• Title, Summary, Keyword: development

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Cloning and characterization of the cardiac-specific Lrrc10 promoter

  • Fan, Xiongwei;Yang, Qing;Wang, Youliang;Zhang, Yan;Wang, Jian;Yuan, Jiajia;Li, Yongqing;Wang, Yuequn;Deng, Yun;Yuan, Wuzhou;Mo, Xiaoyang;Wan, Yongqi;Ocorr, Karen;Yang, Xiao;Wu, Xiushan
    • BMB Reports
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    • v.44 no.2
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    • pp.123-128
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    • 2011
  • Leucine-rich repeat containing protein 10 (LRRC10) is characterized as a cardiac-specific gene, suggesting a role in heart development and disease. A severe cardiac morphogenic defect in zebrafish morphants was recently reported but a contradictory result was found in mice, suggesting a more complicated molecular mechanism exists during mouse embryonic development. To elucidate how LRRC10 is regulated, we analyzed the 5'enhancer region approximately 3 kilo bases (kb) upstream of the Lrrc10 start site using luciferase reporter gene assays. Our characterization of the Lrrc10 promoter indicates it possesses complicated cis-and trans-acting elements. We show that GATA4 and MEF2C could both increase transcriptional activity of Lrrc10 promoter individually but that they do not act synergistically, suggesting that there exists a more complex regulation pattern. Surprisingly, knockout of Gata4 and Mef2c binding sites in the 5’enhancer region (-2,894/-2,889) didn't change the transcriptional activity of the Lrrc10 promoter and the likely GATA4 binding site identified was located in a region only 100 base pair (bp) upstream of the promoter. Our data provides insight into the molecular regulation of Lrrc10 expression, which probably also contributes to its tissue-specific expression.

A Sociological Approach to Sustainable Development (지속가능한 발전의 사회학적 고찰)

  • Jeong, Dai-Yeun
    • Journal of Environmental Impact Assessment
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    • v.12 no.1
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    • pp.55-72
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    • 2003
  • The term sustainable development is being used widely since WCED suggested it in 1987. This paper aims at catching up its sociological implications. For doing this, the paper examined some major existing researches on sustainable development. It was found that sustainable development has been defined as an economic development with the preservation of nature as an environment of human life. In this sense, the existing concept of sustainable development is an economic perspective. Sustainable development as an economic perspective is faced with some limitations and/or problems. They are summarized as follows. The human-made environment is excluded from the concept of sustainable development. Its ideology is anthroponcentric in that the sustainability of nature is a necessary condition for economic development. The objective reference which can measure whether the current state of nature is sustainable or not is not proposed. Consequently, sustainable development results in merely a survivability of economy, a new form of economic utility and/or a successful economy. In terms of sociological perspective, economy and nature can not be sustainable without other social factors being sustainable, because all social factors including economy and nature exist in a causal mechanism. This means that sustainable development should be approached from a multi-dimensional perspective. The multi-dimensional approach can be a framework of sustainable development in terms of whole society, then can be termed sustainable society which implies not a sustainable development, but a societal development. The factors which should be included in the sustainable society are, at least, nature, economy, population as an aggregate, mode of living existence of people as a cultural actor, technology, and social structure.

Promotion of Asexual Development and Inhibition of Sexual Development of Aspergillus nidulans by Short-Chain Primary Amines

  • Song, Myung-Hoon;Kuppusamy Selvam;Park, Chang-Jun;Jahng, Kwang-Yeop;Han, Dong-Min;Chae, Keon-Sang
    • Journal of Microbiology
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    • v.40 no.3
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    • pp.230-233
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    • 2002
  • Effects of short-chain primary amines on Aspergillus nidulans development were analyzed. Propylamine induced asexual development and inhibited sexual development. Even on medium containing lactose as the sole carbon source, on which little conidial heads are formed and sexual structures are formed preferentially, or when sexual development was induced, propylamine induced asexual development and inhibited sexual development. These effects of propylamine seemed to be due to accumulation of mRNA of the brlA gene, which has been identified as a positive regulator of asexual development, and due to the reduction of the veA mRNA level. The veA gene has been identified as an activator of sexual development and also as an inhibitor of asexual development. Other primary amines, methylamine and ethylamine, showed identical effects on development where short-chain primary amino also promoted asexual development and inhibited sexual development.

An Inquiry into the Orientation of Education for Sustainable Development in the 21st Century Knowledge-Based Society (21세기 지식 기반 사회에서의 지속가능발전 교육 방향 탐색)

  • Ji, Seung-Hyun;Nam, Young-Soak
    • Hwankyungkyoyuk
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    • v.20 no.1
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    • pp.62-72
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    • 2007
  • In spite of the perceived importance of sustainable development in society, we still fails to reflect consistently our best understandings about the sustainable development and education for sustainable development. The purpose of this study is to inquire into the orientation of education for sustainable development in the 21st Century knowledge-based society. The results of this study can be summarized as follows. First, it is necessary to provide newly defined sustainable development which enables us to transform unsustainable way of life into environmentally sound and sustainable development. Education for sustainable development is defined as a basic education that have a mature understanding among the human, nature and wisdom of life. Second, we should emphasis on a system thinking, basic communication in order to encourage education for sustainable development as a learning strategy. Third, we should suggest both individual and community learning education for sustainable development. Finally, we develope knowledge system of sustainable development in accordance with the theories of knowledge management. In conclusion, it is necessary to approach education for sustainable development in the context of the knowledge-based society and the information age. It enables us enhance a new awareness and attitudes towards sustainable development. Furthermore, it is expected to develop an education program for the sustainable development of understanding.

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The Study for Correlation Among Auditory Development and Language Development of Children with Hearing Impairment (청각장애 아동의 청능발달과 언어발달간의 상관관계 연구)

  • Park, Sang-Hee;Kwon, Young-Ju
    • Speech Sciences
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    • v.10 no.4
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    • pp.255-261
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    • 2003
  • The purpose of this study was to investigate correlation of auditory development and language development of children with hearing impairment Eighteen subjects with severe or profound hearing loss participated in this study. They were 22-to 55-month-olds who had hearing parents with no additional disabling conditions. The test material was the Meaningful Auditory Integration Scale (MAIS) and MacArthur Communicative Development Inventory-Korea (MCDI-K). A Pearson Correlation Coefficient was determined through a statistical analysis. The results followed as; firstly there was a strong correlation between auditory development and receptive language development. Secondly, there was a strong correlation between receptive language development and expressive language development. Finally, there was a strong correlation between auditory development and education onset time. Therefore, auditory training is important method for auditory rehabilitation and education onset time is important variation for auditory development.

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Waterfront Development Project Pattern Analysis of the Coastal Zone Management of the Osaka Bay

  • Yang, Jae-Joon;Yhang, Wii-Joo
    • Journal of Navigation and Port Research
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    • v.27 no.3
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    • pp.329-333
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    • 2003
  • Study of the background and state of Osaka's waterfront space development and analysis of the functions of 22 chosen major facilities of development project reveals the following four types: amenity-oriented development, large-scale synthesis type development, renewal compound area type development, exchange communication promotion type development. Osaka bay area has served primely as the base of harbors, industry and energy, while analysis of the ongoing project has found that the city has been making a functional transition to a type of development to live up to the needs of the times, suggesting that is wise that Korea's future direction of waterfront development be oriented toward environmental-friendly development by taking advantage of low-density area's natural resources. Given the plurality and complexity of the law of coastal zone, what is needed is a legal maintenance for coastal zone's clear-cut coordinating function and for environmental-friendly development with the limitations of seaside and coastal functions in mind.

A Comparative Study on Rural Development of Korea and EU (한국과 EU의 농촌개발의 비교)

  • Lim, Hyung-Baek;Cho, Joong-Koo
    • Journal of Korean Society of Rural Planning
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    • v.10 no.2
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    • pp.25-34
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    • 2004
  • The objectives of this study were to compare rural development of Korea and EU. According to its traits the peroids of rural development of Korea can be divided into low periods. According to its memberships and traits the periods of rural development of EU can be divided into low periods. There are many similarities between Korea and EU in agricultural situation and rural development. EU introduced multifunctionality of agriculture in 1980s and adopt strong policy to support that in 1990s. And EU made a effort sustainable rural development, integrated rural development and balanced regional development. Recently Korea not only maintain agricultural expanisionism but also pay attention to multifunctionality of agriculture. But rural development of Korea still in the stage of physical planning and agricultural expanisionism. So it leaves much room for improvement to rural development of Korea in rural development regulation, unifying theme, detail planning, integration among policies, balanced regional development, etc.