• Title, Summary, Keyword: Patrinia Scabiosaefolia

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Studies on Components of Patrinia scabiosaefolia

  • Kim, Young-Hee
    • Korean Journal of Pharmacognosy
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    • v.28 no.2
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    • pp.93-98
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    • 1997
  • Rutin, ${\alpha}-hederin$ and kalopanax saponin B and a mixture of hederagenin and 23-hydroxyursolic acid were isolated from the aerial parts of Patrinia scabiosaefolia Fisch.

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A New Triterpene Lactone from the Roots of Patrinia scabiosaefolia

  • Yang, Mi-Young;Choi, Young-Hae;Yeo, Ho-Sup;Kim, Jin-Woong
    • Archives of Pharmacal Research
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    • v.24 no.5
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    • pp.416-417
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    • 2001
  • A new triterpene lactose named patrinolide A (7) has been isolated from the roots of Patrinia scabiosaefolia (Valerianaceae). Its structure was determined to be 11$\beta$,21$\beta$-dihydroxy-3-oxooleanan-28,13$\beta$-olide on the basis of spectral analysis, including 2D-NMR techniques.

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Pharmacognostical Studies on the 'Pae Jang' (패장의 생약학적 연구)

  • Park, Jong-Hee;Choi, Jeong-Kyu
    • Korean Journal of Pharmacognosy
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    • v.37 no.4
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    • pp.302-306
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    • 2006
  • 'Pae Jang (敗醬)' is one of Chinese crude drugs used mainly as a edema, abdominal pain and hemoptysis, etc. With regard to the botanical origin of 'Pae Jang', it has been considered to be Patrinia scabiosaefolia of Valerianaceae, but there has never been studied pharmacognostically. To clarify the botanical origin of the 'Pae Jang', we studied on the anatomical characteristics of the roots of three species growing in Korea. Through our studies, the botanical origin of 'Pae Jang' from Korea was proved to be the under ground portions of Patrinia scabiosaefolia and Patrinia villosa.

Coumarins and Triterpenoid Glycosides from the Roots of Patrinia scabiosaefolia

  • Choi, Jae-Sue;Woo, Won-Sick
    • Archives of Pharmacal Research
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    • v.7 no.2
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    • pp.121-126
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    • 1984
  • From the roots of Patrinia scabiosaefolia Valerianaceae), scopoletin (1), esculetin (2), oleanonic acid (3), 3-O-.alpha.-L-rhamnopyranosyl (1.rarw.2)-.alpha.-l-arabinopyranosyl oleanolic acid (4) and 3-O-.alpha.-L- rhamnopyranosyl (1 .rarw. 2)-.alpha.-L-arabinopyranosyl header agenin (5) were isolated and characterized by spectral data.

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Isolation of Toxic Saponins from the Roots of Patrinia scabiosaefolia

  • Woo, Won-Sick;Choi, Jae-Sue;Shin, Kuk-Hyun
    • Korean Journal of Pharmacognosy
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    • v.16 no.4
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    • pp.248-252
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    • 1985
  • During the biological screening of Chinese drugs, it was found that alcoholic extract of the roots of Patrinia scabiosaefolia (Valerianaceae) caused a significant prolongation of hexobarbital-induced sleeping time and elevation of serum transaminase activities accompanied by severe histopathological changes in the hepatic tissues in mice on three day pretreatments. The systematic fractionation of the methanol extract monitoring by bioassay led to isolation of toxic saponins such as $3-O-{\alpha}-{_L}-arabinopyranosyl$ hederagenin $28-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}6)-{\beta}-{_D}-glucopyranoside$ and its 2'-acetate and $3-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}3)-{\alpha}-{_L}-rhamnopyranosyl\;(1{\rightarrow}2)-{\alpha}-{_L}-arabinopyranosyl$ oleanolic acid and its $28-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}6)-{\beta}-{_D}-glucopyranoside$.

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Lignans Isolated from the Roots of Patrinia scabiosaefolia F. and their IL(Interleukin)-6 Inhibitory Activity (마타리 뿌리로부터 분리한 Lignan 화합물의 IL-6 저해활성)

  • Choi, Eun-Jin;Jin, Qinglong;Shin, Ji-Eun;Kim, Hyun-Gyu;Kim, Jung-Jin;Woo, Eun-Rhan
    • YAKHAK HOEJI
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    • v.53 no.4
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    • pp.201-205
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    • 2009
  • In an ongoing investigation into anti-inflammatory compounds from natural products, the $CH_2Cl_2$ soluble fraction of Patrinia scabiosaefolia F. (Valerianaceae) was found to inhibit IL-6 production in TNF-$\alpha$ stimulated MG-63 cell line. By means of a bioassay-directed chromatographic separation technique, lappaol E (1), and nortrachelogenin (2) were isolated. These compounds have been isolated from this plant for the first time. Compounds $1{\sim}2$ showed potent antioxidative activity using NBT superoxide scavenging assay. Moreover, compound 1 decreased IL-6 production in TNF-$\alpha$ stimulated MG-63 cell line.

Effects of Patriniae Radix and Melandrii Herba on Enzyme Activities in Mice

  • Shin, Kuk-Hyun;Woo, Won-Sick;Lee, Chung-Kyu
    • Korean Journal of Pharmacognosy
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    • v.16 no.1
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    • pp.1-6
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    • 1985
  • Effect of various fractions from the roots of Patrinia scabiosaefolia (Valerianaceae) and whole plants of Melandryum firmum (Caryophyllaceae) on enzyme activities in mice was investigated. The butanol fractions from both plants caused a significant elevation of serum transaminase activities when administered intraperitoneally, but did not, orally. Prolonged exposure by oral administration of both plants elevated hepatic cytochrome p-450 content, indicating the induction of drug metabolizing enzymes in liver.

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Comparitive study on anti-asthmatic activities of Patrinia scabiosaefolia Fischer ex Link and Patrinia villosa Jussieu in a mouse model of asthma (황화패장, 백화패장의 항천식 작용의 비교연구)

  • Cha, Jong-Tae;Lee, Jang-Cheon;Lee, Young-Cheol
    • The Korea Journal of Herbology
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    • v.27 no.3
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    • pp.75-82
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    • 2012
  • Objective : In the present study, we investigated the pharmacological profile of the aqueous extract of $Patrinia$ $scabiosaefolia$ Fischer ex Link (EPS) and $Patrinia$ $villosa$ Jussieu (EPV) for its anti-asthmatic activities. The purpose of this study is to ascertain if EPS result in better anti-asthmatic activities and functional outcome as compared with EPV. Methods : In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges. We investigated the effect of EPS, EPV on the recruitment of pulmonary inflammatory cells, various immune cell phenotypes, Th1/Th2 cytokine gene expression and production and histamine production in serum. Results : In BALB/c mice, we found that EPV-treated groups had more effectively suppressed inflammatory cell infiltration of lung and BALF, B220+IgE+, CD11b+Gr-1+ cell population in lung and these occurred by suppressing the gene expression of IL-4, IL-5 and IL-4 cytokine production in BALF and serum. Conclusions : These results suggest that EPV may play an important role in the control of anti-asthmatic activities by down-regulation of Th2 cytokine (especially IL-4, IL-5). In general, EPV has shown a better anti-asthmatic activities compared to EPS.

Synergistic Antimicrobial Effect of Patrinia scabiosaefolia and Forsythiae fructus Extracts on Food-borne Pathogens (식중독 유발 세균의 증식에 미치는 패장과 연교 추출물의 상승 효과)

  • Bae Ji-Hyun;Son Kug-Hee;Lee Eun-Joo
    • Microbiology and Biotechnology Letters
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    • v.33 no.2
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    • pp.130-135
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    • 2005
  • To investigate the antimicrobial effect of the Patrinia scabiosaefolia extracts against food-borne pathogens, we extracted the P. scabiosaefolia with methanol at room temperature and the fractionation of the methanol extracts was carried out by using petroleum ether, chloroform, ethyl acetate, and methanol, respectively. The antimicrobial activity of the P. scabiosaefolia extracts was determined by using a paper disc method against food-borne pathogens and food spoilage bacteria. The ethyl acetate extracts of P. scabiosaefolia showed the highest antimicrobial activity against Escherichia coli and Shigella sonnei. Synergistic effect in inhibition was observed when P. scabiosaefolia extract was mixed Forsythiae fructus extract as compared to each extracts alone. Finally, the growth inhibition curves were determined by using ethyl acetate extracts of P. scabiosaefolia against Staphylococcus epidermidis and Shigella sonnei. The ethyl acetate extract of P. scabiosaefolia had strong antimicrobial activity against S. sonnei at the concentration of 4,000 ppm. At this concentration, the growth of S. Sonnei was retarded more than 72 hours and up to 48 hours for S. epidermidis. These results suggest that the ethyl acetate extracts of P. scabiosaefolia can be used for the efficient material against the growth of S. epidermidis and S. sonnei.