• Title, Summary, Keyword: Osteoporosis

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The Role and Application of Biomarkers and Surrogate Endpoints for New Drug Development : Focused on Diabetes Mellitus and Osteoporosis (당뇨병 및 골다공증 치료제의 효율적인 신약개발을 위한 생체표지자 및 대리 결과 변수의 역할 및 활용)

  • Seong, Soo-Hyeon;Yun, Hwi-Yeol;Baek, In-Hwan;Kang, Won-Ku;Chang, Jung-Yun;Seo, Kyung-Won;Kwon, Kwang-Il
    • YAKHAK HOEJI
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    • v.52 no.5
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    • pp.331-344
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    • 2008
  • Recently, the FDA (Food and Drug Administration) of the United States and many advanced countries remark biomarkers and surrogate endpoints as a critical path tool on model based drug development. Economic, technical and social profit on model based drug development like a reduction of the length of research and development have been achieved. Therefore we summarize previous studies about biomarkers and surrogate endpoints and suggest a development direction of therapeutic agents. In diabetes mellitus (DM) and osteoporosis, there are remarkable increases in number of patients and most of patients take medicine during their whole lifetime. For this reason, many patients with DM and osteoporosis have a tolerance on their medicine. We expect that research and development on biomarkers and surrogate endpoints will contribute to new drug development on DM and osteoporosis. Biomarkers for DM are blood levels of glucose, insulin, ${HbA}_{1c}$, CRP, alpha-glucosidase, adiponectin and DPP-4. Among these, validated surrogate endpoints for DM are blood levels of glucose, insulin and ${HbA}_{1c}$ Biomarkers for osteoporosis are BMD, BMC, trabecular volume, ICTP, DPD, osteocalcin, the activity of osteoclast and production of osteoblast. The validated surrogate endpoints for osteoporosis are BMD only. This review summarizes all suggested biomarkers and surrogate endpoints in DM and osteoporosis. The biomarkers are classified by drugs, and the method of validation for surrogate endpoints is suggested. This information would contribute to suggest a direction of DM and osteoporosis therapeutic agent development.

A Study of Prevalence and Related Risk Factors of Osteoporosis for Employees (직장 근로자의 골다공증 유병실태와 관련요인 연구)

  • Hong, Sun-An;You, Si-Young
    • The Journal of the Korea institute of electronic communication sciences
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    • v.8 no.4
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    • pp.631-637
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    • 2013
  • Background and Objectives: The study was performed to investigate the status of osteoporosis for S electronics workers in H hospital of G city form April 21 to May 31 2008. Material and Method: The result of this research is following. Results: As results of osteoporosis analysis based on general characteristic, for men, something of 21 was the most frequent and osteoporosis of 13 was the second most frequent, and for women, good of 12 was the most frequent and care was the second most. The results concludes that men have more problems with osteoporosis that women have. In age of 40 years or more, care level of 24(88.9%) was the most frequent and good level of 15 people was the second most. This result concludes that age of 40 year is target subjects for care. In position, senior has 14 people who have care level(42.4%) and 8 people(24.2%)of osteoporosis level. The result concludes than the senior has more osteoporosis than the employ has. Conclusion: In conclusion, the age, position, weight are related to osteoporosis.

Knowledge and Prevention Activity of Osteoporosis among Care Providers in Nursing Home (노인요양시설 간호제공자의 골다공증 관련 지식과 골다공증 예방활동)

  • Shim, Haeun;Park, Miwha;Park, Myungsook
    • Journal of Convergence for Information Technology
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    • v.9 no.12
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    • pp.71-80
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    • 2019
  • This study is a descriptive research study to identify osteoporosis knowledge and osteoporosis prevention activities among care providers in nursing home. The subjects were 142 care providers in S and Y city. The Data were collected from July 1 to July 20, 2019, and analyzed SPSS 24.0 Version. The result showed that the osteoporosis knowledge of among care providers was moderate. It showed differences in educational status, osteoporosis management training experience, residents number and importance awareness of elderly bone health. And prevention activities differed according to osteoporosis management training experience and importance awareness of elderly bone health. There was a positive correlation between knowledge and prevention activities of osteoporosis. Therefore, it is necessary to develop education programs for the management of elderly osteoporosis and to raise importance awareness of elderly bone health among care providers in nursing home. Further studies are needed to evaluate the effects of the program.

The Effect of the Knowledge and Health Beliefs on Osteoporosis Preventive Health Behaviors among Middle-aged Women (중년여성의 골다공증에 대한 지식과 건강신념이 골다공증 예방행위에 미치는 영향)

  • Lee, Jong-Kyung
    • Journal of Korean Academy of Community Health Nursing
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    • v.14 no.4
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    • pp.629-638
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    • 2003
  • Purpose: This study investigated the effects of knowledge and health belief on osteoporosis preventive health behaviors. Methods: The subjects of this study were 266 middle-aged women. Data were collected using a self-reporting questionnaire with 101 questions. The period of data collection was from the 3rd of January to the 28th of February 2003. Data were analyzed using SPSS 10.0 PC+ program. Results: The results were summarized as follows: 1. The average score of knowledge about osteoporosis was 16.93 out of 27. Particularly, middle-aged women had knowledge more about osteoporosis prevention measures than about risk factors. 2. Knowledge, self efficacy and barriers were significantly correlated with osteoporosis preventive health behaviors. 3. As for the relationship between subjects' general characteristics and their health preventive behaviors, the size of living district, economic status, BMI. family history of osteoporosis and perception of health status were found to have significant effects on health preventive behaviors. Conclusions: According to the results presented above, preventive health behaviors may be promoted by increasing knowledge and perceived self-efficacy as well as decreasing individuals' perceived barriers through health education.

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Relationship between the number of remaining teeth and bone health status among the elderly in Korea (한국 노인의 현존치아수와 골 건강상태와의 연관성)

  • Cho, Youn-Young
    • Journal of Korean society of Dental Hygiene
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    • v.18 no.2
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    • pp.205-215
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    • 2018
  • Objectives: The purpose of the study is to investigate the relationship between the number of remaining teeth and bone health status among adults over 65 years old. Methods: The study subjects were 1,843 adults over 65 years old drawn from the Korea National Health and Nutrition Examination Survey (KNHANES) in 2008-2010. Oral health status included the number of remaining teeth, and prosthetic appliance status. Bone health statuses were assessed using dual-energy X-ray absorptiometry (DEXA). Bone health statuses were classified into normal (T-score ${\geq}-1.0$), osteopenia (-2.5 < T-score < -1.0), and osteoporosis (T-score ${\leq}-2.5$). Complex samples chi-square test was used to estimate the relationship between the number of remaining teeth and bone health status, and related factors included in the model were analyzed with the complex samples logistic regression analysis. Results: Using the multinomial logistic regression analytic method, the elderly having 20 or more remaining teeth and those having less than 20 remaining teeth with prosthesis were compared. The latter group had 1.89 times higher rate of being diagnosed as having osteoporosis. Conclusions: This study suggests that oral health is an important factor for geriatric osteoporosis. Therefore, in order to prevent fractures due to osteoporosis and osteoporosis in old age, it is necessary to be aware of the relationship between oral health and osteoporosis, and oral health should be considered when preparing preventive management strategies.

Usefulness of Estimated Height Loss for Detection of Osteoporosis in Women

  • Yeoum, Soon-Gyo;Lee, Jong-Hwa
    • Journal of Korean Academy of Nursing
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    • v.41 no.6
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    • pp.758-767
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    • 2011
  • Purpose: This study was done to examine the threshold value of estimated height loss at which the risk of osteoporosis increases and to verify its discriminative ability in the detection of osteoporosis. Methods: It was conducted based on epidemiological descriptive methods on 732 Korean women at a public healthcare center in Seoul between July and November 2010. ANOVA, Pearson correlation, logistic regression analysis and receiver operating characteristics (ROC) curve were used for data analysis. Results: There was an age-related correlation between bone mineral density (lumbar spine: F=37.88, p<.001; femur: F=54.27, p<.001) and estimated height loss (F=27.68, p<.001). Estimated height loss increased significantly with decreasing bone mineral density (lumbar spine: r=-.23, p<.001; femur: r=-.34, p<.001). The odds ratio for the point at which the estimated height loss affects the occurrence of osteoporosis was found to increase at a cut-off value of 2 cm and the area under ROC curve was .71 and .82 in lumbar spine and femur, respectively. Conclusion: The optimal cut-off value of the estimated height loss for detection of osteoporosis was 2 cm. Height loss is therefore a useful indicator for the self-assessment and prognosis of osteoporosis.

Time Course of Fibular Osteoporosis in Ovariectomized Rats (난소적출 랫트 비골의 시간경과에 따른 골다공증성 변화)

  • Bae, Chun-Sik;Park, Chang-Hyun;Uhm, Chang-Sub
    • Applied Microscopy
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    • v.29 no.3
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    • pp.377-382
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    • 1999
  • Osteoporosis means a deficiency in the amount of bone tissue in the skeleton or part of the skeleton. Osteoporosis is a lesion, not a specific disease. 'Osteoporotic' describes the slate of a bone or skeleton at a given time. Osteoporosis may be diagnosed subjectively by visual appraisal, or objectively by measurement of radiographs, sawn bones, or microscopic sections. This study was carried out to make clear of the influence of ovariectomy on time course of fibular osteoporosis in rats. Seven weeks after ovariectomy, osteoporosis was evident, when the size of the bone marrow cavities significantly increased and the width from the bone marrow cavity and cortex significantly decreased than normal.

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Risk Factors for Postmenopausal Osteoporosis in Korea (한국 폐경 여성의 골다공증 위험 인자에 관한 연구)

  • Lee, Dong-Yun;Gu, Seung-Yeop;Kim, Seok-Hyeon;Choe, Yeong-Min;Mun, Sin-Yong;Kim, Jeong-Gu
    • Journal of Korea Association of Health Promotion
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    • v.2 no.2
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    • pp.137-148
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    • 2004
  • Objective : To identify the risk factors for postmenopausal osteoporosis in Korea Materials and methods : Bone mineral density (BMD) at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry in 808 apparently normal postmenopausal Korean women. Questions about life style, demographic parameters, medical history and social habits etc. were asked on these women; 2ll women with normal bone mineral density, and 597 women with osteopenia or osteoporosis. Results 'Age of >50 years, low body mass index (BMI; <18.5 kg/m2), long duration of menopause(>10 years), and previous history of fracture were associated with increased prevalence of osteopenia or osteoporosis. Women without the outside activity also showed a higher frequency of low bone mass, Risk for osteopenia or osteoporosis was low in women with high BMI (>23 kg/m2) and women with job. The prevalence of low bone mass appeared to be independent of the following parameters: socioeconomic status, familial history, smoking, drinking, exercise, previous use of oral contraceptive, coffee or milk consumption, and degree of sunlight exposure. Conclusion 'Age, BMI, duration of menopause, previous history of fracture and degree of outside activity are the risk factors for postmenopausal osteoporosis in Korea.

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Research on the Bone Mineral Density Performed in Volunteer Medical Service (의료봉사활동에서 시행한 골밀도 검사의 유소견 연구)

  • Park, Chang-Hee
    • Korean Journal of Digital Imaging in Medicine
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    • v.10 no.2
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    • pp.5-10
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    • 2008
  • Thanks to recent development of science and technology, economic standard has been improved and life expectation has been gradually increased. Accordingly, disease aspect and demand for health have been changed in the concept from conventional center of disease to health improvement As the health issue in middle and senior age has also been vital in the national health, osteoporosis, one of the physical maladies occuring in these age group, is on the rise as a matter of important concern so that the researches on the osteoporosis have being accomplished actively in several medical domains. Research has been earned out for 735 examined objects, who have received medical examination of bone mineral density in the volunteer medical service of Daegu and Kyungbuk province for recent 4 years. The result indicated that serious osteoporosis prevailed over osteoporosis for male while osteopenia was majority to osteoporosis and that abnormal bone mineral density was more prominent than normal bone mineral density for both male and female. This study is to present basic data which is indispensible to preparation of senior citizen dominated society afterward, investigating the prevalence rate of osteoporosis.

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A Study on Osteoporosis Knowledge, Health Beliefs and Health Behaviors among Female College Students (여대생의 골다공증 지식, 건강신념, 건강행위에 관한 연구)

  • Min, Hye-Jin;Oh, Hee-Young
    • Journal of Korean Academy of Community Health Nursing
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    • v.22 no.2
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    • pp.111-120
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    • 2011
  • Purpose: The purpose of this study was to investigate osteoporosis knowledge, health beliefs, and influencing factors on health behaviors among female college students. Methods: Using the Osteoporosis Quiz, the Health belief Scale, and the Health Behavior Questionnaire, data were collected from 314 female college students from 4 universities located in Chungcheong providence. Results: The mean scores of knowledge and health belief were $12.7{\pm}3.81$ and $90.9{\pm}12.66$, respectively. There was a statistically significant correlation between osteoporosis knowledge and health belief (p<.001). Also, a statistically significant correlation was found between health belief and health behavior (p<.001). According to the regression model, knowledge, perceived benefit, perceived barrier, family history of osteoporosis, and health interest explained 6.7% of total variance in health behavior. Conclusion: Female college students should be taught to be aware of the importance of proper dietary intake and regular exercise as a way to maintain or promote the health of their bones so that they can prevent osteoporosis.