• Title, Summary, Keyword: bronchointerstitial pneumonia

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Bovine respiratory syncytial virus infection in a Jeju native black calf (제주흑우 송아지에서 소 합포체성 폐렴의 발생)

  • Kim, Hyun-Tae;Jung, Ji-Youl;Jo, Suk-Hee;Lee, Kyoung-Kap;Kim, Jae-Hoon;Kim, Jae-Hoon
    • Korean Journal of Veterinary Research
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    • v.50 no.2
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    • pp.139-143
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    • 2010
  • A 2-month-old male Jeju native black calf with respiratory distress was died and requested to the Veterinary Pathology Laboratory of Jeju National University for diagnosis. Grossly, lungs were focally attached to the pleura and heart with fibrin. Purple red sublobar consolidations were distributed in both apical and cardiac lobes of lungs. Histopathologically, diffuse severe bronchointerstitial pneumonia characterized by multifocal necrotizing bronchiolitis, formation of numerous multinucleated syncytial cells in bronchiolar and alveolar lumens, and diffuse alveolar wall thickening were observed in lungs. Eosinophilic intracytoplasmic inclusions were observed in bronchiolar epithelial cells and syncytial cells. According to reverse transcriptase polymerase chain reaction (RT-PCR), bovine respiratory syncytial virus (BRSV) was detected in the lung of calf. Based on the histopathologic findings and RT-PCR, this calf was diagnosed as BRSV infection. In our best knowledge, this is the first case of BRSV infection in Jeju native black calf.

Canine Distemper Virus Infection in Badgers (오소리의 개 디스템퍼 감염증)

  • Kim, Jae-Hoon;Roh, In-Soon;Bak, Eun-Jung;Jean, Young-Hwa;Hwang, Eui-Kyung;Sohn, Hyun-Joo;Choi, Sang-Ho
    • Korean Journal of Veterinary Pathology
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    • v.1 no.2
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    • pp.145-148
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    • 1997
  • Two dead and two terminally sick badgers with signs of lacrimation and nasal discharge were submitted to the Pathology Division of the National Veterinary Research Institute for necropsy. The major gross findings included chronic dermatitis and pneumonia. histologically intracytoplasmic and intranuclear acidophilic inclusion bodies consistent with Canine Distemper (CD) virus particles in lung kidney urinary bladder skin foot pad stomach and small intestine. Additionally there were diffuse bronchointerstitial pneumonia hyperkeratosis of foot pads and focal non-suppurative encephalitis. Canine distemper infection in these badgers was further confirmed by immuofluorescent technique which demonstrated CD virus-specific antigens in lung and kidney sections.

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The Prevalence of Mycoplasma hyopneumoniae Antigens in Pneumonic Lungs and Serum Antibodies of Slaughtered Pigs in Jeju (제주지역 도축돼지의 페렴병변에서 Mycoplasma hyopneumoniae 항원 및 혈중 항체 조사 연구)

  • Kim Seung-Il;Yang Hyoung-Seok;Kim Jae-Hoon;Bae Jong-Hee
    • Journal of Veterinary Clinics
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    • v.22 no.4
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    • pp.365-370
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    • 2005
  • Enzootic pneumonia caused by Mycoplasma hyopneumoniae is responsible for major economic losses in pig herds of world wide. Mycoplasma hyopneumoniae can also act as a primary pathogen of porcine respiratory disease complex followed by bacterial or viral infection. This study was carried out to investigate the prevalence of mycoplasmal pneumonia of slaughtered pigs in Jeju for two years. The lungs and sera of 214 cases were examined for gross and microscopic lesions of the lungs, immunohistichemistry test for Mycoplasma hyopneumoniae antigen and enzyme-linked immunohistichemistry assay (ELISA) for serum antibody titer. Pulmonary consolidation was observed in the lungs of 163 pigs $(76.1\%)$ with average gross lesion score of $6.0\%$., Bronchointerstitial pneumonia was most frequently observed $(78.5\%)$. The incidence of pulmonary consolidation was decreased in vaccinated pigs compared to that of non-vaccinated pigs. The rate of consolidation in the lungs was significantly decreased in the vaccinated pigs (P<0.05). Antigen of Mycoplasma hyopneumoniae was identified by immunohistichemistry test in the lungs of 174 pigs $(81.3\%)$. ELISh antibodies to Mycoplasma hyopneumoniae were detected in 154 pigs $(72.0\%)$. These results showed the prevalence of swine pneumonia and the incidence of Mycoplasma hyopneumoniae in slaughtered pigs of Jeiu province. We expect that these results would be helpful for the control of swine mycoplasmal pneumonia and porcine respiratory disease complex in Jeju.

Co-infection of Canine Distemper Virus and Toxoplasma gondii in a Dog (개에서 디스템퍼 바이러스와 톡소플라즈마의 혼합 감염)

  • 강홍원;강상철;양형석;배종희;김재훈
    • Journal of Veterinary Clinics
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    • v.21 no.1
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    • pp.80-82
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    • 2004
  • A 3 month-old male dog with clinical signs of anorexia, soft stool, ocular and nasal discharge, cough and respiratory distress was submitted to the Cheju National University for diagnosis. At necropsy, tan to pulp]e-red sublobar to lobar consolidations were presented in apical and cardiac lobe of lung. Histopathologically, severe diffuse bronchointerstitial pneumonia with necrotic bronchiolitis was noted in the lung. The demyelinating encephalitis and astrocytosis were presented in cerebellum and cerebrum. Numerous round, ovoid or cluster of tachyzoites were also identified in alveolar lumen, alveolar wall and cytoplasm of macrophages in the lung. The orgasnisms were demonstrated as Toxoplasma (T) gondii by immunohistochemistry. Intranuclear or intracytoplasmic eosinophilic inclusion bodies were seen in the glial cells of the cerebellum. Canine distemper virus (CDV) specific antigens were demonstrated in the cerebellum by the immunohistochemistry. In our knowledge, this is believed to be the first confirmed report of co-infection of CDV and T gondii in dog in Korea.

Canine distemper outbreak in a zoo (동물원에서 집단 발생한 개 디스템퍼 감염증)

  • Hur, Kwon;Bae, Ji-Seon;Choi, Jae-Hoon;Shin, Nam-Sik;Lee, Ki-Whan;Kwon, Soo-Wahn;Kim, Dae-Yong
    • Korean Journal of Veterinary Pathology
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    • v.2 no.2
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    • pp.139-145
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    • 1998
  • A total of 5 animals including 3 raccoons, 1 badger, and 1 fennec fox kept in outdoor exhibits at the Everland Zoological Gardens showed depression, anorexia, dyspnea, serous oculonasal discharge, diarrhea, and convulsions. All the affected animals died within 10 days after the onset of clinical signs. This outbreak lasted about 4 months. On necropsy, major gross lesions were confined to the lungs. Red to grey sublobular to lobular consolidations with various sized tan to reddish spots were observed in the lungs. Histopathologically, the pulmonary lesions were characterized by acute to subacute bronchointerstitial pneumonia with secondary bacterial or adenoviral infections. Intracytoplasmic eosinophilic inclusion bodies compatible with canine distemper virus (CDV) were found in the lung, urinary bladder, kidney, intrahepatic bile duct, stomach, small and large intestines. Multifocal areas of severe demyelination and accumulation of gitter cells or nonsuppurative inflammation were seen in the brains of 2 raccoons. CDV -specific antigens were demonstrated in the lung sections on immunofluorescent assay. The present report describes an outbreak of CDV infection in a zoo and indicates the range of susceptible zoo animal species.

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Porcine Circovirus Infection in Weaned Pigs with Postweaning Multisystemic Wasting Syndrome in Korea (국내 이유자돈의 써코바이러스 감염에 의한 이유후전신소모성 증후군)

  • Kim, Jae-hoon;Roh, In-soon;Sohn, Hyun-joo;Jean, Young-hwa;Hwang, Eui-kyung;Yoon, Kyoung-jin
    • Korean Journal of Veterinary Research
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    • v.43 no.3
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    • pp.463-469
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    • 2003
  • Eight nursery to grower pigs exhibiting weight loss and sudden death were diagnosed as postweaning multisystemic wasting syndrome (PMWS) based on the results of gross findings, histopathology, immunohistochemistry, fluorescent antibody test, virus isolation, PCR, serology, and electron microscopy. Groosly, the pigs had a rough hair coats and were severely emaciated. And moot lymph nodes were pale and enlarged. Lungs were not fully collapsed and exhibited 10 to 40% pale red cranioventral consolidation. Histopathologically, typical lymphohistiocytic interstitial to bronchointerstitial pneumonia, chronic lymphadenitis, severe lymphoid depletion, and basophilic intracytoplasmic inclusions were noted in the most lymphoid tissues. Porcine circovirus panicles were observed in the inguinal lymph node of the pigs by electron microscopy. Porcine circovirus type 2 (PCV2) antigens or viral DNAs were detected in the lesions of all pigs using immunohistochemistry or PCR. Two PCV2 were isolated from a homogenate of pooled lung and lymph node in 2 of the 5 pigs. Additionally, antigens of porcine reproductive and respiratory syndrome virus (PRRSV) and Hemophilus (H.) parasuis were also detected by immunofluorescent antibody test. Serologically, 55% of randomly selected sows and fattening pigs was serum antibody positive to PCV2 by an indirect fluorescent antibody (IFA) test and approximately 18 % of animals in the herd were serologically pooitive by the ELISA kit for PRRSV. To our knowledge, this is the first report of PMWS co-infected with PCV-2, PRRS, and H. parasuis in Korea.