• Title, Summary, Keyword: acetaldehyde

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Studies on the Fixation of Acetaldehyde by Freeze Drying (냉동건조방법에 의한 Acetaldehyde 고정에 관한 연구)

  • Lee, Young-Chun;Lee, Kyung-Hae
    • Korean Journal of Food Science and Technology
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    • v.21 no.1
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    • pp.13-16
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    • 1989
  • Attempts were made to fix acetaldehyde on base materials, which were selected from carbohydrates, by freeze drying. More acetaldehyde was fixed, in general, on combined base materials than single base materials, and mannitol+lactose were the best among the combined base materials tested. But the combination of mannitol and maltodextrin appeared to be more economical for the mass production. Loss of acetaldehyde during freeze drying was decreased as the concentration of the combined base material was increased, and it reached minimum at 40% of the base material. As dryer chamber pressure was reduced, loss of acetaldehyde during drying was decreased.

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Effects of Antiiflammatory Agents on Acetaldehyde Induced Cytotoxicity (Acetaldehyde 유도 세포독성에 대한 항염증제의 영향)

  • 이수환;이병훈;김강석;문창규
    • Journal of Food Hygiene and Safety
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    • v.8 no.3
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    • pp.157-161
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    • 1993
  • In order to get infonnations on the development of alcohol induced cardiovascular disorders, primary cultured vascular smooth muscle cells (PVSMC) were treated with acetaldehyde, one of the most reactive metabolites of ethanol. Acetaldehyde caused the striking release of lactate dehydrogenase (LDH) from PVSMC and it stimulated the prostaglandin synthesis in the same system. But it didn't induce cyclooxygenase activity. lipoxygenase inhibitors-propyl gallate and nordihydroguaiaretic acid could reverse the effect of acetaldehyde, but dexamethasone, a phospholipase $A_2\;(PIA_2)$ inhibitor and cyclooxygenase inhibitors except indomethacin could not protect the cells from acetaldehyde toxicity. These results indicate that enhanced prostaglandin synthesis by acetaldehyde is not a direct cause of cell death, but secondary effect due to the activation of PIAl and also, the roles of the lipoxygenase metabolites and/or $PIA_2$ activity itself might be more important in the cytotoxicity of acetaldehyde.

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Improvement of Ethanol Yield by Addition of Acetic Acid and Acetatdehyde in Ethanol Fermentation (에탄올 발효에서 초산 및 아세트알데히드 첨가에 의한 에탄올 수율의 증진)

  • 김진현;여주상유영제
    • KSBB Journal
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    • v.10 no.4
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    • pp.370-373
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    • 1995
  • The major by-products in ethanol fermentation by Saccharomyces cerevisiae were glycerol, acetaldehyde, acetic acid, lactic acid, and formic acid. The effects of these by-products on the cell growth and ethanol production were studied. By adding acetaldehyde or acetic acid in the fermentation broth, the cell growth decreased while the ethanol production increased. But glycerol and lactic acid had nearly no effects on the cell growth and the ethanol production. Acetic acid and acetaldehyde inhibited the cell growth by diminishing the growth rate as well as by prolonging the lag phase. The ethanol yield increased with the elevation of concentrations of acetic acid and acetaldehyde in the fermentation broth. The maximum ethanol yield was obtained for $3g/\ell$ acetic acid and $2g/\ell$ acetaldehyde, respectively.

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Photocatalytic Degradation of Gaseous Acetaldehyde through TiO2-Coated Fly Ash Composites (TiO2 코팅 석탄회 복합체의 기상 Acetaldehyde 광분해 특성)

  • Shin, Dae-Yong;Kim, Kyung-Nam
    • Journal of the Korean Ceramic Society
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    • v.45 no.1
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    • pp.43-47
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    • 2008
  • The photocatalyst of $TiO_2$ coated on a fly ash composites (TCF) was prepared from precipitant dropping method to remove the acetaldehyde by photocatalytic reaction. The TCF were characterized by crystal aize, crystal structure and specific surface area. The photodegradation of acetaldehyde has been investigated using a UV-illuminated fixed photocatalytic reactor with TCF catalyst and P-25 catalyst in gas phase. The effect of photodegradation reaction conditions, such as initial concentration of acetaldehyde, concentration of oxidant in mixed gas and the light intensity on the photodegradation of acetaldehyde were investigated. P-25 catalyst showed the highest photodegradation of acetaldehyde and anatase $TiO_2$ coated TCF showed higher decomposition rate than rutile coated TCF. The photodegradation rate of acetaldehyde increased with the decrease of flow rate, initial concentration of acetaldehyde ($C_i$) and water vapor, however, it was increased with the increas of UV light intensity. The optimum conditions were weight of TCF=10 g, flow rate=50 ml/min $C_i$=100 ppm, concentration of oxygen=20%, concentration of water vapor=100 ppm.

Preventive Effect of Ginseng Butanol Fraction against Acetaldehyde - Induced Acute Toxicity (아세트알데히드로 유도된 급성독성에 대한 인삼부탄올 분획의 방어작용)

  • Keun Huh;Tae
    • Journal of Ginseng Research
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    • v.13 no.1
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    • pp.5-7
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    • 1989
  • The objective of this study was to investigate the preventive effect of ginseng on acetaldehyde-induced acute toxicity in mice . Compared to the control group, treatment with acetaldehyde inhibited the hepatic cytosolic xanthine oxidise activity with increase in dose. The inhibition of enzyme activity was not changed after dialysis. Pretreatment with ginseng butanol fraction prevented the inhibition of enzyme activity by acetaldehyde. In conjunction with the our previous results (Yakhak Hoeji, 29, 18 (1985)), these results suggest that the most likely mechanism for the observed preventive effects of ginseng against the acetaldehyde-induced acute toxicity may be the decrease hepatic acetaldehyde level.

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Effect of Water Extract from Artemisiae Argi Folium on Hepatotoxicity Caused by Acetaminophen and Acetaldehyde (Acetaminophen과 Acetaldehyde로 유발된 간세포독성에 대한 애엽 물추출물의 영향)

  • Park, Wan-Su
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.5
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    • pp.1210-1214
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    • 2008
  • The purpose of this study is to investigate the effect of water extract from Artemisiae Argi Folium (WAAF) on hepatotoxicity caused by acetaminophen (AAP) and acetaldehyde which are regarded as hepatotoxin. Artemisiae Argi Folium was known to have the antibacterial, immune-enhancing, and anticoagulative properties. In Korean Medicine, Artemisiae Argi Folium is supposed to be related with 'liver meridian' according to traditional medical theory. AAP and acetaldehyde reduce the intracellular production of hydrogen peroxide ($H_2O_2$) and nitric oxide (NO) production of human hepatocyte HepG2. The intracellular production of hydrogen peroxide ($H_2O_2$) was measured by dihydrorhodamine 123 (DHR) assay. NO production was measured with Griess test. WAAF increased the production of $H_2O_2$ and NO reduced by AAP and acetaldehyde in HepG2 cells. Therefore, It could be suggested that WAAF has the hepatoprotective activity against AAP and acetaldehyde.

Effects of Malotilate on Levels of Ethanol and Acetaldehyde in Blood (혈중 Ethanol 및 Acetaldehyde의 농도에 미치는 Malotilate의 영향)

  • 허인회;이상준;주왕기;허문영;김형춘;송계용
    • YAKHAK HOEJI
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    • v.31 no.6
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    • pp.399-401
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    • 1987
  • A gas chromatographic utilizing procedure headspace gas analysis is performed to study effect of malotilate on levels of ethanol and its metabolite acetaldehyde in a blood sample from the rat. The concentrations of ethanol and acetaldehyde were determined simultaneously at 1, 3, and 6h after ethanol administration. Our results would suggest the malotilate could promote clearances of ethanol and acetaldehyde in blood, and could accelerate it, especially, in $CCl_4$ pretreated rats.

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Ethanol-induced Activiationof Transcription Factor NF-$\kappa$B and AP-1 in C6 Glial Cells

  • Park, Jae -Won;Shim, Young-Sup
    • Preventive Nutrition and Food Science
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    • v.4 no.3
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    • pp.209-214
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    • 1999
  • In this study, the effectof ethanol and acetaldehyde on DNA binding activities of NF-$textsc{k}$B and AP-1 were evaluated in C6 rat glial cells. Both NF-$textsc{k}$B and AP-1 are important transcription factors for the expression of various cytokines in glial cells. Our data showed that neither ethanol nor acetaldehyde induced conspicuous cell death of C6 cells at clinically realistic concentrations. When the DNA binding activities of nuclear NF-$textsc{k}$B and AP-1 were estimated using electrophoretic mobility shift assay (EMSA), ethanol(0.3%) or acetaldehyde(1mM) induced transient activation of these transcription factors, which attained peak levels at 4~8 hours and declined to basal levels at 12 hours after treatement . The supershift analysis showed that the increased activities of NF-$textsc{k}$B in ethanol/acetaldehyde-treated C6 cells were due to the preferential induction of p65/p50 heterodimer complex. The DNA binding activities of these transcriptional factors decreased below basal levels when cells were cultured with either ethanol or acetaldehyde for 24 hours, and showed the inhibitory effect of chronic ehtanol /acetaldehyde treatment on the activities of these transsriptional factors. Our data indicate that either ethanol or acetaldehyde can induce functional changes of glial cells throught bi-directional modulation of NF-$textsc{k}$B and AP-1 DNA binding activities.

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Studies on the Utilization of Persimmons(Part 4)-On the Changes of Acetaldehyde, Alcohol and Tannin During the Removal of Astringency by Carton Dioxide- (감의 이용(利用)에 관(關)한 연구(硏究) 제4보(第四報) -$CO_2$탈삽처리중(脫澁處理中) Acetaldehyde, Alcohol 및 Tannin의 변화(變化)에 대(對)하여-)

  • Choi, Joung-Uck;Sohn, Tae-Hwa
    • Applied Biological Chemistry
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    • v.20 no.1
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    • pp.105-108
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    • 1977
  • The changes of the contents of acetaldheyde and alcohol in Chungdo Bansi was determined during the removal of astringency by treatment of $CO_2$. On the other hand, the difference of acetaldehyde and alcohol contents were determined to comparedits contents in the part of Chungdo Bansi and Buju, respectively. It showed that the variation of acetaldehyde and alchohol contents was higher 10 times non-astringent persimmon than astringent one, and acetaldehyde and alcohol contents in the core of non-astringent persimmon and sweep one were the higher than the other parts. It was assumed that acetaldehyde and ethanol contents had intimately relation to removal of astringency.

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In vitro inhibition of 10-formyltetrahydrofolate dehydrogenase activity by acetaldehyde

  • Mun, Ju-Ae;Doh, Eun-Jin;Min, Hye-Sun
    • Nutrition Research and Practice
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    • v.2 no.4
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    • pp.195-199
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    • 2008
  • Alcoholism has been associated with folate deficiency in humans and laboratory animals. Previous study showed that ethanol feeding reduces the dehydrogenase and hydrolase activity of 10-formyltetrahydrofolate dehydrogenase (FDH) in rat liver. Hepatic ethanol metabolism generates acetaldehyde and acetate. The mechanisms by which ethanol and its metabolites produce toxicity within the liver cells are unknown. We purified FDH from rat liver and investigated the effect of ethanol, acetaldehyde and acetate on the enzyme in vitro. Hepatic FDH activity was not reduced by ethanol or acetate directly. However, acetaldehyde was observed to reduce the dehydrogenase activity of FDH in a dose- and time-dependent manner with an apparent $IC_{50}$ of 4 mM, while the hydrolase activity of FDH was not affected by acetaldehyde in vitro. These results suggest that the inhibition of hepatic FDH dehydrogenase activity induced by acetadehyde may play a role in ethanol toxicity.