• Title, Summary, Keyword: antihyperlipidemic

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Studies on the Development of Antihyperlipidemic Drugs from Oriental Herbal Medicines(II) - Antihyperlipidemic Effects of Oriental Herbal Medicines - (한방약물로부터 항고지혈증 치료약물개발(2) - 수종 한약재의 항고지혈증 효과 -)

  • Jung, Eun-Ah;Kim, Dong-Hyun;Lee, Sang-In;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.31 no.2
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    • pp.190-195
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    • 2000
  • In the previous reports, we selected 80% MeOH extract of 7 herbs including Scutellariae Radix(SR), Paeoniae Radix Rubra(PRR), Moutan Cortex(MC), Angelicae Gigantis Radix(AGR), Crataegi Fructus(CF), Bambusae Caulis in Taeniam(BCT) and Cinnamomi Ramulus(CR), which exhibited the inhibitory effect on HMG-CoA reductase and DPPH free radical scavenging effect in vitro, and antihyperlipidemic effects on antihyperlipidemic rats induced by Triton WR 1339 in vivo. Among them, SR, MC, AGR and BCT showed significant suppression of elevated serum LDL-cholesterol level, and AGR and CF showed significant liver weight increase on high cholesterol diet induced hyperlipidemic mice. And, SR, PRR, AGR, BCT and CR significantly suppressed the elevated serum total cholesterol and triglyceride levels on corn oil induced hyperlipidemic rats. Then, in order to research new antihyperlipidemic agents from the oriental medicinal herbs, we chose SR, AGR, CR and BCT which have the antihyperlipidemic effect in vitro and in vivo, and those herbs were systematically fractionated with organic solvent. EtOAc fraction of SR, hexane fraction of BCT, AGR and chloroform fraction of CR exhibited remarkably inhibitory effect on HMG-CoA reductase activity.

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Rhei Rhizoma and Chunghyuldan Inhibit Pancreatic Lipase

  • Yang, Hyung-Kil;Kim, Young-Suk;Bae, Hyung-Sup;Cho, Ki-Ho;Shin, Ji-Eun;Kim, Nam-Jae;Kim, Dong-Hyun
    • Natural Product Sciences
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    • v.9 no.1
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    • pp.38-43
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    • 2003
  • Pancreatic lipase-inhibitory activity of the rhizome of Rhei Rhizoma and its antihyperlipidemic activity were measured. Rhei Rhizoma inhibited pancreatic lipase with $IC_{50}$ value of 6.5 mg/ml (triolein as a substrate). Rhei Rhizoma significantly inhibited serum TG level in corn oil feeding-induced mice, and serum TG and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, Rhei Rhizoma did not show the hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. When in vitro pancreatic lipase-inhibitory and in vivo antihyperlipidemic activities of Whangryunhaedoktang (WT) and Chunghyuldan (CD), which is consisted of ingredients of WT and Rhei Rhizoma, were measured, CD exhibited more potent inhibitory activities than WT. Therefore these results suggest that antihyperlipidemic activity of Rhei Rhizoma and CD may be more or less originated from the inhibition of pancreatic lipase.

Study for Trends of Antihyperlipidemic Studies using Herbal Plants (생약재를 이용한 고지혈증 치료의 연구 동향 고찰)

  • Choi, Seong-Hwan;Son, Chang-Gue;Kim, Jin-Mi;Seol, In-Chan
    • The Journal of Internal Korean Medicine
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    • v.31 no.3
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    • pp.448-456
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    • 2010
  • Objective : To summarize and make a reference number of antihyperlipidemic herbal plants worldwide. Method : We surveyed all papers of antihyperlipidemic studies using herbal plants in Pubmed database as "hyperlipidemia AND herb", "hyperlipidemia AND herbal", etc. of Default Tag "Title". The number of papers, the formation of experiments, frequency of herbal plants studies, and main studies were analyzed. Result : Total 178 studies were finally selected. The number of papers were rapidly was increased since 1998. RCT studies were most papers(39.9%). Most studies were about plant sterol or plant stanol studies(78%). 10 papers studied about Herbal plants. Crataegus pinnatifida Bunge, Salvia miltiorrhiza Bunge, Alisma orientale(Sam.) Juz. and so forth were relatively studied much. Conclusion : This study produced an overview of worldwide antihyperlipidemic plants. This result may provide a valuable information for development of Korean herbal medicine against hyperlipidemia in the future.

Antihyperlipidemic effects of alcoholic extract of Pongamia pinnata Linn. leaves on high fat diet fed rats

  • Tenpe, CR;Mane, G;Upaganlawar, AB;Ghule, BV;Yeole, PG
    • Oriental Pharmacy and Experimental Medicine
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    • v.8 no.3
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    • pp.311-315
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    • 2008
  • The objective of the study was to investigate the antihyperlipidemic activity of alcoholic extract of Pongamia pinnata Linn. (PPAE) leaves in rats fed with high fat diet (HFD). PPAE was administered orally in the divided doses of 250 and 500 mg/kg/day for 30 days in HFD fed rats. Body weights were observed and the analysis of serum lipid profile was carried out on day 30. Marked decrease in the body weight, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) whereas significant increase in the levels of high density lipoprotein (HDL) were observed after treatment with PPAE. However, PPAE in a dose of 250 mg/kg did not show significant (P < 0.05) increase in HDL levels. The PPAE also lowered TC: HDL-c and LDL: HDL-c ratios significantly suggesting it's antihyperlipidemic and cardioprotective potential. The present work reveals that PPAE at the dose of 500 mg/kg/day exhibited significant (P < 0.01) antihyperlipidemic effects.

Studies on the Development of Antihyperlipidemic Drugs from Oriental Herbal Medicines(I) -Antihyperlipidemic Activities of Oriental Herbal Medicines- (한방약물로부터 항고지혈증 치료약물개발(I) -수종 한약재의 항고지혈증 활성검색-)

  • Jung, Eun-Ah;Kim, Dong-Hyun;Lee, Sang-In;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.30 no.4
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    • pp.368-376
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    • 1999
  • Twenty-four Oriental herbal medicines including Platycodi Radix and Scutellariae Radix, etc., which have been used for the cure of hyperlipidemia, coronary heart, disease were evaluated for the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibition and antioxidant effect on a free radical, 1,1-diphenyl-2-picrylhydrazyl(DPPH) in vitro, and antihyperlipidemic effect on hyperlipidemic rats induced by Triton WR-1339 in vivo. 80% MeOH extract of eight herbs including Scutellariae Radix, Coptidis Rhizoma, Paeoniae Radix Rubra, Moutan Cortex Radicis, Angelicae Gigantis Radix, Bambusae Caulis in Taeniam, Cinnamomi Ramulus and Crataegi Fructus inhibited the HMG-CoA reductase activities and exhibited a radical-trapping action on a stable free radical, DPPH. On Triton WR-1339-induced hyperlipidemic rats, four herbs including Scutellariae Radix, Angelicae Gigantis Radix, Bambusae Caulis in Taeniam and Cinnamomi Ramulus showed respectively the significant suppression of serum total cholesterol, triglyceride, phospholipid and LDL-cholesterol levels and serum transaminase(ALT and AST) activities. From these results, it is suggested that each 80% MeOH extract of Scutellariae Radix, Angelicae Gigantis Radix, Bambusae Caulis in Taeniam and Cinnamomi Ramulus have effective antihyperlipidemic action against hyperlipidemia.

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Effect of Ichnocarpus frutescens extract on antihyperglycemic, antihyperlipidemic and antioxidant status in streptozotocin-induced diabetic rats

  • Dash, Deepak K;Ghosh, Tirtha;Yeligar, Veerendra C;Murugesh, K;Nayak, Siva S;Maiti, Bhim C;Maity, Tapan K
    • Oriental Pharmacy and Experimental Medicine
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    • v.7 no.3
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    • pp.244-253
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    • 2007
  • The present study was carried out to investigate the antihyperglycemic, antihyperlipidemic and antioxidant effect of chloroform and methanol extract of whole plant of Ichnocarpus frutescens (CEIF and MEIF) in streptozotocin (STZ)-induced diabetic rats. Administration of CEIF and MEIF orally at the dose of 200 mg/kg and 400 mg/kg body weight resulted in significant (P<0.01) reduction in blood glucose levels. The body weights were significantly (P<0.001) reduced in STZ-induced diabetic rats when compared to normal rats while the extracts significantly (P<0.01) prevented the decrease in body weight in the CEIF and MEIF treated rats. The study was further undertaken to evaluate the antioxidant and antihyperlipidemic potential of CEIF and MEIF in STZ-induced diabetic rats. The increased levels of lipid peroxidation in the liver tissues of diabetic rats were significantly reverted back to normal levels and a significant increase in activity of antioxidant enzymes such as superoxide dismutase, catalase and the level of reduced glutathione in the liver of diabetic rats after the treatment with CEIF and MEIF was noticed. These results clearly indicate that CEIF and MEIF exhibit significant antihyperglycemic, antihyperlipidemic and in vivo antioxidant activity in STZ-induced diabetic rats and the results were found to be in a dose dependent manner.

Antihyperlipidemic effect of Alpinia oficinarum

  • Shin, Ji-Eun;Han, Myung-Joo;Ma, Eun-Mi;Kim, Dong-Hyun;Baek , Nam-In
    • Proceedings of the PSK Conference
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    • pp.334.2-334
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    • 2002
  • As the part of our continuing study for antihyperlipidemic agents from the herbal medicinal resources. we examined the possibility of the ethylacetate fraction of Alpinia officinarum water extract in vitro and in vivo. We isolated some compounds from the ethylacetate fraction of Alpinia officinarum and measured their antihyperlipidemic activities. The active components isolated by silicagel column lmproved serum TG. HDL and LDL level in corn oil feeding and triton WR-1339 induced hyperlipidemic mice. The most active compound was 3-Methylethergalangin. Consequently. these biologically active gerbal functional foods could be used for preparing the healthy food which might diabetas. hyperlipidemia and other disease.

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Antihyperlipidemic Effects of Bupleuri Radix, padix and Uncariae Ramulus et Uncus on Experimental Hyperlipidemia in rats (고지혈증 랫트를 이용한 시호, 작약, 조구등의 항고지혈 효과)

  • 노환성;고우경;박건구;조영환;박형섭
    • Biomolecules & Therapeutics
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    • v.5 no.1
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    • pp.43-47
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    • 1997
  • Effects of Bupleuri Radix, Paeonie Radix or Uncariae Ramulus et rncus on experimental yperlipidemia were studied. Hyperlipidemia was induced on male Wistar rats by feeding them on high holesterol diet for one week, as previously described by the authors. Blood lipid profile was verified on these ats by measuring total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL) and low ensity lipoprotein cholesterol(LDL). Then, the rats were followed by feeding normal diet. At the same time, ethanol extracts of the three individual herb medicines were orally administered to the rats for 4 weeks and the parameters above mentioned were monitored. Methanol extract of 5Bupleuri radix reduced the TC value significantly at 2 week point and Paeoneae Radix reduced the TC value at 4 week point in compare to control group, suggesting the antihyperlipidemic effect of the two herbal medicines in vivo. The extract of Uncariae Ramulus et Uncus however did not show antihyperlipidemic effect in our experiment.

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Antihyperlipidemic and antioxidant effects of Samhwangsasimtang aqua-acupuncture (삼황사심탕약침의 지질강하 및 항산화효과)

  • Lee, Eun;Lee, Joon-Moo
    • Journal of Pharmacopuncture
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    • v.8 no.1
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    • pp.51-57
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    • 2005
  • Effects of Samhwangsasimtang aqua-acupuncture at gansoo($B_{18}$) and chungwan($CV_{12}$) on antihyperlipidemic and antioxidant were investigated in rat fed high fat diet. Concentrations of triglyceride, free fatty acids, lipoprotein and glucose in plasma showed a tendency to decrease in the aqua-acupuncture groups. In plasma lipid composition, total cholesterol and LDL- cholesterol showed a tendency to decrease in aqua-acupuncture groups, however the values of HDL-cholesterol showed no significantly different in the treatment groups. Concentration of thiobarbituric acid reactive substances(TBARS) in plasma and liver showed a low in the aqua-acupuncture groups. The values of glutathione peroxidase(GSH-Px) and catalase(CAT) activity showed a tendency to increase in aqua-acupuncture groups. However the values of superoxide dismutase(SOD) activity showed no significantly different in the treatment groups.