• Title, Summary, Keyword: central nervous system

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The Literature Review of Central nervous system regeneration (중추신경계의 재생에 관한 문헌고찰)

  • Kim Dong-Hyun;Baek Su-Jeong;Kim Jin-Sang
    • The Journal of Korean Physical Therapy
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    • v.12 no.3
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    • pp.395-406
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    • 2000
  • In general. it is known that central nervous system associated with nerve injury and regeneration in mature cann't regenerate, unlikely peripheral nervous system, due to various reasons. Although a lot of Patients arc suffered with central nervous system injury in the world, but there art a few resolution and researches and investigations. 'rho effect of central nervous system regeneration was partly revealed by many researchers. In this article, we describe about recovery (inclusive of axonal regeneration, remyelination, repair of spinal cord) and associated factors(inclusive of macrophage and autoimmune T-cell. neural stem cells. Nogo) after central nervous system injury.

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The Psychiatric and Central Nervous System Effects of Fructus Mume in Medical Classics (한의학 고문헌을 통한 오매의 정신의학과 중추신경계 관련 효능 연구)

  • Kim, Wu-Young;Jeon, Won Kyung
    • Journal of Haehwa Medicine
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    • v.22 no.1
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    • pp.71-78
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    • 2013
  • Objectives : Fructus mume(F. mume) has been used as a medicine for thousands of years in East Asia and reported to have effect on cognitive deficits induced by chronic cerebral hypoperfusion. We investigated F. mume's effects on psychiatric and central nervous system in medical classics. Methods : 25 materia medica books and Donguibogam were searched to find psychiatric and central nervous system effects of F. mume. Two Korean Medicine doctors reviewed the effects from the clinical point of view. Results : 安心(relieve psychiatric discomfort), 令人得睡 治不眠(Treat insominia), 去煩悶(relieve chest discomfort) were psychiatric effects and 偏枯不仁(hypoesthesia accompanied with hemiplegia) was central nervous system effect of F. mume. Conclusions : Further studies will be needed to demonstrate F. mume's effects found in medical classics.

Effects of Bistortae Rhizoma on Hemostasia, Anti-inflammatory Action and Central Nervous System (권삼(拳蔘)이 지혈(止血).소염작용(消炎作用) 및 중추신경계(中樞神經系)에 미치는 영향(影響))

  • Sun, Jung-Ki;Lee, Dong-Joon
    • The Journal of Internal Korean Medicine
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    • v.21 no.5
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    • pp.781-789
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    • 2000
  • Objective : The purpose of these research was to investigate effects of water extract of Bistortae Rhizoma(BRE) on the hemostasia, anti-inflammatory action and central nervous system. Methods : we used mice and rats administered with the extract of the above herbs. Results : BRE decreased the permeability of evans blue into peritoneal cavity and cotton pellet granuloma formation. BRE did not decrease the acetic acid induced writhing syndrome and the histamine induced mouse paw edema. BRE inhibited the pentylenetetrazole and the strychnine induced convulsion. BRE shortened the bleeding time and plasma prtrombin time. BRE did not affect on the proliferation of Balb/c 3T3 cells. Conclusions : these results suggest that the effects of BRE are the hemostasia, anti-inflammatory action, and mild depressant activity of central nervous system.

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Immunohistochemical Localization of Heat Shock Protein 70 in the Central Nervous System of Nicotine-treated Rat Embryo (태서 중추신경계의 Heat Shock Protein 70 분포에 대한 Nicotine 영향)

  • 최병태;강호성
    • Journal of Life Science
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    • v.7 no.4
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    • pp.276-281
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    • 1997
  • This study was investigated to determine whether nicotine causes the morphological changes and expression of heat shock protein(HSP) 70 in the central nervous system of rat embryo. The pregnant rats were injected s.c. twice daily with 3 mg nicotine per 100g body weight from day 0 to 14 of gestation and embryos were removed on gestation day 15. As morphological changes, retardation of cell proliferaton was observed in the telencephalon of nicotine-treated groups and no changes in the other region were found. Minimal HSP 70 was expressed over chole central nervous system was similar between control and nicotine-treated group, the expression of blood cells in the meinges and chroid plexus was significantly greater in nicotine-treated group than in control.

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Malignant Tumors of the Central Nervous System in Kazakhstan: Component Analysis of Incidence Dynamics

  • Igissinov, Nurbek;Akshulakov, Serik;Kerimbayev, Talgat;Adilbekov, Yerzhan;Aldiyarova, Nurgul;Rakhimbekov, Alexandr;Akpolatova, Gulnur;Tarzhanova, Dinar
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.6
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    • pp.2289-2295
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    • 2015
  • The paper presents the incidence rates of malignant tumors of the central nervous system assessed by the component analysis. The data on primary registered cases of malignant tumors of the central nervous system in the country were used as the material of the study for the period from 2004 to 2011. A general trend of increase in the number of patients with malignant tumors of the central nervous system in Kazakhstan was determined and the potential of their increase was evaluated, which can be due to changes in the morbidity risk and age specifics, as well as the increase in population.

Pharmacological Studies on Prunellae Herba and Thesii Herba (II) -On Central Nervous and Diuretic Actions- (한국산(韓國産) 하고초류(夏枯草類)의 약물학적(藥物學的) 연구(硏究)(II) -중추신경(中樞神經) 및 이뇨작용(利尿作用)에 대하여-)

  • Ko, In-Ja;Yoo, Seung-Jo;Lee, Eun-Bang
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.242-247
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    • 1986
  • This study is an attempt to investigate the effects of the water extracts of the whole plants of Prunella vulgaris (Labiatae) and Thesii chinense (Santalaceae) on the acute toxicity, the activities on central nervous system and the diuretic action. The acute toxicities shown by $LD_{50}$ were estimated to be more than 3000 mg/kg p.o. and 1,000 mg/kg s.c. in the extracts of Prunellae Herba and Thesii Herba, respectively, in mice. The extracts at a dose of 2,000 mg/kg p.o. did not show any activities on central nervous system, i.e, sedative, analgesic, hypothermic and anticonvulsant actions. The urination in rats was increased by 45.5% and 57.6% when 100mg/kg of each of the extracts were given orally. The results obtained revealed that the water extracts possessed weak diuretic actions without any of central nervous system activities. Furthermore, it is considered that the potassium in the extract may play a role in the diuretic action.

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Developmental Anomalies of Central Nervous System in Human

  • Chi, Je G.
    • Toxicological Research
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    • v.17
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    • pp.11-16
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    • 2001
  • The development of the central nervous system is a continuous process during the embryonic and fetal periods. For a better understanding of congenital anomalies of central nervous system, three major events of normal development, i.e., neurulation (3 to 4 weeks), brain vesicle formation (4 to 7 weeks) and mantle formation (over 8 weeks) should be kept in mind. The first category of anomalies is neural tube defect. Neural tube defects encompass all the anomalies arise in completion of neurulation. The second category of central nervous system anomalies is disorders of brain vesicle formation. This is anomaly that applies for "the face predicts the brain". Holoprosencephaly covers a spectrum of anomalies of intracranial and midfacial development which result from incomplete development and septation of midline structures within the forebrain or prosencephalon. The last category of central nervous system malformation is disorders involving the process of mantle formation. In the human, neurons are generated in two bursts, the first from 8 to 10 weeks and next from 12 to 14 weeks. By 16 weeks, most of the neurons have been generated and have started their migration into the cortex. Mechanism of migration disorders are multifactorial. Abnormal migration into the cortex, abnormal neurons, faulty neural growth within the cortex, unstable pial-glial border, degeneration of neurons, neural death by exogenous factors are some of the proposed mechanism. Agyria-pachygyria are characterized by a four-layerd cortex. Polymicrogyria is gyri that are too numerous and too small, and is morphologically heterogeneous. Cortical dysplasia is characterized by the presence Q[ abnormal neurons and glia arranged abnormally in focal areas of the cerebral cortex. Neuroglial malformative lesions associated with medically intractable epilepsy are hamartia or hamartoma, focal cortical dysplasia and microdysgenesis.ysgenesis.

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General Neuropharmacology of Rutaecarpine, a Quinazolinocarboline Alkaloid

  • Chang, Jong-Sun;Jin, Da-Qing;Park, Byung-Chul;Jahng, Yurng-Dong;Yu, Bong-Kyu;Choi, Han-Gon;Yong, Chul-Soon;Jeong, Tae-Cheon;Kim, Jung-Ae
    • Biomolecules & Therapeutics
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    • v.12 no.3
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    • pp.175-178
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    • 2004
  • Rutaecarpine is one of quinazolinocarboline alkaloids found in Evodia rutaecarpa, a Rutaceous plant and it has shown various biological effects including antiinflammation. However, the effect of rutaecarpine on nervous system was not reported yet. In this study we investigated the general pharmacology of rutaecalpine on the central nervous system. Rutaecapine (4O and 400 mg/kg) did not change chemoshock induced by pentylenetetrazole. However, oral administration of rutaecarpine altered motor coordination examined by rotarod test, pentobarbital-induced sleeping time and acetic acid-induced writhing syndrome in mice at the doses of 40 and 400 mg/kg. Rutaecarpine also induced hypothermia in mice at both doses. The results suggest that rutaecapine possesses neuromodulating activities on central nervous system in addition to the various biological effects on the Periphery.

General Pharmacology of Bamboo Salt (죽염의 일반약리작용)

  • 유태무;김순선;노용남;이숙영;김옥희;류항묵;양지선
    • Biomolecules & Therapeutics
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    • v.8 no.1
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    • pp.93-98
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    • 2000
  • This study has been carried out to investigate general pharmacological action of bamboo salt (jukyom) in terms of effects on central nervous system and cardiovascular system in experimental animals. After bamboo salt, crude salt or reagent-grade NaCl were orally administered into male ICR mice with dose of 2.0 g/kg, general behavioural syndromes such as body weight and locomotor activity, spontaneous motor activity, pento-barbital-induced sleeping time, muscle incoordination, electroshock-induced convulsion, body temperature and writhing response caused by 0.6% acetic acid solution were observed. Bamboo salt had no influences in these indices for examinition of effect on central nervous system. Additionally, conscious male Sprague Dawley rats fastened overnight won ere treated with bamboo salt, crude salt or reagent-grade NaCl (2.0 g/kg, p.o.) to examine the effect of these salts cardiovascular system. Systolic, median and diastolic food pressure and heart rate were dertemined using tail cuff indirect method. Treatment with Hydralazine (50 mg/kg, p.o) as a positive control produced the decreases in systolic, median and diastolic blood treasure and an increase in heart rate. whereas no changes were observed in bamboo salt, crude salt and reagent-grade NaCl treated groups. These results strongly suggest that bamboo salt may have no effects on general pharmacology of central nervous systems and cardio-vascular systems.

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Fine Structure of the Neuroganglia in the Central Nervous System of the Harvestman Leiobunum japonicum (Arachnida: Opiliones)

  • Park, Yong-Ki;Gu, Hye-Yoon;Kwon, Hyun-Jung;Kim, Hoon;Moon, Myung-Jin
    • Applied Microscopy
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    • v.48 no.1
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    • pp.17-26
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    • 2018
  • The characteristic features of the arachnid central nervous system (CNS) are related to its body segmentation, and the body in the Opiliones appears to be a single oval structure because of its broad connection between two tagmata (prosoma and opisthosoma). Nevertheless, structural organization of the ganglionic neurons and nerves in the harvestman Leiobunum japonicum is quite similar to the CNS in most other arachnids. This paper describes the fine structural details of the main groups of neuropiles in the CNS ganglia revealed by the transmission electron microscopy. In particular, electron-microscopic features of neural clusters in the main neuroganglia of the CNS (supraesophageal ganglion, protocerebral ganglion, optic lobes, central body, and subesophageal ganglion) could provide indications for the nervous pathways associated with nerve terminations and plexuses. The CNS of this harvestman consists of a supraesophageal ganglion (brain) and a subesophageal mass, and there are no ganglia in the abdomen. Cell bodies of neuroganglia are found in the periphery, but central parts of the ganglia are mostly fibrous in all ganglia. Neuroglial cells occupy the spaces left by nerve cells. Since the nerve cells in the ganglia are typical composed of monopolar neurons, axons and dendrites of neurons are distributed along the same direction.