• Title, Summary, Keyword: cardiac hypertophy

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Effects of Pear Phenolic Compound on Blood Pressure, Plasma Renin, ANP and Cardiac Hypertophy in Hypertensive RAT Induced by 2K1C (배 추출 Phenolic compound 투여가 흰쥐의 혈압 변화, 혈장 Renin, ANP 및 Cardiac hypertrophy에 미치는 영향)

  • Na Chang Su;Yun Dae Hwan;Choi Dong Hee;Kim Jeong sang;Jo Chun Hwa;Eun Jong Bang
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.2
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    • pp.363-367
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    • 2003
  • Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoaction, diabetes in oriental medicine. In this study, it was investigated that pear phenolic compound effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide(ANP) in plasma, Cardiac hypertrophy. The experiments were performed on Sprague Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5mg/Kg(PPC-A) 10mg/Kg(PPC-B) 15mg/Kg(PPC-c) and control group. Pear phenolic compound solution were supplied with them for 3weeks, a day's interval. The results are that The blood pressure was significantly decreased at 15days in PPC-A group than control group. The plasma ANP was increased in PPC-A and PPC-C group, and cardiac hypertrophy was significantly decrease in PPC-C group compared with control group.

The Effect of Pear Pectin on Blood Pressure, Plasma Renin ANP and Cardiac Hypertrophy in Hypertensive Rat Induced by 2K1C (배 추출 펙틴이 2K1C 고혈압 흰쥐의 혈압, 혈장 Renin, ANP 및 Cardiac Hypertrophy 에 미치는 영향)

  • Na, Chang-Su;Yun, Dae-Hwan;Choi, Dong-Hee;Kim, Jeong-Sang;Cao, Chun-Hua;Eun, Jong-Bang
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.5
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    • pp.700-705
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    • 2003
  • Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoactio, diabetes in oriental medicine. In this study, it was investigated that pear pectin effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide (ANP) in plasma, cardiac hypertrophy. The experiments were performed on Sprague-Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5 mg/kg, 10 mg/kg, 15 mg/kg and the control, pear pectin and apple pectin solutions were supplied with them. The blood pressure was more decreased in pear pectin 10 mg/kg than in apple pectin. The plasma ANP was decreased in pear pectin 10 mg/kg, and renin was increased in same concentration of drug. Cardiac hypertrophy had a tendency to decrease in pear pectin 15 mg/kg, but was not statistically significant compared to control group.