• Title, Summary, Keyword: caffeine

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Strategies of Caffeine Loading into Silk Fibroin Film for Weight Loss Patch

  • Yun, Na Kyong;Lee, Ki Hoon
    • International Journal of Industrial Entomology
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    • v.27 no.2
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    • pp.312-316
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    • 2013
  • Caffeine is a thermogenic agent that can be used in weight loss products. In order to achieve a sustained release of caffeine, silk fibroin (SF) film was uses as carrier. It has been shown that the loading method of caffeine into SF film affected the uniform distribution of caffeine in the SF film. When caffeine was added directly into SF solution, gelation has been occurred immediately and prevented the uniform distribution of caffeine. On the other hand, caffeine was dissolved in methanol in order to load the caffeine in SF film and crystallize the SF film at the same time. However, due to the fast evaporation of methanol, caffeine was recrystallized on the surface of SF film rather than penetrating into the film. Finally, caffeine was loaded into pre-crystallized SF film and uniform distribution of caffeine could be achieved. There was an initial burst of caffeine during the first 15 min, but after that a sustained release was achieved.

Effects of Caffeine and Dietary Fat on Mouse Mammary Development (Caffeine과 지방급여가 생쥐의 유선발달에 미치는 효과)

  • Lee, Seung-Yop;Yuh, In-Suh
    • Korean Journal of Animal Reproduction
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    • v.25 no.4
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    • pp.349-357
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    • 2001
  • This study was conducted to examine the effect of caffeine and three dietary levels of fat, i.e., 0%, 5% and 20% on mammary gland development. Mice were assigned to three groups (dietary levels 0%, 5%, 20% fat), and treated caffeine of half within the each group. Caffeine-treated mice with 0% or 20% fat levels significantly increased 4$^{th}$ mammary gland development in comparison with that of no caffeine -treated mice (P<0.05). Caffeine-treated mice significantly increased DNA contents of 4$^{th}$ mammary gland in comparison with that of no caffeine-treated mice (P<0.05), and DNA contents of mammary gland increased as fat levels increased within caffeine-treated or no caffeine-treated group. nteraction effect was shown between caffeine and 20% fat diet, [(20% fat+caffeine) - (20% fat + no caffeine) vs (0% fat + caffeine) - (0% fat + no caffeine)](P<0.01). Conclusively, caffeine significantly increased mouse mammary gland development possibly by inhibiting phosphodiesterase activity, and dietary fat supplements increased mammary gland development as the fat content of the diet increased from 0 to 20%. The stimulatory effect of caffeine in mammary development interacted with high level of fat diet.

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A study on Caffeine containing foods and the effect of caffeine in humans (카페인이 인체에 미치는 영향 및 섭취량 감소 방안에 관한 연구)

  • 이혜원
    • Culinary science and hospitality research
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    • v.6 no.3
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    • pp.343-355
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    • 2000
  • Caffeine is widely consumed ingredient and it belongs to alkaloids. Many foods that we intake contain caffeine ; coffee, tea cocoa, chocolate, and coke. And it is also added to many commercial remedies ; cold tablets, headache tablets, etc. Effect of caffeine that is known to us so far is as follows; 1. Remaining awake for long hours 2. Increasing concentration and decreasing fatigue 3. Increasing basal metabolic rate 4. decomposing glycogen and body fat and providing energy 5. Stimulating gastric acid 6. Increasing urinary excretion. Caffeine containing beverages(especially, coffee)are also favorite food in adult. In case of children and youth, chocolate and coke are favorite food. So, to intake caffeine containing foods moderately can be a vitality of life. But, a long-term intake or overdose of caffeine can result in many side effects. For example, headache, irritability, restlessness, hypertension, fetal abnormality, etc. Therefore, it is desirable that caffeine intake is under 300-400mg per day. To decrease intake of caffeine, 1. Use decaffeinated coffee 2. Product of decaffeinated coffee bean through gene transformation 3. Indicate content and function of caffeine on caffeine-food container 4. Provide an information of caffeine to public.

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Pharmacokinetics of Caffeine in Caffeine Sensitive and Non-Sensitive Volunteers, and in the Obses Rat and the Lean Rat (카페인 약리작용에 민감한 지원자와 둔감한 지원자 및 뚱뚱한 쥐와 마른 쥐에 대한 카페인 약물동태 비교)

  • 윤정옥;권광일
    • YAKHAK HOEJI
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    • v.37 no.4
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    • pp.341-349
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    • 1993
  • To determine the reason of individual variation of the effect of caffeine, the absorption and the disposition of caffeine were studied in caffeine sensitive and caffeine nonsensitive volunteers. And also to study the effect of obesity on caffeine pharmacokinetics, the caffeine disposition in the obese rat and in the lean rat were investigated respectively. In result the caffeine sensitive group showed a longer terminal half-life of caffeine(7.35$\pm$0.71 hr : 5.49$\pm$0.73 hr) and a larger AUC (55.42$\pm$9.09 $\mu\textrm{g}$.$ml^{-1}$.hr:44.0$\pm$7.81$\mu\textrm{g}$.$ml^{-1}$.hr) than that of caffeine non-sensitive group without statistical significance. The obese rat showed a longer terminal half-life (3.47 hr : 2.31 hr) and a larger AUC(35.3 $\mu\textrm{g}$.$ml^{-1}$.hr:26.97$\mu\textrm{g}$.$ml^{-1}$.hr) than that of the lean rat. But there was no correlation in the amount of daily caffeine consumption and obesity. In conclusion, we suggest that the individual variation of the effect of caffeine are being caused from the individual differences of caffeine susceptibility or tolerance rather than the differences of the genetic metabolic capacity or metabolic tolerance.

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철분결핍과 caffeine 섭취가 흰쥐의 혈당과 과산화에 미치는 영향

  • 정현선;김혜영(A)
    • Proceedings of the Korean Nutrition Society Conference
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    • pp.56-56
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    • 2000
  • 본 연구는 철분결핍과 caffeine섭취가 흰쥐의 혈당과 과산화에 미치는 영향을 알아보기 위해서 수행되었다. 생후 2주된 48마리의 Sprague-Dawley 수컷 흰쥐를 철분과 caffeine의 첨가 수준에 따라 6군으로 나누어 4주간 사육하였다(C0F0 : caffeine 0%, Fe 5 ppm diet, C1F0 : caffeine 1%, Fe 5 ppm diet, C4F0 : caffeine 4%, Fe 5 ppm diet, C0F1 : caffeine 0%, Fe 50 ppm diet, C1F1 : caffeine 0%, Fe 50 ppm diet, C4F1 : caffeine 0%, Fe 50 ppm diet).(중략)

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On the Possible Interaction of Caffeine with the Fragmented Sarcoplasmic Reticulum of Rabbit Skeletal Muscle (筋小胞體 切片에 미치는 Caffeine의 작용에 관한 연구)

  • Ha, Doo-Bong;Kim, Han-Do
    • The Korean Journal of Zoology
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    • v.19 no.4
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    • pp.161-170
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    • 1976
  • Since caffeine inhibits the active uptake of Ca by the sarcoplasmic reticulum, the action of caffeine on the fragmented sarcoplasmic reticulum of rabbit skeletal muscle was studied. Caffeine seemed not to bind tightly to the sarcoplasmic reticulum. The determination of sulfhydryl content of the fragmented sarcoplasmic reticulum, however, suggested that caffeine in some unknown manner influences the protein moiety and thereby increases the sulfhydryl content. The inhibition of Ca uptake by caffeine therefore might be considered as due to the result of this change in protein sulfhydryl content.

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Amount of caffeine in caffeine containing products, and the pattern of caffeine consumption (카페인 함유제품의 카페인 함량 및 소비형태에 관한 연구)

  • Yoon, Jeong-ok;Kwon, Kwang-il
    • Korean Journal of Clinical Pharmacy
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    • v.3 no.1
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    • pp.21-30
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    • 1993
  • The contents of caffeine in caffeine containing products in Korea, i.e., coffee. tea, cocoa and cola, and the individual pattern of consumption of caffeine containing beverages were studied to know the pattern of caffeine consumption. The correlation in between the amount of caffeine consumption and the obesity were also investigated. In results, the average contents of caffeine in the instant coffee was $31.8\pm4.4mg/g(mean{\pm}SD)$. The amount of caffeine in coffee were $68.2\pm13.0\;mg/cup$ in the vending machine coffee, and $76.6\pm12.1\;mg/cup$ in the coffee shop coffee. Average daily caffeine consumption per person was investigated to be 128mg with the wide range of 26mg-341mg. There was no correlation in the amount of daily caffeine consumption and the obesity.

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Effects of Caffeine Intake Levels on Iron Metabolism in Male and Female Rats (카페인 섭취 수준이 성별이 다른 흰쥐의 철분대사에 미치는 영향에 대한 연구)

  • 박수진
    • Journal of Nutrition and Health
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    • v.29 no.7
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    • pp.713-720
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    • 1996
  • To study the effect of caffeine intake levels on iron metabolism, the iron utilization, iron contents of serum, liver, spleen, kidney, hemoglobin and hematocrit were compared in rats of different sex fed various levels of caffeine (3.5 and 7.0mg/100g body weight) for three weeks. There were no significant caffeine induced differences in feed intake, body weight gain but feed intake of male rats were significantly lower than that of female rats. Hemoglobin, hematocrit and iron contents of the serum were not significantly different between caffeine free and caffeine groups or male and female rats. Iron contents of kidney were decreased by elevation of injected caffeine levels rather than those of liver and spleen. caffeine male groups showed more increased uine volume, urinary and fecal excretions of iron than caffeine free or caffeine female groups. Apparent digestibility and retention of iron were significantly decreased by increment of injected caffeine levels. Male rate rats were more susceptible to injected caffeine on iron excretion than female rats. Current findings suggest that excessive caffeine consumption can affect iron excretion via urine and feces thereby decrease the utilization of iron, and have more significant effect on male than female rats.

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Effect of Caffeine on Coronary Circulation and Calcium Release in Isolated Guinea Pig Hearts (Guinea Pig Heart의 관상동맥 순환기능과 Calcium Release에 있어서 Caffeine이 미치는 영향)

  • 김은지
    • Journal of Nutrition and Health
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    • v.25 no.7
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    • pp.597-607
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    • 1992
  • The present study examined effects of caffeine on coronary circulation myocardial oxygen me-tabolism and calcium release in isolated perfused guinea pig hearts. Intracoronary caffeine({{{{ {10 }^{-5 } }}}}∼{{{{ { 10}^{-3 } }}}}M) was employed for 10 minutes to measure coronary perfusate flow(CF) and coronary vascular sresistance(CVR) at a constant coronary perfusion pressure of 80 cmH2O Perfusate myocardial oxygen consumption(MVO2) and percent oxygen extraction(%EC2) were calcula-ted. In addition calcium contents in both perfusate samples were measured to calculate calcium release in coronary venous effluent. Caffeine significantly decreased CF and increased CVR during 10 minutes of caffeine perfusion regardless of dose of caffeine perfused exhibiting time-response. While % EO2 was significantly enhanced with caffeine MVO2 was markedly reduced. The coronary venous perfusate pH dcreased during the perfusion with caffeine. These changes were consistent with caffeine-induced metabolic acidosis. Calcium release appeared to be dose-dependent and high dose of caffeine greatly increased venous calcium release even 2 minutes after perfusion with carffeine. These finding in dicate that caffeine produced coronary vasoconst-riction with increased calcium release in isolated perfused guinea pig hearts. Additionaly this vasoconstrictor response mignt be due tin part to the direct actions of caffeine.

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Macro Mineral Responses to Caffeine in Serum and Urine of Healthy Young Females(I) -Na, K, Ca, P, Mg- (Caffeine 섭취에 따른 성인 여자의 혈액과 소변중 다량 무기질 함량 변화에 관한 연구(I) -Na, K, Ca, P, Mg-)

  • 임성아
    • Journal of Nutrition and Health
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    • v.26 no.9
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    • pp.1118-1128
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    • 1993
  • This study was undertaken to investigate the acute effect of caffeine consumption on the change of mineral concentration in serum and urinary mineral excretion in healthy young females. On two separate mornings at one week intervals, each subject drank a coffee which contained no caffeine and 3mg/kg body weight caffeine. To obviate dietary effects on mineral concentration in serum and urine, each subject fasted at least ten hours before consuming the test beverage. At one, two, three and four hours, serum and urine production collected seperately for measurement of sodium, potassium, calcium, phosphorus and magnesium concentration. The results were as following : 1) Mean age of subjects was 20.6$\pm$0.32, Mean body mass index of subjects was 21.64$\pm$0.89, which was within $\pm$10% of ideal body weight. 2) Total urine volume of caffein groups for 4 hour after caffeine consumption was higher than that of decaffeine one, but urine pH was unchanged after caffeine consumption. Total urinary four hour excretion of creatinine was not affected by caffeine consumption and creatinine clearance also was not different from the control value. 3) In serum, mean three hour content of sodium(p<0.01) and phosphorus was higher in the subject given the caffeine. Mean serum magnesium and calcium contents were lower in caffeine group than that of decaffeine one. Mean serum magnesium content for three hour after caffeine ingestion was affected by caffeine consumption(p<0.001). Mean serum content of potassium was unaffected by caffeine consumption. 4) Total urinary four hour excretion of sodium, increased significantly after caffeine consumption(p<0.05), while total urinary four hour excretion of potassium, calcium, phosphorus and magnesium was unchanged after caffeine intake. Urinary excretion of Na, Ca, P and Mg was greatest at one hour after caffeine consumption, especially urinary sodium and potassium excretion was significantly high(p<0.05, p<0.01). The above results show that only 3mg caffeine per kg body weight increase the urinary macro mineral excretion in healthy young females.

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