• Title, Summary, Keyword: Tricalcium phosphate

Search Result 173, Processing Time 0.071 seconds

Sinus Tract Formation with Chronic Inflammatory Cystic Mass after Beta Tricalcium Phosphate Insertion

  • Kim, Hong Jin;Na, Woong Gyu;Jung, Sung Won;Koh, Sung Hoon;Lim, Hyoseob
    • Archives of Craniofacial Surgery
    • /
    • v.18 no.4
    • /
    • pp.282-286
    • /
    • 2017
  • Beta tricalcium phosphate (${\beta}-TCP$) is one of allogenic bone substitute which is known to have interconnected pores that draws cell and nutrients for bone generation. It has been resulted in good outcomes for bone defect coverage or augmentation. However, several studies have also reported negative outcomes and associated complications including unexpected formation of cystic mass, continuous pain and secretion. We present the case of a 36-year-old man with a right cheek cystic mass who had a history of right zygomaticomaxillary (ZM) complex fracture and surgical correction with ${\beta}-TCP$ powder insertion to ZM bone defect. Excisional biopsy under local anesthesia revealed calcified mass in a sinus tract which was found to be connected to the ZM bone defect site in postoperative computed tomography image. Further excision under general anesthesia was performed to remove the sinus tract and fine granules which filled the original defect site. Pathologic report revealed bony spicules and calcification materials with chronic foreign body reaction. Postoperative complications and recurrence were not reported.

Fabrication and Characterization of Hydroxyapatite/Mullite and Tricalcium Phosphate/Al2O3 Composites Containing 30 wt% of Bioactive Components

  • Ha, Jung-Soo
    • Journal of the Korean Ceramic Society
    • /
    • v.52 no.5
    • /
    • pp.374-379
    • /
    • 2015
  • Mullite-matrix and $Al_2O_3$-matrix composites were fabricated with 30 wt% hydroxyapatite (HA) and tricalcium phosphate (TCP), respectively, as additives to give bioactivity. A diphasic gel process was employed to lower the densification temperature of the mullite matrix to $1320^{\circ}C$. A polymer complexation process was used to synthesize a TCP powder that was fully densified at $1250^{\circ}C$, for application to the matrix. For the HA/mullite composite, HA decomposed during sintering by reactions with the matrix components of $Al_2O_3$ and $SiO_2$, resulting in a mixture of $Al_2O_3$, TCP, and other minor phases with a low densification of less than 88% of the theoretical density (TD). In contrast, the TCP/$Al_2O_3$ composite was highly densified by sintering at $1350^{\circ}C$ to 96%TD with no reaction between the components. Different from the TCP monolith, the TCP/$Al_2O_3$ composite also showed a fine microstructure and intergranular fracture, both of which characteristics are advantageous for strength and fracture toughness.

Radiologic Outcome of Beta-Tricalcium Phosphate as a Bone Substitute in Orthopaedic Surgery (정형외과 수술에서 골대체제로써 Beta-Tricalcium Phosphate 사용에 대한 방사선학적 결과)

  • Park, Hyungseok;Moon, Jeong Eun;Cho, Yong Jin
    • The Korean Journal of Health Service Management
    • /
    • v.13 no.4
    • /
    • pp.133-144
    • /
    • 2019
  • Objectives: To analyze the radiologic results of patients treated with bone defects treated with beta-tricalcium phostphate (β-TCP) in orthopedic surgery. Methods: Medical records of 49 patients, consisting of 24 (49.0%) men and 25 (51.0%) women were retrospectively reviewed. Graft incorporation was evaluated based on Irwin's radiologic staging. Results: The explanatory power of the total regression equation in Irwin's stage at 3 months postoperatively according to three explanatory variables, namely graft tightness, age at diagnosis, and lesion volume, was 65.6%; the explanatory power of Irwin's stage at 6 months postoperatively according to two variables, namely lesion volume and graft tightness, was 32.9%; and the explanatory power of Irwin's stage at 9 months postoperatively for two variables, namely longitudinal lesion length and graft tightness in the total regression, was 30.8%. Conclusions: Graft tightness, lesion volume, age at diagnosis, and longitudinal lesion length are the common factors affecting graft incorporation.

A study on the preparation of phosphatic calcium compounds using the shell resources (패각을 이용한 인산칼슘계 화합물의 제조에 관한 연구)

  • 이인곤;김판채
    • Journal of the Korean Crystal Growth and Crystal Technology
    • /
    • v.10 no.2
    • /
    • pp.171-176
    • /
    • 2000
  • The phosphatic calcium compounds such as calcium hydrogen phosphate, bone ash, hydroxyapatite and tricalcium phosphate were prepared using the high purity calcium hydroxide and calcium carbonate obtained from shell resources. Calcium hydrogen phosphate had been prepared using the high purity calcium hydroxide and phosphoric acid solution. Using the calcium hydrogen phosphate as a starting materials, bone ash have been prepared by solid state reaction method and hydroxyapatite could be obtained by hydrothermal treatment method, respectively. The tricalcium phosphate was prepared by the solid state reaction of a stoichiometic mixture of bone ash and high purity calcium carbonate. In this paper, the optimal preparation process and conditions of phosphatic calcium compounds were established.

  • PDF

Biological Availability of Various Sources of Ca and P Supplements in Young Chicks (병아리에서 인산칼슘 첨가제의 생물학적 이용성)

  • 이재호;지규만
    • Korean Journal of Poultry Science
    • /
    • v.15 no.3
    • /
    • pp.219-227
    • /
    • 1988
  • This experiment was carried out to evaluate biological availability of Ca and P in 4 different sources of tricalcium phosphate in young chicks. One hundred and twenty five-day-old male Single Comb White Leghorn chicks (10 treatments$\times$3replication$\times$4chicks) were used in trial 1 and 2, respectively, for 12 days of feeding period. Trial I was to evaluate the availability of phosphorus in the supplements, Standard purified diets were prepared to supply 0.07, 0.14 and 0.21%P using a mixture (1 : 1) of NaH$_2$PO$_4$ and KH$_2$PO$_4$ as the reference Phosphorus sources. Bone breaking strength of the tibia determeined by an Instron instrument appeared inadequate to be used as a criterion due to very high variations of the measurement within a treatment. Thus, tibia bone ash content was utilized as a criterion to evaluate th biological avilability of phosphorus in the supplements. The levels of the biological availability of the four different sources of dicalcium phoshate were 77.1, 91.0, 96.4 and 95.5%, respectively, and those of the three tricalcium phosphate sources were 94.1, 95.0 and 99.5% , respectively. Trial 2 was to determeine the levels of Ca biologically available in the supplements. Standard purified diets were made to supply 0.2, 0.3 and 0.4% Ca using CaCo$_3$ as the reference calcium source. When bone ash content was utilized as a criterion for the availability, the levels of calcium biologically available to the chicks were 78.3, 234.1, 87.6 and 244.5%, respectively, for the 4 different sources of dicalcium phosphate and 99.5, 84.0 and 101.5% , respectively, for the 3 different sources of tricalcium phosphate. The observation that two calcium sources appeared to be utilized with an unusual efficiency can hardly be explained at this moment. When they were revaluated on the basis of body weight gain, the availabilities of the four sources of dicalcium phosphate were 89.2, 58.2, 104.1 and 103.1% and of the three tricalcium phosphate were 112.6, 106.0 and 96.3% , respectively.

  • PDF

Aquatic Toxicity Assessment of Phosphate Compounds

  • Kim, Eunju;Yoo, Sunkyoung;Ro, Hee-Young;Han, Hye-Jin;Baek, Yong-Wook;Eom, Ig-Chun;Kim, Hyun-Mi;Kim, Pilje;Choi, Kyunghee
    • Environmental health and toxicology
    • /
    • v.28
    • /
    • pp.2.1-2.7
    • /
    • 2013
  • Objectives Tricalcium phosphate and calcium hydrogenorthophosphate are high production volume chemicals, mainly used as foodstuff additives, pharmaceuticals, lubricants, synthetic resin, and disinfectants. Phosphate has the potential to cause increased algal growth leading to eutrophication in the aquatic environment. However, there is no adequate information available on risk assessment or acute and chronic toxicity. The aim of this research is to evaluate the toxic potential of phosphate compounds in the aquatic environment. Methods An aquatic toxicity test of phosphate was conducted, and its physico-chemical properties were obtained from a database recommended in the Organization for Economic Cooperation and Development (OECD) guidance manual. An ecotoxicity test using fish, Daphnia, and algae was conducted by the good laboratory practice facility according to the OECD TG guidelines for testing of chemicals, to secure reliable data. Results The results of the ecotoxicity tests of tricalcium phosphate and calcium hydrogenorthophosphate are as follows: In an acute toxicity test with Oryzias latipes, 96 hr 50% lethal concentration ($LC_{50}$) was >100 (measured:>2.14) mg/L and >100 (measured: >13.5) mg/L, respectively. In the Daphnia test, 48 hr 50% effective concentration ($EC_{50}$) was >100 (measured: >5.35) mg/L and >100 (measured: >2.9) mg/L, respectively. In a growth inhibition test with Pseudokirchneriella subcapitata, 72 hr $EC_{50}$ was >100 (measured: >1.56) mg/L and >100 (measured: >4.4) mg/L, respectively. Conclusions Based on the results of the ecotoxicity test of phosphate using fish, Daphnia, and algae, $L(E)C_{50}$ was above 100 mg/L (nominal), indicating no toxicity. In general, the total phosphorus concentration including phosphate in rivers and lakes reaches levels of several ppm, suggesting that phosphate has no toxic effects. However, excessive inflow of phosphate into aquatic ecosystems has the potential to cause eutrophication due to algal growth.

Alterations of Gene Expression by Beta-tricalcium Phosphate in Osteoblast-like MG63 Cells

  • Jeon, Jae-Yun;Im, Tae-Yun;Jeon, Seung-Hwan;Hwang, Kyung-Gyun;Park, Chang-Joo
    • Maxillofacial Plastic and Reconstructive Surgery
    • /
    • v.33 no.4
    • /
    • pp.308-313
    • /
    • 2011
  • Purpose: Beta-tricalcium phosphate (${\beta}$-TCP) is a synthetic calcium phosphate ceramic that has widely been used as a bone material to repair bone defects. Despite many clinical studies, the molecular mechanism whereby this biomaterial alters the gene expression in osteoblasts to promote bone formation is poorly understood. Thus, we attempted to address this question by using microarray techniques to identify the genes that are differentially regulated in osteoblasts exposed to ${\beta}$-TCP. Methods: By using DNA microarrays, we identified several genes whose expression levels were significantly up- or down-regulated in osteoblast-likeMG-63cells cultured with ${\beta}$-TCP at a concentration of 100 mg/10 ml for 24 hours. Results: The differentially expressed genes covered a broad range of functional activities: signal transduction, transcription, cell cycle regulation, vesicular transport, apoptosis, immunity, cytoskeletal elements and cell proliferation and differentiation. Conclusion: The gene expression changes related to cell proliferation and differentiation, vesicle transport, immunity and defense could affect the osteogenic activities of osteoblasts for bone regeneration. However, further studies will be required to verify the relative importance of these genes in bone formation, their temporal and spatial expression patterns and their interactions with each other.