• Title, Summary, Keyword: TMS

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Plasticity Associated Changes in Neurophysiological Tests Following Non Invasive Brain Stimulation in Stroke Rat Model (뇌졸중 쥐모델에서 비침습적뇌자극치료 이후 신경생리학적 검사에서 나타난 뇌가소성과 연관된 변화)

  • Sohn, Min Kyun;Song, Hee-Jung;Jee, Sungju
    • Annals of Clinical Neurophysiology
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    • v.16 no.2
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    • pp.62-69
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    • 2014
  • Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in stroke patients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS) on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: Seventy Sprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successful stroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave on ipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motor evoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the stroke rat was evaluated by the Rota rod and Garcia test. Results: Forty rats ($N_{rTMS}=20;\;N_{sham}=20$) completed all experimental course. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11 (p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group at day 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortex can help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneously associate with changes in neurophysiological activity in brain.

Stroke Recovery Can be Enhanced by using Repetitive Transcranial Magnetic Stimulation Combined with Mirror Therapy

  • Ji, Sang-Goo;Cha, Hyun-Gyu;Kim, Myoung-Kwon
    • Journal of Magnetics
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    • v.19 no.1
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    • pp.28-31
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    • 2014
  • The aim of the present study was to examine whether mirror therapy, in conjunction with repetitive transcranial magnetic stimulation (rTMS), can improve the upper extremity function of stroke patient. This study was conducted with 35 subjects, who were diagnosed as a hemiparesis by stroke. The Mirror plus rTMS group was of 12 members who undertook mirror therapy in conjunction with rTMS, the Mirror group was of 11 members who undertook mirror therapy, and the control group was of 12 members who undertook sham therapy. A motor cortex excitability was performed by motor evoked potential, and upper limb function was evaluated by Fugl-Meyer Assessment, and Box and Block Test. Significant difference was shown after the experiment, in comparison of the groups in terms of latency, and as the result of post hoc test, significant difference was shown between the Mirror plus rTMS group and control group, and between the Mirror group and control group, respectively. Significant difference was shown after the experiment in comparison of the groups in amplitude, and as the result of post hoc test, significant difference was shown between the Mirror plus rTMS group and Mirror group, and between the Mirror plus rTMS group and control group. Significant difference was shown after the experiment, in comparison of the groups in FMA and BBT, and as the result of post hoc test, significant difference was shown between the Mirror plus rTMS group and Mirror group, and between the Mirror group and control group. The study showed that mirror therapy in conjunction with rTMS is more effective to improve upper extremity function, than mirror therapy and sham therapy.

Real-time Implementation of G.723.1A Speech Coder Using a TMS320VC5402 DSP (TMS320VC5402 DSP를 이용한 G.723.1A 음성부호화기의 실시간 구현)

  • Lee, Song-Chan;Chung, Ik-Joo
    • Speech Sciences
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    • v.10 no.2
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    • pp.65-75
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    • 2003
  • This paper describes the issues associated with the real-time implementation of G.723.1A dual-rate speech coder on a TMS320VC5402 DSP. Firstly, the main features of the G.723.1A speech coder and the procedure involved in the implementation using assembly and C languages are discussed. Various real-time implementation issues such as memory/MIPS tradeoffs are also presented. For fixed-point implementation, we converted the ITU-T fixed-point ANSI C code into TMS320VC5402 code in the bit-exact way through verification using the test vectors. Finally, as the result of implementation, we present the MIPS and memory requirement for the real-time operation.

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Real-Time Implementation of an Acoustic Echo Canceller Using TMS320C31 DSP (TMS320C31 DSP를 이용한 음향반향제거기의 실시간 구현)

  • Jang, Byung-Wook;Kim, Si-Ho;Kwon, Hong-Seok;Bae, Keun-Sung
    • Speech Sciences
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    • v.9 no.3
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    • pp.17-24
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    • 2002
  • The goal of this research is the real-time implementation of an AEC (Acoustic Echo Canceller) using the floating-point digital signal processor of TMS320C31. We employ an FIR-type adaptive filter with the conventional NLMS (Normalized Least Mean Square) algorithm for the adaptation of filter coefficients. We program and optimize the system in the assembler level to make it run in real-time. With 8 kHz sampling rate, the implemented AEC requires $46\;\mu$sec and $77\;\mu$sec computational time per sample for 128-and 256-tap filter, respectively. It corresponds to 37% and 62% of maximum computational ability of TMS320C31 DSP.

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Induction of cell death by 2,4,3',5'-tetramethoxystilbene in human acute promyelocytic leukemia (HL-60) cells and its mechanism.

  • Lee, Sang-Kwang;Kim, Mie-Young;Chun, Young-Jin
    • Proceedings of the PSK Conference
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    • pp.149.1-149
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    • 2003
  • We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a synthetic trans-stilbene analogue, is one of the most potently selective inhibitor of human cytochrome P450 1B1 in vitro and in vivo. In the present studies, the apoptotic effects of TMS were investigated in HL-60 cells. The effects of TMS on the proliferation of HL-60 cells were determined with MTT assay. TMS exhibited cytotoxicity with an $IC_50$ value of 37 nM. Cotreatment with TMS and etoposide, a well-known anticancer drug significantly enhanced the cytotoxicity. (omitted)

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Speed control system design using dual core DSP(TMS320F28377D) for the 2 Axis BLDC motor control (2축 BLDC 전동기 제어를 위한 듀얼코어 DSP(TMS320F28377D)를 이용하는 속도 제어 시스템 설계)

  • Lee, Dong-ju;Kim, Hee-chel;Lee, Dong-hyun;Choi, Jung-keyng
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • pp.232-234
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    • 2017
  • In this research, the BLDC motor 2 axis controller was designed using a dual core processor. The controller used TMS320F28377D which is TI's latest dual-core DSP, and the BLDC motor was selected with the position of resolver having high reliavility and the speed sensor built-in type motor.

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Real-Time Implementation of AMR Speech Codec Using TMS320VC5510 DSP (TMS320VC5510 DSP를 이용한 AMR 음성부호화기의 실시간 구현)

  • Kim, Jun;Bae, Keun-Sung
    • MALSORI
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    • no.65
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    • pp.143-152
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    • 2008
  • This paper focuses on the real time implementation of an adaptive multi-rate (AMR) speech codec, that is a standard speech codec of IMT-2000, using the TMS320VC5510. The series of TMS320VC55x is a 16-bit fixed-point digital signal processor (DSP) having low power consumption for the use of mobile communications by Texas Instruments (TI) corporation. After we analyze the AMR algorithm and source code as well as the structure and I/O of 7MS320VC55x, we carry out optimizing the programs for real time implementation. The implemented AMR speech codec uses 55.2 kbyte for the program memory and 98.3 kbyte for the data memory, and it requires 709,878 clocks, i.e. about 3.5 ms, for processing a frame of 20 ms speech signal.

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Study on Growth of Nanocrystalline SiC Films Using TMS (TMS를 이용한 SiC 나노박막의 성장연구)

  • Yang Jae-Woong
    • Journal of the Korean institute of surface engineering
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    • v.38 no.4
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    • pp.174-178
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    • 2005
  • Chemical vapor deposition technique has been used to grow epitaxial SiC thin films on Si wafers using tetramethylsilane(TMS) precursor. The films were observed to grow along (110) direction of 3C-SiC at $800^{\circ}C$. The quality of the films was significantly influenced by the TMS flow rate and growth temperature. Nanocrystal SiC films were grown at flow rates of TMS 10 sccm with $H_2$ carrier gas of 100 sccm. The temperature and gas pressure in the reactor have a great influence on the crystallinity and morphology of the SiC film grown. The growth mechanism of the SiC film on the Si substrate without the carbonization process was discussed based on the experimental results.

Repetitive Transcranial Magnetic Stimulation to Treat Depression and Insomnia with Chronic Low Back Pain

  • Park, Eun Jung;Lee, Se Jin;Koh, Do Yle;Han, Yoo Mi
    • The Korean Journal of Pain
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    • v.27 no.3
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    • pp.285-289
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    • 2014
  • Transcranial magnetic stimulation (TMS) is a noninvasive and safe technique for motor cortex stimulation. TMS is used to treat neurological and psychiatric disorders, including mood and movement disorders. TMS can also treat several types of chronic neuropathic pain. The pain relief mechanism of cortical stimulation is caused by modifications in neuronal excitability. Depression is a common co-morbidity with chronic pain. Pain and depression should be treated concurrently to achieve a positive outcome. Insomnia also frequently occurs with chronic lower back pain. Several studies have proposed hypotheses for TMS pain management. Herein, we report two cases with positive results for the treatment of depression and insomnia with chronic low back pain by TMS.

Effects of Mental Practice in Conjunction with Repetitive Transcranial Magnetic Stimulation on the Upper Limbs of Sub-acute Stroke Patients

  • Ji, Sang-Goo;Kim, Myoung-Kwon;Cha, Hyun-Gyu
    • Journal of Magnetics
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    • v.19 no.4
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    • pp.353-356
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    • 2014
  • The aim of the present study was to examine whether mental practice (MP) in conjunction with repetitive transcranial magnetic stimulation (rTMS) can improve the upper limb function of sub-acute stroke patients. This study was conducted with 32 subjects who were diagnosed with hemiparesis by stroke. The experimental group consisted of 16 members upon each of whom was performed MP in conjunction with rTMS, whreas the control group consisted of 16 members upon each of whom was performed MP and sham rTMS. Both groups received traditional physical therapy for 30 minutes a day, 5 days a week, for 6 weeks; additionally, they received mental practice for 15 minutes a day. The experimental group was instructed to perform rTMS, and the control group was instructed to apply sham rTMS for 15 minutes. A motor cortex excitability analysis was performed by motor evoked potentials (MEPs), and upper limb function was evaluated by Fugl-Meyer Assessment (FMA) and the Box and Block test (BBT). Results showed that the amplitude, latency, FMA, and BBT of the experimental group and the latency, FMA, and BBT of the control group were significantly improved after the experiment (p<0.05). Significant differences were found between the groups in amplitude and latency after the experiment (p<0.05). The results showed that MP in conjunction with rTMS is more effective in improving upper limb function than MP alone.