• Title, Summary, Keyword: brest cancer

Search Result 11, Processing Time 0.036 seconds

Effect of Genistein on Chemopreventive Activity of Human Brest Cancer (Genistein이 유방암예방 활성에 미치는 영향)

  • Shon Yun-Hee;Kim Ho-Chang;Nam Kyung-Soo
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.20 no.1
    • /
    • pp.88-92
    • /
    • 2006
  • Genistein was tested for chemopreventive potential against breast cancer by measuring the effect on proliferation of human breast cancer cells, human placental aromatase activity and cyclooxygenases-2 (COX-2) expression and activity, Genistein inhibited the growth of estrogen-independent MDA-MB-231 human breast cancer cell. However, there is no inhibitory effect of genistein on human placental aromatase activity. The expression of COX-2 was inhibited by genistein in Western blot analysis. Genistein significantly inhibited COX-2 activity at the concentrations of 10 (p<0.05), 25 (p<0.05) and 50 ${\mu}M$ (p<0.01). These results suggest that genistein may have breast cancer chemopreventive potential by inhibiting the growth of human breast cancer cell and expression and activity of COX-2.

A Study on Quality of Life of those who have Breast Cancer Patients taking Chemotherapy (항암 화학요법을 받는 유방암 환자의 삶의 질에 관한 연구)

  • Shim, Ju-Hyeon;Park, Kyung-Sook
    • Korean Journal of Adult Nursing
    • /
    • v.16 no.1
    • /
    • pp.49-59
    • /
    • 2004
  • Purpose: This study is a descriptive research study to measure the quality of life of those who suffer from breast cancer and take the chemotherapy. Method: The Subjects were 70 breast cancer patients who took the chemotherapy from September 2 to October 31, 2003. Quality of life was measured by Ferrell's measurements. Result: Quality of life indicators were spiritual domain=6.44, physical domain=5.45, social domain=4.15, and mental domain=3. 95. Whole quality of life was 4. 68 out of 10 points. The quality of life of those with a practicing religion was significantly higher than those without(F=3.88, P=0.026). Subjects who were less than 2 months post-operation had higher points in the physical domain than those who were more than 2 months post-operation (t= 2.76, p=0.007). Subjects who had less than 4 treatments of chemotherapy had higher points in the physical domain than those who had more than 4 treatments of chemotherapy (t=2.03, p=0.046). Conclusion: The results of this study serve as a meaningful source to promote quality of life of breast cancer patients who undergo chemotherapy. The results can also be applied to the development of education programs and counseling materials for chemotherapy patients. Health care strategy can also raise the quality of life of brest cancer patients.

  • PDF

Acupotomy and venesection in Upper Limb Lymphedema and Peripheral neuropathy following Breast Cancer Surgery (유방암 수술 후 발생한 림프부종과 말초신경병증에 대한 도침술과 정맥자락술 집중치료 증례보고)

  • Jang, Eun-Ha;Kim, So-Yeon;Kim, Hyun-Sik;Kim, Sung-Chul
    • Journal of Pharmacopuncture
    • /
    • v.12 no.4
    • /
    • pp.119-126
    • /
    • 2009
  • Purpose: In order to estimate clinical effects of acupotomy and venesection in a patient with peripheral neuropathy and upper limb lymphedema following breast cancer surgery. Methods: From 17th August, 2009 to 29th August 2009, 1 female patient with peripheral neuropathy and upper limb lymphedema following breast cancer surgery was treated with general oriental medicine therapy(acupuncture, moxibustion, cupping, physical therapy, herbal medication) and acupotomy with venesection. Results: The patient's chief complaints- Lt hand numbness, Lt arm edema, Lt. wrist flexion limitation - were notably improved. Conclusions : This study demonstrates that oriental medical treatment with acupotomy and venesection therapy has significant effect in improving symptoms of peripheral neuropathy and upper limb lymphedema following breast cancer surgery, as though we had not wide experience in this treatment, more research is needed.

Detection of Mammographic Microcalcifications by Pattern Matching (Pattern Matching을 이용한 유방영상의 미세 석회화 검출)

  • Yang, Y.S.;Kim, E.K.;Kim, D.W.
    • Proceedings of the KOSOMBE Conference
    • /
    • v.1997 no.05
    • /
    • pp.68-71
    • /
    • 1997
  • The early detection of brest cancer is clearly a key ingredient for any strategy designed to reduce breast cancer mortality. Microcalcification(MCC) is one of the primary signatures to discriminate between normal and cancerous tissue. The detection and locating procedures can be automated by digital image processing, however, MCCs have various sizes, shapes, and intensity levels in film images, so it is difficult to find accurate locations and sizes. Firstly, we made quantitative analysis for many characteristic features of mammograms that can be used to segment MCCs from normal tissues. Secondly, we developed algorithms proper to segmentation like pattern matching. The performance was evaluated with TP and FP rates.

  • PDF

The Cytotoxicity and Chemosensitizing Effects of native camellia(Camellia japonica) and nutraceutical camellia teas

  • Hwang, Eun-Joo;Park, Min-Hee;Pyo, Byoung-Sik;Cha, Young-Ju;Lee, Sook-Young
    • Proceedings of the Plant Resources Society of Korea Conference
    • /
    • /
    • pp.102-102
    • /
    • 2003
  • The present study has been undertaken to characterize availability of camellia(Camellia japonica L.) as a medicinal plant with antineoplastic and chemosensitizing activities. The crude extracts from fresn camellia flower, young leaves and nutraceutical tea of camellia leaf and flower buds were evaluated on their potential activities against various human cancer cells and multidrug resistance to cancer cells in vitro. The range of cytotoxicity displayed from 120$\mu\textrm{g}$/mL to 200$\mu\textrm{g}$/mL. Catemix 1(CT-1) mixed with camellia and green tea showed high toxicity(respectively IC$\sub$50/=l16$\mu\textrm{g}$/mL, 129$\mu\textrm{g}$/mL) against AML-2/WT, acute myelogenous leukemia cell and MCF-7, brest adenocarcinoma pleual effusion cell. Generally camellia tea mixed with green tea showed higher cytotoxicity than the other camellia teas mixed with some herbs(CH). Methanol extract of steamed camellia tea and roasted camellia tea had a chemosensitizing effect to reverse Pgp-mediated MDR. In addition, camellia flower tea of insignificant cytotoxicity, chemosensitizing effect were increased remarkably chemosensitizing effect in mixed flower tea with some herbs.

  • PDF

Anti-proliferation effect of Gyulyupsanbyonbang extracts on MCF-7 cells (귤엽산변방(橘葉散變方)이 유방암 세포주 MCF-7 생장 억제에 미치는 영향)

  • Yang, Seong-Jung;Cho, Seong-Hee;Cho, Su-In;Jo, Huyn-Jung
    • The Journal of Korean Obstetrics and Gynecology
    • /
    • v.20 no.1
    • /
    • pp.50-60
    • /
    • 2007
  • Purpose : This investigation was undertaken to evaluate the anti-proliferation, in hexane, chloroform, ethyl acetate, butanol and water fraction from extract of Gyulyupsanbyonbang(GYSB) using MCF-7 human breast cancer cells. Methods : GYSB was added to distilled water(1500ml) and was boiled then filtered. The residue was suspended in distilled water and extracted with hexane, chloroform, ethyl acetate, butanol and water. MCF-7 cells were cultured in RPMI1640 complex badge, NIH3T3 was cultered in 37$^{\circ}$C, 5% moisture incubator of carbon dioxide with Dulbecco's Modified Eagle Medium(DMEM) supplemented with 10% fetal bovine serum and antibiotics. Cell cytotoxicity test about cancer cell was measured used MTT assay. Results: When it synthesizes a result, hexane and butanol fraction had shown anti-proliferation effect and safety together, and those anti-proliferation effect operating selectively appeared. Ethyl acetate fraction had anti-proliferation effect however, it was not selective. The Chloroform and water soluble fraction did not almost appear anti-proliferation effect. Conclusion : I can conclude that GYSB have anti-proliferation effect and safety together on MCF-7 cells. It suggest that GYSB may be useful for brest cancer patients.

  • PDF

A Study on BSE - related Knowledge, Attitude, and Practice of Junior Nursing College Students (일부 간호학생의 유방자가검진에 관한 지식, 태도 및 실천에 관한 연구)

  • Park, Kyung-Ae
    • Journal of Korean Academy of Community Health Nursing
    • /
    • v.8 no.2
    • /
    • pp.381-394
    • /
    • 1997
  • This study was conducted to investigate breast self examination ( = BSE) - related knowledge, attitudes and practice of junior nursing college students in Kwangju. Chonnam province. The subjects were 161 nursing students in 3 junior nursing colleges among 10 colleges in K city and Chonnam province. The data was collected from Nov. 16, 1997 to Dec. 16, 1997 and analyzed by an SAS program for t or F test and Pearson's correlation coefficient. The results were as follows: 1. The mean score of BSE - related knowledge was 18.2, that of BSE-related attitudes was 29.1 and that of BSE-related practice was 3.1. 2. The first advantage of BSE-related practice was the early detection of breast cancer. Reasons for not practicing BSE were difficulty in practicing(33%), and indifference to practicing(29%) in that order. 3. In the relationship between BSE-related characteristics and the scores of BSE-related knowledge, groups having breast cancer history in relatives or neighbors tended to have higher scores than groups not having them significantly(t=2.07, p=0.042). In the relationship between BSE-related characteristics and the scores of BSE-related attitudes, groups practicing BSE(t=1.67, p<0.10) and groups not receiving breast examinations from doctors(t=-1.83, p<0.10) tended to have significantly higher scores than those of others. In the relationship between BSE-related characterestics and the scores of BSE-related practice, the group having a breast cancer history in relatives or neighbors tended to have significantly higher scores than those of others(t=2.05, p=0.04). 4. In the correlation among the scores of BSE-related knowledge, attitude and practice, there was slight or little correlation between the score of BSE-related knowledge and that of BSE-related attitude(r=0.30) ; as well as between attitude and practice (r=0.18).

  • PDF

Observation with Calcifications of Breast Tissue Phantoms Using Acoustic Resonance (공명현상을 이용한 유방조직 팬텀의 석회화 관찰)

  • Ha, Myeung-Jin;Kim, Jeong-Koo
    • Journal of radiological science and technology
    • /
    • v.31 no.1
    • /
    • pp.61-69
    • /
    • 2008
  • Diagnosis of breast ultrasound is better than mammography in the early detection of breast cancer, but, it is difficult to detect microcalcification. We studied on detection for calcification of breast tissue using acoustic resonance and power doppler with 7.5 MHz linear probe in breast ultrasound. We first constructed breast tissue phantom made of gelatin and saw breast, and then observed calcification by the change of external vibration. Calcification injected breast tissue phantom visualized the difference for brightness and region of color in ROI regions of power doppler. Acoustic resonance almost never visualized in low frequency regions, plateau constituted in about 300-400 Hz and colors vanished according to the increase of frequency.

  • PDF

Usefulness of Color-overlay Pattern of Breast Elastic Ultrasonography (유방 탄성초음파의 Color overlay pattern에 대한 유용성)

  • An, Hyun;Im, In-Chul
    • Journal of the Korean Society of Radiology
    • /
    • v.11 no.5
    • /
    • pp.401-406
    • /
    • 2017
  • Breast cancer rates are increasing every year, biopsy for diagnosing breast cancer is increasing as well. Biopsy also invasive test, have bad side effects from patients anxiety, infection, bleeding. In this study, Conduct a survey of 69 patients who brest lesion patient, both B-mode ultrasound and elastography exam and B-mode ultrasound was classified according to the BI-RADS category, and the elastography exam was classified according to the Color overlay pattern that the value of the kPa expressed in relation to the propagation velocity of Transverse waves. The optimal cut off value of the highest sensitivity and specificity was 54.70 kPa. In the color overlay pattern, Dark Blue 42 people, Light blue ~ Red 27 people classified results and BI-RADS classification results, benign 40 people and malignant 29 people classified results showed similar results. Therefore, It is judged that the color overlay pattern is positive when classified into Dark Blue, and malignant when classified into Light blue ~ Red. In conclusion, breast elastography is expected to play a innovative role in reducing the number of breast cancer examinations and classify between benign and malignant tumor.