• Title, Summary, Keyword: contact dermatitis

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The Review on the Experimental Studies of Allergic Contact Dermatitis Published in The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology (한방안이비인후피부과학회지에 게재된 알레르기성 접촉 피부염의 실험논문에 대한 고찰)

  • Cho, Young-Sun;Kim, Gyung-Jun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.4
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    • pp.78-94
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    • 2016
  • Objectives : This study was carried out to analyze the trends of clinical studies of allergic contact dermatitis published in the Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology. Methods : We studied 10 research papers on allergic contact dermatitis published in JKOOD. We analyzed about experiment methods, pharmacodynamic effects, therapeutic effects in published papers. Results : 1. The number of searched journal is 10 papers. 2. All experiments was performed using DNCB primed mouse. To demonstrate therapeutic effect of drugs, previous researches observed dermatological and histopathogical conditions, erythema, melasma, white blood cell count, Lymphocyte ratio to white blood cell. 3. Most of drugs have heat-clearing and detoxifying effects. 4. Every drugs have positive effect in treating allergic contact dermatitis. Conclusions : Figuring out how experiment proceeded and tendency of drugs in researching allergic contact dermatitis is significance of this paper. Further research about drugs and their treating methods should be carried out to improve curative effectiveness for allergic contact dermatitis.

Periocular Allergic Contact Dermatitis Associated with the Use of Ofloxacin Ophthalmic Ointment: A Case Report (Ofloxacin 안연고에 의해 유발된 눈주위 알레르기접촉피부염)

  • Jo, Jeong Won;Jeong, Hae Bong;Shin, Young Bin;Kang, Kee Ryeon;Kim, Chi Yeon
    • Korean journal of dermatology
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    • v.56 no.10
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    • pp.624-627
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    • 2018
  • Allergic contact dermatitis is an inflammatory condition associated with periorbital erythema, edema, and pruritus. The periorbital skin is relatively thin compared with the skin over other facial areas; therefore, it is vulnerable to allergen penetration and may show a variety of cutaneous manifestations. Recently, vision enhancement surgery is a widely performed procedure, and the prevalence of senile cataract and glaucoma is increasing. The prevalence of periocular allergic contact dermatitis is increasing secondary to the growing use of topical ophthalmic medications. Several studies in Korea have reported periocular allergic contact dermatitis secondary to the use of topical ophthalmic medications including latanoprost ($Latano^{(R)}$), fluorometholone ($Tolon^{(R)}$), polymyxin B ($Terramycin^{(R)}$), atropine sulfate ($Atropine^{(R)}$), neomycin sulfate ($Cambison^{(R)}$), and befunolol hydrochloride ($Bentos^{(R)}$), among others. However, ofloxacin ($Effexin^{(R)})$-induced allergic contact dermatitis has not been reported in the domestic and/or foreign literature. We report a case of periocular allergic contact dermatitis secondary to the use of ofloxacin ophthalmic ointment.

A Case of Allergic Contact Dermatitis Aggravated by Steroid Ointment (스테로이드 외용제로 악화된 알레르기성 접촉피부염 치험 1례)

  • Song, Mi-Sa;Yoon, Hwa-Jung;Ko, Woo-Shin
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.31 no.3
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    • pp.107-115
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    • 2018
  • Objectives : The purpose of this paper is to report the effect of Korean medicine treatments on allergic contact dermatitis aggravated after applying steroid ointment. Methods : We treated a 63-year-old woman with allergic contact dermatitis on the both forearm, jaw, neck, chest with Korean medicine. Before Korean medicine treatments she has taken oral steroids and applied steroid ointment for several years to treat dermatitis, but long-tern steroid therapy aggravated her symptoms like skin pruritus, erythema, exudates or edema. After Korean medical treatment for 27 days, we found that the size of erythema was reduced, and symptoms like pruritus, exudates and edema were lost. We recorded pictures of changes on symptoms. Results & Conclusions : The symptoms of allergic contact dermatitis were improved. Erythema, edema, exudate were lost. Thus Korean medicine treatments are effective on allergic contact dermatitis and could be a great alternative to steroid treatment.

Four Cases of Contact Dermatitis Treated by Oriental Medicine (접촉피부염 한방치험 4례)

  • Yu, Seung-Min;Choi, In-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.22 no.2
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    • pp.281-289
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    • 2009
  • Background : With the growing use of chemical products such as cosmetics, hair dyes, reports of side effects following application of these products is increasing. Contact dermatitis commonly occurs with the use of chemical products. Objective : This study investigated the effect of Oriental medicine for Four outpatients with contact dermatitis due to chemical products. Method : Four patients were treated with acupuncture, herbal medication etc. We used visual analogue scales(VAS) to estimate erythema, pruritus, edema, scales, etc. We took the photos of lesions. Results : Two patients were due to hair dyes, the other two patients were due to cosmetics. Erythema and Pruritus were decreased from nine days to one month. Conclusion : We expect that Oriental medicine could be helpful for contact dermatitis.

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Effect of Cnidium officinale Mixture on Recovery Capability of DNCB-induced Allergic Contact Dermatitis in Rat

  • Lim, Jae-Hwan;Park, Young-Mi;Jeong, Hyung-Jin;Seo, Eul-Won
    • Biomedical Science Letters
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    • v.17 no.1
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    • pp.47-53
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    • 2011
  • This study is aimed to investigate the skin thickness, plasma components, serum IgE level and antioxidant enzymes activities by mixtures of Cnidium officinale, Saururus chinensis, Houttuynia cordata and Glycyrrhiza uralensis on the allergic contact dermatitis of rat induced by 1-chloro-2,4-dinitrochlorobenzene (DNCB). Mixtures reduced the thickness of the skin and removed the dead skin cells compared to the skin of rats treated with DNCB alone. Also, these mixtures down-regulated the contents of lipid and IgE, and reduced the activities of superoxide dismutase and catalase. These results indicate that the mixtures significantly recovered the contact dermatitis induced by DNCB. In conclusion, it is thought that the mixtures could be useful for the allergic contact dermatitis.

A Case of Allergic Contact Dermatitis Improved after Korean Medicine Treatment Administration (한방 치료 후 호전된 알레르기성 접촉피부염 치험 1례)

  • Bae, Hyo-Bin;Yoon, Hwa-Jung;Ko, Woo-Shin
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.31 no.2
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    • pp.123-132
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    • 2018
  • Objectives : The purpose of this report is to know the effect of Korean medicine treatments on Allergic Contact Dermatitis. Methods : We treated a 63-years-old man patient with Allergic Contact Dermatitis on the left medial calf with Korean medicine. After Korean medical treatment for 26 days, we identified a reduction in size of erythema and loss of color fading, exudates and edema. We recorded pictures of changes on symptoms. Results & Conclusions : The symptoms of Allergic Contact Dermatitis were improved. Erythema, edema, exudate were lost. Thus Korean medicine treatments are effective on allergic contact dermatitis.

Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)

  • Lee, Hyeung-Sik;Lee, Byung-Chang;Ku, Sae-Kwang
    • Toxicological Research
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    • v.26 no.2
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    • pp.123-130
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    • 2010
  • The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Two different dosages of DHU001 (300 and 150 mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference material, dexamethasone (15 mg/kg, intraperitoneal treatment). End of 7 days oral administration of DHU001 extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these contact dermatitis signs induced by DNFB treatment were reduced by treatment of the both different dosages of DHU001 and dexamethasone, respectively. The results obtained in this study suggest that oral treatment of DHU001 extracts also has relatively favorable effects on contact dermatitis.

A Case Study of Chronic Contact Dermatitis from Cement, Treated with Taeeumin Cheonghyeolgangki-tang (태양인(太陰人) 청혈강기탕(淸血降氣湯) 투여 후 호전된 시멘트 접촉 만성 피부염 환자 치험 1례)

  • Kang, Ki-wan;Kim, Min-ji;Kang, Sei-young
    • The Journal of Internal Korean Medicine
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    • v.36 no.1
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    • pp.49-57
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    • 2015
  • Objectives : The purpose of this report is to investigate the effect of Taeeumin Cheonghyeolgangki-tang on chronic contact dermatitis caused by cement. Methods : A 52-year-old male patient was diagnosed with contact dermatitis with the Questionnaire for Sasang Constitutional Classification-II (QSCC-II) as well as the four methods of diagnosis (四診), and treated with Taeeumin Cheonghyeolgangki-tang (qīngxuèjiàngqí-tāng). We observed redness and scaling on both palms, and recorded photographs of any changes during the inpatient and outpatient treatment period. Results : The symptoms of contact dermatitis on both palms were significantly improved. Scaling and cracked skin disappeared and the redness almost resolved. Conclusions : Therefore, Taeeumin Cheonghyeolgangki-tang ( qīngxuèjiàngqí-tāng ) is effective on chronic contact dermatitis caused by cement.

Effects of Chogam-Tang on Rat Skin Induced the Allergic Contact Dermatitis (백서(白鼠)에 유도된 알러지성 피부염에 대한 초감탕(椒甘湯)의 효과)

  • Yoon, Hui-Sung;Park, Owe-Suk;Kim, Hee-Jeong;Kim, Keoo-Seok;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.18 no.3
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    • pp.44-54
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    • 2005
  • Background and Objectives: Allergic contact dermatitis is a common environmental health issue and seriously affect the patient's quality of life. The more our environment industrialized, the number of material that could cause the allergic contact dermatitis has been increased, consequently the prevalence of allergic contact dermatitis has been increased. In oriental medicine, clinically Chogam-Tang has been used fur the treatment of allergic dermatitis, eczema, atopic dermatitis etc. The objective of this study is to investigate the effects of Chogam-Tang on allergic contact dermatitis Meterial and Methods: Fifteen Sprague-Dawley rats were divided into three groups: normal, control, experimental group. Control and experimental group were induced allergic contact dermatitis, by DNCB. Experimental group was orally administered the Chogam-Tang. Each group was observed after 24, 48 and 72 hours. Contact hypersensitivity assay, melanin-erythema measurement, pH measurement skin moisture measurement and biopsy were performed. Results: 1. In contact hypersensitivity assay, experimental group showed decreased ear swelling compared with control group at 48hours. 2. ln melanin measurement there was no difference in three groups. 3. In erythema measurement experimental group showed reduction at 48. 72 hours. 4. In pH measurement, experimental group and control group showed increase in pH but there was no statistical significance. 5. In skin moisture measurement, experimental group showed higher skin moisture level than control group at 24 hours and showed lower skin moisture level at 72 hours, but there was no statistical significance. 6. In biopsy, experimental group showed decrement of Iymphocyte as time goes by, and regeneration of keratin layer was increased compared with normal group. Conclusions: Chogam-Tang shows anti-inflammatory effect in biopsy, improves hydration levels of skin, decreases erythema level on allergic contact dermatitis.

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Effects of Sophorae Radix on skin condition in mice with contact dermatitis induced by Dinitrofluorobenzene (고삼(苦蔘) 추출물이 접촉피부염이 유발된 생쥐의 피부에 미치는 영향)

  • Kim, Hyungwoo;Ryu, Jeonghyun;Jo, Suzy;Cheon, Wonju;Son, Yonghae;An, Won Gun;Cho, Su In
    • The Korea Journal of Herbology
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    • v.28 no.6
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    • pp.25-29
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    • 2013
  • Objectives : The dried root of Sophora flavescens Aiton have been used to treat patient with skin diseases such as eczema in Eastern countries. S. flavescens can clear away heat and dry dampness and purge sthenic-fire from the liver and gallbladder. Recently, anti-allergic effect of S. flavescens has been reported. However, the effect on skin condition of contact dermatitis still remains unknown. Thus, the purpose of this study is to evaluate the efficacy of S. flavescens on contact dermatitis. Methods : In order to investigate the effects of S. flavescens (methanol extract of S. flavescens, MESR) on skin condition, the contact dermatitis was induced in mice skin by using 1-fluoro-2,4-dinitrofluorobenzene (DNFB). As the effective endpoints, skin thickness, skin weight, histopathological change were checked. In addition, effects on skin lesion, body weight and spleen/body weight ratio were also investigated. Results : Topical application of MESR ($500{\mu}g/day$) lowered skin thickness (P < 0.05) and skin weight (P < 0.05), respectively. MESR-treated group showed diminished spongiosis and immune cell infiltration in skin tissues compared to those of non-treated control group. The inhibition of skin lesions was also observed in MESR-treated group. In addition, MESR did not affect body weight gain and spleen/body weight ratio in contrast with those in dexamethasone-treated group. Conclusion : These data suggest that Sophorae Radix could improve skin lesion of contact dermatitis. This indicates the possibility for Sophorae Radix to be used to patients with skin diseases such as contact dermatitis.