• 제목/요약/키워드: Serum

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Changes of Serum Ferritin in Acute Lung Injury Induced by Intestinal Ischemia/Reperfusion

  • Park, Sung-Dong;Park, Yoon-Yub
    • The Korean Journal of Physiology and Pharmacology
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    • 제10권4호
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    • pp.187-191
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    • 2006
  • Serum ferritin levels are increased in subjects at-risk for or with acute lung injury (ALI), and there are observations to suggest that increases in serum ferritin levels may help predict the development of ALI in at-risk individuals. To deepen our understanding of increases of serum ferritin and their relationship to the development of ALI, we measured serum ferritin levels before and after intestinal ischemia/reperfusion (I/R) injury in rats, and found that serum ferritin levels increased significantly following I/R. Increases in serum and lavage ferritin levels paralleled increases in lung inflammation (lavage leukocyte numbers and tissue myeloperoxidase activities) and lung leak (lavage protein levels). In contrast, pre-treatment of rats with mepacrine (60 mg/kg, i.p.), a phospholipase $A_2$ inhibitor, attenuated not only I/R-induced serum and lavage ferritin increases, but also the development of ALI. These findings indicate that, besides of human subjects with ALI, serum ferritin levels increase early on also in an animal model of ALI. Therefore, serum and lavage ferritin can be a candidate for early biomarker of ALI.

사람 혈청 트란스페린수용체의 단클론 항체를 이용한 방사면역측정과 철영양상태의 진단 (Immunoradiometric Assay using Monoclonal Antibody Against Human Serum Transferrin Receptor for Diagnosis of Iron Deficiency)

  • 김승렬
    • Journal of Nutrition and Health
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    • 제29권9호
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    • pp.971-980
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    • 1996
  • The soluble transferrin receptor(TfR) in human serum has been shown recently to be a truncated form of intact membrane bound receptor containing most of the extracellular domain. We purfied the transferin-free TfR from human serum by immounoaffinity chromatography which produced the single protein identity in high resolution gel chormatography. The monoclonal antibodies(MAb) against purifed serum TfR were produced by fusion of spleen cells o fimmunized Balb/c mice and SP2 cells. Ten hybrids producing MAb specific for serum TfR were identifed and determine their iostypes. A immunoraddiometric assay (IRMA) for serum TfR was established using two monoclonal IgG1 antibodies as the coating and indicator antibodies on the bosis of their suitability in sandwich IRMA of serum TfR. The mean serum TfR levels in the 15 normal male, 15 normal female, and 19 iron-deficient subjects were 5.4$\pm$0.98, 4.6$\pm$0/76, and 18.0$\pm$12.8mg/1, respectively, and the difference in mean values between normal and iron deficient subjects was significant(p=0.0005). There existed the inverse logarithmic relationship(r=-0.9336, p<0.0001) between the serum TfR and ferritin levels.

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오디 분말차 급여가 일부 충남지역에 거주하는 중년 남.녀의 혈청 지질 및 심혈관계 인자에 미친 영향 (Effect of Mulberry Fruit Tea on the Serum Lipid Profiles and Cardiovascular Disease Markers of Middle-Aged People Living in Choongnam)

  • 김애정;여정숙;방인수
    • 동아시아식생활학회지
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    • 제16권4호
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    • pp.408-413
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    • 2006
  • This study was conducted to examine the effects of mulberry fruit tea (MFT) on the levels of serum lipid profiles and serum cardiovascular disease markers in sixty middle-aged people(30 males and 30 females) who consumed MFT for 4 weeks. Anthropometric measurements, serum lipid profile levels, and serum cardiovascular disease markers were analyzed before and after consumption of MFT. After consumption of MFT, no significant differences were observed in anthropometric measurements, levels of serum aspartate transaminase (AST) and alanine transaminase (ALT) in males and females. Among serum lipid profiles, triglyceride and LDL-cholesterol were decreased significantly, whereas HDL-cholesterol was significantly increased.

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흰쥐에 사염화탄소 투여가 혈청 Acid Phosphatase활성에 미치는 영향 (An Effect of Carbon Tetrachloride Treatment on the Serum Levels of Acid Phosphatase Activity in Rats)

  • 윤종국;신중규;차상은
    • 한국환경보건학회지
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    • 제17권2호
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    • pp.121-126
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    • 1991
  • To clarify a cause of increased serum level of acid phosphatase in CCl$_{4}$-treated rats, the acid phosphatase activity of liver was compared with that serum. Concomitantly, the serum and liver acid phosphatase activity of CCl$_{4}$-treated rats were compared with that of CCl$_{4}$-treated rats pretreated with prednisolone or actinomycin D. In CCl$_{4}$-treated rats, the activity of serum acid phosphatase was significiantly increased whereas that of liver acid phosphatase was rather slightly decreased. the pretreatment of prednisolone led to the decreased activity of serum and liver acid phosphatase in CCl$_{4}$-treated rats. But the pretreatment of actinomycin D rather increased the activity of liver and serum enzyme. In conclusion, it is likely the increased activity of serum acid phosphatase is based on the excess leaking of acid phosphatase into blood by the increased membrane permeability of both liver cell and lysosome in it.

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Candida증(症) 발생(發生)의 면역학적(免疫學的) 기전(機轉)에 관(關)한 연구(硏究) (Immunological ObservatioIn on Gandidiasis)

  • 김홍식
    • 한국균학회지
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    • 제6권2호
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    • pp.15-18
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    • 1978
  • The study was performed to investigate the inhibitory action on the growth rate of Candida albicans under the various immunological conditions, Candida albicans was grown in broth media containing 0.1ml. (in total broth volume 4.0ml.) of normal human serum, diabetic patient serum, albumin solution, artifical bulla content and nutrient solution as control subject. The inhibitory action of Candida albicans was indicated by mesurement of transparency rate with use of the spectrophotometer. The results are as follows: 1. Normal human serum shows inhibitory effect on the growth of the candida distinctly. 2. Albumin solution reveals almost similar to that of the effect of normal human serum. 3. Artificial bulla content which obtained by irradiation of ultraviolot ray after application of 1% 8-Methoxy-psolaren cream and the diabetic patient serum shows reduction of inhibitory effect as compared with that of the normal human serum. 4. It is estimated that the titer of negative effect of diabetic patient serum is not related with the variation of immunoglobulin titer in patient serum.

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Vitamin D², Thyroxine, 및 Calcium gluconate가 백서악하선적출로 인한 혈중 Calcium농도변화에 미치는 영향

  • 정동균;박노희;김중기
    • 대한치과의사협회지
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    • 제12권12호
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    • pp.919-923
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    • 1974
  • Serum calcium level was decreased by submaxillary gland removal in rate. To investigate the mechanisms involved in the above change, the authors examined the effects of thyroxine, vitamin D₂, and calcium gluconate, which influence the metabolisms of calcium and submaxillary gland, on the serum calcium level of the intact and submaxillary gland removal rats. The results were as follows: 1) Serum calcium level decreased by submaxillary gland removal. 2) Vitamin D₂, increased the serum calcium level significantly. 3) Thyroxine falied to recover the decreased serum calcium level induced by submaxillary gland removal to the control level. 4) In submaxillary gland removal rats, vitamin D₂ failed to increase the serum calcium level. 5) In thyroxine administered rats for 55 days, of which submaxillary glands were removed, vitamin D₂ failed to increase the serum calcium level. 6) The serum calcium level in intact rats was increased slightly, but increased significantly in submaxillary gland removal rats shortly after intravenous injection of calcium gluconate.

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흰쥐의 담즙 상실이 혈청 지질과 Gastrin 대사에 미치는 영향 (Effect of Bile Deprivation on Serum Lipids and Gastrin in the Rat)

  • 송경희
    • Journal of Nutrition and Health
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    • 제20권1호
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    • pp.46-53
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    • 1987
  • The effect of bile deprivation on serum lipid and gastrin contents was investigat\ulcornered after choledocho-urinary cystostomy in Sprague-Dawley rats. Bile deprivated rats were compared with sham operated control group. Gastrin levels in serum and antral tissue were measured and serum lipid concentrations were also measured. Gastrin levels of serum and tissue after bile deprivation were increased significantly compared with those of the controL At the end of 1st and 2nd week after bile deprivation, serum cholesterol and triglyceride contents were significantly lower han those of the control. By 4th week, there was no significant difference between two groups. Increases in serum and antral gastrin levels temporarily coincided well with decreases in serum lipid contents after bile deprivation. These results suggest that there is increase in biosynthesis and release of gastrin and decrease in fat absorption at early stage of bile deprivation.

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아연 보충이 젊은 여성의 혈청 콜레스테롤 농도에 미치는 영향 (Effect of Zinc Supplementation on Serum Cholesterol Concentration of Young Women)

  • 송미영
    • Journal of Nutrition and Health
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    • 제23권4호
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    • pp.237-247
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    • 1990
  • This study was to investigate the effect of zinc supplementation on serum cholesterol concentration of young women. Thirty healthy students were divided into Zn and placebo groups, and were orally given with zinc(50mg/day, 220mg as ZnSO4·7H2O) or placebo for 2 month (June 9-August 7, 1988). Changes of plasma zinc, serum total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol(LDL-C) and total lipid were analyzed from the initiation to 1 month after the end of zinc supplementation at monthly interval. Plasma zinc, serum LDL-C content and LDL-C/HDL-C were significantly increased by zinc supplementation. Serum total cholesterol content tended to be increased by zinc supplementation but was not significantly different between the two groups. Serum HDL-C content was significantly decreased by zinc supplementation. Serum total lipid content was not different between the two groups during experimental period. Thus, in this study considering the effect of zinc supplementation on serum cholesterol concentration, we conclude that the effect of zinc supplementation on coronary heart disease may be negative.

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단백질과 마그네슘 공급수준이 흰쥐의 혈청중 지질함량 및 효소활성에 미치는 영향 (Effect of Dietary Protein and Magnesium Levels on Serum Lipid Contents and Enzyme Activities in Rats)

  • 정복미
    • Journal of Nutrition and Health
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    • 제26권8호
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    • pp.925-932
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    • 1993
  • To study the effects of dietary protein and magnesium level on serum lipid contents and enzyme activities, male Sprague-Dawley rats were divided into six groups. Six groups of animals were fed six experimental diets different with protein(8% and 20%) and magnesium levels (Mg-free, 400mg/kg diet and 800mg/kg diet). The serum lipid contents and enzyme activities of rats fed different dietary protein and magnesium levels were examined. Serum triglyceride contents was significantly decreased as the dietary magnesium level was increased. Serum phospholipid contents was significantly higher in magnesium deficient group than those in the other groups. Serum alkaline phosphatase activity was significantly decreased in magnesium dificient group compared with other groups, but serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities was significantly increased in magnesium dificient group than other groups. In conclusion, serum triglyceride contents in low protein level was remarkably decreased as the dietary magnesium level was increased.

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독활기생탕(獨活寄生湯)이 백서(白鼠)의 혈액(血液)에 미치는 영향(影響) (Effects of Dokwhalgisaentang on the Blood in Rats)

  • 김희철
    • 대한한방내과학회지
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    • 제16권2호
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    • pp.51-60
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    • 1995
  • In order to study the effect of Dokwhalgisaentang on the blood in normal rats with Dokwhalgisaentang extract solution was adminstrated in rats. The rats carried on every day for 5days, l0days and 15days respecitively on the corresponding blood in rats, and thereafter the contents of serum BUN, creatinine, creatine, total protein, albumin, total bilirubin, cholesterol were measured in rats. The following results have been obtained : 1. Dokwhalgisaentang extract decreased the serum BUN significantly in rats. 2. Dokwhalgisaentang extract decreased the serum creatine significantly in rats. 3. Dokwhalgisaentang extract decreased the serum creatinine significantly in rats. 4. Dokwhalgisaentang extract decreased the serum total protein significantly in rats. 5. Dokwhalgisaentang extract decreased the serum albumin significantly in rats. 6. Dokwhalgisaentang extract increased the serum total bilirubin significantly in rats. 7. Dokwhalgisaentang extract decreased the serum cholresterol significantly in rats.

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