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Synthetic Studies on the Nucleophilic Addition of 1-Methyl-5-mercapto-1,2,3,4-tetrazole to Vinylsulfilimines (Vinylsulfilimine유도체에 대한 1-methyl-5-mercapto-1,2,3,4-tetrazole의 친핵성 첨가물에 관한 연구)

  • Tae-Rin Kim;So-Young Lee;Sang-Yong Pyun
    • Journal of the Korean Chemical Society
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    • v.36 no.2
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    • pp.318-323
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    • 1992
  • Following seven new nucleophilic adducts of sulfilimine compounds were prepared by the addition of 1-methyl-5-mercapto-1,2,3,4-tetrazole to vinylsulfilimine derivatives; S-Phenyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine, S-p-tolyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine, S-m-tolyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine, S-p-chlorophenyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine, S-p-bromophenyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine, S-p-methoxyphenyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine and S-p-nitrophenyl-S-2-(1-methyl-1,2,3,4-tetrazole-5-thio)-ethyl-N-p-tosylsulfilimine. The structures of these adducts were confirmed by elemental analyses, MP, UV, IR-and NMR-Spectra.

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EMBEDDING OF WEIGHTED $L^p$ SPACES AND THE $\bar{\partial}$-PROBLEM

  • Cho, Hong-Rae
    • East Asian mathematical journal
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    • v.19 no.1
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    • pp.73-80
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    • 2003
  • Let D be a bounded domain in $\mathbb{C}^n$ with $C^2$ boundary. In this paper, we prove the following inequality $${\parallel}u{\parallel}_{p_2,{\alpha}_2}{\lesssim}{\parallel}u{\parallel}_{p_1,{\alpha}_1}+{\parallel}\bar{\partial}u{\parallel}_{p_1,{\alpha}_1+p_1}/2$$, where $1{\leq}p_1{\leq}p_2<\infty,\;{\alpha}_j>0,(n+{\alpha}_1)/p_1=(n+{\alpha}_1)/p_1=(n+{\alpha}_2)/p_2$, and $1/p_2{\geq}1/p_1-1/2n$.

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Air Ion Distribution of Traffic Volume in Urban Area -Wiryeseong main road, in Songpa-gu, Seoul.- (도심지 가로공간 내 교통량에 따른 이온 분포 -송파구 위례성대로를 중심으로-)

  • Kim, Jeong-Ho;Oh, Deuk-Kyun;Choi, Won-Jun;Yoon, Yong-Han
    • Journal of the Korean Society of Urban Environment
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    • v.17 no.2
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    • pp.137-144
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    • 2017
  • The study conducted a study on the effects of road traffic on the road, which is the main cause of urban air pollution, on the road to traffic congestion. In order to measure the impact of the traffic volume on the road to the curb, the meteorological center, ion measurements were carried out in wiryeseong, Songpa-gu, Seoul. The measuring point of measurement is used median ($P_0$), bicycle path ($P_{1.5}$), reporting ($P_6$), street tree ($P_{10}$) They were divided into 1.5meters and measured weather and ion measurements. The temperature measurements were measured as follows $P_0(35.4^{\circ}C)$ ${\geq}$ $P_{1.5}(35.0^{\circ}C)$ > $P_6(33.5^{\circ}C)$ > $P_{10}(32.8^{\circ}C)$. The relative humidity was measured as follows $P_{10}$(47%) > $P_6$(45%) > $P_{1.5}$(42%) ${\geq}$ $P_0$(42%). Wind vel^{\circ}City was measured as follows $P_0$(0.45 m/s) > $P_{1.5}$(0.37 m/s) ${\geq}$ $P_{10}$(0.36 m/s) > $P_6$(0.34 m/s). Measurement of negative ions is minute traffic is 20 per cent. $P_0(828ea/m^3)$ < $P_{1.5}(854ea/m^3)$ < $P_6(892ea/m^3)$ < $P_{10}(934ea/m^3)$, minute traffic is 40 per cent. $P_0(512ea/m^3)$ < $P_{1.5}(641ea/m^3)$ < $P_6(709ea/m^3)$ < $P_{10}(810ea/m^3)$, minute traffic is 60 per cent. Measurement results of a positive ion are minute traffic is 20 per cent $P_{1.5}(244ea/m^3)$ < $P_6(262ea/m^3)$ < $P_0(263ea/m^3)$ < $P_{10}(330ea/m^3)$, minute traffic is 40 per cent $P_0(487ea/m^3)$ < $P_6(543ea/m^3)$ < $P_{10}(544ea/m^3)$ < $P_{1.5}(564ea/m^3)$, minute traffic is 60 per cent $P_0(509ea/m^3)$ < $P_6(536ea/m^3)$ < $P_{1.5}(540ea/m^3)$ < $P_{10}(541ea/m^3)$ Measurement Results of ion index are minute traffic is 20 per cent $P_{10}$(2.9) < $P_0$(3.1) < $P_6$(3.4) < $P_{1.5}$(3.5), minute traffic is 40 per cent $P_{1.5}$(1.4) < $P_0$(1.5) < $P_6$(1.6) < $P_{10}$(1.8) minute traffic is 60 per cent $P_0$(1.0) < $P_{1.5}$(1.2) < $P_6$(1.3) < $P_{10}$(1.6).

Clinical Analysis According to $p21^{Waf1/Cip1}\;and\;p27^{kip1}$ Expression in Gastric Cancer (위암에서의 $p21^{Waf1/Cip1}\;and\;p27^{kip1}$ 단백 발현)

  • Kim, Sin-Sun;Park, Yong-Geun;Jun, Kyong-Hwa;Jung, Hun;Song, Gyo-Young;Kim, Jin-Joo;Chin, Hyung-Min;Kim, Wook;Park, Cho-Hyun;Park, Seung-Man;Lim, Keun-Woo;Kim, Seung-Nam;Jeon, Hae-Myung
    • Journal of Gastric Cancer
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    • v.6 no.1
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    • pp.36-42
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    • 2006
  • Purpose: The $p21^{Waf1/Cip1}$ protein Inhibits the cell cycle by Inhibiting the phosphorylation at the $G1{\rightarrow}S$ check point, and the $p27^{kip1}$ protein similarly performs the suppressor function by controlling the p27-mediated G1 arrest. In this study, we analysed the clinical status and survival rates in correlations with p21 and p27 expression patterns in gastric cancer. Materials and Methods: Between 1993 and 1997, 192 patients who underwent surgeries in Catholic Medical Center were analysed retrospectively in this study. Immunohistochemical staining was performed and if the nuclei of the tumor cells were stained, we assumed those as positive results. Statistical analysis was based on clinicopathological findings and differences in survival rates. Results: The expression rate of p27 was 28.1% and 15.6% in p21 each. The ratio of T1-2(80.0%) was significantly high in p21 (+), but the ratio of T3-4 (50.6%) was slightly high in p21 (-). There was no statistical significance regarding other factors. The results in p27 was not much different from expression rate of p21 in T-stage. In addition, p27 expression in diffuse type (91.3%) was higher than in intestinal type (62.7%) by Lauren's classification (P<0.05). Also, there was no statistical significance in other factors. In the correlation of p21 and p27, p27 was positive when p21 was positive (53.5%). Conversely, p27 was negative when p21 was negative (76.5%, p<0.05). In the p21 and p27 combination test, there was higher rate of T1-2 (87.5%) in p21 (+)/p27 (+), and higher rate of T3-4 (58.1%) in p21 (-)/p27 (-) (P<0.05). Results showed higher rate of intestinal type (100%) in p21 (+)/p27 (+), and diffuse type (87.0%) was dominant in p21 (-)/p27 (-) (P<0.05) by Lauren's classification. Moreover, there was no statistical significance in the 5-year survival rate in the expression of p21 and p27, and the 5-year survival rate was highest in the case of p21 (+)/p27 (+) without statistical significance. Conclusion: In our study, $p21^{Waf1/Cip1}\;and\;p27^{kip1}$ expressed similar patterns. The expression of $p21^{Waf1/Cip1}\;and\;p27^{kip1}$ affected the degree of invasiveness of the tumor, and. Combined examination result revealed the correlation of $p21^{Waf1/Cip1}\;and\;p27^{kip1}$ with Lauren's classification and depth of invasion of the tumor. However, we assumed that little difference between the survival rates depending on expression of $p21^{Waf1/Cip1}\;and\;p27^{kip1}$ has limited their value as predictable prognostic indicators.

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ON THE INTEGRAL THEORY OVER DIFFERENTIABLE MANIFOLDS (I)

  • KWAK, HYO-CHUL
    • Honam Mathematical Journal
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    • v.1 no.1
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    • pp.1-9
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    • 1979
  • Positive Local Coordmate($(x^1,x^2,{\cdots}x^n)$)을 갖는 Oriented Manifold M을 생각한다. M이 Compact Carrier를 갖는 경우, M위의 n차(次) Differential Form ${\phi}^{(n)}$의 적분(積分)을 $${\int}{\phi}^{(n)}=\sum_{\alpha}{\int}_{-{\infty}}^{\infty}{\cdots}{\int}_{-{\infty}}^{\infty}f_{\alpha}{\phi}^{(n)}dx^1{\cdots}dx^n$$로 정의(定義)하며 (정의(定義) 7), M위의 p 차(次)의 Differential form $\beta^{(p)}$와 Differential simplex $S^{(p)}=(S^{(p)},\;{\pi},\;{\varepsilon})$에 대하여 $S^{(p)}$위의 $\beta^{(p)}$의 적분(積分)을 $${\int}_{^{(p)}S}{\beta}^{(p)}={\int}_{S^{(p)}}{\varepsilon}{\pi}^*{\beta}^{(p)}={\int}_{E^p}f{\cdot}{\varepsilon}{\cdot}{\pi}^*{\beta}^{(p)}$$로 정의(定義)한다 (정의(定義) 9). 단(但) $\bar{S}^{(p)}$$S^{(p)}=(p_0{\cdot}p_1{\cdots}p_p)$에 의(依)하여 Spanning 되는 $E^p$의 Subspace이고 f는 $\bar{S}^{(p)}$의 특성함수(特性函數)이다. 이때 (n-1)차(次)의 Differential Form ${\beta}^{(n-1)}$이 Compart인 Carrier를 가지면 ${\int}d{\beta}^{(n-1)}=0$이 됨을 고찰(考察)하며(정리(定理 8), (p-1)차(次) Differential Form ${\beta}^{(p-1)$과 p차(次) Differential Chain $C^{(p)}$에 관(關)하여 $${\int}_{C^{(p)}}d{\beta}^{(p-1)}={\int}_{{\partial}C^{(p)}}{\beta}^{(p-1)}$$이 성립(成立)함을 구명(究明)하려 한다(정리(定理) 10).

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On Generalized Integral Operator Based on Salagean Operator

  • Al-Kharsani, Huda Abdullah
    • Kyungpook Mathematical Journal
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    • v.48 no.3
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    • pp.359-366
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    • 2008
  • Let A(p) be the class of functions $f\;:\;z^p\;+\;\sum\limits_{j=1}^{\infty}a_jz^{p+j}$ analytic in the open unit disc E. Let, for any integer n > -p, $f_{n+p-1}(z)\;=\;z^p+\sum\limits_{j=1}^{\infty}(p+j)^{n+p-1}z^{p+j}$. We define $f_{n+p-1}^{(-1)}(z)$ by using convolution * as $f_{n+p-1}\;*\;f_{n+p-1}^{-1}=\frac{z^p}{(1-z)^{n+p}$. A function p, analytic in E with p(0) = 1, is in the class $P_k(\rho)$ if ${\int}_0^{2\pi}\|\frac{Re\;p(z)-\rho}{p-\rho}\|\;d\theta\;\leq\;k{\pi}$, where $z=re^{i\theta}$, $k\;\geq\;2$ and $0\;{\leq}\;\rho\;{\leq}\;p$. We use the class $P_k(\rho)$ to introduce a new class of multivalent analytic functions and define an integral operator $L_{n+p-1}(f)\;\;=\;f_{n+p-1}^{-1}\;*\;f$ for f(z) belonging to this class. We derive some interesting properties of this generalized integral operator which include inclusion results and radius problems.

Cross-Correlation Distribution of a p-ary m-Sequence Family Constructed by Decimation (Decimation에 의해 생성된 p-진 m-시퀀스 군의 상호 상관 값의 분포)

  • Seo, Eun-Young;Kim, Young-Sik;No, Jong-Seon;Shin, Dong-Joon
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.33 no.9C
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    • pp.669-675
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    • 2008
  • For an odd prime p, n=4k and $d=((p^2k+1)/2)^2$, there are $(p^{2k}+1)/2$ distinct decimated sequences, s(dt+1), $0{\leq}l<(p^{2k}+1)/2$, of a p-ary m-sequence, s(t) of period $p^n-1$. In this paper, it is shown that the cross-correlation function between s(t) and s(dt+l) takes the values in $\{-1,-1{\pm}\sqrt{p^n},-1+2\sqrt{p^n}\}$ and their, cross-correlation distribution is also derived.

Study on the Segregation Algorithms of the Incompressible Navier-Stokes Equations Using P1P1/P2P1 Finite Element Formulation (P1P1/P2P1 유한요소 공식을 이용한 배압축성 Navier-Stokes 방정식의 분리 해법에 대한 연구)

  • Choi Hyoung-G.;Yoo Jung-Y.;Park Jae-I.;Cho Myung-H.
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.30 no.3
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    • pp.262-269
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    • 2006
  • Segregation algorithms of the incompressible Wavier-Stokes equations using P1P1/P2P1 finite element formulation are newly proposed. P1P1 formulation allocates velocity and pressure at the same nodes, while P2P1 formulation allocates pressure only at the vertex nodes and velocity at both the vertex and the midpoint nodes. For a comparison of both the elapsed time and the accuracy between the two methods, they have been applied to the well-known benchmark problems. The three cases chosen are the two-dimensional steady and unsteady flows around a fixed cylinder, decaying vortex, and impinging slot jet. It is shown that the proposed P2P1 semi-segregation algorithm performs better than the conventional P1P1 segregation algorithm in terms of both accuracy and computation time.

STUDY ON THE SPLITTING ALGORITHMSOF THE INCOMPRESSIBLE NAVIER-STOKES EQUATIONS USING P1P1/P2P1 FINITE ELEMENT FORMULATION (P2P1/P1P1 유한요소 공식을 이용한 비압축성 Navier-Stokes 방정식의 분리 해법에 대한 연구)

  • Cho Myung H.;Choi Hyoung G.;Yoo Jung Y.;Park Jae I.
    • 한국전산유체공학회:학술대회논문집
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    • pp.117-124
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    • 2005
  • Splitting algorithms of the incompressible Navier-Stokes equations using P1P1/P2P1 finite element formulation are newly proposed. P1P1 formulation allocates velocity and pressure at the same nodes, while P2P1 formulation allocates pressure only at the vertex nodes and velocity at both the vertex and mid nodes. For comparison of the elapsed time and accuracy of the two methods, they have been applied to the well-known benchmark problems. The three cases chosen are the two-dimensional steady and unsteady flows around a fixed cylinder, decaying vortex, and impinging slot jet. It is shown that the proposed P2P1 semi-splitting method performs better than the conventional P1P1 splitting method in terms of both accuracy and computation time.

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Characterization of a Putative F-box Motif in Ibd1p/Bfalp, a Spindle Checkpoint Regulator of Budding Yeast Saccharomyces cerevisiae

  • Lee, Kyum-Jung;Hyung-Seo;Kiwon Song
    • Journal of Microbiology
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    • v.39 no.4
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    • pp.286-292
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    • 2001
  • During mitosis. the proper segregation of duplicated chromosomes is corrdinated by a spindle check-point. The bifurcated spindle checkpoint blocks cell cycle progression at metaphase by monitoring unattached kinetochores and inhibits mitotic exit in response to the misorientation of the mitotic spin- dle Ibd1p/Bfa1p is a spindle checkpoint regulator of budding yeast in the Bub2p checkpoint pathway for mitotic exit and its disruption abolishes mitotic arrest when proper organization of the mitotic spin-dls inhibited. Ibd1p/Bfa1p localizes to the spindle pole body, a microtublue-organizing center in yeast, and its overexpression arrests the cell cycle in 80% of cells with an enlarged budy at mitosis and in 20 % of cells with multiple buds. In this study, we found that the C-terminus of Ibd1p/Bfa1p phys-ically interacts with Skp1p, a key component of SCF (Skp1/cullin/F-box) complex for ubiquition-medi-ated proteolysis of cel cycle regulatores as well as an evolutionally conserved kinetochore protein for cell cycle progression. A putative F-box motif was found in the C-terminus of Ibd1p/Bfa1p and its function was investigated by making mutants of conserved residues in the motif. These Ibd1p/Bfa1p mutants of a putative F-box interacted with SKp1p in vitro by two-hybrid assays as wild type Ibd1p/Bfa1p. Also these Ibd1p/Bfa1p utants displayed the overexpression phenotypes of wild type Ibd1p, when over-expressed under inducible promoters . These results suggest that a putative F-box motif of Ibd1p/Bfa1p is not essential for the interaction with SKp1p and its function in mitotic exit and cytokinesis.

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