• Title/Summary/Keyword: antibacterial action

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Antibacterial Activities of Nonactin from streptomyces viridochromogenes JM-4151

  • Lee, Jin-Man;Lee, Dong-Sun;Lee, Sang-Han;Hong, Soon-Duck;Kim, Jong-Guk
    • Journal of Life Science
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    • v.10 no.1
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    • pp.45-47
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    • 2000
  • Nonactin, known as an ionophore antibiotic, was antagonized by the actibity of quercetin, an oxygen radical scavenger. This compound generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. These results suggest that superoxide radical is important in the antibacterial action of this agent.

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Studies on the synthesis and antibacterial action of 2-(5-nitro) furylacrylamino acid (2-(5-nitro)furylacrylamino acid류의 합성및 항균작용에 관한 연구)

  • 고현기
    • YAKHAK HOEJI
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    • v.10 no.2_3
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    • pp.15-19
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    • 1966
  • In order to find 2-(5-nitro)furylacrylic acid derivatives possessing antimicrobial activity, nine new 2-(5-nitro)furylacrylamino acids were synthesized which were obtained by the action of 2-(5-nitro)furylacryla chloride on amino acids, such as $_{L}$-phenylalanine, glycine, $_{L}$-isoleucine, $_{L}$-glutamic acid, $_{DL}$-methionine, $_{L}$-threonine, $_{L}$-valine, $_{L}$-tryptophan and $_{DL}$-alanine, according to Schotten-Baumann method. These compounds generally showed a good bactericidal and bacteriostatic activity against Bacillus subtilis but were less effective against staphylococcus aureus, Proteus vulgaris and Escherichia coli. Of the above nine compounds, 2-(5-nitro)furylacryl glycine exhibited a good bactericidal activity.

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Electron Microscopic Studies on Antibacterial Action of Ulmus pumila L. Extract (유백피 추출물의 항세균 작용에 대한 전자현미경적 연구)

  • Sung, Tae-Kyung;Lee, Heung-Yong;Kim, Chi-Kyung
    • Applied Microscopy
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    • v.22 no.1
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    • pp.70-78
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    • 1992
  • Antibacterial effects of the water-soluble extract of Ulmus pumila L. on Staphylococcus aureus and Escherichia coli were studied by cylinder plate dilution method. The cells of S. aureus and E. coli treated with the extract were comparatively examined by scanning and transmission electron microscopies for their morphological features. The normal cells of S. aureus and E. coli showed thypical coccus and rod shapes, respectively, but the cells of S. aureus treated with the extract showed rough surface structures with many granular protrusions and were destroyed to form ghost cells by liberating their cytoplasmic components. E. coli cells treated with the extract were destoryed without enlarging in size and producing granules on their surfaces.

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The effectiveness of controlled release device against E. faecalis : in vitro study

  • Hong, Sang-Hee;Yoo, Yoon-Jung;Lee, Seung-Jong;Kum, Kee-Yeon
    • Proceedings of the KACD Conference
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    • 2003.11a
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    • pp.560-560
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    • 2003
  • I. Objectives Intracanal medicament with antibacterial action is required to maximize the disinfection of the root canal system. The purpose of this study was to evaluate the efficacy of 2% chlorhexidine digluconate(CHX) and controlled release device(CRD) containing 20% CHX and chitosan coating, compared to calcium hydroxide as intracanal medicament against E. faecalis. II. Materials and Methods One hundred and twenty intact freshly extracted bovine incisors were used and were 0.5% NaOCl. Middle 1/3 portion of roots were sliced into 4mm thick section and cementum was removed using diamond burs and external diameter was approximally 6mm.(omitted)

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Production of Antibacterial Violet Pigment by Psychrotropic Bacterium RT102 Strain

  • Nakamura, Yoshitoshi;Asada, Chikako;Sawada, Tatsuro
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.8 no.1
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    • pp.37-40
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    • 2003
  • The antibacterial action of violet pigment, a mixture of violacein and deoxyviolacein, isolated from phychrotrophic bacterium RT102 strain was examined, and the operational conditions for the effective production of violet pigment were studied. The antibacterial activity of the violet pigment was confirmed for several bacteria such as Bacillus licheniformis, Bacillus subtilis, Bacillus megaterium, Staphylococcus aureus, and Pseudomonas aeruginosa, and the high concentration of violet pigment, above about 15mg/L, caused not only growth inhibition but also death of cells. The growth properties of RT102 strain were clarified under various incubation conditions such as pH, temperature, and dissolved oxygen concentration. The maximum violet pigment concentration, i.e. 3.7 g/L, and the maximum productivity of violet pigment, i.e. 0.12 g .L$\^$-1/H$\^$-1/, were obtained in a batch culture of pH 6, 20$^{\circ}C$, and 1 mg/L of dissolved oxygen concentration.

Anticariogenic activity of piceatannol isolated from Callistemon citrinus fruit against Streptococcus mutans

  • Park, Young-Ki;Lee, Moon-Ho
    • Korean Journal of Plant Resources
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    • v.21 no.6
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    • pp.431-434
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    • 2008
  • Dental caries is the destruction of the enamel of teeth by Streptoccus mutans. S. mutans has been isolated from human dental plaque and is associated with the initial development of enamel lesions. We have studied the antibacterial action of the fruit of Callistemon citrin us against a cariogenic bacterium, S. mutans. From the fruit of C. citrinus, piceatannol (3,3',4',5-tetrahydroxystilbene) was isolated by repeated column chromatography with $SiO_2$ and Sephadex LH-20. Its structure was elucidated by instrumental analysis using 1D-NMR, 2D-NMR and EI-MS. This compound was isolated from the fruit of C. citrin us for the first time. The anticarcinogenic activity of this compound was determined by using agar well-diffusion method and minimal inhibition concentration (MIC).

Systemic Analysis of Antibacterial and Pharmacological Functions of Anisi Stellati Fructus (대회향의 시스템 약리학적 분석과 항균작용)

  • Han, Jeong A;Choo, Ji Eun;Shon, Jee Won;Kim, Youn Sook;Suh, Su Yeon;An, Won Gun
    • Journal of Life Science
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    • v.29 no.2
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    • pp.181-190
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    • 2019
  • The purpose of this study was to acquire the active compounds of Anisi stellati fructus (ASF) and to analyze the genes and diseases it targets, focusing on its antibacterial effects using a system pharmacological analysis approach. Active compounds of ASF were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. This contains the pharmacokinetic properties of active compounds and related drug-target-disease networks, which is a breakthrough in silico approach possible at the network level. Gene information of targets was gathered from the UnitProt Database, and gene ontology analysis was performed using the David 6.8 Gene Functional Classification Tool. A total of 201 target genes were collected, which corresponded to the nine screened active compounds, and 47 genes were found to act on biological processes related to antimicrobial activity. The representative active compounds involved in antibacterial action were luteolin, kaempferol, and quercetin. Among their targets, Chemokine ligand2, Interleukin-10, Interleukin-6, and Tumor Necrosis Factor were associated with more than three antimicrobial biological processes. This study has provided accurate evidence while saving time and effort to select future laboratory research materials. The data obtained has provided important data for infection prevention and treatment strategies.

Studies on the Drug Resources of Caryophyllaceae Plants -Free amino acids and antimicrobial activity- (석죽과식물(石竹科植物)의 의약자원(醫藥資源)에 관(關)한 연구(硏究) -유리(遊離)아미노산(酸)과 항균작용(抗菌作用)-)

  • Chung, Dong-Kyu;Kim, Tae-Hee;Kim, Mong-Ja
    • Korean Journal of Pharmacognosy
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    • v.9 no.2
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    • pp.77-82
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    • 1978
  • Free anino acid contents in alcohol extract of eight plants of Caryophyllaceae and their microbial activities were investigated. 1) Amino acid contents in both of the Pseudostellaria palibiniana and Stellaria media was the highest among them and the contents was less in the order of Cerastium caspitosum and Stellaria aquatica. 2) Of all free amino acids contained in eight plants, valine was the richest, and then glutamic acid, leucine in that order. On the other hand, no methionine was observed and cystine, lysine and histidine were found in small amounts. 3) Of eight plants exhibited good antibacterial action against Sarcina lutea, B. subtilis and Sal. typhi. 4) S.aquatica and Pseudostellaria palibiniana showed antibiotic actions against all bacteria except for fungus, Candida albicans. 5) C. caspitosum and C. brachypetalum showed inhibition zone against B. subtilis and Sal. typhi only. 6) Antibacterial activity against gram(+) bacteria was more potent than gram(-).

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Pharmaceutical Study on Zinc Sulfadiazine Ointments (Zinc Sulfadiazine 연고제(軟膏劑)의 제제학적(製劑學的) 연구(硏究))

  • Lee, Myung-Yuen;Jee, Ung-Kil;Kim, Yang-Su
    • Journal of Pharmaceutical Investigation
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    • v.12 no.1
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    • pp.1-11
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    • 1982
  • Silver sulfadiazine has been introduced to replace silver nitrate in the topical treatment of extensive burns and this drug exerts a prominent antibacterial action against Pseudomonas aeruginosa. The compound is painless upon application and insufficient sulfadiazine is absorbed to cause crystalluria. The primary purpose of the study was to clarify the antimicrobial action of zinc sulfadiazine ointment in comparison with silver sulfadiazine ointment as well as the pharmaceutical properties of the zinc sulfadiazine preparations. The results are summerized as followings: 1) The optimum ratio of two substrate compounds for the synthesis of zinc sulfadiazine are 2 moles of sulfadiazine and 1 mole of zinc sulfate at pH 6.0. 2) The stability of zinc sulfadiazine ointment preparation by using polyethylene glycol base, Beeler's base or polyoxyl 40 stearate base was more stable than that of silver sulfadiazine preparations. 3) The antimicrobial action of zinc sulfadiazine exhibits a stronger antimicrobial activity than that of sulfadiazine against Staphylococcus aureus but the opposite is true against Pseudomonas aeruginosa.

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The Antibacterial Action of Garlic, Onion, Ginger and Red Pepper Juice (마늘, 양파, 생강, 고추즙의 항균작용)

  • 서화중
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.1
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    • pp.94-99
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    • 1999
  • This study was carried out to determine the inhibitory effect of juice of garlic, onion, ginger and red pepper against Staphylococcus aureus, Salmonella enteritidis, Vibrio parahaemolyticus and Enterobacter cloacae which are food born disease organisms. It was found that 1~2.5%(wt/vol.) garlic juice showed strong antimicrobial action against growth of all test bacteria at 1/20$\times$10-6 dilution. Especially 1% garlic juice completly inactivated Vibrio parahaemolyticus but approximately 71.9~88% of reduction at same concentration in other bacteria was occurred. 2.5% onion juice had 28.5% antimicrobial activity on Sal. enteritidis, but 50% reduction was occurred on St.aureus and V. parahaemolyticus at same concentration. Antibacterial activity of ginger juice was similar to that of onion juice. 2.5% ginger juice showed approximately 50% reduction on Sal. enteritidis and V.parahaemolyticus, but less antimicrobial activity was occured on St. aureus and E. cloacae. Red pepper juice showed the least antimicrobial activity on food born disease organism compared to that of other juices. 2.5% red pepper juice showed 11.3%, 18.7% and 8.1% reduction on St. aureus, Sal. enteritidis and V.parahaemolyticus, respectively.

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