• Title, Summary, Keyword: Progression

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Exploring the Progression of Meta-Modeling Knowledge (MMK) and Relationship between MMK Progression Level and Actual Practice for Science Gifted (과학영재 학생들의 메타모델링 지식(MMK) 발달 및 MMK 발달수준과 실제 수행과의 관계 탐색)

  • Kim, Jung-Eun;Kim, Sungki;Paik, Seoung-Hey
    • Journal of the Korean Chemical Society
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    • v.64 no.2
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    • pp.111-118
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    • 2020
  • The purpose of this study is to explore the progression of MMK and the relationship between MMK progression level and actual practice. First, the Rasch model was used to measure MMK progression level of 51 students twice during the interval of one year. Thereafter, chi-squared test was used to determine whether there was a significant change in MMK progression. As a result of chi-squared test, there was no statistically significant change in MMK progression (p>.05). Secondly, we analyzed the relationship between MMK progression level and practice for 7 gifted students. As a result of the analysis, it was confirmed that the student's response in practice can not exceed MMK progression level. There were also cases where students have high MMK progression level showed low response in practice. The results of these two studies show that gifted education programs are needed to increase MMK progression and to provide gifted education that can connect knowledge and practice.

On the Definition of Geometrical Progression of the High school (등비수열의 정의에 대한 연구)

  • Lee, Min-Jung;Lee, Yang
    • The Mathematical Education
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    • v.51 no.3
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    • pp.211-221
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    • 2012
  • We discovered that definition of a Geometrical Progression(Sequence) have some differences in domestic textbooks & some foreign countries' books. This will be able to cause a chaos when students divide whether a sequence is a Geometrical Progression(Sequence) or not, and a question error when teachers compose questions about convergence conditions of Infinite Geometric progressions & series. We took a question investigation for students about definition of a Geometrical Progression(that is called G. P.), we discovered that high level students have an error about definition of a G. P.. So We modified expressions of terminology in domestic textbooks appropriately through a Geometrical Progression(Sequence), infinite series, & infinite geometrical series in some foreign countries' books.

Role of G Protein-Coupled Estrogen Receptor in Cancer Progression

  • Jung, Joohee
    • Toxicological Research
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    • v.35 no.3
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    • pp.209-214
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    • 2019
  • Cancer is the leading cause of mortality worldwide. In cancer progression, sex hormones and their receptors are thought to be major factors. Many studies have reported the effects of estrogen and estrogen receptors (ERs) in cancer development and progression. Among them, G protein-coupled estrogen receptor (GPER), a G protein-coupled receptor, has been identified as an estrogen membrane receptor unrelated to nuclear ER. The mechanism of GPER, including its biological action, function, and role, has been studied in various cancer types. In this review, we discuss the relation between GPER and estrogen or estrogen agonists/antagonists and cancer progression.

Oriental Medicine Music therapy for The treatment of Sasangin's disdases (사상체질인(四象體質人)의 병증(病證) 치료를 위한 한방음악치료(韓方音樂治療)에 관한 연구;장부대소(臟腑大小)와 호흡출납(呼吸出納)을 중심으로)

  • Lee, Seung-Hyun
    • Journal of Korean Medical classics
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    • v.20 no.4
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    • pp.119-126
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    • 2007
  • The biological and pathological states of lung, spleen, liver and kidneys are determined by nature and emotion of sorrow, anger, joy and pleasure, It is considered that the music, besides medicine or acupuncture, can be a way of treating as a therapeutics for the treatment of Sasangin's diseases. This study is to find out a way of music therapy for the treatment of Sasangin's diseases. The ways of music therapy in each constitution based on 'the great and small of Viscera and Bowels' and 'the exhale and inhale, the drawing in and sending out' are as follows: 1. In case of Soeumin, a skip going up melodic progression, dotted rhythm and the major triad harmonic progression are recommended to improve the Qi of warm Yang. 2. In case of Soyangin, in regular sequence down melodic progression, a sixteenth note and the minor triad harmonic progression are recommended to improve the Qi of cool Yin. 3. In case of Taeumin, in regular sequence going up melodic progression, a sixteenth note and the bright and active the major triad harmonic progression are recommended to improve the Qi of dispersing exhale. 4. In case of Taeyangin, a skip down melodic progression, a quarter note and a diminished triad harmonic progression are recommended to improve the Qi of gathering inhale.

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The Use of MR Perfusion Imaging in the Evaluation of Tumor Progression in Gliomas

  • Snelling, Brian;Shah, Ashish H.;Buttrick, Simon;Benveniste, Ronald
    • Journal of Korean Neurosurgical Society
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    • v.60 no.1
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    • pp.15-20
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    • 2017
  • Objective : Diagnosing tumor progression and pseudoprogression remains challenging for many clinicians. Accurate recognition of these findings remains paramount given necessity of prompt treatment. However, no consensus has been reached on the optimal technique to discriminate tumor progression. We sought to investigate the role of magnetic resonance perfusion (MRP) to evaluate tumor progression in glioma patients. Methods : An institutional retrospective review of glioma patients undergoing MRP with concurrent clinical follow up visit was performed. MRP was evaluated in its ability to predict tumor progression, defined clinically or radiographically, at concurrent clinical visit and at follow up visit. The data was then analyzed based on glioma grade and subtype. Resusts : A total of 337 scans and associated clinical visits were reviewed from 64 patients. Sensitivity, specificity, positive and negative predictive value were reported for each tumor subtype and grade. The sensitivity and specificity for high-grade glioma were 60.8% and 87.8% respectively, compared to low-grade glioma which were 85.7% and 89.0% respectively. The value of MRP to assess future tumor progression within 90 days was 46.9% (sensitivity) and 85.0% (specificity). Conclusion : Based on our retrospective review, we concluded that adjunct imaging modalities such as MRP are necessary to help diagnose clinical disease progression. However, there is no clear role for stand-alone surveillance MRP imaging in glioma patients especially to predict future tumor progression. It is best used as an adjunctive measure in patients in whom progression is suspected either clinically or radiographically.

Stereotactic body radiation therapy for liver oligo-recurrence and oligo-progression from various tumors

  • Cha, Yu Jin;Kim, Mi-Sook;Jang, Won-Il;Seo, Young Seok;Cho, Chul Koo;Yoo, Hyung Jun;Paik, Eun Kyung
    • Radiation Oncology Journal
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    • v.35 no.2
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    • pp.172-179
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    • 2017
  • Purpose: To evaluate the outcomes of stereotactic body radiation therapy (SBRT) for patients with liver oligo-recurrence and oligo-progression from various primary tumors. Materials and Methods: Between 2002 and 2013, 72 patients with liver oligo-recurrence (oligo-metastasis with a controlled primary tumor) and oligo-progression (contradictory progression of a few sites of disease despite an overall tumor burden response to therapy) underwent SBRT. Of these, 9 and 8 patients with uncontrollable distant metastases and patients immediate loss to follow-up, respectively, were excluded. The total planning target volume was used to select the SBRT dose (median, 48 Gy; range, 30 to 60 Gy, 3-4 fractions). Toxicity was evaluated using the Common Toxicity Criteria for Adverse Events v4.0. Results: We evaluated 55 patients (77 lesions) treated with SBRT for liver metastases. All patients had controlled primary lesions, and 28 patients had stable lesions at another site (oligo-progression). The most common primary site was the colon (36 patients), followed by the stomach (6 patients) and other sites (13 patients). The 2-year local control and progression-free survival rates were 68% and 22%, respectively. The 2- and 5-year overall survival rates were 56% and 20%, respectively. The most common adverse events were grade 1-2 fatigue, nausea, and vomiting; no grade ${\geq}3$ toxicities were observed. Univariate analysis revealed that oligo-progression associated with poor survival. Conclusion: SBRT for liver oligo-recurrence and oligo-progression appears safe, with similar local control rates. For liver oligo-progression, criteria are needed to select patients in whom improved overall survival can be expected through SBRT.

The reasonable timing of the adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent: suggestion based on progression patterns

  • Yu, Jeong Il;Choi, Doo Ho;Huh, Seung Jae;Park, Won;Oh, Dongryul;Bae, Duk Soo
    • Radiation Oncology Journal
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    • v.31 no.2
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    • pp.72-80
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    • 2013
  • Purpose: We designed this study to identify and suggest the reasonable timing of adjuvant radiotherapy in the treatment of uterine carcinosarcoma according to the surgical intent and patterns of progression. Materials and Methods: We retrospectively analyzed a total of 50 carcinosarcoma patients diagnosed between 1995 and 2010. Among these 50 patients, 32 underwent curative surgery and 13 underwent maximal tumor debulking surgery. The remaining five patients underwent biopsy only. Twenty-six patients received chemotherapy, and 15 patients received adjuvant radiotherapy. Results: The median follow-up period was 17.3 months. Curative resection (p < 0.001) and stage (p < 0.001) were statistically significant factors affecting survival. During follow-up, 30 patients showed progression. Among these, eight patients (16.0%) had loco-regional progression only. The patients who had received adjuvant radiotherapy did not show loco-regional progression, and radiotherapy was a significant negative risk factor for loco-regional progression (p = 0.01). The time to loco-regional progression was much earlier for non-curative than curative resection (range, 0.7 to 7.6 months vs. 7.5 to 39.0 months). Conclusion: Adjuvant radiotherapy in the treatment of carcinosarcoma might be related to a low loco-regional progression rate. Radiotherapy should be considered in non-curatively resected patients as soon as possible.

Characteristics Detected on Computed Tomography Angiography Predict Coronary Artery Plaque Progression in Non-Culprit Lesions

  • Tan, Yahang;Zhou, Jia;Zhou, Ying;Yang, Xiaobo;Yang, Junjie;Chen, Yundai
    • Korean Journal of Radiology
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    • v.18 no.3
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    • pp.487-497
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    • 2017
  • Objective: This study sought to determine whether variables detected on coronary computed tomography angiography (CCTA) would predict plaque progression in non-culprit lesions (NCL). Materials and Methods: In this single-center trial, we analyzed 103 consecutive patients who were undergoing CCTA and percutaneous coronary intervention (PCI) for culprit lesions. Follow-up CCTA was scheduled 12 months after the PCI, and all patients were followed for 3 years after their second CCTA examination. High-risk plaque features and epicardial adipose tissue (EAT) volume were assessed by CCTA. Each NCL stenosis grade was compared visually between two CCTA scans to detect plaque progression, and patients were stratified into two groups based on this. Logistic regression analysis was used to evaluate the factors that were independently associated with plaque progression in NCLs. Time-to-event curves were compared using the log-rank statistic. Results: Overall, 34 of 103 patients exhibited NCL plaque progression (33%). Logistic regression analyses showed that the NCL progression was associated with a history of ST-elevated myocardial infarction (odds ratio [OR] = 5.855, 95% confidence interval [CI] = 1.391-24.635, p = 0.016), follow-up low-density lipoprotein cholesterol level (OR = 6.832, 95% CI = 2.103-22.200, p = 0.001), baseline low-attenuation plaque (OR = 7.311, 95% CI = 1.242-43.028, p = 0.028) and EAT (OR = 1.015, 95% CI = 1.000-1.029, p = 0.044). Following the second CCTA examination, major adverse cardiac events (MACEs) were observed in 12 patients, and NCL plaque progression was significantly associated with future MACEs (log rank p = 0.006). Conclusion: Noninvasive assessment of NCLs by CCTA has potential prognostic value.

A Framework for Progression in the Professional Development and Learning of Secondary Science Teachers' Teaching Practice (중등 과학교사의 수업 실행 전문성의 발달과 학습 틀)

  • Choi, Young;Lee, Musang;Song, Myungseub
    • Journal of Science Education
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    • v.34 no.1
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    • pp.124-139
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    • 2010
  • The purpose of this study was to develop and apply a framework for progression in the professional development and learning of secondary science teachers' teaching practice. The progression in the professional development was modified Pilhee Woo's framework(2010), and in the learning was developed by the researchers. The former included 6 elements and 36 aspects. The progression of each aspect was composed of five level criteria. The content validity is 96.4% and the reliability is .96. The latter was composed of another five level criteria. The content validity is 96.0% and the reliability is .95. Internet-online test and the questionnaire were administered to 203 secondary science teachers who were selected by convenience sampling. The mean level of the progression in the professional development and learning were 2.21 and 2.95. ANOVA, t-test and correlation analysis were conducted to compare differences by the characteristics of teachers. The level of the progression in the professional development and learning was significant difference according to almost all of teachers' characteristics. The level of the progression in the professional development was significantly correlated with the level of the progression in the learning.

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Carotid Intraplaque Hemorrhage is Associated with Acute Cerebral Ischemic Events and Progression of Stenosis on Magnetic Resonance Imaging

  • Ryu, Hye Ji;Jeon, Se Jeong;Choi, See Sung
    • Investigative Magnetic Resonance Imaging
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    • v.21 no.4
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    • pp.242-251
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    • 2017
  • Purpose: To investigate the association of carotid intraplaque hemorrhage (IPH) with acute cerebral ischemic events and progression of stenosis using magnetic resonance (MR) imaging. Materials and Methods: From April 2014 to December 2016, 53 patients underwent carotid plaque MR imaging, including magnetization-prepared rapid acquisition with gradient-echo (MPRAGE) sequence. A total of 66 carotid arteries in 53 patients had carotid stenosis, and they were included in this study. Carotid arteries were classified according to the presence of IPH, the age of hemorrhage, and degree of stenosis. We assessed ipsilateral cerebrovascular event rates and progression of stenosis between the IPH and no-IPH groups. Results: Of the 61 carotid arteries assessed, 34 (56%) had IPH, and 27 (44%) had no IPH. Acute cerebral ischemic events were more frequent in the IPH group (47% vs. 22%, P = 0.045), especially in the < 30%-stenosis group (100% vs. 0%, P = 0.028). However, there was no significant difference in the incidence of ischemic events according to the age of hemorrhage (50% vs. 44%, P = 0.492). Among the 61 carotid arteries, 20 carotid arteries had previously undergone carotid artery imaging and were evaluated for plaque progression. The trend for progression of stenosis favored the IPH group versus the no-IPH group, with a marginal P-value ($20%{\pm}12.7$ vs. $9.6%{\pm}5.7$, P = 0.063). Conclusion: IPH was associated with an increased incidence of acute ischemic events, especially in the mild-stenosis group and it was also associated with progression of stenosis. Evaluation of the carotid IPH by carotid plaque MR could improve discrimination of carotid plaques that cause ischemic events and progression of stenosis.