• Title, Summary, Keyword: PCT

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A study of the effectiveness of using the serum procalcitonin level as a predictive test for bacteremia in acute pyelonephritis

  • Lee, Ga Hee;Lee, Yoo Jin;Kim, Yang Wook;Park, Sihyung;Park, Jinhan;Park, Kang Min;Jin, Kyubok;Park, Bong Soo
    • Kosin Medical Journal
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    • v.33 no.3
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    • pp.337-346
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    • 2018
  • Objectives: Serum procalcitonin (PCT) is a specific biomarker that rises after bacterial infection, and levels of PCT are known to correlate with the severity and mortality of patients with pneumonia and sepsis. However, the usefulness of PCT levels in acute pyelonephritis is unknown. This study aimed to evaluate the effectiveness of using the PCT level as a predictive test for bacteremia in acute pyelonephritis. Methods: Between January 2012 and June 2013, 140 patients diagnosed with acute pyelonephritis were admitted to Haeundae Paik Hospital. Serum PCT, C-reactive protein (CRP), and white blood cell (WBC) levels at pre- and post- treatment were measured. Blood and urine cultures were obtained from all patients. The levels of PCT, CRP, and WBCs were each compared between the blood culture-positive and blood culture-negative groups to assess their effectiveness in predicting bacteremia. Results: Pre-treatment PCT level was 0.77 ng/mL (95% CI: 0.42-1.60 ng/mL) in the blood culture-negative group and 4.89 ng/mL (95% CI: 2.88-9.04 ng/mL) in the blood culture-positive group, and the increase between the two groups was statistically significant. The area under the receiver operating characteristic curve of PCT level for prediction of bacteremia was 0.728. A cut-off value of 1.23 ng/mL indicated a sensitivity of 79.0 % and specificity of 60.0 % for PCT level. Conclusions: Serum PCT level is a useful predictive test for bacteremia in acute pyelonephritis. Through the early detection of bacteremia, serum PCT level can help estimate the prognosis and predict complications such as sepsis.

Usefulness of Procalcitonin in the Assessing the Severity of Community-Acquired Pneumonia Patient (지역사회획득폐렴 환자의 중증도 평가에서 Procalcitonin 유용성)

  • Park, Hun-Pyo;Lee, Jung-Soo;Jang, Ye-Su;Kim, Min-Su
    • Tuberculosis and Respiratory Diseases
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    • v.67 no.5
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    • pp.430-435
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    • 2009
  • Background: Thus far, research studies on community-acquired pneumonia (CAP) have focused on its clinical severity. Recently, it has been determined that procalcitonin (PCT) level is correlated with severity of CAP. A retrospective study conducted at our hospital used risk predictability and PCT to determine whether or no PCT is useful in assessing the severity of CAP. Methods: This study covered 92 CAP cases that were admitted to the respiratory department at Changwon Fatima Hospital between July 1, 2008 and June 30, 2009. All enrolled subjects were measured for infection markers and risk predictability. Results: Based on hospital admission data, enrolled subjects had Pneumonia Severity Index (PSI) scores serving as risk predictors showed that both PCT and white blood cell (WBC) were statistically significant as infection markers (p=0.001, 0.037). Thus, this study used ROC curves in PSI for data analysis. As a result, it was determined that the area under curve (AUC) of PCT and WBC was 0.694 and 0.593 respectively, indicating that PCT has a higher test value for WBC, when PCT was higher than 0.745 ng/mL. In addition, it was found that PCT levels higher than 0.745 ng/mL had higher PSI scores than the group with PCT lower than 0.745 ng/mL (p=0.032). Conclusion: In order to predict risk of pneumonia cases admitted due to symptoms of CAP, it is important to consider PCT as well as PSI, and follow-up monitoring of PCT cases.

Development of Modified Product Consistency Test

  • Park, Kwansik;Jiawei Sheng;Maeng, Sung-Jun;Song, Myung-Jae
    • Proceedings of the Korean Nuclear Society Conference
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    • pp.391-396
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    • 1998
  • Modified product Consistency Test (M-PCT) has been developed as an alternative to other existing methods in determining the leachability of glass. M-PCT, the leaching method, is a hybrid of MCC-l and PCT, but can provide quicker sample preparation. Larger diameter glass sample (1.0-2.0 mm) than in the PCT method can be used so that the glass beads are more easily produced and cleaned. From the M-PCT, the total mass loss (ML) of glass, the normalized elemental release rate (NLi), pH value of leachate have been obtained. For some selected glasses in which leaching rates have been known, their chemical durablility have been tested using the M-PCT method. The results are compared to the literature data for the glasses. It is found that M-PCT method is reasonable and suitable in determining the leachability of Low and Intermediate level Radioactive Waste glass form, such as the pH, elemental loss and total mass loss.

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PCT Application System (PCT국제출원 제도)

  • Won, Jeong-Uk;Lee, Sang-Mu;Song, Geun-Jang
    • Electronics and Telecommunications Trends
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    • v.12 no.5
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    • pp.121-130
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    • 1997
  • 본 고는 앞으로 자주 사용하게 될 PCT 국제특허 출원제도를 소개하여 이를 활성화하고자 작성하였다. 국제출원의 개요를 설명하고 PCT 출원 처리절차 특히 국제조사, 국제공개, 국제예비심사까지의 일련의 과정을 설명하여 연구원들의 이해를 높이고 장단점을 비교하여 어떻게 이 제도를 사용할 것인지를 설명하였다.

DB가이드 - PCT(특허협력조약) 데이터베이스

  • Lee, Ik-Sang
    • Digital Contents
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    • no.11
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    • pp.74-78
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    • 1998
  • PCT는 WIPO IPDL(WIPO Intellectual Property Digital Library) 프로젝트에 의해 만들어진 데이터베이스이며, PCT를 통해 출원된 국제특허자료를 인터넷을 통해 무료로 검색해 볼 수 있다.

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The influencing factors on procalcitonin values in newborns with noninfectious conditions during the first week of life

  • Lee, Jueseong;Bang, Yong Hyeon;Lee, Eun Hee;Choi, Byung Min;Hong, Young Sook
    • Korean Journal of Pediatrics
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    • v.60 no.1
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    • pp.10-16
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    • 2017
  • Purpose: Although procalcitonin (PCT) level is useful for the diagnosis of neonatal sepsis, PCT reliability is inconsistent because of the varied conditions encountered in neonatal intensive care units. This study aimed to investigate PCT levels and factors influencing increased PCT levelin newborns without bacterial infection during the first week of life. Methods: In newborns hospitalized between March 2013 and October 2015, PCT levels were measured on the first, third, and seventh days after birth. Newborns with proven bacterial (blood culture positive for bacteria) or suspicious infection (presence of C-reactive protein expression or leukocytosis/leukopenia) were excluded. Various neonatal conditions were analyzed to identify the factors influencing increased PCT level. Results: Among 292 newborns with a gestational age of $35.2{\pm}3.0$ weeks and a birth weight of $2,428{\pm}643g$, preterm newborns (n=212) had higher PCT levels than term newborns (n=80). Of the newborns, 7.9% had increased PCT level (23 of 292) on the firstday; 28.3% (81 of 286), on the third day; and 3.3% (7 of 121), on the seventh day after birth. The increased PCT level was significantly associated with prenatal disuse of antibiotics (P=0.004) and surfactant administration (P<0.001) on the first day after birth, postnatal use of antibiotics (P=0.001) and ventilator application (P=0.001) on the third day after birth, and very low birth weight (P=0.042) on the seventh day after birth. Conclusion: In newborns without bacterial infection, increased PCT level was significantly associated with lower gestational age and respiratory difficulty during the first week of life. Further studies are needed for clinical applications.

An Experimental Study on Compressive Loading Capacity of Precast Concrete Truss System (프리캐스트 콘크리트 트러스 시스템의 압축 내하력 실험 연구)

  • Han, Man-Yop;Jeon, Se-Jin
    • Journal of The Korean Society of Civil Engineers
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    • v.33 no.3
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    • pp.889-900
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    • 2013
  • In a large scale of excavation for the foundation of large-sized structures and underground structures, a considerable amount of earth pressure can occur. Steel beams that have been used to form a temporary structure to support earth pressure may be less economical and less efficient in resisting the high earth pressure. To cope with this problem, PCT(Precast Concrete Truss) system has been devised and investigated both experimentally and analytically. A proper connection method between the concrete truss members was proposed to accommodate fast assembly and disassembly. Full-scale test of PCT system was performed to verify the load-carrying capacity of the PCT system including the connections. The test results were compared with those of structural analysis. The test specimen which corresponds to PCT strut attained the ultimate load without buckling, but the detail of connector members needs to be improved. It is expected that precast concrete truss members can be efficiently incorporated into a temporary structure for deep and large excavation by replacing conventional steel beams.

Investigation of PCT Behavior in IBLOCA Counterpart Tests between the ATLAS and LSTF Facilities (중형냉각재상실사고의 PCT에 대한 ATLAS와 LSTF 장치의 대응 실험 검토)

  • Kim, Yeon-Sik;Kang, Kyoung-Ho
    • Journal of Energy Engineering
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    • v.28 no.3
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    • pp.26-33
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    • 2019
  • A comparison of CL 13% and 17% IBLOCA counterpart tests(CPTs) between the ATLAS and LSTF facilities was carried out and the behavior of peak cladding temperatures(PCTs) and related thermal hydraulic phenomena were investigated and discussed. There appeared quite a big difference in PCT behavior between the two CPTs and a further comparison of reactor coolant system design between the two facilities was performed. As a result, there was a difference in fuel alignment plate (FAP) design, e.g., one FAP in ATLAS, a combination of upper core plate and upper end box in LSTF, respectively. The FAP design mainly affects the reflux condensate behavior in IBLOCA tests and any difference in FAP design can be a possible reason for different PCT behavior between the two facilities. It should be a further study to find the reason of different PCT behvior between the two facilites.

Pressure Cycling Technology-assisted Protein Digestion for Efficient Proteomic Analysis

  • Choi, Hyun-Su;Lee, Sang-Kwang;Kwon, Kyung-Hoon;Yoo, Jong-Shin;Ji, Kelly;Kim, Jin-Young
    • Bulletin of the Korean Chemical Society
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    • v.32 no.2
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    • pp.599-604
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    • 2011
  • In typical proteomic analysis, trypsin digestion is one of the most time-consuming steps. Conventional proteomic sample preparation methods use an overnight trypsin digestion method. In this study, we compared high-pressure cycling technology (PCT) during enzyme digestion for proteome analysis to the conventional method. We examined the effect of PCT on enzyme activity at temperatures of 25, 37, and $50^{\circ}C$. Although a fast digestion (1 h) was used for the standard protein mixture analysis, the PCT-assisted method with urea showed better results for protein sequence coverage and the number of peptides identified compared with the conventional method. There was no significant difference between temperatures for PCT-assisted digestion; however, we selected PCT-assisted digestion with urea at $25^{\circ}C$ as an optimized method for fast enzyme digestion, based on peptide carbamylation at these conditions. The optimized method was used for stem cell proteome analysis. We identified 233, 264 and 137 proteins using the conventional method with urea at $37^{\circ}C$ for 16h, the PCT-assisted digestion with urea at $25^{\circ}C$ for 1 h, and the non-PCT-assisted digestion with urea at $25^{\circ}C$ for 1 h, respectively. A comparison of these results suggests that PCT enhanced the enzyme digestion by permitting better access to cleavage sites on the proteins.

An Experimental Study on Compressive Loading Capacity of PCT System (PCT System의 압축내하력에 관한 실험적 연구)

  • Han, Man-Yup;Kim, Jae-Hong;Kang, Sang-Hun;Jin, Kyung-Seok;Jeon, Yong-Sik;Cho, Byung-Ku
    • Proceedings of the Korea Concrete Institute Conference
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    • pp.41-44
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    • 2008
  • The PCT that supports the walls of long span temporary shoring facility is previously manufactured in the way of prestressing, and it which is composed of concrete is improved precast structure to satisfy enough stiffness. The components of PCT are manufactured as a fixed form, and they are close to the inner side of the wall of temporary shoring facility by fixed means in PCT. PCT system as support structure is that the ends of concrete filled segment members are united by the means of connection and also they have connection hole. In this study, PCT has enough bearing power for the long span temporary shoring facility, and also make the term of work reduce due to that the time of curing reduce through the method of precast.

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