• Title, Summary, Keyword: catecholamine

Search Result 312, Processing Time 0.038 seconds

Synthesis of Dopamine by Plasma (플라즈마를 이용한 도파민 합성)

  • Kim, Seong-In;Lee, Deok-Yeon;Lee, Hae-Sin
    • Proceedings of the Korean Vacuum Society Conference
    • /
    • /
    • pp.121.2-121.2
    • /
    • 2014
  • Synthesis of catecholamine from aniline is achieved by plasma enhanced CVD process. Catecholamine has a variety of functions in body such as brain and bloodstream controls. Catecholamine also has an interesting property of a material independent ability of functionalizing surface, which is found at mussels' adhesive nature. Synthesis of catecholamine has only been available from DOPA by chemical reduction and oxidation. This study presents the direct synthesis of catecholamine from further elemental source, aniline, which has not been achieved by a conventional chemical method. The process also indicates that a variety of catecholamine can be formed by controlling reactant gases. In additional to PECVD's very useful properties such as conformal, ultrathin and uniform coatings, a direct synthesis from aniline and a capability of controlling formation of a variety catecholamine is believed to open up a numerous applications.

  • PDF

불소가 발육중인 백서악하선의 Catecholamine에 미치는 영향

  • Cheong, Dong-Kyun;Lee, Sang-Sin
    • The journal of the Korean dental association
    • /
    • v.12 no.3
    • /
    • pp.155-158
    • /
    • 1974
  • Catecholamine levels were determined in the submandibular glands of new born rats treated with physiologieal saline solution or large doses of sodium fluoride (10mg/kg) for verying periods of time. In control group, catecholamine levels were gradually increased from fifth day of life until twenty-fifth day of life. When fluoride treatment was started on the fifth day after birth and continued daily to the thirty-fifthday of life, decreased catecholamine levels were obsrved on the fifth, through all experiments, and thirth-fifth day. Daily fluoride treatment from the fifteenth through the thirty-fifth day after birth induced the decreased catecholamine levels which were higher than the levels in submandibular glands of rats treated from the fifth day to the thirty-fifth day after birth with NaF. These experiments suggest that fluoride may be affecting catecholamine biosynthetic mechanisms which were duveloping during the fifteenth to twenty-fifth day of life.

  • PDF

Variations of Catecholamine Contents in Rat Urine by Environmental Stress (환경 Stress에 의한 횐쥐뇨중 catecholamine의 변화)

  • 김형석
    • Environmental health and toxicology
    • /
    • v.3 no.3_4
    • /
    • pp.9-15
    • /
    • 1988
  • The word of stress crime from Latin language as stringere and it was used in medical fields from 1935. According to Selye, all the biological bodies reveal physilolgical changes when some stimulation exceed normal levels, and consequently the pituitary gland and adrenal systems are activated. Jacob expressed that stress is the loss of homeostasis by physical, chemical, and emotional stimulation. When biological organisms receive extreme stress the amount of catecholamine excretion are increase. Author investigated the catecholamine contents in rat urine after giving the low temperature stress, noise stress, and water immersion stress. The 24 hours rat urine was collected by adding 1 ml 6 N-HCl and the sample is passed through Bio-Rex 70 samples treatment column to extract catecholamine and detected the catecholamine with HPLC-fluorescence detetor. The highest epinephrine concentration was 67.14 ng in water immersion stress condition and the dopamine concentration of 221.37 ng was shown in the low temperature stress condition.

  • PDF

Effect of Anjungtang on the Contents of Catecholamine in Plasma and Urine of Rats Stressed by Immobilization (안정탕(安定湯)이 구속(拘束)Stress 흰쥐의 혈액(血液) 및 뇨(尿) Catecholamine 함량(含量)에 미치는 영향(影響))

  • Lee Jeong-Ho;Chung Dae-Kyoo
    • Journal of Oriental Neuropsychiatry
    • /
    • v.6 no.1
    • /
    • pp.51-59
    • /
    • 1995
  • This experiments were conducted to study anti-stress effects of Anjungtang on the contents of catecholamine in plasma and urine of rats stressed by immobilization. The main results, obtained were summerized as follow: 1 The contents of plasma and urine catecholamine increased significantly in the group of rats stressed by immobilization. 2 The contents of plasma catecholamine decreased with statistical significance in the group administered Anjungtang of rats stressed by immobilization compared with in the group administered non Anjungtang. 3.The contents of urine catecholamine decreased with in the group administered Anjungtang of rats stressed by immobilization compared with in the group administered non Anjungtang. Particulaly the content of urine norepinephrine decreased with statistical significance. 4. The weight of the body increased in the group administered Anjungtang of rats stressed immobilization compared with in the group administered non Anjungtang. According to the above results, this experiments concluded that Anjungtang had significant effecrs in reducing stress.

  • PDF

Catastrophic catecholamine-induced cardiomyopathy rescued by extracorporeal membrane oxygenation in recurrent malignant pheochromocytoma

  • Min, Daniel
    • Yeungnam University Journal of Medicine
    • /
    • v.36 no.3
    • /
    • pp.254-259
    • /
    • 2019
  • Pheochromocytoma (PCC) is a rare catecholamine-producing tumor with the incidence in hypertension of 0.1-0.6%. PCC crisis is an endocrine emergency that can lead to hemodynamic disturbance and organ failure such as catecholamine-induced cardiomyopathy. The circulatory collapse caused by it often requires mechanical support. The author reports an unusual case in which a patient who previously underwent surgery for malignant PCC developed catecholamine-induced cardiomyopathy, and successfully recovered using extracorporeal membrane oxygenation.

The Influence of Sodium Fluoride on the Release of Catecholamine from Perfused Organs and Monoamine Oxidase Activity (Fluoride가 적출장기(摘出臟器)의 Catecholamine 유리(遊離) 및 Monoamine Oxidase 활성도(活性度)에 미치는 영향(影響))

  • Cheon, Yun-Sook;Kim, Sung-Sook;Lee, Kyung-Hee;Shin, Kyung-Chul
    • The Korean Journal of Pharmacology
    • /
    • v.8 no.2
    • /
    • pp.41-47
    • /
    • 1972
  • Fluorides were supposed to exert a stimulatory action on the catecholamine release. In this study, the authors attempted to investigate the action of sodium fluoride on the catecholamine release from the isolated perfused cow adrenal gland and rat heart. And also the inhibitory effect of sodium fluoride on the monoamine oxidase activity in rat heart and liver mitochondria was investigated. The monoamine oxidase activity was measured by the conversion of benzylamine to benzaldehyde. The results obtained were follows; 1. Sodium fluoride stimulated the release of catecholamine from the isolated perfused cow adrenal gland and rat heart. 2. Sodium fluoride inhibited the rat heart and liver mitochondrial monoamine oxidase activity.

  • PDF

A Study on the Catecholamine under the Room Temperature and $5^{\circ}C$ Refrigerator Environment in Rat (실온과 $5^{\circ}C$ 냉장고 환경에서 흰쥐 Catecholamine 분비에 관한 연구)

  • Hong, Seyng-Eui;Yoon, Tai-Young;Kim, Hyung-Suk
    • Journal of Preventive Medicine and Public Health
    • /
    • v.20 no.2
    • /
    • pp.215-220
    • /
    • 1987
  • Under the extreme change of the environment, animals react physiologically to adapt to the stress and secrete catecholamines. Cold exposure is a kind of the environmental stress. Author tried to determine the amount of catecholamines in rat urine as a parameter of physiological response to cold stress. Urinary catecholamine was measured by using HPLC with fluorescence detector, cation exchange column prepacked with Bio·Rex 70 and ammonium pentaborate as catecholamine eluent. The amount of dopaminc in normal state rat urine was 42.0 ng, but under the low temperature of $5^{\circ}C$, the dopamine amount was increased to 221.25 ng/5 ml. Above findings are suggesting that catecholamine secretion, especially dopamine, increases in the stressful condition such as cold exposure.

  • PDF

Glucose Modulation of Release of Endogenous Catecholamines from Hypothalamic Fragments in Vitro (시상하부 조각에서 내재성 카테콜아민의 분비에 대한 포도당의 조절작용)

  • Jung, Jun-Sub;Hwang, Hyung-Sik;Wie, Myung-Bok;Song, Dong-Keun;Kim, Yong-Sik;Kim, Yung-Hi
    • The Korean Journal of Pharmacology
    • /
    • v.29 no.2
    • /
    • pp.183-188
    • /
    • 1993
  • Effects of glucose on the catecholamine release from the hypothalamic fragments in vitro were studied. Basal release of catecholamines was inversely related to the concentrations $(5{\sim}30\;mM)$ of glucose in the incubation medium. Glucose did not affect the 30 mM $K{^+}-stimulated$ release of catecholamine. In the presence of tetrodotoxin $(10\;{\mu}M)$, the inhibitory effect of glucose on the basal release of catecholamines was largely persisted, but the inhibitory effect of 30 mM glucose on dopamine release was largerly blocked. In the presence of both tetrodotoxin $(10\;{\mu}M)$ and desipramine $(3\;{\mu}M)$, glucose failed to affect the basal catecholamine release. The results suggest that glucose modulates the catecholamine release through a direct action on the catecholaminergic nerve terminals, as well as through a trans-synaptical action. The glucose-modulation of the catecholamine release may explain, at least in part, the diabetes-induced changes in the hypothalamic catecholamine metabolism.

  • PDF

An Experimental Study on the Effects of Gungsindodamtang and Dangquibohyultang on the contents of Serotonin and Catecholamine in the Brain and the Plasma of the Reserpine treated rats (궁신도담탕(芎辛導痰湯) 및 당귀보혈탕(當歸補血湯)이 뇌(腦) 및 혈장(血漿)의 Serotonin과 Catecholamine 함량(含量)에 미치는 영향(影響))

  • O, So-Jeo;Park, Seong-Sik;Lee, Won-Cheol
    • The Journal of Dong Guk Oriental Medicine
    • /
    • v.3
    • /
    • pp.91-106
    • /
    • 1994
  • This Study was performed to prove the effects of Gungsindodamtang (GDT) and Dangquibohyultang (DBT) on the cosntents of Serotonin and Catecholamine in the Brain and the Plasma of the Reserpine treated rats. High-Perfomance Liquid Chromatography was used for measuring the contents of the Serotonin and Catecholamine. The results were as follows. 1. norepinephrine contents in the Brain were increased significantly in GDT-treated group and DBT-treated group in comparison with the control group. 2. epinephrine and serotonin contents in the Brain were increased in all the sample groups but have not significance. 3. norepinephrine contents in the plasma were increased significantly in all the sample groups in comparison with the control group. 4. epinephrine contents in the plasma were increased in all the sample groups but have not significance. 5. serotonin contents in the plasma were increased significantly in DBT-treated group in comparison with the control group, and inreased in GDT-treated group but have not significance. According to the above results, it is considered that Dangquibohyultang could be applied more effectively than Gungsindodamtang in decrease of the serotonin and catecholamine and other symptoms induced by Reserpine.

  • PDF