• Title, Summary, Keyword: Regional cerebral blood flow(rCBF)

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EFFECT OF BATRYTICATUS BOMBYCIS ON THE CEREBRAL HEMODYNAMICS OF RATS (백강잠(白?蠶)의 뇌혈류역학(腦血流力學)에 관한 연구(硏究))

  • Whang Kyung-Taig;Han Jong-Hyun;Kang Sung-Yong
    • Herbal Formula Science
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    • v.7 no.1
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    • pp.121-130
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    • 1999
  • Oriental medicine prescription has been used for the treatment of various clinical symptoms associated with cerebral apoplexy. However, single herb drug does not used cerebral apoplexy and there mechanisms of action have not been defined, and it is not yet known what effects they have on the hemodynamics of cerebral circulation. The study was aimed to investigate the effect batryticatus bombycis(BB) on the vascular systems including changes in blood pressure (BP), and regional cerebral blood flow (rCBF) and of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry. 1. Blood pressure was not affected by BB in rats. 2. rCBF was increased by BB in a dose-dependent manner. 3. Pretreatment with methylene blue(1mg/kg), and propranolol(1mg/kg) did not inhibited BB induced increased in rCBF. 4. Pretreatment with propranolol(1mg/kg) was increased by BB in a dose-dependent manner in blood perssure. 5. Pretreatment with ODQ($10{\mu}g/kg$) and L-NNA(1mg/kg) were inhibited BB induced increased in rCBF. 6. Pretreatment with L-NNA(1mg/kg) was increased rCBF in a dose-dependent manner. These results suggest that BB causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased in rCBF is also mediated by nitric oxide synthease and guanylate cyclase.

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Effect of Acupuncture and Moxibustion Treatment at the K 1 on the Blood Pressure and regional Cerebral Blood Flow (용천혈(湧泉穴)의 자극(刺戟) 및 애구(艾灸) 시술(施術)이 혈압(血壓)과 국소뇌혈류량(局所腦血流量)에 미치는 영향(影響))

  • Cho Nam-Geun
    • Journal of Acupuncture Research
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    • v.15 no.2
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    • pp.227-236
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    • 1998
  • This study dealed with the effects of the blood pressure and regional cerebral blood fIow(rCBF) on acupuncture and moxibustion treatment to the acu-point equivalent to K 1 of sprague dawley rats(SDR). Acupuncture treatment of K 1 significantly decreased BP in SDR. 2. Acupuncture treatment of K 1 significantly increased rCBF in SDR. 3. Moxibustion treatment of K 1 significantly increased BP in SDR. 4. Moxibustion treatment of K 1 significantly increased rCBF in SDR. These results suggest that acupuncture and moxibustion causes a diverse response of blood pressure and reginal cerebral blood flow. During the moxibustion treatment of K 1 increased BP and rCBF, but after moxibustion recorved BP and rCBF. During the acupunture tretment of K 1 decreased BP and then recorved, rCBF was significantly increased.

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A Mechanism Study of Geopungdodam-tang on the Change of Cerebral Blood Flow in Rats (거풍도담탕의 백서의 뇌혈류 변화에 미치는 기전연구)

  • Song Jeong Suk;Jeong Hyun Woo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.16 no.1
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    • pp.99-103
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    • 2002
  • Geopungdodam-tang(GDT) have been used in oriental medicine for many centuries as a therapeutic agent of apoplexy. The mechanism of GDT on the cerebral blood flow is not known. The purpose of this Study was to investigate effects of GDT on the pial arterial diameter and action mechanism of GDT-induced increased regional cerebral blood flow(rCBF). The changes of regional cerebral blood f1ow(rCBF) was determinated by Laser-Doppler Flowmetry(LDF), and the changes of pial arterial diametet were determinated by video microscopy methods and video analyzer. The results were as follows ; 1. Pial arterial diameter was significantly increased by GDT in a dose-dependent manner. 2. Pretreatment with L-NNA significantly inhibited GDT induced increased rCBF. 3. Pretreatment with methylene blue significantly inhibited GDT induced increased rCBF. 4. Pretreatment with indomethacin inhibited GDT induced increased rCBF. These results suggest that GDT causes a diverse response of cerebral hemodynamics(rCBF and pial arterial diameter). The cerebral hemodynamics is also mediated by nitric oxide synthase, cyclic GMP(guanylyl cydase) and prostaglandin(cyclooxygenase).

Effect of SAENGMAEGSAN extract on the Cardiovascular System and Regional Cerebral Blood Flow (생맥산(生脈散)이 심혈관계(心血管系) 및 국소뇌혈류량(局所腦血流量)에 미치는 영향(影響))

  • Shin, Dae-Chul;Kim, Young-Kyun
    • The Journal of Internal Korean Medicine
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    • v.20 no.1
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    • pp.153-166
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    • 1999
  • SAENGMAEGSAN(SMS) has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. The effect of SMS on the vascular system is not known. The purpose of this study was to determine the effect of SMS on blood pressure, regio-nal cerebral blood flow(rCBF). 1. Blood pressure did not change by SMS in rats. 2. rCBF was increased by SMS in a dose-dependent manner. 3. Pretreatment with propranolol. methylene blue and indomethacin significantly inhibited SMS induced increase in rCBF. These results suggest that SMS causes a diverse response of blood pressure, regional cerebral blood flow (rCBF) and pial arterial diameter. The increase in rCBF is also mediated by prostaglandins. cyclic GMP and adrenergic ${\beta}$receptor.

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Effects of Yupoongyangyeong-tang(YYT) on the Changes of Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats (유풍양영탕(愈風養營湯)이 정상 흰쥐의 국소 뇌혈류량 및 평균혈압에 미치는 영향(影響))

  • Cho, Gook-Ryung;An, Ga-Yong;Jeon, Sang-Yun
    • The Journal of Internal Korean Medicine
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    • v.30 no.2
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    • pp.298-305
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    • 2009
  • Objectives: The present study was carried out to investigate the effects of Yupoongyangyeong-tang(YYT) on changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. In addition, the author also investigated action mechanisms of YYT on changes in rCBF and MABP. Methods and Results : In this study, treatment with YYT elevated rCBF in a dose-dependent manner, but MABP levels were elevated only in the 10 mg/ml treatment group. Pre-treatment with indomethacin. an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. Pre-treatment with methylene blue, an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by YYT, too. In addition. pre-treatment with indomethacin also inhibited increase of MABP. However, pre-treatment with methylene blue did not affect MABP levels. Conclusion : These results suggest that YYT is useful to treat patients with diseases related to cerebral ischemia, because YYT can increase rCBF. In addition, the mechanisms are thought to be related to both cyclooxygenase and guanylate cyclase.

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Effect of Yongyanggaktang(YYG) on Regional Cerebral Blood Flow in Rats (영양각탕(羚羊角湯)이 뇌혈류량(腦血流量)에 미치는 영향(影響))

  • Kang Sung-Hyun;Yun Young-Gab
    • Herbal Formula Science
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    • v.10 no.1
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    • pp.105-112
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    • 2002
  • Yongyanggaktang has been used in oriental medicine as a therapeutic agent for cerebral disease and eclampsia for many years. The purpose of this study was to determine the effect of Yongyanggaktang and its exception of Cornu Saigae Tataricae(羚羊角) in YYG about regional cerebral blood flow(rCBF) in rats. 1. rCBF was increased by Yongyanggaktang in dose dependently. 2. rCBF was increased by exception of Cornu Saigae Tataricae(羚羊角) in YYG at high dosages. 3. rCBF was decreased by Yongyanggaktang pretreated propranolol. 4. L-NNA did not affect rCBF. 5.ODQ did not affect rCBF. Above the results. Yongyanggaktang relates to the symphathetic action.

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The Experimental Study of Cheonghunhwadam-tang Gamypang on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats(III) (청훈화담탕가미방이 국소뇌혈류량 평균혈압에 미치는 실험적 연구(III))

  • Jeong Hyun Woo;Rho Young Ho;Kim Cheon Joong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.3
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    • pp.746-750
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    • 2003
  • Cheonghunhwadam-tang have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CHT Gamypang(CTG) was CHT adding Aurantii Fructus(AF). The effects of CTG on the regional cerebral blood f1ow(rCBF) and mean arterial blood pressure(MABP) is not known. The mechanical Study of CTG on the cerebral hemodynamics is not known too. Therefore, purpose of this Study was to investigate effects of CTG on the rCBF and MABP, mechanism of CTG on the cerebral hemodynamics in rats. The changes of rCBF and BP was determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; CTG extract was significantly decreased rCBF in a dose-dependent, but the change of MABP was not shown. Pretreatment with propranolol(3mg/kg, i.v.) was significantly increased CTG(10 mg/kg, i.v.) induced decrease of rCBF. Pretreatment with indomethacin(3mg/kg, i.v.) and methylene blue(10㎍/kg, i.v.) were increased CTG induced decrease of rCBF too. This results suggest that the mechanism of CTG is mediated by adrenergic β - receptor, guanylate cyclase and cyclooxygenase.

Effect of Cuscutae Semen Extract on Blood Pressure, Regional Cerebral Blood Flow and Pial Arterial Diameter in Rats (토사자가 혈압(血壓), 국소뇌혈류량(局所腦血流量) 및 뇌연막동맥(腦軟膜動脈)에 미치는 영향(影響))

  • Kang Sung-Yong;Kim Kyung-Soo;Kim Kyong-Yoo;Lee In
    • Herbal Formula Science
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    • v.6 no.1
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    • pp.187-197
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    • 1998
  • The study was aimed to investigate the effect cuscutae semen(CS) on the vascular systems including changes in blood pressure (BP), regional cerebral blood flow(rCBF) and pial arteriolar diameter of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry, and the changes in diameter of pial arteriole were measured through a closed crainal window. 1. Blood pressure was not affected by CS in rats. 2. rCBF was increased by CS in a dose-dependent manner. 3. Pretreatment with methylene blue(Img/kg), and propranolol(1mg/kg) significantly inhibited CS induced increased in rCBF. 4. Pretreatment with indomethacin(1mg/kg) did not inhibited CS induced increased in rCBF. 5. Pial arterial diameter was increased by CS in a dose-dependent manner. These results suggest that CS causes a diverse response of blood pressure, regional cerebral blood flow(rCBF), and pial arteral diameter. The increased in rCBF is also mediated by adrenergic ${\beta}-receptor $ and guanylate cyclase.

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Effects of SosokMyeongTang extract on the Regional Cerebral Blood Flow and Blood Pressure in Rats (소속명탕(小續命湯)이 백서(白鼠)의 국소뇌혈류량(局所腦血流量)과 혈압(血壓)에 미치는 영향(影響))

  • Kim, Young-Kyun;Kwon, Jung-Nam;Kim, Kyung-Min;Cho, Eun-Hee;Park, Ji-Eun
    • The Journal of Internal Korean Medicine
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    • v.21 no.5
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    • pp.851-857
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    • 2000
  • SosokMyeongTang(SMT) have been used in oriental medicine for many centuries as a therapeutic agent for cerebral disease. The effects of SMT on the vascular system is not known. The purpose of this study was to investigate the effects of SMT on the changes in blood pressure(BP) and regional cerebral blood flow(rCBF) of rats. SMT consists of the following components : Radix Ledebouriellae(防風), Radix Cocculi or Stephaniae(防己), Semen Armeniacae(杏仁), Cortex Cinnamomi(肉桂), Radix Scutellariae(黃芩), Radix Paeoniae Lactiflorae(白芍藥), Radix Ginseng(人蔘), Rhizoma Cnidll(川芎), Herba Ephedrae(麻黃), Radix Glycyrrhizae(甘草), Radix Aconiti(附子?), Fructus Zizyphi Jujubae(大棗), Rhizoma Zingiberis(生薑) and the changes of BP and rCBF were tested Leser-Doppler Flowmetry(LDF) The experimental results were as follows ; BP was not affected by SMT in rats, but rCBF was increased significantly by SMT in a dose dependent manner. SMT increased previous decreasd rCBF due to pretreatment methylene blue, but did not increased previous decreasd rCBF due to pretreatment L-NNA, indomethacin. Pretreatment with indomethacin decreased BP compaired with control group. These results suggest that SMT causes a diverse response of blood pressure and regional cerebral blood flow(rCBF). The increased rCBF is mediated by nitric oxide synthease.

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The Mechanism Study of Cheonghunhwadam-tang Gamypang on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats(IV) (청훈화담탕가미방이 국소뇌혈유량 및 평균혈압에 미치는 작용기전 연구(IV))

  • Jeong Hyun Woo;Kim Cheon Joong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.4
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    • pp.1013-1018
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    • 2003
  • Cheonghunhwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CTG was CHT adding Aurantii FructusㆍGastrodae Rhizoma. CTG was significantly increased regional cerebral blood f1ow(rCBF) in a dose-dependent, and CTG was decreased mean arterial blood pressure(MABP) compared with normal MABP(100%) in a low dosage, but was increased MABP in a dose-dependent, was aliked with normal MABP in a high-dosage. Therefore, purpose of this Study was to investigate experimental mechanism of CHTAG on the cerebral hemodynamics(rCBF, MABP) in rats. The changes of rCBF and MABP were determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; Pretreatment with indomethacin(3㎎/㎏, i.v.) was significantly inhibited CTG induced increase of rCBF and pretreated with propranolol(3㎎/㎏, i.v.) was inhibited CTG induced increase of rCBF, but pretreatment with methylene blue(10㎍/㎏, i.v) was increased CTG induced increase of rCBF. Pretreatment with indomethacin was decreased CTG induced increase of MABP, but pretreatment with propranolol and methylene blue were increased CTG induced increase of MABP. This results suggest that the mechanism of CTG is mediated by cyclooxygenase.