• Title, Summary, Keyword: cholesterol-lowering

Search Result 469, Processing Time 0.057 seconds

Isolation and characterization of cholesterol-lowering lactic acid bacteria from kimchi (김치에서 분리된 콜레스테롤 감소능을 가진 젖산세균의 특성)

  • Park, Hong-Yeop;Park, Seul-Ki;Kim, Bo-Geum;Ryu, Dae-Gyu;Lim, Eun-Seo;Kim, Young-Mog
    • Korean Journal of Food Science and Technology
    • /
    • v.49 no.4
    • /
    • pp.377-382
    • /
    • 2017
  • The objective of this study was to isolate and characterize lactic acid bacteria (LAB) exhibiting cholesterol-lowering activity from the Korean traditional fermented food, kimchi. The previously isolated LAB strains were assessed for cholesterol-lowering efficacy in the presence of 0.1% cholesterol. All LAB strains tested in this study were able to assimilate cholesterol at varying levels, ranging from 35.0 to 99.4%. Among them, the Lactobacillus plantarum FMB 31 strain exhibited the highest cholesterol-lowering effect with 99.4% cholesterol removal efficiency. The strain was stable in the presence of acid, bile, and salt stress, and showed high adherence on HT-29 cells, a human colon line. In addition, the LAB strain showed no pathogenic properties such as the production of hemolysin and biogenic amines. Thus, this study suggests that the L. plantarum FMB 31 strain isolated from kimchi can be a potential source of probiotic products with strong cholesterol-lowering effect.

Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

  • Wang, Lijun;Zhou, Baihua;Zhou, Xue;Wang, Yang;Wang, Hongwei;Jia, Shengying;Zhang, Zhipeng;Chu, Chao;Mu, Jianjun
    • Journal of Microbiology and Biotechnology
    • /
    • v.29 no.3
    • /
    • pp.473-481
    • /
    • 2019
  • Statins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in combination with rosuvastatin. We were able to show that Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.

Some Factors Affecting Lipid Metabolism (지질대사(脂質代謝)에 관여하는 인자(因子))

  • Nam, Hyun-Keun
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.15 no.2
    • /
    • pp.191-200
    • /
    • 1986
  • It is now generally accepted that individuals at increased risk for cardiovascular disease may be identified by certain traits or habbits. The factors such as high blood pressure, elevated blood cholestrol, age, sex and obesity are associated with increseaed frequency of disease. The blood cholesterol level lowering will decrease cardiovascular disease risk. The regression of atherosclerosis can be achieved by lowering the level of circulating cholesterol. Those things are connected with the quantity and quality of protein, fats, carbohydrates, especially soluble and non-soluble fiber, magnesium and calcium. The lipoprotein and lipid metabolism are connected with the lipid transport. The factors on lipid absorption and blood serum lipid pattern of human are exist. The factors have a variety of materials with different chemical and physical properties. The soluble fiber diet make a low blood and liver lipids. Many kind of soluble fiber results in a lowering of blood cholesterol and triglyceride levels. The cholesterol lowering effects of dietery fiber may be a results of alterations of in intestinal handling of fats, hepatic metabolism of fatty acid or triglyceride acid metabolism of lipoprotein. It is investigated that the high density lipoprotein (HDL) is inversely related to coronary artery disease. It has been postulated that HDL may be an important factor in cholesterol efflux from the tissues, therby reducing the amount of cholesterol deposited there. Alternatively, the HDL may pick up cholestyl ester and phospholipid during normal VLDL lipolysis in the plasma. The HDL levels are relatively insensitive to diet. At present time, the cause-and -diet effect of HDL's inverse relation to CHD remains unclear.

  • PDF

Effects of Yam on Lowering Cholesterol Level and Its Mechanism (마(Dioscorea)의 콜레스테롤 저하작용 및 그 작용기전)

  • 권정숙
    • Journal of Nutrition and Health
    • /
    • v.32 no.6
    • /
    • pp.637-643
    • /
    • 1999
  • The effects of yam(Dioscorea) on lowering cholesterol level and its mechanism were investigated. The concentrations of plasma and liver lipids, and the excretions of fecal neutral sterol and bile acid were measured in male Sprague-Dawley rats. Five Groups of 8 rats were fed hypercholesterolemic diet(1% cholesterol, 10% lard ; control), hypercholesterolemic diet plus 15% or 30% dried yam powder prepared by either hot-air(15HY, 30HY) or freeze dry(15FY, 30FY) for 4wk. Plasma total lipid, total cholesterol and cholesterol level was also significantly lower(28%, p<0.05), buy HMG-CoA reductase activity was higher in 30FY(230%, p<0.05) than in control. Although no significant differences in fecal neutral sterols were observed among groups, the yam-fed rats apparently had less bacterial degradation of cholesterol as indicated by a significantly greater of fecal cholesterol to coprostanol than in controls. Total fecal bile acids were significantly greater in rats fed yam(15HY : 5 folds, 15FY ; 12,30HY ; 12, 20FY ; 22) than in controls. The ratio of secondary to primary bile acids was almost 8 times lower in 30FY than in control. These data indicate that yam lowers cholesterol both in plasma and in liver through increasing fecal bile acid excretion as well as HMG-CoA reductase activity. Freeze-dried yam, which possesses viscosity, was more effective in cholesterol-lowering action than hot-air dried one.

  • PDF

Lecithin : Cholesterol Acyltransferase Activities in Rats Fed Cow량s Milk with Different Levels of Cholesterol (식이 콜레스테롤의 섭취량에 따라 우유가 흰쥐의 Lecithin: Cholesterol Acyltransferase 활성에 미치는 영향)

  • 최명숙
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.23 no.3
    • /
    • pp.371-379
    • /
    • 1994
  • The effect of milk in low and high cholesterol diets were investigated on serum cholesterol esterification. Weanling male Sprague-Dawley rats were divided into low(0.01% w/w) and high (1.01% w/w) cholesterol-diets groups. Bothlow and high cholesterol groups were consisted of three groups : control , LM(low heat milk), and HM (high heat milk) groups. After feeding these experimental diets for six weeks, serum cholesterol (free cholesterol and cholestryl ester) concentration and activity of lecithin.: cholesterol acyltransferase (LCAT) were measured, and serum lipoprotein profile was examined using gel column chromatography. According to the result, activity of LCAT was elevated independently by intakes of high cholesterol and milk , which resulted in the increase of daily turnover of serum cholesteryl ester. However, the turnover of HDL-cholesteryl ester increased only by milk. LCAT activity was moderately correlated with levels of total-and HDL-free choelsterol. It is concluded from the present study that milk had the cholesterol-lowering effect which partly appears to be mediated through facilitated reverse cholesterol transport.

  • PDF

Studies on the Substrances Contained in Glucomannan Lowering Liver and Serum Cholesterol Levels (구약고구마(Glucomannan)의 섬유질이 간 및 혈청지질에 미치는 영향)

  • 이숙경
    • Journal of Food Hygiene and Safety
    • /
    • v.6 no.2
    • /
    • pp.73-78
    • /
    • 1991
  • As reported previously, it was found that glucomannan, contains a potent cholesterol-lowering material. This study was designed to characterize this material further. Both the water sluble and the alcohol soluble extracts of glucomannan were prepared, and each of these extracts were capable of reducing serum and liver cholestrol levels of rats: This finding indicates that a potent cholesterol-lowering material contained in glucomannan is an organic compound with hydrophilic groups.

  • PDF

Development of Phytosterol Ester-added Cheddar Cheese for Lowering Blood Cholesterol

  • Kwak, H.S.;Ahn, H.J.;Ahn, J.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.18 no.2
    • /
    • pp.267-276
    • /
    • 2005
  • This study was carried out to investigate the effect of phytosterol ester addition on lowering blood cholesterol in cholesterol-reduced Cheddar cheese. For cholesterol removal, separated cream was treated with 10% ${\beta}$-cyclodextrin at 800 rpm, then blended with remaining skim milk and homogenized with 1,000 psi at $70^{\circ}C$. Experimental cheeses were manufactured by five different levels of phytosterol addition. After the cholesterol reduction process by ;${\beta}$-cyclodextrin, the cholesterol removal rate was in the range of 91.0 to 92.1%. Amount of short-chain free fatty acid and free amino acids increased with an increase of phytosterol ester, and those were significantly different from that of control in all ripening periods. All rheological properties also increased with an increase of phytosterol ester during ripening period. In sensory analysis, the scores of rancid, bitterness Cheddar flavor and off-flavor intensities increased significantly, while texture was decreased during ripening in phytosterol ester-added groups. Total blood cholesterol was reduced by 18% when rats were fed Cheddar cheese treated with 8% phytosterol. The present study indicated that phytosterol ester addition resulted in a profound lowering effect of blood with cholesterol-reduced Cheddar cheese.

Comparison of Jujube Extract with Tangerine Peel Extract in Lowering Plasma Lipids and Activities of Cholesterol Regulating Enzymes in Cholesterol-Fed Rats

  • Park, Myung-Sook;Bok, Song-Hae
    • Preventive Nutrition and Food Science
    • /
    • v.6 no.2
    • /
    • pp.122-125
    • /
    • 2001
  • A potential mechanism through which the jujube extract might produce a cholesterol-lowering effect was compared with that of tangerine peel extract in vivo. Two extracts were prepared using ethanol. Male rats were fed a high cholesterol (1%, w/w) lab chow with jujube extract (1.2%) or tangerine peel extract (6.3%, w/w) for 3 weeks. Activities of hepatic HMG-CoA reductase (289.6$\pm$12.9 and 296.7$\pm$11.6 nmole/min/mg vs. 347.9$\pm$17.5 nmole/min/mg) and ACAT (554.8$\pm$18.2 and 451.7$\pm$19.4 nmole/min/mg vs. 602.6$\pm$21.4 nmole/min/mg) were significantly lowered by both supplements compared to the control group. These two supplements also substantially reduced the concentrations of plasma cholesterol (103.3$\pm$15.9 and 101.6$\pm$19.4 mg/dL vs. 141.6$\pm$18.1 mg/dL) and triglyceride (61.3$\pm$5.5 and 55.5$\pm$3.9 mg/dL vs. 96.0$\pm$4.2 mg/dL). The inhibition of HMG-CoA reductase resulting from the supplementation of jujube or tangerine extracts could count for the reduction in plasma cholesterol. Accordingly, lipid-lowering action of both supplements appears to be similar in high-cholesterol fed rats.

  • PDF

Effect of Chitosan and N. O-Carboxymethyl Chitosan of Different Sources and Molecular Weights on Lipid Metabolism (급원과 분자량이 다른 Chitosan 과 N, O-Carboxymethyl Chitosan이 지방대사에 미치는 영향)

  • 배계원
    • Journal of Nutrition and Health
    • /
    • v.30 no.7
    • /
    • pp.770-780
    • /
    • 1997
  • This study was performed to investigate the effect of chitosan and NOCC from different sources and of different molecular weights on lipid metabolism. Sprague-Dawley rats were blocked into 26 groups according to body weight, and were raised for 4 weeks. Cadmium chloride was given at the level of 0 or 400 ppm in diet. Various chitosan and NOCC sources were given at the level of 0%(w/w) of diet. Total serum cholesterol and serum triglyceride concentrations were little affected by chitosan and NOCC supplements. However, HDL-cholesterol concentration and HDL : total cholesterol ratio were increased , and liver lipid, cholesterol , and triglyceride concentration were decreased by chitosan and NOCC supplements. The cholesterol and lipid lowering activity depends on fiber sources(crab and shrimp); type (chitosan and NOCC); and molecular weight(low , medium , and high). Among cadmium-free groups, chitosan-fed groups showed greater activity than NOCC -fed groups in lowering cholesterol and lipid levels, and greater fecal excretion of lipids and bile acids. Crab chitosans were more effective in cholesterol and lipid lowering activity than shrimp chitosans. The group fed high molecular weight crab chitosan showed the highest fecal excretion of lipids and bile acids. This indicated that high molecular weight crab chitosan was most effective in interfering with cholesterol and lipid absorption.

  • PDF

Studies on the Substances Contained in Gyrophora Esculanta Lowering Plasma and Liver Cholesterol Levels Part III. On the Chemical Structure of the Compounds Contained in Gyrophora Esculanta (석이버섯(Gyrophora Esculanta)중에 함유되어있는 간장 및 혈장 Cholesterol 의 저하 생리활성물질에 관한 연구 -석이버섯중에 함유되어 있는 Cholesterol의 저하성 물질의 화학구조 관한 연구)

  • 김천호
    • Journal of Nutrition and Health
    • /
    • v.19 no.3
    • /
    • pp.155-160
    • /
    • 1986
  • This study was conducted to purify and characterize further a potent cholesterol lowering material found in Sogi. The ethanol extract of Sogi was purified with acetone and ethanol, and a white powder was obtained. This material yielded t재 spots on a Silicagel thin layer chromatogram. The major material identified by M.P. measurement, elementary analysis and spectrography was considered to be gyrophoric acid. Beside this, minor components (orsellic and leccanolic acids ) were detected.

  • PDF