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Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines

  • Iqbal, Muhammad Arsalan;Hong, Kwonho;Kim, Jin Hoi;Choi, Youngsok
    • BMB Reports
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    • v.52 no.11
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    • pp.625-634
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    • 2019
  • Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell+ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B+NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

Development of Environmental Control Systems for Windowless Pig-housing (II) - Growth Performance of Weaned Piglets and Growing Pigs - (무창돈사의 환경제어 시스템 개발 (II) - 자돈과 육성돈의 사양성적 -)

  • 장동일;장홍희;임영일;박창식;이봉덕;이형석
    • Journal of Biosystems Engineering
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    • v.24 no.5
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    • pp.425-430
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    • 1999
  • Complex environmental control systems were developed, which control properly the pig's environment in windowless pig-housing based on the thermoregulatory behaviors of pigs and concentrations of noxious gases (CO2 and NH3). The this study was conducted to assess the performance of complex environmental control systems by raising weaned piglets and growing pigs under different seasonal conditions. Average daily gain of pigs in the experimental pig-housing was slightly higher than that of pigs in the conventional pig-housing. Average daily gain was not significantly different in winter and spring(P>0.05), but was significantly different in summer(P<0.05). Feed conversion rate of pigs in the experimental pig-housing was smaller than that of pigs in the conventional pig-housing. Feed conversion rate was not significantly different in environment for weaned piglets and growing pigs resulted in the improved daily gain, feed conversion rate, and carcass quality of the finishing pigs. These results showed that the performance of the complex environmental control systems in windowless pig-housing was excellent for weaned piglets and growing pigs.

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Erratum to: Severe combined immunodeficiency pig as an emerging animal model for human diseases and regenerative medicines

  • Iqbal, Muhammad Arsalan;Hong, Kwonho;Kim, Jin Hoi;Choi, Youngsok
    • BMB Reports
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    • v.52 no.12
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    • pp.718-727
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    • 2019
  • Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell+ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B+NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

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Effect of Yeemosan(二母散) extract on the contraction of isolated Guinea Pig Trachea Smooth Muscle (이모산(二母散)이 Guinea Pig의 기관지(氣管支) 평활근(平滑筋)에 미치는 영향(影響))

  • Lee, Choon-Jae
    • The Journal of Internal Korean Medicine
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    • v.13 no.1
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    • pp.70-79
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    • 1992
  • This study was carried out to investigate the effect of Yeemosan extract on the contractile force of the isolated guinea pig trachea smooth muscle and elucidate its mechanism. The results were obtained as follows: 1. The contractile response of the trachea smooth muscle of isolated guinea pig to acetylcholine was significantly inhibited by Yeemosan. 2. The contractile response of the trachea smooth muscle of isolated guinea pig pretreated propranolol was significantly inhibited by Yeemosan. 3. Effects of Yeemosan extract on the contractile response of the isolated guineapig trachea smooth muscle pretreated methylene blue was not significant. 4. The contractile response of the trachea smooth muscle of isolated guinea pig to prostaglandin $F2{\alpha)$ was significantly inhibited by Yeemosan. 5. Effects of prostaglandin $F2{\alpha)$ on the contractile response of the isolated guinea pig trachea smooth muscle pretreated Yeemosan was not significant. According to the above results. it was suggested that the contractile response mechanism of the guinea pig trachea smooth muscle to Yeemosan was related to sympathetic nervous system receptor and other mechanism should have further study.

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Dyeing of Pig Skin with Coptis chinensis Franch (황련을 이용한 돈피 염색에 관한 연구)

  • Cho, Sung-Kyo
    • Journal of the Korean Home Economics Association
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    • v.47 no.1
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    • pp.85-91
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    • 2009
  • Dyeability and antimicrobial property of dyed pig skin with Coptis chinensis Franch was investigated. Dyestuff was extracted with water and concentrated. Pig skin was dyed and mordanted according to various dyeing temperature, dyeing time, dyestuff concentration, mordanting methods and kinds of mordants. The results of this experiment were as follows: 1. Dyeability of pig skin with Coptis chinensis Franch was best at 200%(owf) dyestuff concentration, 50${^{\circ}C}$ dyeing temperature, and 20min. dyeing time. 2. Pre-mordanting by Cu improved the K/S values of dyed pig skin. 3. Surface color and color difference of dyed pig skin showed various results according to the mordants used : generally their color was yellow, Al post-mordanted pig skin showed the greatest color difference. 4. Color fastness to drycleaning was considerably high in case of staining compared to fading. Fastness to light was improved by Cu-mordanting while other treatments were not effective. 5. Antimicrobial property of samples was not different (99.9%) between untreated and treated.

Production of Transgenic Micro-Pig Expressing Human Heme Oxygenase 1

  • Koo, Ok Jae;Oh, Hyun Ju;Lee, Byeong Chun
    • Journal of Embryo Transfer
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    • v.30 no.4
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    • pp.305-313
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    • 2015
  • Xenotransplantation of pig islet regarded as a good alternative to allotransplantation. However, cellular death mediated by hypoxia-reoxygenation injury after transplantation disturb success of this technique. In the present study, we produce transgenic pig expressing human heme oxygenase 1 (HO1) genes to overcome cellular death for improving efficiency of islet xenotransplantation. Particularly, Korean miniature pig breed, Micro-Pig, was used in the present study. Somatic cell nuclear transfer (SCNT) technique was used to produce the HO1 transgenic pig. Six alive transgenic piglets were produced and all the transgenic pigs were founded to have transgene in their genomic DNA and the gene was expressed in all tested organs. Also, in vitro cultured fibroblasts derived from the HO1 transgenic pig showed low reactive oxygen species level, improved cell viability and reduced apoptosis level.

Oviduct-specific Glycoprotein 1 Locus is Associated with Litter Size and Weight of Ovaries in Pigs

  • Niu, B.Y.;Xiong, Y.Z.;Li, F.E.;Jiang, S.W.;Deng, C.Y.;Ding, S.H.;Guo, W.H.;Lei, M.G.;Zheng, R.;Zuo, B.;Xu, D.Q.;Li, J.L.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.5
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    • pp.632-637
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    • 2006
  • Oviduct-specific glycoprotein 1 (OVGP1) is implicated in playing a role in fertilization and early embryo development. In this study, we have obtained the sequence of intron 9 of OVGP1 gene in swine. Comparative sequencing of Meishan (a native Chinese breed) and Large White pig breeds revealed an A/T substitution at position 943. A PCR-EcoRI-RFLP assay was developed to detect this mutation. Polymorphism analysis in Qingping animals showed that pigs with BB genotype had lower number of piglets born alive (NBA) in multiple parities than pigs with AA (p<0.05) and AB genotype (p<0.01). In Large $White{\times}Meishan$ ($LW{\times}M$) $F_2$ offspring, the weight of both ovaries (OW) of the BB genotype was significantly lighter than that of AB (p = 0.05) and AA (p<0.01) genotypes. Analysis of the data also revealed that the mutation locus affected these two traits mostly by additive effects. These studies indicated that the polymorphism was associated with NBA and OW in two distinct populations and further investigations in more purebreds or crossbreds are needed to confirm these results.

Image Processing and Deep Learning Techniques for Fast Pig's Posture Determining and Head Removal (돼지의 빠른 자세 결정과 머리 제거를 위한 영상처리 및 딥러닝 기법)

  • Ahn, Hanse;Choi, Wonseok;Park, Sunhwa;Chung, Yongwha;Park, Daihee
    • KIPS Transactions on Software and Data Engineering
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    • v.8 no.11
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    • pp.457-464
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    • 2019
  • The weight of pig is one of the main factors in determining the health and growth state of pigs, their shipment, the breeding environment, and the ration of feed, and thus measuring the pig's weight is an important issue in productivity perspective. In order to estimate the pig's weight by using the number of pig's pixels from images, acquired from a Top-view camera, the posture determining and the head removal from images are necessary to measure the accurate number of pixels. In this research, we propose the fast and accurate method to determine the pig's posture by using a fast image processing technique, find the head location by using a fast deep learning technique, and remove pig's head by using light weighted image processing technique. First, we determine the pig's posture by comparing the length from the center of the pig's body to the outline of the pig in the binary image. Then, we train the location of pig's head, body, and hip in images using YOLO(one of the fast deep learning based object detector), and then we obtain the location of pig's head and remove an outside area of head by using head location. Finally, we find the boundary of head and body by using Convex-hull, and we remove pig's head. In the Experiment result, we confirmed that the pig's posture was determined with an accuracy of 0.98 and a processing speed of 250.00fps, and the pig's head was removed with an accuracy of 0.96 and a processing speed of 48.97fps.

A Study on the Method of Magnetic Flux Leakage NDTfor Detecting Axial Cracks (축방향 미소결함 검출을 위한 자기누설 비파괴 검사 방법에 관한 연구)

  • Yun, Seung-Ho;Park, Gwan-Soo
    • Journal of the Korean Magnetics Society
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    • v.21 no.1
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    • pp.23-31
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    • 2011
  • From among the NDT (nondestructive testing) methods, the MFL (magnetic flux leakage) method is specially suitable for testing pipelines because pipeline has high magnetic permeability. The system applied to MFL method is called the MFL PIG. The previous MFL PIG showed high performance in detecting the metal loss and corrosions. However, MFL PIG is highly unlikely to detect the cracks which occur by exterior-interior pressure difference in pipelines and the shape of crack is long and very narrow. In MFL PIG, the magnetic field is performed axially and there is no changes of cross-sectional area at cracks that the magnetic field passes through. Cracks occur frequently in the pipelines and the risk of the accident from the cracks is higher than that from the metal loss and corrosions. Therefore, the new PIG is needed to be researched and developed for detecting the cracks. The circumferential MFL (CMFL) PIG performs magnetic fields circumferentially and can maximize the magnetic flux leakage at the cracks. In this paper, CMFL PIG is designed and the distribution of the magnetic fields is analyzed by using 3 dimensional nonlinear finite element method (FEM). In CMFL PIG, cracks, standards of NACE, are detectable. To estimate the shape of crack, the leakage of magnetic fields for many kinds of cracks is analyzed and the method is developed by signal processing.

Dynamic Modeling of PIG Flow in Natural Gas Pipelines (천연가스배관내 피그흐름의 동적모델링)

  • Kim, Sang-Bong;Nguyen, Tan Tien;Yoo, Hui-Ryong;Rho, Yong-Woo
    • Proceedings of the KSME Conference
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    • pp.241-246
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    • 2001
  • This paper introduces modeling and solution for the dynamics of pipeline inspection gauge (PIG) flow in natural gas pipeline. Without of bypass flow, the dynamic behavior of the PIG depends on the different pressure between the rear and nose parts, which is generated by injected gas flow behind the tail of the PIG and expelled gas flow in front of its nose. With bypass flow, the PIG dynamics also depends on the amount of bypass flow across its body. The mathematical model are derived for unsteady compressible flow of the PIG driving and expelled gas, and for dynamics of the PIG. The bypass flow is assumed to be incompressible with the condition of its Mach number smaller than 0.45. The method of characteristic (MOC) and the Runge-Kutta method are used to solve the system governing equations. The simulation is performed with a pipeline segment in the Korea Gas Corporation (KOGAS) low pressure system, Ueijungboo-Sangye line. The simulation results show that the derived mathematical model and the proposed solution are effective for estimation the dynamics of the PIG with and without bypass flow under given operational condition.

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