• Title, Summary, Keyword: TIA

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Design of a 1-Gb/s CMOS Optical Receiver for POF Applications (1-Gb/s CMOS POF 응용 광수신기 설계)

  • Lee, Jun-hyup;Lee, Soo-young;Jang, Kyu-bok;Yu, Chong-gun
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • pp.241-244
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    • 2012
  • In this paper, three types of optical receivers are designed using a $0.35-{\mu}m$ standard CMOS technology for plastic optical fiber (POF) applications. Basic common-source transimpedance amplifier (CS-TIA), common-gate TIA (CG-TIA), and regulated-cascode TIA (RGC-TIA) are optimally designed, and their transimpedance gain (TZ gain), 3-dB bandwidth, and noise characteristics are compared and analyzed. As a result of simulations, the RGC-TIA indicates better TZ gain and 3-dB bandwidth than other topologies, and CS-TIA has the best noise performance. Each optical receiver occupies area of $0.35mm^2$.

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Multi-channel Transimpedance Amplifier Arrays in Short-Range LADAR Systems for Unmanned Vehicles (무인차량용 단거리 라이다 시스템을 위한 멀티채널 트랜스임피던스 증폭기 어레이)

  • Jang, Young Min;Kim, Seung Hoon;Cho, Sang Bock;Park, Sung Min
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.12
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    • pp.40-48
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    • 2013
  • This paper presents multi-channel transimpedance amplifier(TIA) arrays in short-range LADAR systems for unmanned vehicles, by using a 0.18um CMOS technology. Two $4{\times}4$ channel TIA arrays including a voltage-mode INV-TIA and a current-mode CG-TIA are introduced. First, the INV-TIA consists of a inverter stage with a feedback resistor and a CML output buffer with virtual ground so as to achieve low noise, low power, easy current control for gain and impedance. Second, the CG-TIA utilizes a bias from on-chip bandgap reference and exploits a source-follower for high-frequency peaking, yielding 1.26 times smaller chip area per channel than INV-TIA. Post-layout simulations demonstrate that the INV-TIA achieves 57.5-dB${\Omega}$ transimpedance gain, 340-MHz bandwidth, 3.7-pA/sqrt(Hz) average noise current spectral density, and 2.84mW power dissipation, whereas the CG-TIA obtains 54.5-dB${\Omega}$ transimpedance gain, 360-MHz bandwidth, 9.17-pA/sqrt(Hz) average noise current spectral density, and 4.24mW power dissipation. Yet, the pulse simulations reveal that the CG-TIA array shows better output pulses in the range of 200-500-Mb/s operations.

Synergistic effects of oxytetracycline and tiamulin against swine respiratory bacteria and their pharmacokinetics in the pigs (돼지호흡기세균에 대한 oxytetracycline과 tiamulin의 시험관내 상승작용 및 돼지에서의 약물동태학)

  • Park, Seung-chun;Yun, Hyo-in;Lee, Keun-woo
    • Korean Journal of Veterinary Research
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    • v.42 no.1
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    • pp.45-54
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    • 2002
  • The study was carried out to characterize the pharmacokinetics after intravenous (iv, 20 mg/kg) and oral (p.o. 100 mg/kg) administration as oxytetracycline (OTC) and tiamulin (TIA) mixture in swine and to determine interaction between OTC and TIA against various pig pathogenic bacteria. The antibacterial effects of OTC in combination with TIA in vitro showed synergistic effect against Salmonella typhimurium 1925, Pasteurella multocida Type A, P. multocida Type D, Krebsiella Pneumoniae 2001, K. Pneumoniae 1560, K. Pneumoniae 2208, Haemophillus pleuropneumonia S 2, and H. pleuropneumonia S 5, but against additive effect E. coli K88ab and S. choleraesuis on the basis of fractional inhibitory concentration (FIC) index. On the while, after i.v. and p.o. administration of OTC and TIA mixture, each OTC and TIA concentrations in plasma were fitted to an open two-compartment model. After i.v. administration of OTC-TIA mixture, the mean distribution half-life ($T_{1/2{\alpha}}$) of OTC and TIA in plasma showed 0.29 h and 0.17 h, and the mean elimination half-life ($T_{1/2{\beta}}$) of those was 4.36 h and 6.64 h, respectively. The mean volume of distribution at steady state ($Vd_{ss}$) of OTC and TIA was $0.85{\ell}/kg$ and $2.44{\ell}/kg$, respectively. After oral administration of OTC and TIA mixture, the mean maximal absorption concentrations ($C_{max}$) of OTC and TIA were $0.60{\mu}g/m{\ell}$ at 1.07 h ($T_{max}$) and $1.68{\mu}g/m{\ell}$ at 1.85 h ($T_{max}$), respectively. The mean elimination half-life ($T_{1/2{\beta}}$) of those showed 6.84 h and 6.36 h. In conclusion, we could suggest in this study that the combination of OTC and TIA may be recommended for the antibacterial therapy against polymicrobial infections, and both OTC and TIA showed large distribution to tissues and high $C_{max}$ after p.o. administration.

Comparison of TIA with ELISA for circulating antibody detection in clonorchiasis (간흡충증에 있어서 항체검출을 위한 Enzyme-linked Immunosorbent Assay와 Thin Layer Immunoassay의 비교)

  • 이용기;유재숙이근태정경일
    • The Korean Journal of Parasitology
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    • v.21 no.2
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    • pp.265-269
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    • 1983
  • A comparison was made of a new serological method, thin layer immunoassay (TIA), and an established method, enzyme-linked immunosorbent assay (ELISA), in the detection and quantiacation of antibodies in clonorchiasis. Saline extract of Iyophilized Clonorchis sinensis adult worm was used as antigen, and TIA by the method of Elwing et at. (1976) and ELISA by Voller et at. (1974) were performed. Using sera from known clonorchiasis cases,100% of the sera tested were Positive by TIA and 88.35 by ELISA. TIA produced false positive results in 14 out of 36 cases, which were 10 amoebiasis cases, 16 paragonimiasis cases and 10 healthy controls. ELISA. however, produced a small number of false positives, 7 out of 55 cases. There was correlation between Immunoglobulin G level in sera and ELISA value (correlation coefficient, 0.69), whereas no correlation between Immunoglobulin G level and TIA result. The Performance of TIA and ELISA was not correlated in the results using homologous antigen.

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Design of Low-power Regulated Cascode Trans-impedance Amplifier for photonic bio sensor system (광 바이오 센서 시스템을 위한 RGC 기법의 저전럭 전치증폭기 설계)

  • Kim, Se-Hwan;Hong, Nam-Pyo;Choi, Young-Wan
    • 한국정보통신설비학회:학술대회논문집
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    • pp.364-366
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    • 2009
  • 광 바이오 센서 시스템에서 Trans-Impedance amplifier (TIA)는 광검출기로부터 입력단으로 들어오는 미세한 전기 신호를 원하는 신호레벨까지 증폭하는 역할을 한다. TIA는 광 바이오 센서 시스템의 감도 (sensitivity)를 결정하는 매우 중요한 회로로 저잡음, 저전력, 낮은 입력 임피던스 등의 특성이 요구되어진다. 본 논문에서는 광 바이오 센서 시스템에서 요구되어 지는 저전력, 저잡음 성능을 구현하기 위하여 regulated cascode (RGC) TIA를 설계하였다. 본 연구에서는 기존 common gate (CG) 기법의 TIA에서 전류원 역할을 하는 current source를 저항으로 대체하고, local feedback stage를 이용하는 RGC TIA를 저잡음, 저전력 특성 및 회로 면적 감소의 장점을 갖도록 설계하였다.

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Thin Layer Immnunoassay (TIA) for circulating antibody detection in clonorchiasis (간흡충에 대한 항체검출을 위한 Thin Layer Immounoassay (TIA))

  • 임경일
    • The Korean Journal of Parasitology
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    • v.21 no.1
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    • pp.1-5
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    • 1983
  • Thin layer immunoassay was carried out to demonstrate antibodies against Clcnorchis sinensis in sera from clonorchiasis patients. Saline extract of adult worm was used as antigen. TIA technique was performed as described earlier by Elwing et at. (1976), but agarose was used instead of agar. The antibody titres of sera in 60 clonorchiasis casts were higher than that of 10 healthy and 10 amoebiasis cases, but not different comparing with that of 10 paragonimiasis cases. Antibody litres in clonorchiasis gave no differences according to the age, sex, EPG in feces, eosinophilia degree of blood, level of alkaline phosphatase and transaminase (SGOT, SGPT) in sera. It is suggested that, after evaluation, the TIA might supplement or be used as an alternative to other immunodiagnostic tests already in use for the diagnosis of clonorchiasis.

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ForTIA : A Tool Supporting Formal Method based on LOTOS (ForTIA: LOTOS 기반의 정형기법 지원도구)

  • Cho, Soo-Sun;Cheon, Yoon-Sik;Oh, Young-Bae;Chung, Yun-Dae
    • Journal of KIISE:Computing Practices and Letters
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    • v.6 no.2
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    • pp.161-172
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    • 2000
  • In this paper, we introduce the development of a LOTOS-based tool, supporting formal methods, called ForTIA (A Formalism for Telecommunication and Information Systems). By using LOTOS, an ISO standard formal specification language, the user requirements and system models can be abstracted and represented formally. Therefore, the system can be validated and verified on the specifications, before implementations. ForTIA supports light-weight formal methods based on validation to be used in real industry. Key functions of ForTIA are simulation and C++ code generation. In simulation, tree based visual validation mechanism is provided and in code generation, the full C++ source code is generated to be used for system implementations.

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10Gb/s CMOS Transimpedance Amplifier Designs for Optical Communications (광통신용 10Gb/s CMOS 전치증폭기 설계)

  • Sim, Su-Jeong;Park, Sung-Min
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.10
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    • pp.1-9
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    • 2006
  • In this paper, a couple of 10Gb/s transimpedance amplifiers are realized in a 0.18um standard CMOS technology for optical communication applications. First, the voltage-mode inverter TIA(I-TIA) exploits inverter input configuration to achieve larger effective gm, thus reducing the input impedance and increasing the bandwidth. I-TIA demonstrates $56dB{\Omega}$ transimpedance gain, 14GHz bandwidth for 0.25pF photodiode capacitance, and -16.5dBm optical sensitivity for 0.5A/W responsivity, 9dB extinction ration and $10^{-12}$ BER. However, both its inherent parasitic capacitance and the package parasitics deteriorate the bandwidth significantly, thus mandating very judicious circuit design. Meanwhile, the current-mode RGC TIA incorporates the regulated cascade input configuration, and thus isolates the large input parasitic capacitance from the bandwidth determination more effectively than the voltage-mode TIA. Also, the parasitic components give much less impact on its bandwidth. RGC TIA provides $60dB{\Omega}$ transimpedance gain, 10GHz bandwidth for 0.25pF photodiode capacitance, and -15.7dBm optical sensitivity for 0.5A/W responsivity, 9dB extinction ration and $10^{-12}$ BER. Main drawback is the power dissipation which is 4.5 times larger than the I-TIA.

The Trypsin Inhibitor Activity and Protein Pattern of the Soybean During Germination (대두발아(大豆發芽)에 따른 Trypsin Inhibitor Activity와 Protein Pattern의 변화(變化))

  • Son, Hye-Sook;Park, Jyung-Rewng;Lee, Sung-Woo
    • Applied Biological Chemistry
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    • v.20 no.2
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    • pp.182-187
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    • 1977
  • This investigation was to determine the changes in the trypsin inhibitor activity(TIA) and electrophoresis patterns of the soybean cotyledon and axis during germination. The TIA of the cotyledon decreased slightly and that of the axis decreased rapidly to 50% activivity after 7 day germination. At the 2nd, 3rd and 4th day's germination the TIA of the defatted dry axis was higher than that of cotyledon. However, the TIA of the fresh cotyledon was lower than that of the axis, due to its higher moisture content. Results from the electrophoretic studies showed that band 1 (polymer, 15S etc.), 2(11S), and 3(7S) whichare the major reserve proteins of soybean were decreased consid erably in cotyledon and axis and the fragments with Rm values between 0.5 and 1.0 were increased and band 5 showed up during germination. The band 4 of the cotyledon and band 6 of axis were not changed during germination. Generally speaking, the TIA and thereserve protein decreased as germination proceed.

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Effect of Cultivars, Cooking and Processing on the Trypsin Inhibitor Activity of Soybean

  • Felipe, Penelope;Yang, Yoon-Hyung;Lee, Jung-Hee;Sok, Dai-Eun;Kim, Hyoung-Chin;Yoon, Won-Kee;Kim, Hwan-Mook;Kim, Mee-Ree
    • Preventive Nutrition and Food Science
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    • v.10 no.1
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    • pp.6-10
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    • 2005
  • The trypsin inhibitor activity (TIA) of various soybean cultivars was evaluated by measuring the inhibition of trypsin activity using N-benzoyl-DL-arginine-p-nitro-anilide (BAPNA) as the substrate. The TIA values of eleven white shelled soybean cultivars including a glyphosate-tolerant soybean (16.58 to 17.90㎎/g) were not significantly different among cultivars. Black shelled soybeans had higher TIA values, ranging from 40.09 to 52.11㎎/g, compared to white shelled soybeans (p<0.05). When the TIA of commercially processed soybean foods were determined, no TIA was detected in soysauce, tofu and soybean paste. During conventional moist heating, the IT/sub 50/ (Time required to reach 50% inhibition of TIA) values were decreased as heating temperature and cooking pressure increased. The IT/sub 50/ values of moist heating were estimated to be 91.68, 37.71 and 19.50 min at 60, 80 and 100℃, respectively. The IT/sub 50/ value of microwave cooking was 4.75 min at medium heat, while that of the pressure cooking at 120℃ was only 2.62min. Moreover, there was a negative relationship between temperature and IT/sub 50/ values (R=0.92, p<0.01). The TIA of soybean sprouts was completely inactivated after heating at 100℃ for 5 min, although fresh soybean sprouts showed one fifth of the TIA value of white shelled soybeans. Based on our results, pressure cooking is the most effective cooking method to reduce TIA in soybeans.