• Title, Summary, Keyword: biotype

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Pattern Analysis of Volume of Basal Ganglia Structures in Patients with First-Episode Psychosis (초발 정신병 환자에서 기저핵 구조물 부피의 패턴분석)

  • Min, Sally;Lee, Tae Young;Kwak, Yoobin;Kwon, Jun Soo
    • Korean Journal of Biological Psychiatry
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    • v.25 no.2
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    • pp.38-43
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    • 2018
  • Objectives Dopamine dysregulation has been regarded as one of the core pathologies in patients with schizophrenia. Since dopamine synthesis capacity has found to be inconsistent in patients with schizophrenia, current classification of patients based on clinical symptoms cannot reflect the neurochemical heterogeneity of the disease. Here we performed new subtyping of patients with first-episode psychosis (FEP) through biotype-based cluster analysis. We specifically suggested basal ganglia structural changes as a biotype, which deeply involves in the dopaminergic circuit. Methods Forty FEP and 40 demographically matched healthy participants underwent 3T T1 MRI. Whole brain parcellation was conducted, and volumes of total 6 regions of basal ganglia have been extracted as features for cluster analysis. We used K-means clustering, and external validation was conducted with Positive and Negative Syndrome Scale (PANSS). Results K-means clustering divided 40 FEP subjects into 2 clusters. Cluster 1 (n = 25) showed substantial volume decrease in 4 regions of basal ganglia compared to Cluster 2 (n = 15). Cluster 1 showed higher positive scales of PANSS compared with Cluster 2 (F = 2.333, p = 0.025). Compared to healthy controls, Cluster 1 showed smaller volumes in 4 regions, whereas Cluster 2 showed larger volumes in 3 regions. Conclusions Two subgroups have been found by cluster analysis, which showed a distinct difference in volume patterns of basal ganglia structures and positive symptom severity. The result possibly reflects the neurobiological heterogeneity of schizophrenia. Thus, the current study supports the importance of paradigm shift toward biotype-based diagnosis, instead of phenotype, for future precision psychiatry.

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Variations in Leg Characters Among Three Biotypes of the Brown Planthopper, Nilaparvata lugens (Stal), in Korea (한국산 벼멸구 생태형의 계량형태적 분류)

  • ;R. C. Saxena;A. A. Barrion
    • Korean journal of applied entomology
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    • v.32 no.1
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    • pp.68-75
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    • 1993
  • Morphometric investigations of the leg characters of both sexes of brachypterous Korean N. lugens biotypes were made. Simple and multivariate statistical analyses revealed that the three N. lugens biotypes differed from one another. The amount of variation and segregation between and among the three biotype populations were approximated by the scatter plot diagrams based on the computed discriminant scores. The variables of leg characters provided the most significant segregations of three biotype populations, thus, categorizing the three biotypes as distinct intraspecific populations of N. lugens.

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Classification of the Three Korean Biotypes of the Brown Planthopper, Nilaparvata lugens(Stal), By Morphological Variation (한국산 벼멸구 생태형의 형태적 분류)

  • ;;R. C. Saxena;A. A. Barrion
    • Korean journal of applied entomology
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    • v.32 no.3
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    • pp.317-322
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    • 1993
  • Morphological investigations of the abdominal lateral lobes in females and the unguitractor p plates in the tarsi of legs in male and female N. lugens among the three Korean N. lugeηs bio-types revealed that the three biotypes varied from one another. The presence of a distinct ‘cut’ on the lateral lobes in brachypterous females distinguished Biotype 2 from Biotypes 1 and 3. The highest frequency of inserted unguitractor plates in fore-and mid-tarsal segments was exhibited by Biotype 2 in both sexes of each morphs.

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Serotype and biotypes of Salmonella strains isolated from pigeons and aquatic birds (비둘기와 수생조류(水生鳥類)에서 분리(分離)한 Salmonella속균(屬菌)의 혈청형(血淸型) 및 생물형(生物型))

  • Park, No-chan;Choi, Won-pil;Lee, Hi-suk
    • Korean Journal of Veterinary Research
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    • v.30 no.2
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    • pp.193-201
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    • 1990
  • An attempt was made to isolate Salmonella(S) organisms from a total of 4,587 fecal samples of birds during the period from May 1987 to March 1988, and serotype and biotypes of the isolates were also investigated. One hundred and sixty-six Salmonella strains were isolated from 151(3.3%) of 4,587 fecal samples of birds, and their serotype was all identified as S typhimurium var copenhagen. The positive samples of S typhimurium var copenhagen were 149 samples(5.1%) in pigeons and 2 samples (0.8%) in aquatic birds. No Salmonella was obtained from ducks, pheasant, and other birds. The isolation frequencies of S typhimurium var copenhagen from pigeons varied from 1.1 to 12.8% at 5 parks, it was higher in September and November. Biotypes of 166 S typhimurium var copenhagen strains isolated from pigeons and aquatic birds were all biotype 10 according to Brandis' method, and were biotype 25hi (78.3%), 27 hi (14.5%), 25 fhi (3.6%), 25 bhi (1.8%), 27 bhi (0.6%), 27 hiz (0.6%), and 9 hi (0.6%) according to Duguid's scheme. Appearance of different biotypes indicated the occurrence of exotic infection sources on the parks.

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Effective Herbicides for Control of Sulfonylurea-Resistant Monochoria vaginalis in Paddy Field

  • Kuk, Yong-In;Kwon, Oh-Do
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.48 no.4
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    • pp.286-291
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    • 2003
  • Monochoria vaginalis is one of the most troublesome resistant weeds in Korean rice culture. Thus, the objectives of this study were to evaluate the response of M. vaginalis resistant to sulfonylurea(SU) herbicides and to determine alternative herbicides for the control of resistant M. vaginalis in direct seeded and transplanted rice culture in Korea. In greenhouse studies, the resistant biotype was 31-, 38-, 3172-, and 7-fold more resistant to ben-sulfuron-methyl, cyclosulfamuron, imazosulfuron, and pyrazosulfuron-ethyl, respectively, than the susceptible biotype, indicating cross-resistance to the SU herbicides used in this study. Non-SU herbicides, butachlor, carfentrazone-ethyl, mefenacet, pretilachlor, pyrazolate, and thiobencarb, several SU herbicide-based mixtures, ethoxysulfuron plus fentrazamide, pyrazosulfuron-ethyl plus pyrazolate plus simetryn, and non-SU herbicide-based mixtures, pyrazolate plus butachlor, pyrazolate plus pretilachlor, simetryn plus molinate, carfentrazone-ethyl plus butachlor, and carfentrazone-ethyl plus thiobencarb can be used to control both the resistant and susceptible biotypes of M. vaginalis when applied before the second leaf stage. In the field experiment, the resistant biotype of M. vaginalis that survived from the paddy fields treated with a SU herbicide-based mixture could effectively be controlled by using mixtures of bentazone plus MCPA, bentazone plus mecoprop-P, and bentazone plus 2,4-D when applied at 2 or 4 main leaves. Our results suggest that the SU-resistant M. vaginalis had not developed multiple resistances to herbicides with different modes of action. In particular, bentazone plus MCPA and bentazone plus mecoprop-P were effective control measures after failure to control resistant M. vaginalis in Korean rice culture.

Development of the Brown Planthopper, Nilaparvata lungens Sta$\{aa}$l, Biotypes and Their Hybrid Progenies Fed on Different Cultivars of Rice with Various Resistance Gene and Damage of Different Rice Cultivars (벼멸구 생태형의 교잡종별 발육 및 수도 품종별 피해)

  • 최주수;박영도
    • Journal of Life Science
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    • v.7 no.4
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    • pp.347-354
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    • 1997
  • Some attempts were made to investigate the gentic characteristics of the brown planthopper(BPH), Nilaparvata lugens Sta${\aa}$l, biotypes. In terms of egg and nymphal periods, egg hatcgability, emergence ratio, and population change of BPH and plant damage of rice cultivars by the infestation of BPH biotypes and their hybrid progenies in field conditions. The egg and nymphal periods of the three of BPH biotypes and their hybrid progenies on Dongjinbyeo with no resistance gene were shorter than on rice cultivars with resistance gene. But the periods of biotype-2(♀) X 2(♂) (E) on Samgangbyeo with Bph-1 gene and biotype-3(♀) X 3(♂)(I) on Mirying 63 with bph-2 gene were as short as on Dongjinbyeo. The egg hatchability and emergence ratio of the three Bph biotypes and their hybrid progenies on Dongjinbyeo were higher than on the other rice cultivars, and those of E on Samgangbyeo and I on Miryang 63 were as high as on Dongjinbyeo. In rice paddy field, biotype-1(♀) X 1(♂)(A)$\sim$I infested on Dongjinbyeo, E onSamgangbyeo, and I on Miryang 63 were increased their population densities remarkably in next generation. Dongjinbyeo infested by A$\sim$I, and Myryang 63 infested by I were hopperburned at 60 days after infestation and had a damage rating of 0.9. But Samgangbyeo infested by E was no hopperburn(damage rating: 7.3) though it showed high BPH population at 60 days after infestation.

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Expressed Sequence Tags of the Wheat-rye Translocation Line Possessing 2BS/2RL

  • Jang, Cheol-Seong;Hong, Byung-Hee;Seo, Yong-Weon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.44 no.3
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    • pp.302-307
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    • 1999
  • Hamlet (PI549276) possessing 2RL was obtained by cross between a wheat cultivar ND7532 (Froid/Centurk) and a rye cultivar Chaupon. Chaupon was known to have resistant gene to biotype L of Hessian fly [Mayetiola destructor (Say)] larvae. The wheat-rye translocation line (Coker797*4/Hamlet) was also known to be resistant to biotype L of Hessian fly larvae. We analysed a set of 96 ESTs from the wheat-rye translocation line (2BS/2RL). ESTs were classified by various physiological processings, such as primary metabolism, secondary metabolism, transcription, translation, transport, signal transduction, defense, transposable element, and others. Three sequences encoding thioredoxin peroxidase, 26S rRNA, and rubisco small subunits were homologous to registered genes in rye. Although limited number of clones were used to develop ESTs, these clones and their sequence information may be useful for researchers studying general physiology and molecular biology on the translocation line.

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The significance of soft tissue for maintenance of prosthesis (보철 건강유지를 위한 연조직의 중요성)

  • Kim, Ok-Su
    • The Journal of the Korean dental association
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    • v.48 no.9
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    • pp.664-669
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    • 2010
  • All prosthetic and restorative therapies require a healthy periodontium as a prerequisite for success. Understanding of the concepts of periodontal-restrorative interaction, especially with regard to interactions at the gingival margin is important. The aim of this article gives the information about the essential considering factor for successful prosthesis; biologic width, periodontal biotype, width of attached gingiva, margin of restoration. If a restorative margin must be extended below the gingival margin, it is critical that adequate band of attached gingiva is present, the margin does not violate the biologic width, the margin is closed and properly finished.