• Title, Summary, Keyword: di-ethylhexyl phthalate

Search Result 114, Processing Time 0.045 seconds

Toxicogenomic Gene Profiles using KISTCHIP-400 in MCF-7 cells after Exposure to Di(2-ethylhexyl) Phthalate (DEHP) and Dibutyl Phthalate (DBP)

  • Yun, Hye-Jung;Kim, Youn-Jung;Kim, Eun-Young;Kim, Ick-Young;Ryu, Jae-Chun
    • Proceedings of the Korean Society of Toxicology Conference
    • /
    • /
    • pp.128-128
    • /
    • 2003
  • There are many synthetic chemicals, such as di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP), used in chemical reaction processes in industry. The establishment of toxicity and detection of synthetic chemicals that may pose a genetic hazard in our enviornment is subjects of great concern at present.(omitted)

  • PDF

The Level of Total Phthalate Esters and Di-(2-ethylhexyl) Adipate in Disposable Sanitary Gloves (일회용 위생장갑에서 Phthalate류 및 Di-(2-ethylhexyl) adipate 분석)

  • Lee, Kwang-Ho;Kwon, Ki-Sung;Kwak, In-Shin;Choi, Jae-Chon;Jeon, Dae-Hoon;Jeong, Dong-Youn;Choi, Byung-Hee;Kim, Sung-Wook;Lee, Sun-Hee;Lee, Chul-Won
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
    • /
    • v.6 no.1
    • /
    • pp.41-46
    • /
    • 2000
  • The level of plasticizer such as diethyl phthalate (DEP), di-n-propyl phthalate (DprP), di-n-butyl phthalate (DBP), di-n-pentyl phthalate (DPP), butylbenzyl phthalate (BBP), di-(2-ethylhexyl) phthalate (DEHP), dicyclohexyl phthalate (DCHP) and di-(2-ethylhexyl) adipate (DEHA) was determined in disposable sanitary gloves. Samples of disposable sanitary gloves were taken at retail shops, and their overall extractions in carbon tetrachloride were measured, after establishment of soxhlet appratus in 6 hours. All of 8 samples of disposable sanitary gloves at retail shops were polyethylene (PE). All of the manufactures was voluntarily labelled their boxes of gloves in line Korea Food Code. The level of phthalate esters and DEHA in all of 8 samples were not exceed the detection limit. The detection limits of DEP, DprP, DBP, DPP, BBP, DEHP, DCHP and DEHA were 1.8, 1.9, 1.3, 1.1, 0.9, 0.7, 2.1 and 0.8 mg/L, respectively.

  • PDF

Biomarker-Based Exposure to Phthalates and Related Factors with Demographics (프탈레이트의 노출 정도 및 인구학적 특성과의 관련요인)

  • 구정완;이강숙;박정일;구현정;이병무
    • Toxicological Research
    • /
    • v.19 no.4
    • /
    • pp.297-301
    • /
    • 2003
  • To investigate biomarker-based exposure to phthalates and related factors with demographics, 100 subjects who had participated in comprehensive health check-up were selected. We collected demographics through questionnaires and analyzed urine samples for 5 phthalates. Statistical likelihoods and regression methods were applied for data analysis using censored data. The highest levels of urine phthalates were 216$\mu\textrm{g}$/ml in di-isodecyl phthalate, 29.0$\mu\textrm{g}$/ml in di-butyl phthalate, 5.78$\mu\textrm{g}$/ml in di-(2-ethylhexyl) phthalate. The median values of di-(2-ethylhexyl) phthalate were 0.2340 $\mu\textrm{g}$/ml for male smokers, 0.0399 $\mu\textrm{g}$/ml for male non-smokers and 0.0085 $\mu\textrm{g}$/ml for female non-smokers, respectively. Di-(2-ethylhexyl) phthalate, benzyl butyl phthalate and di-isodecyl phthalate were higher in males than in females. In addition, mono-2-ethylhexyl phthalate was decreased with age. Our findings suggest that there might be significant demographic variations in exposure and/or metabolism of phthalates, and that health-risk assessment for phthalate exposure in humans should consider different potential risk groups.

A Study on Nonylphenol, Octylphenol, and Di (2-ethylhexyl)phthalate in Sewage Sludge (하수슬러지 중 Nonylphenol, Octylphenol, Di (2-ethylhexyl)phthalate 의 연구)

  • Kim, Jong-Hun
    • Analytical Science and Technology
    • /
    • v.15 no.5
    • /
    • pp.451-458
    • /
    • 2002
  • Determination were performed for the presence of three common environmental endocrine disrupting compounds (EDC), namely nonylphenol (NP), octylphenol (OP), di (2-ethylhexyl)phthalate in sewage sludge from 67 wastes plants, using Soxhlet extraction and GC/MS-SIM. NP and DEHP were detected in almost every sludges but OP was not detected. The range and mean value for NP of all sludge samples were nd~593, $62{\mu}g/g$ dry and the two statistic values for DEHP of those were 13~4733, $1176{\mu}g/g$ dry respectively. DEHP content was 20 times greater than NP in sludges. Concentrations of NP and DEHP in sludge from individual area were increased as following order ; Jeolla South and North Province (Cheju) < Chungcheong South and North Province (Kwangwon) < Gyungsang South and North Province < Wide City < Kyunggi Province.

In vivo Effects of Di-n-butyl Phthalate and Di-2-ethylhexyl Phthalate on the Nonspecific Defense Mechanism of the Bagrid Catfish, Pseudobagrus fulvidraco

  • Masroor Fatima;Jee Jung-Hoon;Keum Yoo-Hwa;Kang Ju-Chan
    • Fisheries and aquatic sciences
    • /
    • v.9 no.1
    • /
    • pp.14-21
    • /
    • 2006
  • The aim of this study was to investigate in vivo toxicity and effects of two phthalate esters (PEs), di-n-butylphthalate (DBP) and di-2-ethylhexyl phthalate (DEHP), on the immune system of the bagrid catfish, Pseudobagrus fulvidraco. Groups of experimental fish were subjected to daily intraperitoneal injections of 300 or 1000 mg $kg^{-1}$ of DBP or DEHP for 3 days, and the cellularity and functional activity of phagocytes were measured in the spleen and pronephros (head kidney). The number of spleen leukocyte cells increased significantly (p<0.05) in response to low and high doses of DEHP and DBP, respectively; however, the cellularity of the pronephros was more susceptible to higher dose of DEHP than DBP. Nonspecific immunity, as determined by the phagocytic index (PI) and phagocytic capacity (PC), was significantly depressed by DEHP at 1000 $1000mg\;kg^{-1}\;day^{-1}$ in the pronephros at 3 days after injection. Furthermore, significantly (p<0.05) increased levels of serum glutamic oxaloacetate transaminase (GOT) and glutamic pyruvate transaminase (GPT) indicated marked hepatic dysfunction in immunosuppressed fish. Treated fish showed a significant reduction in total serum protein but no significant alteration in lysozyme activity. These results demonstrate the sensitivity of the fish immune response for predicting PE-induced immunotoxicity.

Thermal Decomposition Products of Phthalates with Poly(vinyl chloride) and Their Mutagenicity

  • Katsuhiko Saido;Hiroyuki Taguchi;Satoru Yada;Ryu, In-Jae;Chung, Seon-Yong
    • Macromolecular Research
    • /
    • v.11 no.3
    • /
    • pp.178-182
    • /
    • 2003
  • The thermal decomposition of phthalate alone and with poly(vinyl chloride) (PVC) was carried out under a nitrogen atmosphere in a 4-necked separable flask. The thermal decomposition of phthalate in the presence of PVC began at 150$^{\circ}$, about 10$0^{\circ}C$ lower than the decomposition of phthalate alone. The formation of octyl chloride indicated an interaction reaction between phthalate and PVC. From the analysis of the composition of commercially plasticized PVC sheet (film and board), the phthalates (dibutyl phthalate, dihexyl phthalate) and di(2-ethylhexyl) phthalate), 2-ethyl-1-hexanol, phthalic anhydride, and 2-ethylhexyl hydrogen phthalate were identified. The mutage-nicities of these decomposition products were higher than those of phthalic diesters (phthalates).

Di(2-ethylhexyl) Phthalate Induces the Apoptotic Cell Death Mediated by Production of Reactive Oxygen Species in Human Keratinocyte (미세먼지의 di(2-ethylhexyl) phthalate가 유도한 피부상피세포 사멸 신호전달기전 연구)

  • Park, Jeong-Bae;Kim, Ji-Yun;Sung, Junghee;Kim, Yong-ung;Lee, Sei-Jung
    • Journal of Environmental Science International
    • /
    • v.29 no.3
    • /
    • pp.249-255
    • /
    • 2020
  • Particulate matter with an aerodynamic diameter of less than 2.5 μM (PM2.5) is one of the major environmental pollutants. Di(2-ethylhexyl) phthalate (DEHP), an endocrine disrupting chemical in PM2.5, has been utilized for the manufacturing of polyvinyl chloride to increase the flexibility of final products. In the present study, we investigated the ecotoxicological effect of DEHP on the viability of skin keratinocytes (HaCaT). DEHP induced apoptotic cell death mediated by phosphorylation of extracellular signal-regulated kinase through the production of intracellular Reactive Oxygen Species (ROS). Interestingly, we found that DEHP induces the phosphorylation of the nuclear factor-kappa B responsible for the expression of cleaved caspase-3 as an executional cell death protease in HaCaT cells. On the basis of these results, we suggest that DEHP in PM2.5 induces the apoptotic death of human keratinocytes via ROS-mediated signaling events.