• Title, Summary, Keyword: corticosterone

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Effect of Corticosterone on Hypothalamic Corticotropin-releasing Hormone Expression in Broiler Chicks (Gallus gallus domesticus) Fed a High Energy Diet

  • Song, Zhigang;Yuan, Lei;Jiao, Hongchao;Lin, Hai
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.12
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    • pp.1736-1743
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    • 2011
  • This paper reports the peripheral and central effect of corticosterone on feed intake and hypothalamic corticotropinreleasing hormone (CRH) gene expression in chicks fed a high energy diet. Three experiments were conducted: corticosterone was supplemented to the feed (30 mg/kg diet), injected subcutaneously (s.c., 4 mg/kg body weight) or intracerebroventricularly (i.c.v., 4 ng). The results showed that dietary corticosterone significantly increased feed intake. The s.c. corticosterone administration increased feed intake within 1 to 3 h and at 1 to 5 h after the injection. The i.c.v. corticosterone administration increased feed intake within 1 h after the injection, but not at 1 to 3 h. Dietary supplementation and s.c. injection of corticosterone decreased the CRH gene expression in the hypothalamus. Therefore, peripheral corticosterone exerted a decreased effect on hypothalamic CRH mRNA levels, and corticosterone had a stimulating effect on feed intake in broiler chicks fed a high energy diet.

Effects of Dietary Corticosterone on Yolk Colors and Eggshell Quality in Laying Hens

  • Kim, Yeon-Hwa;Kim, Jimin;Yoon, Hyung-Sook;Choi, Yang-Ho
    • Asian-Australasian Journal of Animal Sciences
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    • v.28 no.6
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    • pp.840-846
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    • 2015
  • The objective of this study was to investigate the effects of dietary corticosterone on egg quality. For 2 weeks hens received either control or experimental diet containing corticosterone at 30 mg/kg diet. Feed intake and egg production were monitored daily, and body weight measured weekly. Egg weights and egg quality were measured daily. Corticosterone treatment resulted in a remarkable increase in feed intake and sharp decrease in egg production compared with control (p<0.05) whereas body weight remained unchanged. Decreased albumen height, but no changes in egg weight, led to decreased Haugh unit (p<0.05). Corticosterone caused elevated eggshell thickness (p<0.05) without altering weight and strength, suggesting possible changes in shell structure. Yolk color and redness were increased by corticosterone (p<0.05) but lightness and yellowness were either not changed or inconsistent over the time period of measurements. Increased concentrations in plasma were also found for corticosterone, glucose, cholesterol, creatinine, uric acid, albumin, aspartate aminotransferase, creatine kinase, lactate dehydrogenase, total protein, and amylase (p<0.05), suggesting that corticosterone increased protein breakdown, renal dysfunctions and pancreatitis. Together, the current results imply that dietary corticosterone affects egg quality such as yolk colors and shell thickness, in addition to its effects on feed intake and egg production.

Effect of Corticosterone Pretreatment on the Production of LPS-Induced Inflammatory Mediators in RAW 264.7 Cells (RAW 264.7 Cell에서 리포폴리사카라이드로 유도된 염증성 매개인자들의 생산에 있어서 Corticosterone 전처리 효과)

  • Chae, Byeong Suk
    • YAKHAK HOEJI
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    • v.59 no.5
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    • pp.215-221
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    • 2015
  • Glucocorticoids are known to have anti-inflammatory effect. To investigate whether corticosterone pretreatment enhances or not lipopolysaccharide (LPS)-induced production of inflammatory mediators, RAW 264.7 cells were pretreated with various concentrations of corticosterone for 24 h and then cultured without corticosterone in the presence or absence of LPS. Our results demonstrated that LPS remarkably increased production of TNF-${\alpha}$, IL-6, IL-$1{\beta}$, vascular endothelial growth factor (VEGF), and NO (nitric oxide). Corticosterone pretreatment significantly attenuated LPS-induced production of TNF-${\alpha}$, IL-$1{\beta}$, and VEGF, while significantly enhanced IL-6 and NO. These findings suggest that corticosterone pretreatment may contribute to LPS-induced inflammatory responses in macrophages via pro- and anti-inflammatory imbalance of inflammatory mediators.

Enhancement of Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated Injections of Corticosterone

  • Lim, Hee-Na;Jang, So-Yong;Lee, Yeon-Ju;Moon, So-Hyeon;Kim, Ji-Eun;Oh, Sei-Kwan
    • Biomolecules & Therapeutics
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    • v.20 no.4
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    • pp.418-424
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    • 2012
  • Repeated stress induces corticosterone release. However, it is not clear that stress results in further elevation of corticosterone levels, and the roles of released corticosterone to aggravate stress-related symptoms are also not clear. This study investigated whether neuronal modulation was induced in the amygdala after two kinds of stress, that is, such as electric shock and corticosterone injection. It was found that stress by electric shock decreased the expression of tyrosine hydoroxylase (TH) in the amygdala while the expression of pERK was increased. However, there is no difference in the expressions of TH and pERK in the frontal cortex compared with those of the control group. The level of corticosterone was significantly increased in the serum after stress. To determine the effect of corticosterone on the induction of anxiety and the expression of TH, the rats received corticosterone (20 mg or 40 mg/kg i.p.) for 1 day, 1 week, 2 weeks and 3 weeks, respectively. The spent time in open arms of the EPM (elevated plus maze) test was significantly decreased after 1 week, 2 weeks and 3 weeks. The time spent in open arms of the EPM test after repeated injections of corticosterone was significantly decreased in a dose-dependent manner. The expression of TH in the amygdala was reduced after following repeated corticosterone treatment for 2 weeks and 3 weeks. Collectively, this study suggests that corticosterone has a major role in the induction of anxiety and the modulation of TH expression, at least, in the amygdala.

Influence of Chlordiazepoxide on the Changes of Blood Sugar and Plasma Corticosterone Level Induced by ACTH and Picrotoxin in Mice (ACTH와 Picrotoxin에 의(依)한 혈당(血糖)과 혈장(血漿) Corticosterone 치(値)의 변동(變動)에 미치는 Chlordiazepoxide의 영향(影響))

  • Kim, Young-Gyu;Shin, Man-Ryun
    • The Korean Journal of Pharmacology
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    • v.16 no.2
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    • pp.39-44
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    • 1980
  • Marc et al. reported that diazepam increased plasma corticosterone level and Dasgupta et al. suggested that chlordiazepoxide(CDP) supressed the adrenal response to ACTH. In this paper, the influence of CDP on the changes of blood sugar and plasma corticosterone level induced by ACTH and picrotoxin were investigated in male mice. The results obtained were summarized as follows; 1) The blood sugar and plasma corticosterone level were increased by CDP, ACTH, and picrotoxin, respectively. 2) The hyperglycemia induced by ACTH and picrotoxin were not affected by the CDP pretreatment. 3) The increase of plasma corticosterone level induced by ACTH was inhibited by the CDP pretreatment. 4) The increase of plasma corticosterone level appeared 30 minutes after picrotoxin injection was slightly enhanced, but the level of 120 minutes after picrotoxin injection was significantly inhibited by the CDP pretreatment.

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Influences of Diazepam and Naloxine on the increase of Plasma Corticosterone Level induced by Morphine and Pentazocine (Morphine과 Pentazocine의 혈장 Corticosterone 증가작용에 미치는 Naloxone 및 Diazepam의 영향)

  • Chun, Boe-Gwun;Park, Jung-Yul;Cho, Geun-Haeng;Kim, Soo-Kyung
    • The Korean Journal of Pharmacology
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    • v.19 no.1
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    • pp.115-122
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    • 1983
  • The influences of diazepam and naloxone on the increase of plasma corticosterone level induced by morphine, pentazocine, ACTH, or picrotoxin were investigated in male mice. The results obtained were summarized as follows: 1) The increase induced by morphine or pentazocine of plasma corticosterone level was not affected by naloxone pretreatment but markedly suppressed by diazepam pretreatment. 2) The increase induced by ACTH of plasma corticosterone level was not affected by diazepam or naloxone pretreatment. 3) The picrotoxin markedly increased plasma corticosterone level, and the inceease was not affected by diazepam or naloxone pretreatment. This above results suggest that the increase induced by opioids of plasma corticosterone level seems to be rather related with other than opiate- or GABArerecptor.

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Effects of Glycyrrhizae Radix on Serum Corticosterone and Blood Histamine Content by Immobilization Stress in Mice (감초(甘草) 엑기스가 Immobilization Stress 부하(負荷)후 혈중(血中) Corticosterone 및 Histamine 함량변화(含量變化)에 미치는 영향)

  • Eun, Jae-Soon;Oh, Chan-Ho;Han, Jong-Hyun
    • Korean Journal of Pharmacognosy
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    • v.20 no.1
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    • pp.37-42
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    • 1989
  • This study was carried out to investigate the effect of Glycyrrhizae Radix on serum corticosterone and blood histamine content by immobilization stress in mice. Corticosterone secretion and blood histamine level was significantly increased in mice by subjecting the animals to immobilization stress 1 hr. after intraperitoneal injection of Glycyrrhizae Radix extract (150 mg/kg) and glycyrrhizinic and (15 mg/kg). whereas, administration of cortisol $(7.5\;{\mu}g/kg)$ provoked a decrease in corticosterone secretion and histamine levels. These results suggested that glycyrrhizinic acid was effective on cortiosterone release provoked by immobilization stress and this release was mediated in part by histamine.

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Effect of Each Constituent-Herb of Sagoonja-Tang on the Change of Corticosterone Level induced by Heat Stress in Mice (Heat Stress로 유발된 생쥐의 혈중 corticosterone 농도변화에 대한 사군자탕(四君子湯) 구성약물의 효능)

  • Jo Yong-Kook;Lee Tae-Hee
    • Herbal Formula Science
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    • v.11 no.2
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    • pp.147-158
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    • 2003
  • This study aimed to investigate the effect of each constituent-herb of Sagoonja-Tang on the plasma corticosterone level in mice exposed to heat stress. Each formula(0.5g/kg, 1.0g/kg) was injected intragastrically to mice exposed to forced hot water swimming(42$^{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 15 minutes after the heat stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group didn't show significant changes. 3. Atractylodis group showed significant decrease at 0.5g/kg dose(P<0.05). But it showed slightly increase at 1.0g/kg dose. 4. Poria group didn't show significant changes. 5. Glycyrrhizae group showed slightly increase, but insignificant. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level in mice exposed to heat stress.

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Effects of Dietary Green Tea on Egg Storage in Laying Hens Under Stress (녹차의 급여가 스트레스하의 산란계가 생산한 계란의 저장성에 미치는 영향)

  • Kim, Jimin;Yoon, Hyung-Sook;Choi, Yang-Ho
    • Korean Journal of Organic Agriculture
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    • v.22 no.4
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    • pp.815-823
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    • 2014
  • Green tea has been known to show beneficial effects on alleviating stress. The present study was conducted to determine the effects of dietary green tea on quality of eggs, during storage, laid by laying hens treated with corticosterone in order to mimic the current practice of the egg market. Hens were fed for 2 weeks one of three diets containing green tea at 0.0, 0.4 or 1.0%. Each dietary group was divided into two subgroups receiving corticosterone at 0 or 30 mg/kg for 1 week. Eggs, laid at 5-7 days following the initiation of corticosterone treatment, were stored at $10^{\circ}C$ for 1 or 5 weeks and then analyzed for egg quality. After 1 week of storage, egg weight was significantly increased by green tea (p<0.025) but decreased by corticosterone (p<0.0001), but no interaction was observed between both. Corticosterone decreased shell color (p<0.0001) but green tea significantly decreased shell strength (p<0.006). Yolk color, albumen height and Haugh unit were not affected by both treatments. After 5 weeks of storage, corticosterone resulted in reduced egg weight (p<0.01) and eggshell color (p<0.001) and increased shell strength, which were not attenuated by green tea. Taken together, the results of the current study show that dietary corticosterone reduces egg quality during storage, which are attenuated in part by dietary green tea.

Effect of Each Constituent-Herb of Sagoonja-Tang on the Change of Corticosterone Level induced by Cold Stress in Mice (Cold Stress로 유발된 생쥐의 혈중 corticosterone 농도변화에 대한 사군자탕(四君子湯) 구성약물의 효능)

  • Kwon Yong-Uk;Lee Tae-Hee
    • Herbal Formula Science
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    • v.11 no.2
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    • pp.83-94
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    • 2003
  • This study aimed to investigate the effects of each constituent-herb of Sagoonja- Tang on the plasma corticosterone level in mice exposed to cold stress. Sagoonja-Tang is composed of Ginseng Radix, Atractylodis Radix, Poria, and Glycyrrhizae Radix. Each constisuent-herb(0.5g/kg, 1.0g/kg) was administered intragastrically to mice 1hr prior to expose to forced cold water swimming($4{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 30 minutes after the cold stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group(PGR group) didn't show any significant changes. 3. Atractylodis group(AR group) showed significant decrease at 0.5g/kg dose (P<0.01). But it didn't show significant changes at 1.0g/kg dose. 4. Poria group(P group) didn't show significant changes. But it showed slightly increase at 1.0g/kg dose. 5. Glycyrrhizae group(GR group) didn't show significant changes. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level and the dose of herbs had a different effect on the plasma corticosterone level in mice exposed to cold stress.

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