• Title/Summary/Keyword: PEG

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Quality Properties of Enteric-Coated Soft Capsule Using PEG as a Plasticizer (PEG를 가소제로 사용한 장용성 연질캡슐의 코팅 품질 특성)

  • Yang, Joo Hwan;Han, Joon Taek;Oh, In Ho;Park, Geum Duck
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.2
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    • pp.260-267
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    • 2015
  • We investigated the applicability of polyethylene glycol (PEG) as a plasticizer in enteric-coated soft capsules based on determination of quality characteristics according to molecular weight and concentration of enteric-coating PEG solution. There was no difference according to molecular weight of PEG, whereas a low PEG concentration in the enteric-coating solution was associated with higher whiteness index and slower disintegration time in pH 6.8 media. Brittleness was observed in the coating film at seam areas in 5% PEG enteric-coating solution after 2 weeks of storage at room temperature. The enteric-coating properties of PEG were compared with those of acetylated monoglyceride (AMG) and triacetin, which are enteric-coating plasticizers. Enteric-coated soft capsule containing PEG as a plasticizer showed a lower whiteness index and faster dissolution profile than AMG and triacetin. Moreover, enteric-coated soft capsule containing AMG and triacetin as plasticizers showed coating film brittleness at seam areas after 2 months of accelerated storage [$40^{\circ}C$, relative humidity (RH) 75%] but no difference at room temperature storage ($25^{\circ}C$, RH 60%). The present study suggests that concentration of PEG is important to determine enteric-coating quality, regardless of the molecular weight of PEG. In conclusion, PEG has potential as a plasticizer due to its transparency and storage stability in enteric-coated soft capsules.

Surface Modification of Polyurethane Using Sulfonated PEG Grafted Polyrotaxane for Improved Biocompatibility

  • Park Hyung Dal;Bae Jin Woo;Park Ki Dong;Ooya Tooru;Yui Nobuhiko;Jang Jun-Hyeog;Han Dong Keun;Shin Jung-Woog
    • Macromolecular Research
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    • v.14 no.1
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    • pp.73-80
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    • 2006
  • Sulfonated poly(ethylene glycol) (PEG-$SO_{3}$) grafted polyrotaxanes (PRx-PEG-$SO_{3}$) were prepared in order to utilize the unique properties of PEG-$SO_{3}$ and the supramolecular structure of PRx, in which PEG-$SO_{3}$ grafted $\alpha$-cyclodextrins ($\alpha$-CDs) were threaded onto PEG segments in a PEG-b-poly(propylene glycol) (PPG)-b-PEG triblock copolymer (Pluronic) chain capped with bulky end groups. Some of the PRx-PEG-$SO_{3}$ demonstrated a higher anticoagulant activity in case of PRx-PEG-$SO_{3}$ (P 105), and compared with the control they showed a lower fibrinogen adsorption in PRx-PEG-$SO_{3}$ (F68) and a higher binding affinity with fibroblast growth factor. The obtained results suggested that polyrotaxane incorporated with PEG-$SO_{3}$ may be applicable to the surface modification of clinically used polymers, especially for blood/cell compatible medical devices.

Effect of Polycaprolactone on the Mechanical Properties of PEG/HMX Propellant (Polycaprolactone이 PEG/HMX 추진제의 기계적 성질에 미치는 영향)

  • 정병훈;홍명표;임유진
    • Journal of the Korean Society of Propulsion Engineers
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    • v.2 no.3
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    • pp.62-69
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    • 1998
  • Mechanical properties of polyethyleneglycol(PEG)/cyclo-tetramethylene tetranitramine(HMX) propellant were studied by adding polycaprolactone(PCP) and silane derivatives as coupling agent. Mechanical properties of the propellant were enhanced by increasing the content of PCP which was partially replaced with PEG. PCP/HMX propellant showed 17% increase in maximum tensile strength and 59% increase in elongation compared to those of PEG/HMX propellant. However, as the content of PCP was increased, the hydrolytic stability of this propellant was found to be deteriorated due to the ester group of PCP by measuring hardness drop of cured propellant and swell ratio difference of PEG/PCP binder stored at $40^{\cire}C$ and 90% relative humidity. Hardness of the PEG/PCP/HMX propellant was decreased with increasing triethoxysilyl propionitrile(TESPN) and dinitrosalicylic acid (DNSA) content from accelerated aging at $60^{\cire}C$.

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Characteristics of PU/PEG Hybrid Scaffolds Prepared by Electrospinning (전기방사법으로 제조한 PU/PEG 복합 지지체의 특성)

  • Seol, Bokyung;Shin, Ji-Yeon;Oh, Gayeon;Lee, Deuk Yong;Lee, Myung-Hyun
    • Journal of Biomedical Engineering Research
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    • v.38 no.5
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    • pp.248-255
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    • 2017
  • Polyurethane/polyethylene glycol(PU/PEG) hybrid scaffolds with various concentrations of PEG (0 to 50wt%) were prepared by electrospinning to evaluate the mechanical properties and the biocompatibility of the PU/PEG blend scaffolds. The 12wt% PU/PEG polymers were studied due to the absence of beads. The ultimate tensile strength of 12wt% PU was $8.2{\pm}0.5MPa$. The strength increased to $9.2{\pm}0.7MPa$ when 10% PEG was added to PU. However, the dry and the wet strength of PU/PEG scaffolds began to decrease dramatically when the PEG content was more than 10wt%. No cytotoxicity was observed for all the PU/PEG scaffolds investigated, indicating that the PU/PEG hybrid scaffolds are clinically safe and effective to small-diameter vascular grafts. In addition, the L-929 cells attached and proliferated well on the PU/PEG hybrid scaffolds.

PEG Distribution in the Cell Walls of PEG-treated Woods using SEM-EDS (SEM-EDS를 이용한 PEG처리재 세포벽내의 PEG분포 분석)

  • Kwon, Gu-Joong;Kim, Nam-Hun
    • Journal of the Korean Wood Science and Technology
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    • v.34 no.4
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    • pp.9-14
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    • 2006
  • This study was carried out to investigate the distribution and penetration of PEG molecules into the cell wall of wood by SEM-EDS method. SEM observation indicated that the cell walls of PEG-treated specimen were swollen, and didn't show any change in their shapes, while the cells of untreated specimen were more or less collapsed. The results of X-ray analyses of potassium stained samples revealed the distribution of the impregnated chemicals within the cell walls, when considering the distribution of potassium ions in the cell walls. Consequently, this study supported the possibility of PEG molecules penetrated into the wood cell wall play an important role in enhancing the dimensional stability of wood.

Preparation and Characterization of O-Carboxymethyl Chitosan Ion-complexed Poly(L-Lysine) for Drug and Gene Delivery System (약물 및 유전자 전달체로 응용하기 위한 Poly(L-Lysine)이 결합된 O-Carboxymethyl Chitosan PEG의 제조와 특성)

  • Nam, Joung-Pyo;Kim, Young-Min;Park, Jin-Su;Lee, Eung-Jae;Choi, Chang-Yong;Jang, Mi-Kyeong;Nah, Jae-Woon
    • Applied Chemistry for Engineering
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    • v.21 no.6
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    • pp.643-647
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    • 2010
  • O-carboxymethyl water-soluble chitosan (OCMCh) prepared for enhance the application of chitosan was modified with mthoxy polyethyleneglycol (mPEG) by ion-complex for long circulation in the blood. OCMCh-PEG-PLLs was prepared by forming ion-complex with OCMCh-PEG and Poly(L-Lysine) (PLL) for drug and gene delivery system. The physicochemcal characterisitcs of OCMCh-PEG-PLLs were investigated by FT-IR, $^1H$-NMR. These results showed that CMCh-PEG-PLLs were successfully syntehsized by ion-complex. Particle size distribution and zeta potential of the OCMCh-PEG-PLLs were determined using dynamic light scattering technique. Transmission electron microscopy (TEM) was also used to observe the morphology of the OCMCh-PEG-PLLs. OCMCh-PEG-PLLs have spherical shapes with particle size 290∼390 nm. OCMCh-PEG-PLLs were showed when the feeding amount of mPEG ratio was increased, particle size and zeta potential were decreased. Based on these results, it is possible to introduction of the OCMCh-PEG-PLLs into various biomedical fields such as drug and gene delivery system.

Determination of PEG Concentration and Solvent Selection for Freeze-Drying of Highly-Degraded Waterlogged Woods (고함수율 수침고목재의 동결 건조를 위한 PEG 전처리 농도 및 용매 설정)

  • Kim, Soo-Choul;Park, Won-Kyu;Yi, Yong-Hee
    • Journal of Conservation Science
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    • v.9 no.1
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    • pp.40-47
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    • 2000
  • Dimension stability was examined after PEG pretreatment and post freeze-drying treatment in order to determine the PEG(#3350) concentration and solvent for pre-treatment of freeze-drying of highly-degraded waterlogged ash woods(Fraxinus spp.; ca. 5,700 BP) excavated from peat lands at Pyungtack, Kyounggi-do. At the low concentration (<30-40%) of PEG soaking in both water and t-butanol, the weight increases abruptly, but at high concentration (>50%) gradually, consequently, taking longer treatment time. PEG loading was higher in t-butanol solution than in water. However, the best dimesional stability was obtained from freeze-drying after lower PEG solution (40% in water) soaking. Low dimensional stability, found in the samples treated with higher PEG solutions (60%-70% in t-butanol), might come from incomplete freezing and excess PEG absorbing moisture. The samples air-dried after 70% PEG treatment had collapse defects. In conclusion, the use of low concentration (about 40% in water) PEG solution was the most suitable pretreatment for freeze drying of highly-degraded waterlogged ash woods.

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Preparation and Characterization of Cellulose Acetate/Poly Ethylene Glycol Blend Having High Melt Processibility (우수한 용융특성을 갖는 Cellulose acetate/Poly ethylene glycol 조성물의 제조 및 특성 해석)

  • Lee, Hae Sung;Lee, Sung Jun;Jung, Sang Won;Kim, Hyun-Chul;Kim, Eunjoo;Go, Young Jun;Lee, Se Guen
    • Journal of Korean Ophthalmic Optics Society
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    • v.17 no.1
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    • pp.1-10
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    • 2012
  • Purpose: Cellulose acetate (CA) was blended with polyethyleneglycol (PEG) having different molecular weight at various mixing conditions to enhance melt-processibility of CA, which might prevent the harmful effect resulted from the introduction of phthalic plasticizer. Methods: To establish optimal plasticizing conditions, CA/PEG blends were examined under various plasticizing conditions: PEG concentration, molecular weight of PEG, and plasticzing temperature. Mechanical properties of the CA/PEG blends, as well as migration and exudation of the PEG, were performed in order to evaluate the efficiency of plasticization. Results: Compared to industrial CA resin plasticized by diethyl phthalate, CA/PEG blends exhibited similar thermal plasticization. It was established that the optimum condition was to blend 30~40 phr PEG with molecular weight 400 at $175{\sim}180^{\circ}C$. CA/PEG blend showed superior glassness, PEG stability, and mechanical properties. Conclusions: CA/PEG blends would be a eco-friendly glasses frame to substitute traditional CA glasses frame prepared phthalate plasticizers.

Synthesis and Biological Evaluation of Water-Soluble Oleanolic Acid Derivatives for use as Melanogenesis Inhibitors (멜라닌 생합성 억제제로서 수용성 Oleanolic Acid 유도체의 합성 및 활성 평가)

  • An, Hyun-Jin;Yoon, Young-kyung;Lee, Jae-Duck;Jeong, Noh-Hee
    • Applied Chemistry for Engineering
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    • v.31 no.6
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    • pp.653-659
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    • 2020
  • This study was focused on the synthesis of methoxy polyethylene glycol-oleanolic acid ester (mPEG-OA derivative) and investigation of its water solubility and anti-melanogenic effects. mPEG-OA derivative was identified by 1H and 13C NMR and FT-IR spectroscopic measurements. The water solubilities of mPEG-OA derivative and OA were found to be 13 and 0.013 mg/mL and that of mPEG-OA was found to be 1000-fold higher than that of OA. The effects of mPEG-OA derivative and OA on cell viability were measured using B16F10 melanoma cells. The viability of cells treated with mPEG-OA derivative (250 μM) increased 4-fold compared to that of cells treated with OA (62.5 μM). At mPEG-OA derivative and OA concentrations where the cell viability was unaffected, the inhibitory effect of mPEG-OA derivative and OA on the melanogenesis in B16F10 melanoma cells were 36 and 35% at 50 and 10 μM, respectively. The expression level of microphthalmia-associated transcription (MITF) was also reduced in B16F10 melanoma cells treated with mPEG-OA and OA. Overall, mPEG-OA derivative showed excellent water solubility and inhibitory effects of the melanogenesis, which could be used as a potential formulation for use in whitening functional cosmetic material.

Effects of Polyethylene Glycol on Glucoamylase Production in Recombinant Yeast Culture (Polyethylene Glycol이 재조합 효모 배양에 의한 Glucoamylase 생산에 미치는 영향)

  • 차형준;유영제
    • KSBB Journal
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    • v.11 no.3
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    • pp.311-316
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    • 1996
  • The effects of polyethylene glycol (PEG) on glucoamylase production in recombinant Saccharomyces cerevisiae were studied. By PEG addition, the cell growth was not affected. However, the glucoamylase production was increased in all range of PEG molecular weights and concentrations. The optimal molecular weight of PEG was 6000 and the optimal concentration was 1g/L. Using these optimals, the extracellular glucoamylase activity was 23% higher in PEG-containing medium than that in medium without PEG.

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