• Title, Summary, Keyword: PSP

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The Purification and Immunogenicity of Pneumococcal Surface Protein (PspA) from Invasive Streptococcus pneumoniae KNIH1156 Isolated in Korea (국내 임상 분리주 Streptococcus pneumoniae KNIH1156으로부터 PspA 단백 항원의 정제 및 면역원성 확인)

  • 정경석;배송미
    • Korean Journal of Microbiology
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    • v.38 no.1
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    • pp.38-44
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    • 2002
  • Pneumococcal surfacce protein A (PspA) is an important virulence factor and an antigenically variable surface protein of the pneumococci. To purify the PspA from S. pneumoniae KNIH1156 , a clinical isolate (type 19F), we have taken advantage of the fact that PspA is released from the surface of pneumococci into the medium by growing in a CDM-ET medium and PspA is capable of binding human lactoferrin, the iron carrier protein. PspA of S. pneumoniae KNIH1156 was purified from culture supernatant by human lactoferrin (hLf) affinity chromatography. The purified PspA was confirmed with anti-PspA antiserum and also had the binding capacity to hLf specifically. To determine whether the purified PspA could elicit protection in mice against pneumococcal inflection, we immunized the mice with purified PspA and subsequently challenged with S. pneumoniae KNIH1156. Immunization with purified PspA protected mice from 500 times the $LD^{50}$ of S. pneumoniae KNIH1156. Therefore, it has been shown that purified PspA fromS. pneumoniae KNIH1156 (type 19F) is a protective immunogen.

Application and Construction of PSP Calibration System (PSP 압력 측정 Calibration 시스템 구축 및 적용)

  • Jeon, Young-Jin;Seo, Hyung-Seok;Byun, Yung-Hwan;Lee, Jae-Woo
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • pp.99-102
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    • 2007
  • Pressure Sensitive Paint(PSP) means a reacting paint in pressure. The calibration of PSP and the wind tunnel test of PSP painted model are required to measure pressure using by PSP. Therefore, the post processing from these results shows the information and image of the pressure distribution. PSP can show the information of total pressure from the wind tunnel test and the calibration. In this study, equipments of PSP are composed, and calibration is accomplished using by PSP. Results of design and manufacturing calibration chamber till ability of advance calibration system study.

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Construction of the Pressure Sensitive Paint System (PSP 압력측정 시스템의 구축)

  • Jeon, Young-Jin;Kim, Ki-Su;Seo, Hyung-Seok;Byun, Yung-Hwan;Lee, Jae-Woo
    • Journal of the Korean Society of Propulsion Engineers
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    • v.12 no.1
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    • pp.7-15
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    • 2008
  • Pressure Sensitive Paint(PSP) means a reacting paint in pressure. The calibration of PSP and the wind tunnel test of PSP painted model are required to measure pressure by using PSP. Therefore, the post processing from these results shows the information and image of the pressure distribution. PSP can show the information of total pressure from the wind tunnel test and the calibration. In this study, equipments of PSP are composed, and experiment is accomplished by using PSP. The surface pressure distribution around the wall of nozzle is measured by PSP. The measured pressure has similar results to those of the CFD and pressure tap measurement.

Pneumococcal Surface Protein A of Streptococcus pneumoniae Isolates from Koreans (한국인에서 Streptococcus pneumoniae 분리주의 폐구균 표면 단백 A)

  • Kim, Kyung Hyo
    • Clinical and Experimental Pediatrics
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    • v.48 no.11
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    • pp.1206-1211
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    • 2005
  • Purpose : Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer a broad range of protection against different strains. PspA elicits protection in mice against fatal sepsis as well as carriage and lung infection. This study was performed to investigate the frequency of PspA families among Streptococcus pneumoniae recovered from Korean children and adults. Methods : A total of 89 pneumococcal isolates was included in the study. They were capsule serotyped by the slide agglutination assay with commercial antisera. PspA families were determined with polymerase chain reaction using the pair of primers for family 1 and family 2. Results : Seventeen pneumococcal serotypes were found in a total of 89 isolates. PspA typing was able to ascertain 79 of the 89 isolates (88.8 percent). Among these, 20 (22.5 percent) isolates were family 1 PspA, 59 (66.3 percent) were family 2. Moreover, because 9 (10.1 percent) isolates were of positive reactions for both, families 1 and 2 primers, the potential coverage of PspA vaccine was 98.9 percent. PspA families were not associated with age group, source of isolates, or penicillin susceptibility. However, the relative distribution of family 1 isolates to family 2 isolates was significantly different over capsular serotypes. Conclusion : The finding that 98.9 percent of Korean isolates belonging to PspA families 1 and 2 support the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective. The monitoring of the PspA families derived from large population-based isolates will be necessary in the context of vaccine development.

The Peak Systolic Pressure-End Systolic Volume Index Relation in Patients with Coronary Artery Disease Using Radionuclide Gated Blood Pool Scintigraphy (관상동맥질환에서 심장풀스캔을 이용한 최고수축기혈압-수측기말용적곡선의 분석)

  • Kim, Byung-Tae;Koong, Sung-Soo;Bom, Hee-Seung;Chung, June-Key;Park, Young-Bae;Lee, Myung-Chul;Lee, Young-Woo;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.21 no.2
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    • pp.175-182
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    • 1987
  • For measurement of ventricular performance, ejection fraction (EF) has gained wide acceptance. But EF is influenced not only by changes in muscle function but also by changes in cardiac loading conditions. In case of valvular heart disease which is variable in loading conditions, EF cannot be reliable as an index of myocardial contractility. The end systolic pressure (ESP)-end systolic volume (ESV) relation, howver, is known to represent myocardial contractility, independent of changes in loading conditions. Similar results can be obtained by using peak-systolic pressure (PSP) instead of ESP. To evaluate the utility of the peak systolic pressure-end systolic volume index (PSP-ESVI) relation as an index of myocardial function, we measured $PSP&ESVI$ in 19 partents with coronary artery disease before $(PSP_1\;&\;ESVI_1)$ and after $(PSP_2\;&\;ESVI_2)$ sublingual administration of nitroglycerin. PSP was measured with standard mercury sphygmomanometer during gated blood pool scintigraphic study. ESVI was measured by count derived method after attenuation correction. $PSP_2\;&\;ESVI_2$ measurement was started when the fall of PSP was greater than 5 mmHg after 7-14 minutes post-administration of nitroglycerin. Mean values $({\pm}S.D.)$ of $PSP_1\;&\;ESVI_1$ was $124.9({\pm}20.7)mmHg\;&\;59.4({\pm}39.9)ml/M^2$. Mean values $({\pm}S.D)$ of $PSP_2\;&\;ESVI_2$, was $113.2({\pm}19.9)mmHg\;&\;37.5({\pm}26.1)ml/M^2$. There was a significant difference between mean values of $PSP_1\;&\;PSP_2$, (p<0.01), and mean values of $ESVI_1\;&\;ESVI_2$, (p<0.01). $PSP_1-PSP_2/ESV_1-ESVI_2,\;PSP_1/ESVI_1$ and EF were in the range of 0.14-5.19 mmHg/ml/$M^2$, 0.67-7.68 mmHg/ml/$M^2$ and 10.8%-74.5% respectively. $PSP_1-PSP_2/ESVI_1-ESVI_2$, and EF showed exponential correlation (r=0.85, P<0.01). The correlation coefficient between $PSP_1/ESVI_1$ and EF was 0.73(p<0.01). With the above results, we suggest that $PSP_1-PSP_2/ESVI_1-ESVI_2$, and $PSP_1/ESVI_1$, can be used as an index of myocardial function.

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The Effects of the Arabinoxylane and the Polysaccharide Peptide (PSP) on the Antiallergy, Anticancer (Arabinoxylane과 PSP의 항암 효과 및 알레르기 억제 효과 검증)

  • 배만종;이성태;채수연;신성해;권상호;박미현;송미경;황성주
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.3
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    • pp.469-474
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    • 2004
  • The objective of the current study was to determine the effects of arabinoxylane and polysaccharide peptide (PSP) on the immune cell functions. Both arabinoxylane and PSP increased plaque forming cell (10-15%) and rosette forming cell (10-30%) formation. Stimulation of macrophage with PSP (18%) and arabinoxylane (22%) resulted in increased phagocytic effects. Both arabinoxylane and PSP induced the tumor suppressive effect in mice injected sarcoma-180 cell intracutaneously. When the mice injected intraperitoneal cavity with sarcoma 180 cells, survival ratio was increased in the mice fed on arabinoxylane and PSP. The ratio of PCA was slightly decreased in the mice fed on PSP, especially fed on arabinoxylane than in the control mice. The concentrations of blood histamine were slightly decreased in the mice fed on arabinoxylane and PSP. These results suggest that the capacity of arabinoxylane and PSP seems to act as a potent immunomodulator causing augmentation of immune cell activity, and with the absence of notable side-effects, arabinoxylane and PSP could be used as a biological response modifier having possible therapeutic effects against immunological disorders.

나를 돋보이게 하는 SONY PSP

  • Gwon, Gyeong-Hui
    • Digital Contents
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    • no.8
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    • pp.72-73
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    • 2005
  • 지하철에서 부러운 시선이 한 곳으로 모인다. 그 시선의 끝은 PSP에 쏠려있다. 일본 및 북미에서 선풍적인 인기를 누린데 이어 국내에서 온라인상으로 예약 판매를 시작하자마자 기다렸다는 듯 엄청난 트래픽이 발생했던 소니의 PSP. 오프라인 판매 시작 전날에는 PSP를 조금이라도 빨리 손안에 넣기 위해 밤새도록 줄을 서서 기다리는 진풍경을 벌이게 했던 기기다. 일본 내 지하철에서는‘만화책을 읽는 사람 아니면 PSP를 들고 있는 사람뿐이다’라는 농담도 나올 정도로 PSP는 식을 줄 모르는 인기를 누리고 있다. 이 PSP가 많은 이들을 열광시키는 이유는 무엇인지, 한번 자세히 살펴 보자.

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Effect of Arabinoxylane and PSP on Activation of Immune Cells (Arabinoxylane과 PSP의 면역세포 활성화 효과)

  • 채수연;신성해;배만종;박미현;송미경;황성주;이성태
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.2
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    • pp.278-286
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    • 2004
  • The objective of the current study was to determine the effects of arabinoxylane and PSP on mouse splenocytes, T cells, B cells and macrophages in vitro. Arabinoxylane and PSP directly induced the proliferation of spleen cells in a dose-dependent manner and increased IFN-${\gamma}$ synthesis. Especially, PSP induced IL-2, IL-4 and IL-10 production, Both arabinoxylane and PSP increased PFC (plaque forming cell) and RFC (rosette forming cell) formation. Arabinoxylane was not induced the proliferation of T cells, but PSP directly induced the proliferation of T cells in a high dose. Arabinoxylane and PSP increased the proliferation of B cells and the phagocytic effects of macrophage. When arabinoxylane and PSP were used in macrophage cell line stimulation, there was a marked induction of NO synthesis in a dose-dependent and an increased TNF-$\alpha$ and IL-6 synthesis. Especially, PSP also induced IL-1$\beta$ production. When arabinoxylane and PSP treated in macrophage cell line, there was induction of MHC class II expression. These results suggest that the capacity of arabinoxylane andPSP seem to act as a potent immunomodulator causing augmentation of immune cell activity, and with the absence of notable side-effects, arabinoxylane and PSP could be used as a biological response modifier having possible therapeutic effects against immunological disorders.

프로그램 언어 과정에서의 Personal Software Process(PSP) 교육

  • 윤영현
    • Journal of the Korea Computer Industry Society
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    • v.4 no.12
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    • pp.999-1012
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    • 2003
  • To produce quality software products, engineers must feel personally responsible for the qualify of products. Superior products are not produced by mistake; engineers must strive to do quality work. Every engineer is different and has own process improvement method. To be most effective, engineers must plan their work and they must base their plans on their own personal data. To consistently improve their performance, engineers must personally use well-defined and measured processes. The Personal Software Process(PSP) is a self-improvement process designed to help software engineers control, manage, and improve the way they work. It is a structured framework of forms, guidelines, and procedures for developing software. Properly used, the PSP provides the historical data you need to better make and meet commitments and it makes the routine elements of your job more predictable and more efficient. Then, PSP is the very useful tool to train the students in Programming Language Course. This paper is to provide the concept of PSP/TSP and the sample curriculums for Program Language Training Courses. Personal Software Process(PSP) to train students of Programming Language Courses

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Development of Pressure Sensitive Paint(PSP) technique for low-speed flows and its application (아음속 저속 유동용 Pressure Sensitive Paint의 개발과 응용)

  • Kang, Jong-Hoon;Lee, Sang-Joon
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.32 no.4
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    • pp.12-17
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    • 2004
  • The PSP technique has been used to measure pressure distribution on model surfaces ins high-speed flows. The objective of this study is to develop a PSP technique which can be applied to low-speed aerodynamic flows. Four different PSP formulations including two porphyrins (PtOEP and PtTFPP) and two polymers (Poly(TMSP) and RTV-118) were tested and the performance of each combination was evaluated. In a static calibration, the luminescent intensity of the PSP coatings was measured from 0kPa to 11kPa with 0.5, 1, 2kPa increments. Among 4 PSP formulations tested, the combination of PtOEP and RTV-118 shows the best performance. The developed PSP technique was applied to an oblique impinging jet to measure the pressure field distribution on the impinging plate.