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Cytosolic prion protein induces apoptosis in human neuronal cell SH-SY5Y via mitochondrial disruption pathway

  • Wang, Xin;Dong, Chen-Fang;Shi, Qi;Shi, Song;Wang, Gui-Rong;Lei, Yan-Jun;Xu, Kun;An, Run;Chen, Jian-Ming;Jiang, Hui-Ying;Tian, Chan;Gao, Chen;Zhao, Yu-Jun;Han, Jun;Dong, Xiao-Ping
    • BMB Reports
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    • v.42 no.7
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    • pp.444-449
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    • 2009
  • Different neurodegenerative disorders like prion disease, is caused by protein misfolding conformers. Reverse-transfected cytosolic prion protein (PrP) and PrP expressed in the cytosol have been shown to be neurotoxic. To investigate the possible mechanism of neurotoxicity due to accumulation of PrP in cytosol, a PrP mutant lacking the signal and GPI (CytoPrP) was introduced into the SH-SY5Y cell. MTT and trypan blue assays indicated that the viability of cells expressing CytoPrP was remarkably reduced after treatment of MG-132. Obvious apoptosis phenomena were detected in the cells accumulated with CytoPrP, including loss of mitochondrial transmembrane potential, increase of caspase-3 activity, more annexin V/PI-double positive-stained cells and reduced Bcl-2 level. Moreover, DNA fragmentation and TUNEL assays also revealed clear evidences of late apoptosis in the cells accumulated CytoPrP. These data suggest that the accumulation of CytoPrP in cytoplasm may trigger cell apoptosis, in which mitochondrial relative apoptosis pathway seems to play critical role.

A study on the application of the intelligent control algorithms to the flow control system (유량제어계통에 대한 지능형 제어 알고리즘 적용연구)

  • 김동화;조일인
    • 제어로봇시스템학회:학술대회논문집
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    • pp.1792-1795
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    • 1997
  • It is difficulte to control in the flow system because there are many disturbance. So it is impossible to control delicately sometimes by PI or PID. In this paper, we study on the application of intellignet control algorithms such as 2DOF PID control, neural network, Fuzzy contro, Relay feedback to the flow control system. the resultings are 2DOF-PID control is more good response.

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Improved Mold Level Control for Continuous Steel Casting by Fuzzy Logic Control

  • Kueon, Yeongseob;Xiao, Wendong
    • Transactions on Control, Automation and Systems Engineering
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    • v.1 no.1
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    • pp.1-7
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    • 1999
  • This paper gives a simulation study of a new fuzzy logic control(FLC) approach for the mold level control in continuous casting processes. The proposed FLC is PID type hybridizing the conventional fuzzy PI control and Fuzzy PD control with a simplified design scheme. It is shown that, compared with the conventional control, this new control strategy can achieve superior performance for steady-state response and is more robust against process parameter variations and disturbances.

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A Comparison of the performance of mean, median, and precedence control charts for nonnormal data

  • Kim, Jung-Hee;Lee, Sung-Im;Park, Heon-Jin;Lee, Jae-Cheol;Jang, Young-Chul
    • Proceedings of the Korean Statistical Society Conference
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    • pp.197-201
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    • 2005
  • In this article, we will compare the performance of the mean control chart, the median control chart, the transformed mean control chart, the transformed median control chart, and the precedence control chart by simulation study. For control charts with transformed data, Yeo-Johnson transformation is used. Under the in-control condition, ARL's in all control charts coincide with the designed ARL in the normal distribution, but in the other distributions, only the precedence control chart provides the in-control ARL as designed. Under the out-of-control condition, the mean control chart is preferred in the normal distribution and the median control chart is preferred in the heavy-tailed distribution and the precedence control chart outperforms in the short-tailed distribution.

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Decentralized energy market-based structural control

  • Lynch, Jerome Peter;Law, Kincho H.
    • Structural Engineering and Mechanics
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    • v.17 no.3_4
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    • pp.557-572
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    • 2004
  • Control systems are used to limit structural lateral deflections during large external loads such as winds and earthquakes. Most recently, the semi-active control approach has grown in popularity due to inexpensive control devices that consume little power. As a result, recently designed control systems have employed many semi-active control devices for the control of a structure. In the future, it is envisioned that structural control systems will be large-scale systems defined by high actuation and sensor densities. Decentralized control approaches have been used to control large-scale systems that are too complex for a traditional centralized approach, such as linear quadratic regulation (LQR). This paper describes the derivation of energy market-based control (EMBC), a decentralized approach that models the structural control system as a competitive marketplace. The interaction of free-market buyers and sellers result in an optimal allocation of limited control system resources such as control energy. The Kajima-Shizuoka Building and a 20-story benchmark structure are selected as illustrative examples to be used for comparison of the EMBC and centralized LQR approaches.

Improved Nonlinear Speed Control of PM Synchronous Motor Using Time Delay Control

  • Baik, In-Cheol
    • Journal of Power Electronics
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    • v.3 no.3
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    • pp.197-204
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    • 2003
  • An improved nonlinear speed control of a permanent magnet synchronous motor (PMSM) is presented A quasi-linearized and decoupled model including the influence of parameter variations and speed measurement error on the nonlinear speed control of a PMSM is derived Using this model, to overcome the drawbacks of conventional nonlinear control scheme, the improved nonlinear control scheme which employs time delay control (TDC) scheme is proposed. To show the validity of the proposed control scheme, simulation studies are carried out and compared with the conventional control scheme.

A Method of Select Sequence Control by Remote Control in Process Control designed by SFC (SFC로 설계된 공정제어에서 Remote Control에 의한 선택 시퀀스 제어 방법)

  • You, Jeong-Bong
    • Proceedings of the KIEE Conference
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    • pp.134-136
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    • 2007
  • Sequential Function Chart(SFC) is very easy to grasp the sequential flow of control logic and has the compatability for a maintenance, In process control, when an error is occurred, to execute other routine by force, we control the process by remote control. In this paper, we proposed the method of select sequence control by remote control in process control designed by Sequential Function Chart(SFC).

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Vibration Suppression Control for an Articulated Robot;Effects of Model-Based Control Integrated into the Position Control Loop

  • Itoh, Masahiko
    • 제어로봇시스템학회:학술대회논문집
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    • pp.2016-2021
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    • 2003
  • This paper deals with a control technique of eliminating the transient vibration with respect to a waist axis of an articulated robot. This control technique is based on a model-based control in order to establish the damping effect on the driven mechanical part. The control model is composed of reduced-order electrical and mechanical parts related to the velocity control loop. The parameters of the control model can be obtained from design data or experimental data. This model estimates a load speed converted to the motor shaft. The difference between the estimated load speed and the motor speed is calculated dynamically, and it is added to the velocity command to suppress the transient vibration. This control method is applied to an articulated robot regarded as a time-invariant system. The effectiveness of the model-based control integrated into the position control loop is verified by simulations. Simulations show satisfactory control results to reduce the transient vibration at the end-effector.

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Optimal Learning Control Combined with Quality Inferential Control for Batch and Semi-batch Processes

  • Chin, In-Sik;Lee, Kwang-Soon;Park, Jinhoon;Lee, Jay H.
    • 제어로봇시스템학회:학술대회논문집
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    • pp.57-60
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    • 1999
  • An optimal control technique designed for simultaneous tracking and quality control for batch processes. The proposed technique is designed by transforming quadratic-criterion based iterative learning control(Q-ILC) into linear quadratic control problem. For real-time quality inferential control, the quality is modeled by linear combination of control input around target qualify and then the relationship between quality and control input can be transformed into time-varying linear state space model. With this state space model, the real-time quality inferential control can be incorporated to LQ control Problem. As a consequence, both the quality variable as well as other controlled variables can progressively reduce their control error as the batch number increases while rejecting real-time disturbances, and finally reach the best achievable states dictated by a quadratic criterion even in case that there is significant model error Also the computational burden is much reduced since the most computation is calculated in off-line. The Proposed control technique is applied to a semi-batch reactor model where series-parallelreactions take place.

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Control Improvement of Control Loop with Deadband Control Valve (데드밴드 제어밸브를 가진 제어루프의 제어 개선)

  • Lee, Kwang-Dae;Oh, Eung-Se;Yang, Seung-Ok
    • Proceedings of the KIEE Conference
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    • pp.318-320
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    • 2006
  • A control valve with deadband characteristics influences on the control dynamics. A control loop with deadband component shows cyclic control results and causes the wears of mechanical parts. A valve on the important process that require nonstop operation cannot be improved during operation. In case of control loops with deadband dynamics, the optimal control parameters based on the performance only are not sure of the good operation in point of protecting the control component. To improve the control performance and control oscillation, the control parameters should be changed to meet both control qualify and protection of control components.

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