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The effects of Bee Venom and Sweet Bee Venom to the preadipocyte proliferation and lipolysis of adipocyte, localized fat accumulation (Bee Venom과 Sweet Bee Venom이 지방세포 대사에 미치는 영향)

  • Kim, Min-Ki;Lee, Si-Hyeong;Shin, Jo-Young;Kim, Kang-San;Cho, Nam-Guen;Rhim, Tae-Jin;Kwon, Ki-Rok
    • Journal of Pharmacopuncture
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    • v.10 no.3
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    • pp.5-19
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    • 2007
  • Objectives The purpose of this study was to investigate the effects of Bee Venom and Sweet Bee Venom to the primary cultured preadipocyte, adipocytes, and localized fat tissue. Methods Decreased preadipocyte proliferation and decreased lipogenesis are mechanisms to reduce obesity. So, preadipocytes and adipocytes were performed on cell cultures using Sprague-Dawley Rats and treated with 0.01-1mg/ml Bee Venom and Sweet Bee Venom. And porcine skin including fat tissue after treated Bee Venom and Sweet Bee Venom according to the dosage dependent variation are investigated the histologic changes after injection of these Pharmacopuncture. Result Following results were obtained from the preadipocyte proliferation and lipolysis of adipocyte and histologic investigation of fat tissue. 1. Bee Venom and Sweet Bee Venom showed the effect of decreased preadipocyte proliferation depend on concentration. 2. Bee Venom and Sweet Bee Venom showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) significantly. 3. Bee Venom was not showed the effect of lipolysis, but Sweet Bee Venom was increased in low dosage and decreased in high dosage. 4. Investigated the histologic changes in porcine fat tissue after treated Bee Venom and Sweet Bee Venom, we knew that these Pharmacopuncture was activated nonspecific lysis of cell membranes depend on concentration. Conclusion These results suggest that Bee Venom and Sweet Bee Venom efficiently induces decreased proliferation of preadipocyte and lipolysis in adipose tissue.

Review of article about bee venom and arthritis (관절염(關節炎) 관련 봉독(蜂毒) 연구에 대한 문헌적 고찰)

  • Cho, Nam-hun;Kang, Sung-keel;Lee, Jae-dong
    • Journal of Acupuncture Research
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    • v.20 no.6
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    • pp.13-26
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    • 2003
  • Background and Objectives: Bee venom therapy is a new acupuncture theraphy using both acupuncture effect and a medical effect that the biochemical peculiar material affects body. The bee venom theraphy is efficacious of injecting region of disease and acupoint with extracting bee venom from bee and processing it. There have been more than 20 dissertations in Korea about bee venom and the bee venom research has actively been carrying done in other countries such as US, China, Russia, Northern Europe since 1980s. This paper is to understand the trend of arthritis and bee venom, and will be contributed to further bee venom study by analyzing local and international theses. Material and Method: This paper is reported by analyzing the dissertations regarding arthritis and bee venom of Korea and other countries and referencing PubMed. The reference terminology is as follows. bee venom, bee venom therapy, apitoxin, apitherapy, bee sting, bee sing therapy, arthritis, rheumatoid, rheumatic arthritis and so on. Results and Conclusions: The following result have been obtained. 1. Bee venom has an effect on both in vivio and in vitro of arthritisthis with suppressing inflammation, fever and pain. 2. Occasionally bee venom may induce either pain or inflammation. 3. Bee venom induces acute pain in healthy condition, while it suppresses inflammation and pain in regional inflammation state. 4. Bee venom may either induce or suppress pain and inflammation according to the used dosage.

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봉독과 Sweet Bee Venom의 항균 및 항산화능 비교연구

  • An, Joong-Chul;Kwon, Ki-Rok;Lee, Seong-Bae;Lim, Tae-Jin
    • Journal of Pharmacopuncture
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    • v.9 no.3
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    • pp.97-104
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    • 2006
  • Objectives : This study was conducted to compare antibacterial activities and free radical scavenging activity between the Bee Venom and Sweet Bee Venom in which the allergy-causing enzyme is removed. Methods : To evaluate antibacterial activities of the test samples, gram negative E. coli and gram positive St. aureus were compared using the paper disc method. For comparison of the antioxidant effects, DPPH(1,1-diphenyl-2picrylhydrazyl) free radical scavenging assay and Thiobarbituric Acid Reactive Substances(TBARS) assay were conducted. Results : 1. Antibacterial activity against gram negative E. coli was greater in the Sweet Bee Venom group than the Bee Venom group. 2. Antibacterial activity against gram positive St. aureus was similar between the Bee Venom and Sweet Bee Venom groups. 3. DPPH free radical scavenging activity of the Bee Venom group showed 2.8 times stronger than that of the Sweet Bee Venom group. 4. Inhibition of lipid peroxidation of the Bee Venom group showed 782 times greater than that of the Sweet Bee Venom group. Conclusions : The Bee Venom group showed outstanding antibacterial activity against gram positive St. aureus, and allergen-removed Sweet Bee Venom group showed outstanding antibacterial activity against both gram negative E. coli and gram positive St. aureus. For antioxidant effects, the Bee Venom was superior over the Sweet Bee Venom and the superiority was far more apparent for lipid peroxidation.

봉약침(Bee Venom)과 Sweet Bee Venom의 Allergy 반응에 대한 비교연구

  • Lee, Jin-Seon;Lee, Jong-Young;Kwon, Ki-Rok;Lee, Hee-Choon
    • Journal of Pharmacopuncture
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    • v.9 no.3
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    • pp.61-77
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    • 2006
  • Objectives : Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom in which the allergy causing enzyme is removed. Methods : 95 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of bee venom pharmacopuncture and Sweet BV pharmacopuncture was equally at 0.1mg/ml and the experiment was conducted as the double blind test. Experiment groups were classified into low dosage groups(0.1ml for both bee venom pharmacopuncture and Sweet BV) and high dosage groups where 0.4ml of respective administrations were rendered made observations for allergic responses. Results : Participants of the study was comprised of 71 men and 24 women with the average age of 29.0 years. According to results of the low dosage groups, Sweet BV group showed significant reduction in pain after 4 hours and 24 hours compared to the bee venom pharmacopuncture group. Other allergic responses were insignificant between the groups. For the high dosage groups, Sweet bee venom group showed reduction in pain after 30 minutes and 4 hours. Other allergic responses such as edema, itchiness, dizziness from hypersensitivity, and fatigue were significantly lower in the Sweet bee venom administered group after 30 minutes. Conclusions : As a result of removed allergen, Sweet bee venom significantly inhibits allergic responses both locally and throughout the body. This indicates wider and easier application of Sweet bee venom for the symptoms applicable to the bee venom pharmacopuncture. Further comparative studies should be conducted to yield more objective verification.

The clinical studies to developing BV Partner (BV Partner 개발을 위한 임상적 연구)

  • Kwon, Gi-Rok;Kang, Jae-Chun
    • Journal of Pharmacopuncture
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    • v.4 no.3
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    • pp.93-99
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    • 2001
  • Objective : This study was performed to examine the Herbal Acupuncture decrease the side effect of Bee Venom. Methods: We treated Bee Venom and various Herbal Acupuncture mixed Bee Venom using double blind test to 70th health youth, and checked pain, edema size, CBC, Serum biochemistry and Thermography. Results: 1. Herbal Acupuncture made by Morus bombycis Koidzumi showed good results to decrease the side effect of Bee Venom than any other Herbal Acupuncture. 2. We examined CBC, ESR and Serum biochemistry before and after treated. Special change was not showed. 3. We observed the pain and edema after treated Bee Venom and Morus bombycis Koidzumi Herbal Acupuncture mixed Bee Venom. We knew that Morus bombycis Koidzumi Herbal Acupuncture was decrease the pain and edema due to Bee Venom. 4. According to these clinical studies, Morns bombycis Koidzumi Herbal Acupuncture has a possibility to be a good partner of Bee Venom.

The Comparison of Effectiveness between Bee Venom and Sweet Bee Venom Therapy on Low back pain with Radiating pain. (요각통 환자에 대한 Bee Venom과 Sweet Bee Venom의 효능 비교 연구)

  • Lee, Tae-Ho;Hwang, Hee-Sang;Chang, So-Young;Cha, Jung-Ho;Jung, Ki-Hoon;Roh, Jeong-Du;Lee , Eun-Young
    • Journal of Pharmacopuncture
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    • v.10 no.3
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    • pp.85-89
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    • 2007
  • Objective The aim of this study is to investigate if Sweet Bee Venom therapy has the equal effect in comparison with Bee Venom Therapy on Low back pain with Radiation pain. Methods Clinical studies were done 24 patients who were treated low back pain with radiation pain to Dept. of Acupuncture & Moxibusition, of Oriental Medicine Se-Myung University from April 1, 2007 to September 30, 2007. Subjects were randomly divided into two groups ; Bee Venom treated group(Group A, n=10), Sweet Bee Venom treatred group(Group B, n=14). In Bee Venom treated group(Group A), we treated patients with dry needle acupuncture and Bee Venom therapy. In Sweet Bee Venom treatred group(Group B), we treated patients with dry needle acupuncture and Sweet Bee Venom therapy. All process of treatment were performed by double blinding method. To estimate the efficacy of controlling pain. we checked Visual Analog Scale(VAS). For evaluating functional change of patients, Straight Leg Raising Test(S.L.R.T) was measured. Results 1. In controlling pain, Sweet Bee Venom treatred group(Group B) had similar ability in comparison with Bee Venom treated group(Group A). 2. In promoting function, Sweet Bee Venom treatred group(Group B) had similar ability in comparison with Bee Venom treated group(Group A). Conclusions It may be equal effects as compared with using Bee Venom to treat low back pain with radiation pain using Sweet Bee Venom. We can try to treat other disease known to have effect with Bee Venom.

Bee Venom Pharmacopuncture Responses According to Sasang Constitution and Gender

  • Kim, Chaeweon;Lee, Kwangho
    • Journal of Pharmacopuncture
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    • v.16 no.4
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    • pp.43-48
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    • 2013
  • Objectives: The current study was performed to compare the bee venom pharmacopuncture skin test reactions among groups with different sexes and Sasang constitutions. Methods: Between July 2012 and June 2013, all 76 patients who underwent bee venom pharmacopuncture skin tests and Sasang constitution diagnoses at Oriental Medicine Hospital of Sangji University were included in this study. The skin test was performed on the patient's forearm intracutaneously with 0.05 ml of sweet bee venom (SBV) on their first visit. If the patients showed a positive response, the test was discontinued. On the other hand, if the patient showed a negative response, the test was performed on the opposite forearm intracutaneously with 0.05 ml of bee venom pharmacopuncture 25% on the next day or the next visit. Three groups were made to compare the differences in the bee venom pharmacopuncture skin tests according to sexual difference and Sasang constitution: group A showed a positive response to SBV, group B showed a positive response to bee venom pharmacopuncture 25%, and group C showed a negative response on all bee venom pharmacopuncture skin tests. Fisher's exact test was performed to evaluate the differences statistically. Results: The results of the bee venom pharmacopuncture skin tests showed no significant differences according to Sasang constitution (P = 0.300) or sexual difference (P = 0.163). Conclusion: No significant differences on the results of bee venom pharmacopuncture skin tests were observed according to two factors, Sasang constitution and the sexual difference.

An Experimental Study on the Bee Venom Collector Using the Photovoltaic System (전원장치로 태양광을 이용하는 봉독 채집기에 관한 실험적 연구)

  • Cho, Nam-Cheol;Lee, Chae-Moon;Kim, Choul-Goo
    • Journal of the Korean Solar Energy Society
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    • v.31 no.4
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    • pp.122-127
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    • 2011
  • A bee venom is very useful and expensive medical resource. A bee venom collector has some difficulties and inconveniences because of its complex component. This is used normal battery as an electric power. However, using the solar cell of the bee venom collector reduces economic burden and guarantees high efficiency. We have performed comparative experiment between the bee venom collector to use battery and the one to use solar cell(polycrystalline silicon) by collecting the bee venom simultaneously. At the same electricity, the electric frequency(AC),312 Hz is more superior than 450Hz. This paper verified through the experiments that the bee venom collector to adopt solar cell is more effective than normal collector.

The Clinical Observation of Bee Venom Hypersensitivity Reaction after Bee Venom Pharmacopuncture Treatment (봉독약침 시술 후 발생한 봉독 과민반응에 대한 임상고찰)

  • Yoon, Kwang-Sik;Cho, Eun;Kang, Jae-Hui;Lee, Hyun
    • Journal of Haehwa Medicine
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    • v.21 no.1
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    • pp.117-124
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    • 2012
  • Objective : The purpose of this report is to introduce hypersensitivity reaction of bee venom pharmacopuncture, and remind caution when use bee venom pharmacopuncture. Methods : After skin test, we were treated with bee venom pharmacopuncture to severe lower back pain and facial palsy patients depending on the state of the individual. After the treatment, bee venom hypersensitivity reaction was appeared, and we retreated hypersensitivity reaction depending on progress. Result & Conclusion : Hypersensitivity reaction of bee venom appears as various symptoms depending on the patient's condition, procedure amount and procedure point. We might reinforce skin test, and remind caution when use bee venom pharmacopuncture.

Component Analysis of Sweet BV and Clinical Trial on Antibody Titer and Allergic Reactions (Sweet BV의 성분분석과 항체역가 및 allergy 반응에 대한 임상적 연구)

  • Choi, Suk-Ho;Cha, Bae-Chun;Kwon, Ki-Rok
    • Journal of Pharmacopuncture
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    • v.9 no.2
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    • pp.79-86
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    • 2006
  • Objectives : The aim of this study was to observe prevention of allergic reactions of Sweet Bee Venom (removing enzyme components from Bee Venom). Methods: Content analysis of Sweet Bee Venom and Bee Venom was rendered using HPLC method and characterization of Anti-Sweet Bee Venom in Rabbit Serum. Clinical observation was conducted for inducement of allergic responses to Sweet BV. Results : 1. Analyzing melittin content using HPLC, Sweet BV contained 34.9% more melittin than Bee venom pharmacopuncture at same concentration. 2. Observing chromatogram of HPLC, removal of the enzyme was successfully rendered on Sweet BV. 3. The anti-serum of Sweet BV showed high titers against melittin and bee venom and relatively low titer against phospholipase A2. 4. After conducting approximately 3,000 cases of Sweet BV administration, not a single case of generalized anaphylatic reaction occurred in clinical observation. 5. Mild compared to the bee venom pharmacopuncture, Sweet BV showed some acute hypersensitive reactions of edema, itchiness, and aching locally. 6. Sweet BV was administered on six patients with previous history of suffering from generalized acute hypersensitive reactions with the bee venom. None of the patients showed allergic reactions with Sweet BV, suggesting it can effectively prevent anaphylatic shock which may occur after the bee venom pharmacopuncture procedure. Conclusion : Summarizing above results, Sweet Bee Venom appears to be an effective measurement against allergic reactions from the bee venom pharmacopuncture especially against anaphylatic shock.