were higher than for men. Despite gender difference in prevalence, osteoporosis was underdiagnosed and undertreated for both genders. Specialized public education and routine health screenings according to gender could be effective strategies to increase osteoporosis awareness and treatment.